Adf-1, nal, nalyot, l(2)01349, l(2)04065
Please see the JBrowse view of Dmel\Adf1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.48
Gene model reviewed during 5.44
Stop-codon suppression (UAA) postulated; FBrf0216884
Low-frequency RNA-Seq exon junction(s) not annotated.
1.9 (northern blot)
253 (aa); 29 (kD)
O-glycosylated; contains N-acetylglucosamine side chains.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Adf1 using the Feature Mapper tool.
Comment: maternally deposited
Comment: reported as plasmatocytes anlage
Adf1 is expressed at nearly constant levels throughout the embryo from around 4 or 5 hours after fertilizaton onward. Expression is seen in the nuclei of nearly all cells with the exception of the pole cells.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Adf1 in GBrowse 22-55
2-56.0
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for merge of: Adf-1 l(2)01349
Source for merge of: Adf1 CG15845
Source for merge of: Adf1 l(2)k14805
Adf1 mutants have defects in larval locomotion.
dsRNA has been made from templates generated with primers directed against this gene. RNAi of Adf1 results in increased arborization of ddaD and ddaE neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development.
Adf1 may be a critical regulatory switch involved in terminal stages of synapse maturation.
Comprehensive mapping of the functional domains of Adf1 to study the role of transactivators in the process of gene activation.
Shown, by partial sequencing, to be an allele of Adf1.
Encodes a transcription factor first identified by its binding to Adh enhancer sequences, but probably quite ubiquitous. The gene was also identified in a P-element screen for learning and memory defective mutations by Tully (FBrf0075143).