MRE11, dIMP, l(1)G0072, IMP-1, KH-domain protein
zipcode-binding protein - regulator of RNA transport in oocytes and neurons - regulates aging of the Drosophila testis stem-cell niche - contributes to the localized expression of mRNA in the oocyte - counteracts endogenous small interfering RNAs to stabilize mRNAs
Gene model reviewed during 5.55
Gene model reviewed during 5.46
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.
Gene model reviewed during 5.56
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Imp using the Feature Mapper tool.
Imp transcripts are detected early and late in embryogenesis but transcripts containing the 3' UTR extension (~8.5 kb) are only detected at later stages and appear after the maternal-to-zygotic transition. The 3' UTR extension isoforms are highly enriched in nervous system tissues.
Immunolocalization shows that Imp is expressed in the -- and pole cells in blastoderm embryos and in the ventral nerve cord in stage 14-16 embryos. Double staining with an antibody to futsch reveals that Imp is expressed in peripheral sensory neurons and some futsch-negative cells surrounding them. Overlap with pros expression reveals Imp expression in the scolopale cells of chordotonal organs and in sheath cells of the external sensory organs. No staining was observed in peripheral motor axons or in muscle.
Imp protein is cytoplasmic and present in all cells of the oocyte, follicle cells, nurse cells, and the oocyte. Within the germline, the pattern changes with time. It is initially uniform in the dividing germ line cells of each cyst but becomes rapidly concentrated in the oocyte. By stage S7, the uniform levels in the oocyte are noticably reduced but by stage S8 and S9 Imp levels are elevated in a narrow zone between the nucleus and the anterior and dorsolateral margins of the oocyte (an area which coincides with the region where grk mRNA and protein accumulate). This localizaton is lost by mid-stage 9. Imp also localizes to a crescent at the posterior pole of the oocyte.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Imp in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: IGF-II CG1691
Source for merge of: Imp anon-WO0140519.39 Source for merge of Imp anon-WO0140519.39 was sequence comparison ( date:051113 ).
Source for identity of IGF-II CG1691 was sequence comparison ( date:000414 ).