Limk, Dlimk, agn, agnostic, LIM kinase
Gene model reviewed during 5.50
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Interacts with LATS1, and this interaction inhibits phosphorylation of tsr/cofilin.
Phosphorylated on serine and/or threonine residues by ROCK1. Phosphorylated by PAK4 resulting in increased LIMK1 ability to phosphorylate cofilin. May be dephosphorylated and inactivated by SSH1 (By similarity).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\LIMK1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\LIMK1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi experiments show that dsRNA targetted at this gene suppresses the Pten-dsRNA-induced cell shape changes in Kc167 cells.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
agn controls calmodulin properties by encoding a calmodulin-inhibiting protein.
Known from temperature sensitive lethal mutations that affect phosphodiesterase and adenyl cyclase activity, and have learning defects.