FlyBase Gene Report: Dmel\IP3K2

General Information

Symbol

Dmel\IP3K2

Species

D. melanogaster

Name

Inositol 1,4,5-triphosphate kinase 2

Annotation Symbol

CG45017

Feature Type

protein_coding_gene

FlyBase ID

FBgn0283680

Gene Model Status

Current

Stock Availability

39 publicly available

Enzyme Name (EC)

inositol-trisphosphate 3-kinase (2.7.1.127)

Gene Summary

Inositol 1,4,5-triphosphate kinase 2 (IP3K2) encodes a kinase that regulates calcium levels by influencing IP3 signaling. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

wy, wavy, dmIP3Kβ

Key Links

Genomic Location

Cytogenetic map

11E9-11E11

Sequence location

X:13,303,633..13,329,303 [+]

Recombination map

1-42

RefSeq locus

NC_004354 REGION:13303633..13329303

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables calcium-dependent protein binding

inferred from direct assay

(Lloyd-Burton et al., 2007)

enables calmodulin binding

inferred from direct assay

(Lloyd-Burton et al., 2007)

enables inositol-1,4,5-trisphosphate 3-kinase activity

inferred from direct assay

(Seeds et al., 2004)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables inositol hexakisphosphate kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000274018

(GO Reference Genome Project, 2011-)

enables kinase activity

inferred from electronic annotation with InterPro:IPR005522

(InterPro Project Members, 2004-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in autophagic cell death

inferred from mutant phenotype

(Nelson et al., 2014)

inferred from genetic interaction with FLYBASE:mir-14; FB:FBgn0262447

(Nelson et al., 2014)

involved_in inositol phosphate biosynthetic process

inferred from direct assay

(Seeds et al., 2004)

involved_in negative regulation of cytosolic calcium ion concentration

inferred from mutant phenotype

(Nelson et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in inositol phosphate biosynthetic process

inferred from biological aspect of ancestor with PANTHER:PTN004357288

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR005522

(InterPro Project Members, 2004-)

involved_in phosphatidylinositol phosphate biosynthetic process

inferred from biological aspect of ancestor with PANTHER:PTN000274018

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Lloyd-Burton et al., 2007)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000963625

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000963625

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

INOSITOL PHOSPHATE KINASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

inositol-1,4,5-trisphosphate 3-kinase activity

1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5- tetrakisphosphate + ADP + H(+) (2.7.1.127)

RHEA 11020:

Summaries

Gene Snapshot

Inositol 1,4,5-triphosphate kinase 2 (IP3K2) encodes a kinase that regulates calcium levels by influencing IP3 signaling. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

INOSITOL PHOSPHATE KINASES -: Inositol phosphate kinases catalyze the phosphorylation of inositol phosphates. (Adapted from PMID:17954248)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

wy: wavy

wy: wavy

From Nachtsheim, 1928, Z. Indukt. Abstamm. Vererbungsl. 48: 245-58.

Wings transversely waved, usually turned up at tip. Abdomen long and narrow. Marginal vein kinked even when other characters overlap wild type. RK2.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\IP3K2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7KV26)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.53

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

IP3K2-RA

FBtr0344170

NM_132647

2683

669

IP3K2-RB

FBtr0344171

NM_167358

2807

669

IP3K2-RC

FBtr0344169

NM_001103499

2554

467

IP3K2-RD

FBtr0344168

NM_001298271

2222

467

IP3K2-RG

FBtr0346133

NM_132645

2979

691

IP3K2-RH

FBtr0346134

NM_001298272

2355

467

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

IP3K2-PA

FBpp0310584

73.2

669

6.73

FBpp0310585

73.2

669

6.73

FBpp0310583

51.3

467

7.34

FBpp0310582

51.3

467

7.34

FBpp0311961

76.3

691

4.98

FBpp0311962

51.3

467

7.34

Q9VYE7

NP_001285201

AHN59671

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

467 aa isoforms: IP3K2-PC, IP3K2-PD, IP3K2-PH

669 aa isoforms: IP3K2-PA, IP3K2-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\IP3K2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.17

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 10

head mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

procrystal cell

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

garland cell primordium

(Fisher et al., 2012)

anterior midgut primordium

(Fisher et al., 2012)

plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Lloyd-Burton et al., 2007)

Expression Deduced from Reporters

Reporter: P{GawB}IP3K2^NP2758

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

CNS surface glial cell

(Olson et al., 2019)

adult stage | female

adult brain | restricted

(Shuai et al., 2015)

mushroom body extrinsic neuron

(Shuai et al., 2015)

mushroom body gamma lobe slice 1

(Shuai et al., 2015)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\IP3K2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\IP3K2

View exonic expression by tissue for Dmel\IP3K2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0266375

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32285/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0283680

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0283680

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 26 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of IP3K2

Transgenic constructs containing regulatory region of IP3K2

Aberrations (Deficiencies and Duplications) ( 9 )

Inferred from experimentation ( 9 )

Gene disrupted in

Df(1)BSC766

(Dean et al., 2015)

Df(1)C246

(Deak et al., 1982, Craymer and Roy, 1980)

Df(1)Exel6245

(Dean et al., 2015, Ryder, 2004.4.26)

Df(1)N12

(Deak et al., 1982, Craymer and Roy, 1980, Lefevre and Peterson, 1972)

Gene not disrupted in

Df(1)JA26

(Craymer and Roy, 1980)

Df(1)N105

(Deak et al., 1982)

Gene not duplicated in

Dp(1;3)v⁺74c

(Schalet, 1986)

Dp(1;4)r⁺l

(Schalet, 1986)

Gene duplicated in

Dp(1;f)y⁺wy⁺

(Brower et al., 1995)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | male

IP3K2^274-2

viable

viable, with Scer\GAL4^Mef2.PR

IP3K2^GD8778

viable, with Scer\GAL4^pnr-MD237

IP3K2^GD8778

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal oxidative stress response, with Scer\GAL4^Uro.PT

visible

visible, with Scer\GAL4^nub-AC-62

IP3K2^GD8778

visible (with Df(1)Exel6245)

visible (with IP3K2^wy-1)

visible (with IP3K2^wy-2)

visible (with IP3K2^wy-74i)

Phenotype manifest in

Allele

abdomen

IP3K2^wy-1

salivary gland | somatic clone, with Scer\GAL4^Act.PU

wing

wing, with Scer\GAL4^nub-AC-62

IP3K2^GD8778

wing (with Df(1)Exel6245)

wing (with IP3K2^wy-1)

wing (with IP3K2^wy-2)

wing (with IP3K2^wy-74i)

wing vein L1

IP3K2^wy-1

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (7)

Hsap\ITPKB

9 of 14

Yes

Hsap\ITPKA

8 of 14

Yes

Hsap\ITPKC

7 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (7)

Rnor\Itpka

9 of 14

Yes

Rnor\Itpkb

9 of 14

Yes

Rnor\Itpkc

8 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (7)

Mmus\Itpka

9 of 14

Yes

Mmus\Itpkb

8 of 14

Yes

Mmus\Itpkc

8 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (10)

Xtro\itpka

6 of 13

Yes

Xtro\itpkc

6 of 13

Yes

Xtro\fxyd6

5 of 13

Yes

Xtro\itpkb

5 of 13

Yes

5 of 13

4 of 13

3 of 13

2 of 13

Yes

Xtro\ip6k1

1 of 13

Xtro\ip6k2

1 of 13

Danio rerio (Zebrafish) (10)

Drer\itpkb

10 of 14

Yes

Drer\itpka

9 of 14

Yes

Drer\itpkcb

9 of 14

Yes

Drer\itpkca

7 of 14

Yes

5 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\lfe-2

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (5)

Agam\AgaP_AGAP002194

9 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

Yes

Arabidopsis thaliana (thale-cress) (2)

Atha\IPK2a

2 of 13

Yes

Atha\IPK2BETA

2 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\ARG82

1 of 13

Yes

Scer\KCS1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\SPAC607.04

1 of 12

Yes

Spom\SPCC970.08

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:IP3K2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (3)

IP3K1

7 of 13

Ip6k

3 of 13

Ipk2

3 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

IP3K2^GD8778

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Al-Ramahi et al., 2018)

IP3K2^KK112292

ameliorates Parkinson's disease 1

modeled by Hsap\SNCA^UAS.cFa

(Di Leva et al., 2023)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ITPKB; inositol-trisphosphate 3-kinase B

9 of 14

147522

ITPKA; inositol-trisphosphate 3-kinase A

8 of 14

147521

ITPKC; inositol-trisphosphate 3-kinase C

7 of 14

606476

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-RNA

Physical Interaction

Assay

References

IP3K2 - mir-14

western blot, necessary binding region

(Nelson et al., 2014)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

IP3K2

suppressible

Itpr

(Dean et al., 2015)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

mir-14

suppressible

IP3K2

(Nelson et al., 2014)

External Data

Linkouts

MIST (protein-protein) - An integrated Molecular Interaction Database

32285

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Synthesis of IP3 and IP4 in the cytosol

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synthesis of IP3 and IP4 in the cytosol

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-42

Cytogenetic map

11E9-11E11

Sequence location

X:13,303,633..13,329,303 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

11E9-11E11

Limits computationally determined from genome sequence between P{EP}EP1461 and P{EP}CG1640^EP1626

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-42

(FlyBase, 2016)

1-42.3

(Comeron et al., 2012)

1-40.7

Left of (cM)

P{EP}Tango2^G517

(Dean et al., 2015)

Right of (cM)

PBac{WH}CG12096^f05782

(Dean et al., 2015)

Notes

Stocks and Reagents

Stocks (39)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

168

IP3K2^wy-1

Korea

13038

P{VT061206-GAL4}attP2

10797

11213

11317

105765

1630R-1

12724R-2

12724R-3

15745R-1

v102730

v102772

More stocks available...

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (82)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE35745

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0283680

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: IP3K2 CG12724

(FlyBase Genome Annotators, 2007)

Source for merge of: IP3K2 CG15745

(FlyBase Genome Annotators, 2013)

Source for merge of: IP3K2 wy

(Dean et al., 2015)

Additional comments

Annotations CG34359 and CG15745 merged as CG45017 in release 5.53 of the genome annotation. Merge supported by RNA-seq junction data.

(FlyBase Genome Annotators, 2013)

Annotations CG1630 and CG12724 merged as CG34359 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Nomenclature History

Source for database identify of

Source for identity of: IP3K2 CG1630

(Tricoire, 2002.12.19)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (18)

Reported As

Symbol Synonym

CG12724

CG15745

(Van Bortle et al., 2015, Terriente-Felix et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Kong et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Kapelnikov et al., 2008, Haag-Liautard et al., 2007, Qin et al., 2005)

CG1630

(Lecci et al., 2008, Lloyd-Burton et al., 2007, Nelson et al., 2005, Seeds et al., 2004, Stanyon et al., 2004, Giot et al., 2003)

CG34359

(Ni et al., 2010.12.1, Keleman et al., 2009.8.5, FlyBase Genome Annotators, 2007)

CG45017

(National Institute of Genetics Fly Stocks, 2022-, FlyBase Genome Annotators, 2013)

D-IP3K2

(Monnier et al., 2002)

DIP3K2

(Tricoire, 2002.12.19)

IP₃K-2

(Terhzaz et al., 2010)

IP₃K2

(Lloyd-Burton et al., 2007)

NP2758

(Krashes et al., 2009)

dmIP3K2

(Seeds et al., 2004)

dmIP3Kβ

(Lecci et al., 2008, Seeds et al., 2004)

dmIP₃β

(Lloyd-Burton et al., 2007)

ip3k2

(Lucas et al., 2015, Nelson et al., 2014)

(Dean et al., 2015)

Name Synonyms

CG12724

Inositol 1,4,5-triphosphate kinase 2

(Nelson et al., 2005, Monnier et al., 2002)

wavy

(Dean et al., 2015)

Secondary FlyBase IDs

FBgn0266375
FBan0001630
FBgn0085388
FBgn0030471
FBgn0030470
FBgn0030469
FBgn0004031

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 62 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32285

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7KV26

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7KV26

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0266375

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32285/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0283680

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0283680

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG45017

MARRVEL_MODEL - MARRVEL (model organism gene)

32285

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0283680

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0283680

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

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Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synthesis of IP3 and IP4 in the cytosol

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Synthesis of IP3 and IP4 in the cytosol

References (89)

The following external sites may use different assemblies or annotations than FlyBase.

-1.17

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