FB2025_01 , released February 20, 2025
Gene: Dmel\Impβ11
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General Information
Symbol
Dmel\Impβ11
Species
D. melanogaster
Name
Importin beta11
Annotation Symbol
CG33139
Feature Type
protein_coding_gene
FlyBase ID
FBgn0284254
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Ranbp11, Imp β11, importin-β11

Key Links
Genomic Location
Cytogenetic map
52B5-52B5
Sequence location
Recombination map
2-75
RefSeq locus
NT_033778 REGION:15682719..15687415
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables small GTPase binding
inferred from electronic annotation with InterPro:IPR001494
(InterPro Project Members, 2004-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in intracellular protein transport
inferred from electronic annotation with InterPro:IPR001494
(InterPro Project Members, 2004-)
involved_in protein import into nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000108134
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000108134
(GO Reference Genome Project, 2011-)
is_active_in nuclear envelope
inferred from biological aspect of ancestor with PANTHER:PTN000108134
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
BETA IMPORTINS -
Importin-β family proteins are nucleocytoplasmic transport receptors that import and export proteins and RNAs through the nuclear pores. In some import/export pathways, importin-β directly interacts with the cargo. For cargo containing a classical nuclear localization (cNLS) signal, importin-α acts as an adaptor linking the cargo to importin-β. (Adapted from FBrf0235243, FBrf0131350 and PMID:21029754).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Impβ11 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7K0Q2)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.40

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Impβ11-RA
FBtr0087278
NM_176177
3395
1075
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Impβ11-PA
FBpp0086416
122.0
1075
5.32
Q7K0Q2
NP_788357
AAF58114
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Impβ11 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.73

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval neuromuscular junction
(Higashi-Kovtun et al., 2010)
embryonic/larval hypodermal muscle cell
(Higashi-Kovtun et al., 2010)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 11
organism

Comment: 0-6h AEL

(Higashi-Kovtun et al., 2010)
first instar larval stage
organism
(Higashi-Kovtun et al., 2010)
third instar larval stage
organism
(Higashi-Kovtun et al., 2010)
organism
• cytosol
(Higashi-Kovtun et al., 2010)
organism
• nucleus
(Higashi-Kovtun et al., 2010)
adult stage
adult head | restricted

Comment: assay used the synaptosome fraction

(Higashi-Kovtun et al., 2010)
Additional Descriptive Data

Subcellularly, Impbeta11 protein is detected in the cytosol and weakly in the nuclear fractions in third instar larval stage lysates. Expression is also found in the synaptosome fraction in adult head lysates. Expression of Impbeta11 in third instar larvae localises to the nuclear envelope of motor neurons at the neuromuscular junction.

(Higashi-Kovtun et al., 2010)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Impβ11 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Impβ11
Transgenic constructs containing regulatory region of Impβ11
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(2R)BSC398
(Kahsai et al., 2016)
Df(2R)ΔM22-103
(Higashi-Kovtun et al., 2010)
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (6)
Hsap\IPO11
12 of 14
Yes
Yes
Hsap\IPO9
2 of 14
No
No
Hsap\IPO11-LRRC70
2 of 14
No
Yes
Hsap\CSE1L
1 of 14
No
No
Hsap\IPO7
1 of 14
No
No
Hsap\IPO8
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (6)
Rnor\Ipo11
12 of 14
Yes
Yes
Rnor\Ipo9
2 of 14
No
No
Rnor\Cse1l
1 of 14
No
No
Rnor\Ipo7
1 of 14
No
No
Rnor\Ipo8
1 of 14
No
No
Rnor\LOC314407
1 of 14
No
Yes
Mus musculus (laboratory mouse) (6)
Mmus\Ipo11
12 of 14
Yes
Yes
Mmus\Ipo9
2 of 14
No
No
Mmus\Ipo11-lrrc70
2 of 14
No
Yes
Mmus\Cse1l
1 of 14
No
No
Mmus\Ipo7
1 of 14
No
No
Mmus\Ipo8
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\ipo11
11 of 13
Yes
Yes
Xtro\ipo8
1 of 13
No
No
Xtro\ipo9
1 of 13
No
No
Danio rerio (Zebrafish) (5)
Drer\ipo11
13 of 14
Yes
Yes
Drer\cse1l
1 of 14
No
No
Drer\ipo7
1 of 14
No
No
Drer\ipo8
1 of 14
No
No
Drer\ipo9
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\xpo-2
1 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (4)
Agam\AgaP_AGAP002970
11 of 12
Yes
Yes
Agam\AgaP_AGAP007299
1 of 12
No
No
Agam\AgaP_AGAP010711
1 of 12
No
No
Agam\AgaP_AGAP011156
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (5)
Atha\AT3G08960
13 of 13
Yes
Yes
Atha\AT1G26170
2 of 13
No
No
Atha\AT2G46520
1 of 13
No
No
Atha\AT3G59020
1 of 13
No
No
Atha\SAD2
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\KAP120
12 of 13
Yes
Yes
Scer\CSE1
2 of 13
No
No
Scer\KAP114
1 of 13
No
No
Scer\NMD5
1 of 13
No
No
Scer\SXM1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\kap113
11 of 12
Yes
Yes
Spom\kap109
1 of 12
No
No
Spom\kap114
1 of 12
No
No
Spom\SPCC550.11
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Impβ11. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (3)
Ipo9
4 of 13
Cse1
3 of 13
msk
3 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    IPO11; importin 11
    12 of 14
    610889
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Show/hide secondary interactors 
        (data from AllianceMine provided by esyN)
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Other Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        Impβ11 - Act5C
        pull down, autoradiography
        (Borkúti et al., 2022)
        Impβ11 - fz2
        anti tag coimmunoprecipitation, anti tag western blot
        (Mosca and Schwarz, 2010)
        Summary of Genetic Interactions
        esyN Network Diagram
        Show/hide secondary interactors 
        (data from AllianceMine provided by esyN)
        esyN Network Key:
        Suppression
        Enhancement
        Other Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Impβ11
        suppressible
        sax
        (Higashi-Kovtun et al., 2010)
        Impβ11
        suppressible
        tkv
        (Higashi-Kovtun et al., 2010)
        Impβ11
        enhanceable
        wit
        (Higashi-Kovtun et al., 2010)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        wit
        enhanceable
        Impβ11
        (Higashi-Kovtun et al., 2010)
        External Data
        Linkouts
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map
        2-75
        Cytogenetic map
        52B5-52B5
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        52B5-52B5
        Limits computationally determined from genome sequence between P{lacW}Vha36k07207 and P{lacW}l(2)k05713k05713
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        52C1-52C2
        (Oh et al., 2003)
        Experimentally Determined Recombination Data
        Location

        2-75

        (FlyBase, 2016)

        2-79.0

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (7)
        Genomic Clones (14)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (16)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Higashi-Kovtun et al., 2010)
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments

                Ranbp11 is primarily required presynaptically for normal bouton formation and arborization.

                (Higashi-Kovtun et al., 2010)

                1 allele of l(2)SH0971 recovered in a P-insertion screen.

                (Oh et al., 2003)
                Relationship to Other Genes
                Source for database merge of

                Source for merge of: Ranbp11 l(2)SH0971

                (Kahsai et al., 2016)
                Additional comments

                Source for identity of Ranbp11 CG8212 was sequence comparison ( date:000605 ).

                (FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)
                Nomenclature History
                Source for database identify of

                Source for identity of: Ranbp11 CG8212

                (FlyBase, 1996-)

                Source for identity of: Impβ11 Ranbp11

                (Higashi-Kovtun et al., 2010)
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (15)
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 28 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                References (46)