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General Information
Symbol
Dmel\ds
Species
D. melanogaster
Name
dachsous
Annotation Symbol
CG17941
Feature Type
FlyBase ID
FBgn0284247
Gene Model Status
Stock Availability
Gene Snapshot
In progress.Contributions welcome.
Also Known As
l(2)01855
Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:640,013..714,983 [-]
Recombination map
2-1.5
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
Predictions / Assertions
Summaries
Gene Group (FlyBase)
CADHERINS -
The cadherin superfamily represent a diverse group of transmembrane receptors which mediate cell-cell adhesion. Cadherins are defined by the presence of cadherin domains, typically organised in tandem repeats, which mediate calcium-dependent homophilic interactions between cadherin molecules. (Adapted from FBrf0146675).
Pathway (FlyBase)
Positive Regulators of Hippo Signaling Pathway -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Positive regulators of the pathway, enhance the cytosolic retention of yki, negatively regulating tissue growth (Adapted from FBrf0224870).
Negative Regulators of Hippo Signaling Pathway -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Negative regulators of the pathway promote the nuclear accumulation of yki, enhancing yki-mediated transcriptional regulation and the expression of genes that positively regulate tissue growth (Adapted from FBrf0224870).
Protein Function (UniProtKB)
Required for normal morphogenesis of adult structures derived from imaginal disks (PubMed:7601355, PubMed:26073018). Plays a role in planar cell polarity and in determining body left-right asymmetry. Expression in segment H1 of the imaginal ring and interaction with Myo31DF are required to induce changes of cell shape and orientation in segment H2, which then gives rise to normal, dextral looping of the adult hindgut (PubMed:26073018).
(UniProt, Q24292)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
ds: dachsous
thumb
ds: dachsous
Edith M. Wallace, unpublished.
Wings shorter, blunter, and broader; crossveins uniformly very close together. Abdomen and legs chunky. Slight dominance of close crossveins. Stronger alleles may exhibit enhanced dominance, reduced viability, female sterility, delayed emergence, widely spaced scutellar bristles, and erect costal bristles. Strong interaction with d, fj, and cg; double homozygotes often have excessive growth of thoracic parts and sometimes conversion of one organ into another {e.g., hyphertrophy of notum, duplication of wings and antennae, and transformations of tarsus to arista, eye to antenna or palpus, or wing to notum [Waddington, 1943, J. Genet. 45: 29-43 (fig.); 1962, New Patterns in Genetics and Development, Columbia University Press, pp. 208-15 (fig.)]}. Tarsal shortening enhanced by homozygous ssa and ssaB (Villee, 1945, Genetics 30: 26-27). RK1.
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\ds or the JBrowse view of Dmel\ds for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.52
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0078045
12427
3556
FBtr0343249
12134
3556
Additional Transcript Data and Comments
Reported size (kB)
12.4 (compiled cDNA)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0077708
385.8
3556
4.70
FBpp0309926
385.8
3556
4.70
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

3556 aa isoforms: ds-PA, ds-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts (via cytoplasmic region) with Myo31DF.
(UniProt, Q24292)
Post Translational Modification
Phosphorylated by fj on Ser/Thr of cadherin domains.
(UniProt, Q24292)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ds using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (32 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:ft; FB:FBgn0001075
inferred from physical interaction with UniProtKB:P33450
(assigned by UniProt )
inferred from physical interaction with FLYBASE:Dlish; FB:FBgn0034264
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN002555229
(assigned by GO_Central )
Biological Process (26 terms)
Terms Based on Experimental Evidence (23 terms)
CV Term
Evidence
References
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from physical interaction with UniProtKB:P33450
(assigned by UniProt )
inferred from mutant phenotype
Terms Based on Predictions or Assertions (8 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN002555229
(assigned by GO_Central )
non-traceable author statement
inferred from electronic annotation with InterPro:IPR002126
(assigned by InterPro )
inferred from sequence or structural similarity
traceable author statement
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
ds transcripts persist throughout embryogenesis and reappear in larvae and adults. They are expressed in ectodermally derived tissues. They are first detected in six weak epidermal stripes and a prominent stripe at the amnioproctodeal invagination during gastrulation. During germ band extension, they are present in 14 segmental stripes and in the procephalon. Prominent expression is observed in the extended germ band stage in the forming tracheal pits. At stage 14, expression is also observed in the anterior spiracles and in the primordial leg discs. By late stage 14, expression is observed in the nearly fused labial buds and at invagination of the maxillary segment, along the segmental folds, and probably in the apodemes. ds transcripts are also expressed in specific areas of the larval brain and imaginal discs. In the supraoesophageal ganglion, ds is expressed in two areas of the optic lobe and in a region that may correspond to the mushroom body. In imaginal discs, strong ds expression is observed frequently along the folds separating the anlagen of distinct imaginal structures. It is observed in limited regions of the eye-antennal, humeral, labial, genital, leg, wing, and haltere discs.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
ds protein is detected in third instar wing discs in a ring of cells surrounding the wing pouch and in the later regions of the prospective notum.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{lacZ.ry+}ds2D60b
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{PZ}ds05142
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ds in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 59 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ds
Transgenic constructs containing regulatory region of ds
Deletions and Duplications ( 15 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
axon & larval optic lobe
costal vein & trichome
glial cell & larval optic lobe
leg (with ds38k)
trichome & abdominal tergite
trichome & abdominal tergite | somatic clone | cell non-autonomous, with Scer\GAL4αTub84B.PL
wing hair & wing basal cell, with Scer\GAL4salm-459.2
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
7 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
 
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
11 of 15
Yes
Yes
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (8)
11 of 13
Yes
Yes
3 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
3 of 12
Yes
Yes
2 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
Danio rerio (Zebrafish) (14)
8 of 15
Yes
Yes
5 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (4)
11 of 15
Yes
Yes
4 of 15
No
No
2 of 15
No
Yes
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919002G )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915001F )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W002W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X002N )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0048 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (12)
6 of 10
5 of 10
3 of 10
3 of 10
2 of 10
2 of 10
2 of 10
2 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 4 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    suppressible
    suppressible
    suppressible
    suppressible
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    enhanceable
    External Data
    Subunit Structure (UniProtKB)
    Interacts (via cytoplasmic region) with Myo31DF.
    (UniProt, Q24292 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    Positive Regulators of Hippo Signaling Pathway -
    The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Positive regulators of the pathway, enhance the cytosolic retention of yki, negatively regulating tissue growth (Adapted from FBrf0224870).
    Negative Regulators of Hippo Signaling Pathway -
    The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Negative regulators of the pathway promote the nuclear accumulation of yki, enhancing yki-mediated transcriptional regulation and the expression of genes that positively regulate tissue growth (Adapted from FBrf0224870).
    External Data
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-1.5
    Cytogenetic map
    Sequence location
    2L:640,013..714,983 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    21D1-21E2
    Left limit from in situ hybridisation (FBrf0067338) Right limit from in situ hybridisation (FBrf0067338); Limits computationally determined from genome sequence between P{lacW}l(2)k09610k09610&P{lacW}Sk09538a and P{PZ}l(2)1068510685&P{lacW}Tango14k00619
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    21D1-21D1
    Left limit from in situ hybridisation (FBrf0067338) Right limit from in situ hybridisation (FBrf0067338); (determined by in situ hybridisation)
    21D2-21D3
    21D1-21D2
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (67)
    Genomic Clones (41)
    cDNA Clones (324)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        Other clones
        RNAi and Array Information
        Linkouts
        Antibody Information
        Laboratory Generated Antibodies
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of
        Source for merge of: ds l(2)01855
        Additional comments
        Other Comments
        Clonal analysis indicates that the ds/ft system and the stan/fz system act independently to confer planar cell polarity in the adult abdomen; each system confers and propagates polarity and can do so in the absence of the other.
        The extracellular domain of the ds product in necessary for its planar cell polarity role in the wing.
        ds is required for the proper orientation of of cell division during organ development, which determines organ shape.
        Uniform overexpression of ds in the wing has very limited effects planar cell polarity, suggesting that a gradient of ds expression is not required for planar cell polarity in the wing.
        Gradients of fj and ds expression appear to provide partially redundant positional information essential for specifying the polarisation axis in the eye. The fidelity of planar cell polarity in the eye appears to result from the combined action of the fj and ds gradients acting through ft.
        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
        ds and ft gene products maintain each other's localization in neighbouring cells.
        In the wing, as well as in the eye, fj, ds and ft orient the direction of the fz-mediated intercellular feedback loop.
        The cadherin ds regulates dorsal ventral signalling in the eye.
        ds play an important role in the regulation planar polarity in the compound eye.
        Mutations in ds cause a tissue polarity phenotype in the wing by altering the direction of fz signaling.
        ds encodes a member of the cadherin superfamily that controls imaginal disc morphogenesis. The phenotypes of, and genetic interactions between ds and ft are consistent with a model in which cell proliferation and morphogenesis of imaginal structures depends on the coupled equilibria between homo- and heterophilic interactions of the ds and ft cadherin proteins.
        "G00608; BDGP:Dm0344 ; BDGP:l (2)05142" was stated as revision.
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 41 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (15)
        Reported As
        Symbol Synonym
        cad2
        ds
        (Garrido-Jimenez et al., 2018, Gou et al., 2018, Lee et al., 2018, Mangione and Martín-Blanco, 2018, Matamoro-Vidal et al., 2018, Miller et al., 2018, Montes and Morata, 2017, Wang et al., 2017, Gene Disruption Project members, 2016-, Gomez et al., 2016, Misra and Irvine, 2016, Moulton and Letsou, 2016, Saha et al., 2016, Duff et al., 2015, González-Morales et al., 2015, Hosono et al., 2015, Morgante et al., 2015, Okumura et al., 2015, Bosch et al., 2014, Gold and Brand, 2014, Ikmi et al., 2014, Mouri et al., 2014, Degoutin et al., 2013, Hazelwood and Hancock, 2013, Kwon et al., 2013, Lawrence and Casal, 2013, Marcinkevicius and Zallen, 2013, Perea et al., 2013, Sharma and McNeill, 2013, Southall et al., 2013, Webber et al., 2013, Ambegaonkar et al., 2012, Bosveld et al., 2012, Bosveld et al., 2012, Brittle et al., 2012, Krzemien et al., 2012, Lee and Fischer, 2012, Legent et al., 2012, Matakatsu and Blair, 2012, Sagner et al., 2012, Weber et al., 2012, Bao et al., 2011, Goodrich and Strutt, 2011, Hogan et al., 2011, Kawamori et al., 2011, Luo et al., 2011, Olguín et al., 2011, Olguín et al., 2011, Rauskolb et al., 2011, Aigouy et al., 2010, Brittle et al., 2010, Harumoto et al., 2010, Ho et al., 2010, Li et al., 2010, Reddy et al., 2010, Wasbrough et al., 2010, Zecca and Struhl, 2010, Ziosi et al., 2010, Chung et al., 2009, Feng and Irvine, 2009, Flaherty et al., 2009, Ida et al., 2009, Li et al., 2009, Mao et al., 2009, Sopko et al., 2009, Zartman et al., 2009, Zhu, 2009, Baena-Lopez et al., 2008, Fabre et al., 2008, Matakatsu and Blair, 2008, Rogulja et al., 2008, Terriente et al., 2008, Willecke et al., 2008, Beltran et al., 2007, Dietzl et al., 2007, Lawrence et al., 2007, Tyler et al., 2007, Casal et al., 2006, Cho et al., 2006, Matakatsu and Blair, 2006, Molnar et al., 2006, Baena-Lopez et al., 2005, Lim et al., 2005, Strutt and Strutt, 2005, Fanto and McNeill, 2004, Stanyon et al., 2004, Fanto et al., 2003)
        Name Synonyms
        cadherin-2
        lethal (2) 01855
        Secondary FlyBase IDs
        • FBgn0000497
        • FBgn0010499
        Datasets (1)
        Study focus (1)
        Experimental Role
        Project
        Project Type
        Title
        • bait_protein
        Interaction map generated by purification of Hippo pathway factors, with identification of copurifying proteins by mass spectrometry.
        References (324)