FlyBase Gene Report: Dmel\Rap2l

RAS GTPASES -: The Ras family are members of the Ras superfamily of small GTPases. Ras proteins act in signal transduction cascades, generally the activated GTPase recruits and activates downstream effectors. Members this family are typically membrane-associated via isoprenylation of a CaaX motif in the C-terminus. (Adapted from PMID:15731001).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Rap2l or the JBrowse view of Dmel\Rap2l for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.40

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Rap2l-RA

FBtr0072177

NM_058054

1002

182

Rap2l-RC

FBtr0343334

NM_001299887

574

116

Rap2l-RD

FBtr0343335

NM_001299888

660

116

Additional Transcript Data and Comments

Reported size (kB)

0.66 (longest cDNA)

(Toba et al., 1999)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Rap2l-PA

FBpp0072086

20.5

182

5.04

NP_477402

AAF47155

Rap2l-PC

FBpp0309992

13.2

116

7.85

NP_001286816

AHN56611

Rap2l-PD

FBpp0309993

13.2

116

7.85

NP_001286817

AHN56612

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

116 aa isoforms: Rap2l-PC, Rap2l-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

182 (aa)

(Toba et al., 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rap2l using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Gene Ontology (8 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

GDP binding

inferred from biological aspect of ancestor with PANTHER:PTN000631348

(assigned by GO_Central )

(Gaudet et al., 2011)

GTP binding

inferred from biological aspect of ancestor with PANTHER:PTN000631348

(assigned by GO_Central )

(Gaudet et al., 2011)

GTPase activity

inferred from biological aspect of ancestor with PANTHER:PTN000631348

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity

(Jekely, 2003)

Biological Process (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

germ-line stem cell population maintenance

inferred from genetic interaction with FLYBASE:PDZ-GEF; FB:FBgn0265778

(Wang et al., 2006)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

negative regulation of cell migration

inferred from biological aspect of ancestor with PANTHER:PTN000631627

(assigned by GO_Central )

(Gaudet et al., 2011)

Rap protein signal transduction

inferred from sequence or structural similarity with MGI:MGI:1919315

(FlyBase Curators, 2008--)

inferred from biological aspect of ancestor with PANTHER:PTN000631627

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

membrane

inferred from sequence or structural similarity with MGI:MGI:1919315

(FlyBase Curators, 2008--)

plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000631348

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Rap2l in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Rap2l

View exonic expression by tissue for Dmel\Rap2l

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0025806

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3204-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3204

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Rap2l

Transgenic constructs containing regulatory region of Rap2l

Deletions and Duplications ( 1 )

Disrupted in

Df(2R)Exel6081

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Rap2l^GD4703

lethal, with Scer\GAL4^29BD

Rap2l^GS2069

lethal, with Scer\GAL4^c355

Rap2l^GS2069

lethal | recessive

Rap2l^SH0581

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

Rap2l^GD4703

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Rap2l^GD4703

viable, with Scer\GAL4^tin.CΔ4

Rap2l^GD4703

Other Phenotypes

Allele

flight defective, with Scer\GAL4^Mef2.PR

Rap2l^GD4703

neuroanatomy defective | larval stage

Rap2l^GD4703

some die during pupal stage, with Scer\GAL4^pnr-MD237

Rap2l^GD4703

visible, with Scer\GAL4^hs.2sev

Rap2l^GS2069

visible, with Scer\GAL4^pnr-MD237

Rap2l^GD4703

Phenotype manifest in

Allele

eye, with Scer\GAL4^hs.2sev

Rap2l^GS2069

ganglion mother cell | larval stage

Rap2l^GD4703

larval neuroblast | larval stage

Rap2l^GD4703

mesothoracic tergum, with Scer\GAL4^pnr-MD237

Rap2l^GD4703

trichogen cell, with Scer\GAL4^pnr-MD237

Rap2l^GD4703

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\RAP2A

12 of 15

Yes

Hsap\RAP2B

12 of 15

Yes

Hsap\RAP2C

12 of 15

Yes

3 of 15

3 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Rap2a

12 of 15

Yes

Mmus\Rap2b

12 of 15

Yes

Mmus\Rap2c

12 of 15

Yes

Mmus\Gm266

3 of 15

Yes

3 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (16)

Rnor\Rap2b

11 of 13

Yes

Rnor\Rap2c

11 of 13

Yes

Rnor\Rap1a

3 of 13

Rnor\Rap1b

3 of 13

Rnor\Rap2a

3 of 13

Yes

Rnor\Diras3

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (13)

Xtro\rap2b

11 of 12

Yes

Xtro\rap2c

11 of 12

Yes

Xtro\rap2a

8 of 12

Yes

3 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (18)

Drer\rap2b

12 of 15

Yes

Drer\rap2ab

11 of 15

Yes

Drer\LOC100332969

10 of 15

Yes

Drer\rap2c

9 of 15

Yes

3 of 15

3 of 15

3 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (7)

Cele\rap-2

12 of 15

Yes

Cele\rap-1

3 of 15

Cele\rap-3

3 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (3)

Atha\GB2

1 of 9

Yes

Atha\RABA6a

1 of 9

Yes

Atha\RABB1a

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\RSR1

4 of 15

Yes

Scer\RAS1

1 of 15

Scer\RAS2

1 of 15

Scer\RHB1

1 of 15

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\ras1

1 of 12

Yes

Spom\rhb1

1 of 12

Yes

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190GVL )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA24803

Drosophila persimilis

Dper\GL11660

Drosophila willistoni

Dwil\GK21923

Drosophila virilis

Dvir\GJ20446

Drosophila mojavensis

Dmoj\GI20698

Drosophila grimshawi

Dgri\GH20176

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150CJB )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17015935

Glossina morsitans

Tsetse fly

Gmor\GMOY009236

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_10065

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_08200

Mayetiola destructor

Hessian fly

Mdes\Mdes007519

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL003306

Anopheles darlingi

American malaria mosquito

Adar\ADAC008888

Anopheles gambiae

Malaria mosquito

Agam\AGAP004769

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ014407

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ014919

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0FE5 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA003457

Bombyx mori

Silkmoth

Bmor\ras3

Danaus plexippus

Monarch butterfly

Dple\DPOGS203660-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS210727-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL006948

Heliconius melpomene

Postman butterfly

Hmel\HMEL006432

Apis florea

Little honeybee

Aflo\2204442740

Apis florea

Little honeybee

Aflo\4536148356

Apis mellifera

Western honey bee

Amel\Rap2l

Apis mellifera

Western honey bee

Amel\R

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP21485

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP23685

Bombus terrestris

Buff-tailed bumblebee

Bter\15207272

Bombus terrestris

Buff-tailed bumblebee

Bter\15211131

Linepithema humile

Argentine ant

Lhum\LH12998

Linepithema humile

Argentine ant

Lhum\LH13043

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00207a

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG005966

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG008956

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_03235

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_02389

Tribolium castaneum

Red flour beetle

Tcas\TC001470

Tribolium castaneum

Red flour beetle

Tcas\TC001713

Pediculus humanus

Human body louse

Phum\PHUM226110

Pediculus humanus

Human body louse

Phum\PHUM502600

Rhodnius prolixus

Kissing bug

Rpro\RPRC013508

Rhodnius prolixus

Kissing bug

Rpro\RPRC012940

Cimex lectularius

Bed bug

Clec\CLEC011076

Cimex lectularius

Bed bug

Clec\CLEC007918

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009428

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007731

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_15125

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_13005

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0FDQ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR001863

Strigamia maritima

European centipede

Smar\SMAR011770

Strigamia maritima

European centipede

Smar\SMAR002474

Ixodes scapularis

Black-legged tick

Isca\ISCW010282

Stegodyphus mimosarum

African social velvet spider

Smim\KFM79411.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM80225.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g02920

Tetranychus urticae

Two-spotted spider mite

Turt\tetur14g02670

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_231811

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_318262

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0OOG )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Rap2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Rap2l

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Rap1

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000001232

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000018468

Gallus gallus

Domestic chicken

Ggal\RAP2C

Gallus gallus

Domestic chicken

Ggal\RAP1A

Gallus gallus

Domestic chicken

Ggal\RAP1B

Gallus gallus

Domestic chicken

Ggal\RAP2A

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (15)

Gene Symbol

Score

Source

Alignment

4 of 10

3 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

Ric

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RAP2A; RAP2A, member of RAS oncogene family

12 of 15

179540

RAP2B; RAP2B, member of RAS oncogene family

12 of 15

179541

RAP2C; RAP2C, member of RAS oncogene family

12 of 15

301016

RAP1A; RAP1A, member of RAS oncogene family

3 of 15

179520

RAP1B; RAP1B, member of RAS oncogene family

3 of 15

179530

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Rap2l - Arf102F

experimental knowledge based

(Guruharsha et al., 2011)

Rap2l - CCT6

experimental knowledge based

(Guruharsha et al., 2011)

Rap2l - CG13220

experimental knowledge based

(Guruharsha et al., 2011)

Rap2l - CG15098

experimental knowledge based

(Guruharsha et al., 2011)

Rap2l - CG2064

experimental knowledge based

(Guruharsha et al., 2011)

Rap2l - CG3164

experimental knowledge based

(Guruharsha et al., 2011)

Rap2l - CG5447

experimental knowledge based

(Guruharsha et al., 2011)

Rap2l - CG7668

experimental knowledge based

(Guruharsha et al., 2011)

Rap2l - Droj2

experimental knowledge based

(Guruharsha et al., 2011)

Rap2l - GCS2β

experimental knowledge based

(Guruharsha et al., 2011)

Rap2l - KdelR

experimental knowledge based

(Guruharsha et al., 2011)

Rap2l - Kr-h2

experimental knowledge based

(Guruharsha et al., 2011)

Rap2l - Ldh

experimental knowledge based

(Guruharsha et al., 2011)

Rap2l - Mcad

experimental knowledge based

(Guruharsha et al., 2011)

Rap2l - Mec2

experimental knowledge based

(Guruharsha et al., 2011)

Rap2l - Rpt2

experimental knowledge based

(Guruharsha et al., 2011)

Rap2l - mt:CoII

experimental knowledge based

(Guruharsha et al., 2011)

Rap2l - porin

experimental knowledge based

(Guruharsha et al., 2011)

Rap2l - spidey

experimental knowledge based

(Guruharsha et al., 2011)

Rap2l - wal

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

PDZ-GEF

enhanceable

Rap2l

(Singh et al., 2006)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

63429

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37850

MIST (protein-protein) - An integrated Molecular Interaction Database

Rap2l

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neutrophil degranulation

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-106

Cytogenetic map

60B7-60B7

Sequence location

2R:24,063,051..24,065,405 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

60B7-60B7

Left limit from in situ hybridisation (FBrf0157097) Right limit from in situ hybridisation (FBrf0157097)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

60B7-60B7

(Oh et al., 2003)

60B-60B

(Toba, 1998.12.4)

60B-60B

(determined by in situ hybridisation)

(Toba et al., 1999)

Experimentally Determined Recombination Data

Location

2-106

(FlyBase, 2016)

2-109.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Bloomington

29568

y¹ v¹; P{TRiP.JF03247}attP2

15446

w¹¹¹⁸; P{EPgy2}Rap2l^EY05485/CyO, P{sevRas1.V12}FK1

51840

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03412}attP2

Kyoto

205038

y¹ w^67c23; P{GSV1}Rap2l^GS2069/SM1

VDRC

v107745

P{KK108605}VIE-260B

v45228

w¹¹¹⁸; P{GD4703}v45228

v45230

w¹¹¹⁸; P{GD4703}v45230

v341996

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01343}attP40/CyO-GFP

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (25)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0283666

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Rap2l CG3204

(Wang, 1999.11)

Source for database merge of

Source for merge of: Rap2l l(2)SH0581

(Singh et al., 2006)

Additional comments

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

1 allele of l(2)SH0581 recovered in a P-insertion screen.

(Oh et al., 2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37850

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0025806

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0283666

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3204

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG3204

Linkouts

BioGRID - A database of protein and genetic interactions.

63429

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3204-RA

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37850

MIST (protein-protein) - An integrated Molecular Interaction Database

Rap2l

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neutrophil degranulation

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG3204

(Cammarato et al., 2011, Ling and Salvaterra, 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Walker et al., 2006, Colicelli, 2004)

Dm Rap21

(Jekely, 2003)

O96692

(Rojas et al., 2012)

Rap2

(Shirinian et al., 2010)

Rap21

(Diez et al., 2011, Orian et al., 2003)

Rap2L

(Walker et al., 2006)

Rap2l

(Yoo et al., 2016, Bischof and FlyORF project members, 2014.6.20, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Ling and Salvaterra, 2011, Neumüller et al., 2011, Bakal et al., 2007, Khoo et al., 2007, Stuart et al., 2007, Singh et al., 2006, Wang et al., 2006)

l(2)SH0581

l(2)SH2 0581

(Oh et al., 2002.3.24)

Name Synonyms

Ras-associated protein 2-like

(Cammarato et al., 2011, Ling and Salvaterra, 2011)

lethal (2) SH0581

Secondary FlyBase IDs

FBgn0025806
FBgn0065713

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (56)

Report Sections

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