Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\muc using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\muc in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of CG5261 anon-WO0118547.121 was sequence comparison ( date:051113 ).
FlyBase curator comment: FBrf0078801 states that 'muc' encodes "the E2 subunit of pyruvate dehydrogenase". GO annotation and orthology analyses suggest there is only one such gene in D. melanogaster - CG5261 - which maps to the same chromosomal region as that recorded for 'muc'. Furthermore, all 4 conference abstracts (including FBrf0078801) and the research paper (FBrf0058570) previously associated with 'muc' are from the same group, while the information on transcript length ("a 2.3 kb transcript") and expression levels ("most abundantly expressed during pupal stages and in adults") corroborates the link to CG5261.
Area matching Drosophila ESTs AI259166 and AI296787. Sequence similarity to Dihydrolpamide acetyltransferase component of pyruvate dehydrogenase (human). Probable intron in gene represented by EST AI259166.
Mutations of muc produces defects in mitochondrial function which is associated with clear behavioural effects in adults.
Mutants of muc have altered neural circuitry of the thoracic nervous system.
Identification: Screen to identify defects which alter the neural circuitry required for proper grooming behaviour.