FlyBase Gene Report: Dmel\Dlat

General Information

Symbol

Dmel\Dlat

Species

D. melanogaster

Name

Dihydrolipoamide S-acetyltransferase

Annotation Symbol

CG5261

Feature Type

protein_coding_gene

FlyBase ID

FBgn0283658

Gene Model Status

Current

Stock Availability

13 publicly available

Enzyme Name (EC)

pyruvate dehydrogenase system (1.2.1.104)

dihydrolipoyllysine-residue acetyltransferase (2.3.1.12)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

muc, midline uncoordinated

Key Links

Genomic Location

Cytogenetic map

27F4-27F4

Sequence location

2L:7,426,866..7,430,329 [+]

Recombination map

2-26

RefSeq locus

NT_033779 REGION:7426866..7430329

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables acyltransferase activity

inferred from electronic annotation with InterPro:IPR001078

(InterPro Project Members, 2004-)

enables dihydrolipoyllysine-residue acetyltransferase activity

inferred from biological aspect of ancestor with PANTHER:PTN002351721

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR006257

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with UniProtKB:P08461

(Gene Ontology Curators, 2002-)

contributes_to pyruvate dehydrogenase (NAD+) activity

inferred from sequence or structural similarity with UniProtKB:P10515

(Gene Ontology Curators, 2002-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in grooming behavior

inferred from mutant phenotype

(Phillis et al., 1993)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in acetyl-CoA biosynthetic process from pyruvate

inferred from electronic annotation with InterPro:IPR045257

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000568044

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:P08461

(Gene Ontology Curators, 2002-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in major mitochondrial derivative

inferred from direct assay

(Laurinyecz et al., 2019)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in mitochondrion

inferred from sequence or structural similarity with UniProtKB:P08461

(Gene Ontology Curators, 2002-)

part_of pyruvate dehydrogenase complex

inferred from sequence or structural similarity with UniProtKB:P08461

(Gene Ontology Curators, 2002-)

inferred from electronic annotation with InterPro:IPR045257

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR006257, InterPro:IPR045257

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000568044

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

S-ACETYLTRANSFERASES

PYRUVATE DEHYDROGENASE COMPLEX - PDHA1 VARIANT

PYRUVATE DEHYDROGENASE COMPLEX - PDHA2 VARIANT

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

dihydrolipoyllysine-residue acetyltransferase activity

N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)- acetyldihydrolipoyl]-L-lysyl-[protein] + CoA (2.3.1.12)

RHEA 17017: pyruvate dehydrogenase (NAD+) activity

pyruvate + NAD(+) + CoA = acetyl-CoA + CO2 + NADH (1.2.1.104)

RHEA 28042:

Summaries

Gene Group (FlyBase)

S-ACETYLTRANSFERASES -: S-acetyltransferases catalyze the transfer of an acetyl group to a sulfur atom on the acceptor molecule.
PYRUVATE DEHYDROGENASE COMPLEX - PDHA1 VARIANT -: The eukaryotic Pyruvate Dehydrogenase Complex (PDC) is a multi-enzyme complex organized around a dodecahedral core formed by the dihydrolipoyl transacetylase (E2) component. To this core, multiple copies of the thiamin diphosphate-dependent pyruvate dehydrogenase (E1) component, the FAD-containing dihydrolipoamide dehydrogenase (E3) component, and one to two copies each of pyruvate dehydrogenase kinase (PDK) and pyruvate dehydrogenase phosphatase (PDP, which comprises a catalytic and regulatory subunit) are tethered via non-covalent interactions. The PDC functions in the mitochondrial matrix to catalyze the oxidative decarboxylation of pyruvate to produce acetyl-CoA and NADH and as such is the gate-keeper enzyme that links glycolysis to the Krebs cycle and lipogenic pathways. (Adapted from PMID:19081061.)
PYRUVATE DEHYDROGENASE COMPLEX - PDHA2 VARIANT -: The eukaryotic Pyruvate Dehydrogenase Complex (PDC) is a multi-enzyme complex organized around a dodecahedral core formed by the dihydrolipoyl transacetylase (E2) component. To this core, multiple copies of the thiamin diphosphate-dependent pyruvate dehydrogenase (E1) component, the FAD-containing dihydrolipoamide dehydrogenase (E3) component, and one to two copies each of pyruvate dehydrogenase kinase (PDK) and pyruvate dehydrogenase phosphatase (PDP, which comprises a catalytic and regulatory subunit) are tethered via non-covalent interactions. The PDC functions in the mitochondrial matrix to catalyze the oxidative decarboxylation of pyruvate to produce acetyl-CoA and NADH and as such is the gate-keeper enzyme that links glycolysis to the Krebs cycle and lipogenic pathways. (Adapted from PMID:19081061.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Dlat for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VM14)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Dlat-RA

FBtr0079445

NM_164749

1955

421

Dlat-RB

FBtr0079444

NM_135274

2331

512

Dlat-RC

FBtr0332526

NM_001273264

2078

473

Dlat-RD

FBtr0332527

NM_001273265

2126

489

Dlat-RE

FBtr0332528

NM_001273266

2147

496

Dlat-RF

FBtr0332529

NM_001273267

2195

512

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Dlat-PA

FBpp0079073

44.1

421

9.25

FBpp0079072

54.3

512

10.17

FBpp0304794

50.3

473

9.98

FBpp0304795

51.7

489

10.03

FBpp0304796

52.8

496

10.13

FBpp0304797

54.3

512

10.17

Q9VM14

NP_001260196

AGB92732

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

512 aa isoforms: Dlat-PB, Dlat-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dlat using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.83

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010, Dorus et al., 2006)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in major mitochondrial derivative

inferred from direct assay

(Laurinyecz et al., 2019)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Dlat in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Dlat

View exonic expression by tissue for Dmel\Dlat

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34021/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0283658

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031912

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0283658

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5261

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dlat

Transgenic constructs containing regulatory region of Dlat

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2L)Exel7031

(Ryder, 2004.4.26)

Gene not disrupted in

Df(2L)mir-275-305^KO

(Foronda et al., 2014)

Inferred from location ( 14 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Dlat^GD16843

viable, with Scer\GAL4^tin.CΔ4

Dlat^GD16843

Other Phenotypes

Allele

abnormal behavior

Dlat^muc-1

abnormal behavior | recessive

Dlat^muc-1

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Dlat^GD16843

abnormal wound healing | larval stage, with Scer\GAL4^repo

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

Dlat^GD16843

wild-type, with Scer\GAL4^ap-md544

Dlat^EP816

Phenotype manifest in

Allele

larval multidendritic class IV neuron, with Scer\GAL4^repo

wing blade posterior compartment, with Scer\GAL4^en-e16E

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (4)

Hsap\DLAT

14 of 14

Yes

Hsap\PDHX

4 of 14

Yes

Hsap\DBT

2 of 14

Hsap\DLST

2 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (4)

Rnor\Dlat

14 of 14

Yes

Rnor\Pdhx

3 of 14

Yes

Rnor\Dbt

2 of 14

Rnor\Dlst

2 of 14

Mus musculus (laboratory mouse) (4)

Mmus\Dlat

14 of 14

Yes

Mmus\Pdhx

3 of 14

Yes

Mmus\Dbt

2 of 14

Mmus\Dlst

2 of 14

Xenopus tropicalis (Western clawed frog) (3)

Xtro\dlat

11 of 13

Yes

Xtro\pdhx

2 of 13

Yes

Xtro\dbt

1 of 13

Danio rerio (Zebrafish) (4)

Drer\dlat

14 of 14

Yes

Drer\pdhx

4 of 14

Yes

Drer\dlst

2 of 14

Drer\dbt

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\dlat-1

14 of 14

Yes

Cele\dlat-2

4 of 14

Yes

Cele\dbt-1

2 of 14

Cele\dlst-1

2 of 14

Anopheles gambiae (African malaria mosquito) (3)

Agam\AgaP_AGAP007975

11 of 12

Yes

Agam\AgaP_AGAP000549

2 of 12

Agam\AgaP_AGAP004055

1 of 12

Arabidopsis thaliana (thale-cress) (8)

Atha\AT1G54220

12 of 13

Yes

Atha\AT3G13930

12 of 13

Yes

Atha\LTA3

6 of 13

Yes

Atha\EMB3003

5 of 13

Yes

Atha\LTA2

5 of 13

Yes

Atha\AT4G26910

2 of 13

Atha\AT5G55070

2 of 13

Atha\BCE2

2 of 13

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\LAT1

13 of 13

Yes

Scer\PDX1

3 of 13

Yes

Scer\KGD2

2 of 13

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\lat1

12 of 12

Yes

Spom\pdx1

3 of 12

Yes

Spom\kgd2

2 of 12

Escherichia coli (enterobacterium) (2)

Ecol\aceF

3 of 11

Yes

Ecol\sucB

2 of 11

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Dlat. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

Dbct

3 of 13

Dlst

3 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

DLAT; dihydrolipoamide S-acetyltransferase

model of pyruvate decarboxylase deficiency

IEA

(FlyBase, 2019-)

PDHX; pyruvate dehydrogenase complex component X

model of pyruvate decarboxylase deficiency

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DLAT; dihydrolipoamide S-acetyltransferase

14 of 14

608770

PYRUVATE DEHYDROGENASE E2 DEFICIENCY; PDHDD

pyruvate decarboxylase deficiency

PDHX; pyruvate dehydrogenase complex component X

4 of 14

608769

PYRUVATE DEHYDROGENASE E3-BINDING PROTEIN DEFICIENCY; PDHXD

pyruvate decarboxylase deficiency

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Dlat - Atu

experimental knowledge based

(Guruharsha et al., 2011)

Dlat - CG10494

experimental knowledge based

(Guruharsha et al., 2011)

Dlat - Dld

experimental knowledge based

(Guruharsha et al., 2011)

Dlat - cbc

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Wu et al., 2021)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Cdc42

enhanceable

Dlat

(Raymond et al., 2004)

suppressible

Dlat

(Müller et al., 2005)

pnr

enhanceable

Dlat

(Pena-Rangel et al., 2002)

Rac1

enhanceable

Dlat

(Raymond et al., 2004)

RacGAP84C

enhanceable

Dlat

(Raymond et al., 2004)

External Data

Linkouts

MIST (genetic) - An integrated Molecular Interaction Database

34021

MIST (protein-protein) - An integrated Molecular Interaction Database

34021

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

pyruvate decarboxylation to acetyl CoA I

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-26

Cytogenetic map

27F4-27F4

Sequence location

2L:7,426,866..7,430,329 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

27F4-27F4

Limits computationally determined from genome sequence between P{PZ}cuc¹⁰⁶⁰⁷ and P{EP}EP2419^EP2419&P{EP}EP575

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

28A-28A

(determined by in situ hybridisation)

(Phillis et al., 1993)

Experimentally Determined Recombination Data

Location

2-26

(FlyBase, 2016)

2-24.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

40922

y¹ v¹; P{TRiP.HMS02170}attP40/CyO

20846

y¹ w^67c23; P{EPgy2}Dlat^EY12882/CyO

68071

y¹ sc^* v¹ sev²¹; P{TOE.GS00462}attP40

91891

y¹ sc^* v¹ sev²¹; P{TKO.GS03050}attP40

44439

y¹ sc^* v¹ sev²¹; P{TRiP.GLC01404}attP2

Kyoto

124034

w¹¹¹⁸; P{RS3}Dlat^CB-6300-3

NIG-Fly

5261R-3

P{NIG.5261R}3

5261R-7

P{NIG.5261R}7

HMS02170

y¹ v¹; P{TRiP.HMS02170}attP40/CyO

VDRC

v48941

P{GD16843}v48941

v110735

P{KK102893}VIE-260B

v48939

w¹¹¹⁸; P{GD16843}v48939

More stocks available...

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (166)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0283658

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Area matching Drosophila ESTs AI259166 and AI296787. Sequence similarity to Dihydrolpamide acetyltransferase component of pyruvate dehydrogenase (human). Probable intron in gene represented by EST AI259166.

(Davies, 2001.3.15)

Mutations of muc produces defects in mitochondrial function which is associated with clear behavioural effects in adults.

(Klenz et al., 1995)

Mutants of muc have altered neural circuitry of the thoracic nervous system.

(Murphy and Phillis, 1993)

Identification: Screen to identify defects which alter the neural circuitry required for proper grooming behaviour.

(Phillis et al., 1993)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG5261 EP816

(Müller et al., 2005)

Source for merge of: CG5261 anon-WO0118547.121

(FlyBase, 1996-)

Source for merge of: Dlat muc

(FlyBase, 1992-)

Additional comments

Source for merge of CG5261 anon-WO0118547.121 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

FlyBase curator comment: FBrf0078801 (a 1995 ADRC abstract) states that the non-CG gene 'muc' encodes "the E2 subunit of pyruvate dehydrogenase". There is only one CG gene annotated to encode that protein: 'Dlat' (CG5261). Moreover, the cytological mapping information ("28A"), transcript length ("a 2.3 kb transcript") and expression levels ("most abundantly expressed during pupal stages and in adults") recorded for 'muc' are consistent with those determined for 'Dlat'.

(FlyBase, 1992-)

Nomenclature History

Source for database identify of

Source for identity of: Dlat CG5261

(Saj et al., 2010)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG5261

(Kolkhof et al., 2017, Rosa-Ferreira et al., 2015, Tixier et al., 2013, Tixier et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Cammarato et al., 2011, Ni et al., 2010.12.1, Wasbrough et al., 2010, Keleman et al., 2009.8.5, Liu et al., 2009, Andersen and Tapon, 2008, Levine and Begun, 2008, Stuart et al., 2007, Beller et al., 2006, Dorus et al., 2006, Molnar et al., 2006, Raymond et al., 2004)

DLAT

(Saj et al., 2010)

Dlat

(Marygold, 2024)

EP(2)0816

(Pena-Rangel et al., 2002)

EP816

PDH-E2

(Schell et al., 2017)

anon-WO0118547.121

muc

(Ramesh et al., 2023, Li et al., 2020, Laurinyecz et al., 2019, Levis, 2018.8.30, Transgenic RNAi Project members, 2017-)

Name Synonyms

Dihydrolipoamide S-acetyltransferase

Dihydrolipoyllysine-residue acetyltransferase

(Liu et al., 2009)

midline uncoordinated

(Phillis et al., 1993)

Secondary FlyBase IDs

FBgn0013711
FBgn0031912
FBgn0062231
FBgn0062641

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 79 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34021

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VM14

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VM14

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34021/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0283658

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0283658

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG5261

MARRVEL_MODEL - MARRVEL (model organism gene)

34021

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0283658

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031912

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0283658

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

pyruvate decarboxylation to acetyl CoA I

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5261

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC005597

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

34021

MIST (protein-protein) - An integrated Molecular Interaction Database

34021

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

References (73)

The following external sites may use different assemblies or annotations than FlyBase.

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