FlyBase Gene Report: Dmel\VhaAC39-1

General Information

Symbol

Dmel\VhaAC39-1

Species

D. melanogaster

Name

Vacuolar H⁺ ATPase AC39 subunit 1

Annotation Symbol

CG2934

Feature Type

protein_coding_gene

FlyBase ID

FBgn0285910

Gene Model Status

Current

Stock Availability

17 publicly available

Gene Snapshot

Vacuolar H[+] ATPase AC39 subunit 1 (VhaAC39-1) encodes a subunit of the Vacuolar H[+] ATPase required for acidification of intracellular vesicles and the lysosome. It is involved in endocytic trafficking, and VhaAC39-1 mutations block Notch signaling in follicle cells and imaginal disc cells. [Date last reviewed: 2019-09-26]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

VhaAC39, cho, chocolate

Key Links

Genomic Location

Cytogenetic map

3F1-3F4

Sequence location

X:3,880,748..3,882,967 [+]

Recombination map

1-5

RefSeq locus

NC_004354 REGION:3880748..3882967

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

contributes_to proton-transporting ATPase activity, rotational mechanism

inferred by curator from GO:0033181

(Allan et al., 2005)

enables proton-transporting ATPase activity, rotational mechanism

inferred from sequence or structural similarity with SGD:S000004439

(Dow, 1999)

inferred from biological aspect of ancestor with PANTHER:PTN000111953

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (6 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in terminal branching, open tracheal system

inferred from mutant phenotype

(Francis and Ghabrial, 2015)

involved_in vacuolar acidification

inferred from mutant phenotype

(Yan et al., 2009)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in cellular iron ion homeostasis

inferred from sequence or structural similarity with UniProtKB:P61421

(assigned by UniProt )

(UniProt Curators, 2002-)

involved_in cellular response to increased oxygen levels

inferred from sequence or structural similarity with UniProtKB:P61421

(assigned by UniProt )

(UniProt Curators, 2002-)

involved_in proton transmembrane transport

inferred by curator from GO:0033181

(Allan et al., 2005)

involved_in vacuolar acidification

inferred from biological aspect of ancestor with PANTHER:PTN000111953

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in vacuolar transport

inferred from biological aspect of ancestor with PANTHER:PTN000111953

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

part_of plasma membrane proton-transporting V-type ATPase complex

inferred from mutant phenotype

(Allan et al., 2005)

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

located_in early endosome

inferred from biological aspect of ancestor with PANTHER:PTN000867164

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in lysosomal membrane

inferred from biological aspect of ancestor with PANTHER:PTN000111953

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of plasma membrane proton-transporting V-type ATPase complex

inferred from biological aspect of ancestor with PANTHER:PTN000867164

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of vacuolar proton-transporting V-type ATPase complex

inferred from biological aspect of ancestor with PANTHER:PTN000111953

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of vacuolar proton-transporting V-type ATPase, V0 domain

inferred from sequence or structural similarity with SGD:S000004439

(Dow, 1999)

Gene Group (FlyBase)

VACUOLAR ATPASE V0 DOMAIN SUBUNITS

Protein Family (UniProt)

Belongs to the V-ATPase V0D/AC39 subunit family. (Q9W4P5)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

VACUOLAR ATPASE V0 DOMAIN SUBUNITS -: The V0 domain of V-ATPases is the integral membrane domain responsible for the translocation of protons across the membrane. It is assembled from four to five different subunits (a, c, c'', d and e in D.mel) that are expressed as multiple isoforms in a tissue-specific manner. (Adapted from PMID:20450191 and FBrf0188241).

Protein Function (UniProtKB)

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity).

(UniProt, Q9W4P5)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

cho: chocolate

Eye color brown with whitish highlights. Paler than se, less purplish than pn. In cho2 2-amino-4-hydroxypterine absent; isoxanthopterin II present in excess (McKay, 1972, DIS 48: 62). Malpighian tubes of larvae and adults contain brown pigment like red. Larvae easily distinguished from wild type. Malpighian tube color autonomous in mosaic larvae [Falk, Orevi, and Menzel, 1973, Nature (London) New Biol. 246: 19-20]. Brown pigment of Malpighian tubes absent when cho is combined with v, cn, or st, mutations which prevent formation of brown eye pigment. Eye color of cho v is yellowish, but cho g cannot be distinguished from g. Separability, viability, and fertility excellent. RK1.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\VhaAC39-1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.40

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

VhaAC39-1-RA

FBtr0070611

NM_130724

1792

350

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

VhaAC39-1-PA

FBpp0070584

39.9

350

4.52

NP_570080

AAF45902

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

(UniProt, Q9W4P5)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9W4P5

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\VhaAC39-1 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

adult stage

adult hindgut

(Allan et al., 2005)

adult posterior hindgut

(Allan et al., 2005)

adult Malpighian tubule

(Allan et al., 2005)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of plasma membrane proton-transporting V-type ATPase complex

inferred from mutant phenotype

(Allan et al., 2005)

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\VhaAC39-1 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\VhaAC39-1

View exonic expression by tissue for Dmel\VhaAC39-1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG2934-RA

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of VhaAC39-1

Transgenic constructs containing regulatory region of VhaAC39-1

Deletions and Duplications ( 58 )

Not disrupted in

Df(1)bi-D2

(Oliver et al., 1988)

Df(1)bi-DL5

(Oliver et al., 1988)

Df(1)BSC834

(Grant et al., 2016)

Df(1)BSC877

(Grant et al., 2016)

Df(1)C149

(Oliver et al., 1988)

Df(1)d03180-e04316

(Grant et al., 2016)

Df(1)e04316-d02176

(Grant et al., 2016)

Df(1)GA56

(Oliver et al., 1988)

Df(1)JC70

(Oliver et al., 1988, Schalet, 1986)

Df(1)N-8

(Sturtevant, 1955)

Df(1)N73

(Oliver et al., 1988)

Df(1)ovo6

(Oliver et al., 1988)

Df(1)ovo7

(Oliver et al., 1988)

Df(1)ovo41

(Steinmann-Zwicky, 1988)

Df(1)ovo44

(Steinmann-Zwicky, 1988)

Df(1)rb1

(Goode et al., 1996, Oliver et al., 1988)

Df(1)rb13

(Oliver et al., 1988)

Df(1)rb14

(Steinmann-Zwicky, 1988)

Df(1)rb27

(Steinmann-Zwicky, 1988)

Df(1)rb29

(Steinmann-Zwicky, 1988)

Df(1)rb30

(Oliver et al., 1988)

Df(1)rb33

(Oliver et al., 1988)

Df(1)rb35

(Steinmann-Zwicky, 1988)

Df(1)rb42

(Steinmann-Zwicky, 1988)

Df(1)rb44

(Steinmann-Zwicky, 1988)

Df(1)rb46

(Oliver et al., 1988)

Df(1)rb48

(Steinmann-Zwicky, 1988)

Df(1)rb50

(Steinmann-Zwicky, 1988)

Df(1)RC40

(Oliver et al., 1988, Steinmann-Zwicky, 1988, Craymer and Roy, 1980)

Df(1)Sp(rb)

(Schalet, 1986)

Not duplicated in

Dp(1;2)w-ec

(Schalet, 1986)

Dp(1;3)sn^13a1

(Schalet, 1986)

Dp(1;Y)dx⁺1

(Florence, 1999.7.22)

Dp(1;Y)dx⁺2

(Florence, 1999.7.22)

Dp(1;Y)dx⁺3

(Florence, 1999.7.22)

Dp(1;Y)dx⁺5

(Florence, 1999.7.22)

Duplicated in

Dp(1;3)DC068

(Popodi et al., 2010-)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

VhaAC39-1^GD9859

lethal | pupal stage, with Scer\GAL4^pnr-MD237

VhaAC39-1^GD9859

lethal | recessive

viable

viable, with Scer\GAL4^tin.CΔ4

VhaAC39-1^GD9859

Sterility

Allele

fertile

Other Phenotypes

Allele

exocytosis defective | third instar larval stage, with Scer\GAL4^{SPARC-MI00329-GAL4}

VhaAC39-1^HMS01442

eye color defective

eye color defective (with VhaAC39-1^cho-1)

VhaAC39-1^cho-2

eye color defective (with VhaAC39-1^cho-2)

VhaAC39-1^cho-1

neuroanatomy defective | adult stage | somatic clone

visible | adult stage

VhaAC39-1^unspecified

visible | adult stage | somatic clone

Phenotype manifest in

Allele

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^{SPARC-MI00329-GAL4}

VhaAC39-1^HMS01442

extracellular matrix | third instar larval stage, with Scer\GAL4^{SPARC-MI00329-GAL4}

VhaAC39-1^HMS01442

eye

VhaAC39-1^unspecified

eye | somatic clone

follicle cell | somatic clone

VhaAC39-1^FZ29

Malpighian tubule

VhaAC39-1^cho-1

pigment cell

pigment cell (with VhaAC39-1^cho-1)

VhaAC39-1^cho-2

pigment cell (with VhaAC39-1^cho-2)

VhaAC39-1^cho-1

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ATP6V0D1

14 of 15

Yes

Hsap\ATP6V0D2

8 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Atp6v0d1

14 of 15

Yes

Mmus\Atp6v0d2

7 of 15

Yes

Rattus norvegicus (Norway rat) (2)

Rnor\Atp6v0d1

13 of 13

Yes

Rnor\Atp6v0d2

8 of 13

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\atp6v0d1

9 of 12

Yes

Xtro\atp6v0d2

9 of 12

Yes

Danio rerio (Zebrafish) (1)

Drer\atp6v0d1

14 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\vha-16

11 of 15

Yes

Arabidopsis thaliana (thale-cress) (2)

Atha\AT3G28710

9 of 9

Yes

Atha\AT3G28715

9 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\VMA6

13 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\vma6

11 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190A3U )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00006116

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA15530

Drosophila persimilis

Dper\GL14761

Drosophila willistoni

Dwil\GK16475

Drosophila willistoni

Dwil\GK10228

Drosophila virilis

Dvir\GJ16024

Drosophila mojavensis

Dmoj\GI16480

Drosophila grimshawi

Dgri\GH17612

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915063W )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17021898

Musca domestica

House fly

Mdoa\17021896

Glossina morsitans

Tsetse fly

Gmor\GMOY002728

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_04922

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL011025

Anopheles darlingi

American malaria mosquito

Adar\ADAC002548

Anopheles gambiae

Malaria mosquito

Agam\AGAP000721

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009947

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W064P )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA003196

Danaus plexippus

Monarch butterfly

Dple\DPOGS211216-PA

Apis florea

Little honeybee

Aflo\2905658068

Apis mellifera

Western honey bee

Amel\VhaAC39

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP21057

Bombus terrestris

Buff-tailed bumblebee

Bter\15211289

Linepithema humile

Argentine ant

Lhum\LH19186

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002041

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG007455

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_01858

Tribolium castaneum

Red flour beetle

Tcas\TC013357

Pediculus humanus

Human body louse

Phum\PHUM410380

Rhodnius prolixus

Kissing bug

Rpro\RPRC005881

Cimex lectularius

Bed bug

Clec\CLEC005654

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003170

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_13147

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0609 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR003159

Strigamia maritima

European centipede

Smar\SMAR000894

Ixodes scapularis

Black-legged tick

Isca\ISCW002101

Stegodyphus mimosarum

African social velvet spider

Smim\KFM75562.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur13g02330

Tetranychus urticae

Two-spotted spider mite

Turt\tetur14g00290

Tetranychus urticae

Two-spotted spider mite

Turt\tetur02g08570

Tetranychus urticae

Two-spotted spider mite

Turt\tetur13g02310

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_300127

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G09L5 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Vhaac39

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000005663

Gallus gallus

Domestic chicken

Ggal\ATP6V0D2

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000028020

Gallus gallus

Domestic chicken

Ggal\ATP6V0D1

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000026096

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

7 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ATP6V0D1; ATPase H+ transporting V0 subunit d1

14 of 15

607028

ATP6V0D2; ATPase H+ transporting V0 subunit d2

8 of 15

618072

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

VhaAC39-1 - ATP6AP2

experimental knowledge based

(Guruharsha et al., 2011)

VhaAC39-1 - CAP

two hybrid

(Hu et al., 2017.6.13)

VhaAC39-1 - CG13829

experimental knowledge based

(Guruharsha et al., 2011)

VhaAC39-1 - CG7071

experimental knowledge based

(Guruharsha et al., 2011)

VhaAC39-1 - CG7289

experimental knowledge based

(Guruharsha et al., 2011)

VhaAC39-1 - Dgat2

experimental knowledge based

(Guruharsha et al., 2011)

VhaAC39-1 - Vha100-1

experimental knowledge based

(Guruharsha et al., 2011)

VhaAC39-1 - Vha100-2

experimental knowledge based

(Guruharsha et al., 2011)

VhaAC39-1 - Vha14-1

experimental knowledge based

(Guruharsha et al., 2011)

VhaAC39-1 - VhaAC45

experimental knowledge based

(Guruharsha et al., 2011)

VhaAC39-1 - VhaM9.7-b

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

LKRSDH

enhanceable

VhaAC39-1

External Data

Subunit Structure (UniProtKB)

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

(UniProt, Q9W4P5 )

Linkouts

BioGRID - A database of protein and genetic interactions.

57861

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

31342
44508

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-5

Cytogenetic map

3F1-3F4

Sequence location

X:3,880,748..3,882,967 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

3F1-3F4

Left limit from inclusion within Df(1)cho19 (FBrf0047948) Right limit from non-inclusion within Df(1)rb33 (FBrf0048195); Limits computationally determined from genome sequence between P{EP}CG2930^EP1352 and P{EP}EP425

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-5

(FlyBase, 2016, Dambly-Chaudiere and Leyns, 1992)

1-4.6

(Comeron et al., 2012)

1-5.4

(Sturtevant, 1955)

1-5.5

Left of (cM)

(Sturtevant, 1955)

Right of (cM)

(Sturtevant, 1955)

Notes

Stocks and Reagents

Stocks (17)

Bloomington

82670

y¹ v¹; P{TKO.GS04992}attP40

186

y² VhaAC39-1^cho-2 flw¹

7153

Df(1)10-70d, VhaAC39-1^cho-1 sn³/FM6

41811

y¹ w^* VhaAC39-1^FY38 P{neoFRT}19A/FM7c

41812

y¹ w^* VhaAC39-1^FZ29 P{neoFRT}19A/FM7c

14394

y¹ w^67c23 P{Mae-UAS.6.11}VhaAC39-1^GG01465/FM7c

35029

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01442}attP2

Kyoto

105777

y² VhaAC39-1^cho-2

105778

y² VhaAC39-1^cho-2 flw¹

105806

y¹ fs(1)N¹² VhaAC39-1^cho-1 f¹/FM3

VDRC

v20950

w¹¹¹⁸ P{GD9859}v20950

v20951

w¹¹¹⁸ P{GD9859}v20951

More stocks available...

Genomic Clones (10)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (146)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD24653

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: VhaAC39 CG2934

(Bayraktaroglu, 2000.11.2)

Source for merge of: VhaAC39 anon- EST:GressD5

(Ashburner, 2004.6.30)

Source for merge of: VhaAC39-1 cho

(Grant et al., 2016)

Additional comments

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 27 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31342

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9W4P5

Other crossreferences

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG2934

Linkouts

BioGRID - A database of protein and genetic interactions.

57861

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG2934-RA

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

31342
44508

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

ATP6V0D1

(Adamson et al., 2011)

CG2934

(Cammarato et al., 2011, Ni et al., 2011.7.19, Khanna et al., 2010, Derré et al., 2007, Allan et al., 2005, Ashburner, 2004.6.30, Wang et al., 2004)

V0d

(Francis and Ghabrial, 2015)

VhaAC39

(Nikolova and Metzstein, 2015, Japanese National Institute of Genetics, 2012.5.21, Abruzzi et al., 2011, Popodi et al., 2010-, Tan et al., 2009, Tio et al., 2009, Yan et al., 2009, Sepp et al., 2008, Derré et al., 2007, Stuart et al., 2007, Gilfillan et al., 2006)

VhaAC39-1

(Vásquez-Procopio et al., 2020, Wissel et al., 2018, Hu et al., 2017.6.13, Transgenic RNAi Project members, 2017-, Grant et al., 2016, Francis and Ghabrial, 2015, Van Bortle et al., 2015, Zhang et al., 2015, Bischof and FlyORF project members, 2014.6.20, Chang et al., 2013, Chintapalli et al., 2013)

Vhaac39

(Bandyopadhyay et al., 2006)

anon-EST:GressD5

cho

(Grant et al., 2016, Kondo and Ueda, 2013, Kamleh et al., 2009, Peralta et al., 2009, Sturtevant, 1955)

vhaAC39

(Stark et al., 2005, Dow, 1999)

vhaAC39-1

(Zhao et al., 2018, Chintapalli et al., 2013, Adamson et al., 2011, Zoncu et al., 2011, Allan et al., 2005, Wang et al., 2004)

Name Synonyms

V-ATPase V0 d subunit

(Yan et al., 2009)

Vacuolar H+ ATPase AC39 subunit 1

Vacuolar H+ ATPase subunit AC39-1

Vacuolar H+-ATPase C39 subunit

VhaAC39

(Cammarato et al., 2011, Khanna et al., 2010, Sepp et al., 2008)

VhaAC39-1

(Salazar and Yamamoto, 2018)

chocolate

(Grant et al., 2016)

vacuolar ATPsintase subunit 1

(Tio et al., 2009)

Secondary FlyBase IDs

FBgn0000310
FBgn0028665
FBgn0025327
FBgn0029680

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (91)

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