FB2020_06, released Dec 22, 2020

Gene: Dmel\Rab1

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General Information
Symbol
Dmel\Rab1
Species
D. melanogaster
Name
Rab1
Annotation Symbol
CG3320
Feature Type
protein_coding_gene
FlyBase ID
FBgn0285937
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Snapshot
Rab1 (Rab1) encodes a small GTPase which regulates endoplasmic reticulum to Golgi and intra Golgi trafficking through different effectors. It has been involved in Notch signaling, cell migration, autophagy and cytokinesis. [Date last reviewed: 2019-03-28]
Other Summaries
Also Known As

Rab-protein 1, omt, omelette, dRab1, DmRab1

Key Links
Genomic Location
Cytogenetic map
93D2-93D2
Sequence location
3R:21,266,029..21,269,060 [-]
Recombination map

3-71

RefSeq locus
NT_033777 REGION:21266029..21269060
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (28 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables Golgi transport complex binding
inferred from direct assay
(Sechi et al., 2017)
enables GTPase activity
inferred from mutant phenotype
(Sechi et al., 2017)
enables protein binding
inferred from physical interaction with UniProtKB:A1Z8W8
(Sechi et al., 2017)
inferred from physical interaction with UniProtKB:Q9VQ93
(Sechi et al., 2017)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTP binding
inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR003579, InterPro:IPR005225
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables GTPase activity
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN001292747
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (17 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
involved_in anterograde axonal transport
inferred from mutant phenotype
(Cao et al., 2014)
involved_in carbohydrate homeostasis
inferred from mutant phenotype
(Cao et al., 2014)
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport
inferred from mutant phenotype
(Ke et al., 2018)
involved_in male meiosis cytokinesis
inferred from mutant phenotype
(Sechi et al., 2017)
involved_in mitotic cytokinesis
inferred from mutant phenotype
(Sechi et al., 2017)
involved_in negative regulation of viral entry into host cell
inferred from high throughput mutant phenotype
(Hodgson et al., 2019)
involved_in positive regulation of dendrite morphogenesis
inferred from mutant phenotype
(Ye et al., 2007)
involved_in positive regulation of insulin secretion
inferred from mutant phenotype
(Cao et al., 2014)
involved_in positive regulation of synapse pruning
inferred from mutant phenotype
(Wang et al., 2018)
involved_in protein localization to cleavage furrow
inferred from mutant phenotype
(Sechi et al., 2017)
involved_in protein localization to Golgi apparatus
inferred from mutant phenotype
(Sechi et al., 2017)
involved_in protein secretion
inferred from mutant phenotype
(Ching et al., 2008)
inferred from genetic interaction with FLYBASE:Rab1; FB:FBgn0285937
(Ke et al., 2018)
involved_in regulation of cell migration
inferred from mutant phenotype
(Wang et al., 2010)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in autophagosome assembly
inferred from biological aspect of ancestor with PANTHER:PTN000636233
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport
traceable author statement
(Lecuit and Pilot, 2003)
involved_in intracellular protein transport
inferred from biological aspect of ancestor with PANTHER:PTN001292747
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in Rab protein signal transduction
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(FlyBase Curators, 2008--)
involved_in vesicle-mediated transport
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(FlyBase Curators, 2008--)
Cellular Component (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
located_in cleavage furrow
inferred from mutant phenotype
(Sechi et al., 2017)
located_in cytoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
located_in endoplasmic reticulum exit site
inferred from direct assay
(Ke et al., 2018)
located_in Golgi apparatus
inferred from mutant phenotype
(Sechi et al., 2017)
located_in neuronal cell body
inferred from high throughput direct assay
(Chan et al., 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in endomembrane system
inferred from biological aspect of ancestor with PANTHER:PTN001292747
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in vesicle
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(FlyBase Curators, 2008--)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
RAB GTPASES -
The Rab family are members of the Ras superfamily of small GTPases. Rabs regulate vesicle trafficking including cargo selection, vesicle budding, transport, docking and targeting. They localize to different intracellular compartments directed by specific isoprenylation of C-terminal motifs. (Adapted from PMID:15731001).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Rab1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 6.02

Sequence Ontology: Class of Gene
gene
gene_with_edited_transcript
(Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Rab1-RA
FBtr0084104
NM_169953
1804
205
Additional Transcript Data and Comments
Reported size (kB)

1.7 (longest cDNA)

(Satoh et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Rab1-PA
FBpp0083503
22.8
205
5.10
NP_732610
AAF55873
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

205 (aa)

(Satoh et al., 1997)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rab1 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cleavage furrow
inferred from mutant phenotype
(Sechi et al., 2017)
located_in cytoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
located_in endoplasmic reticulum exit site
inferred from direct assay
(Ke et al., 2018)
located_in Golgi apparatus
inferred from mutant phenotype
(Sechi et al., 2017)
located_in neuronal cell body
inferred from high throughput direct assay
(Chan et al., 2011)
Expression Deduced from Reporters
Reporter: PBac{810.P.FSVS-2}Rab1CPTI004256
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain | restricted

Comment: No expression in central complex, antennal lobes and mushroom bodies.

(Knowles-Barley, 2011.8.24)
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
Reporter: PBac{810.P.FSVS-2}Rab1CPTI004394
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain | faint | ubiquitous
(Knowles-Barley, 2011.8.24)
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
Reporter: PBac{I-SceI(FRT.Rab1-GAL4.ATG(loxP.3xP3-RFP))}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
neuropil glial sheath
(Jin et al., 2012)
Bolwig organ | restricted
(Jin et al., 2012)
embryonic/larval mushroom body | intense
(Jin et al., 2012)
eye disc | restricted
(Jin et al., 2012)
embryonic/larval optic stalk sheath cell | intense
(Jin et al., 2012)
ventral thoracic disc | restricted
(Jin et al., 2012)
wing disc | restricted
(Jin et al., 2012)
embryonic/larval salivary gland | restricted
(Jin et al., 2012, Chan et al., 2011)
neuron of embryonic/larval brain
(Chan et al., 2011)
glial cell | subset of embryonic/larval brain
(Chan et al., 2011)
neuron | subset of ventral nerve cord
(Chan et al., 2011)
wing disc
(Chan et al., 2011)
eye disc
(Chan et al., 2011)
ventral thoracic disc
(Chan et al., 2011)
pupal stage P6 -- P7
neuropil glial sheath

Comment: 30-40h APF

(Jin et al., 2012)
glial cell of second optic chiasma | intense

Comment: 30-40h APF

(Jin et al., 2012)
neuron of adult optic lobe | faint

Comment: 30-40h APF

(Jin et al., 2012)
mushroom body

Comment: 30-40h APF

(Jin et al., 2012, Chan et al., 2011)
eye photoreceptor cell

Comment: 30-40h APF

(Jin et al., 2012)
neuron of pupal brain

Comment: 30-40h APF

(Chan et al., 2011)
adult stage
adult ensheathing glial cell
(Jin et al., 2012)
adult inner optic chiasma giant glial cell | intense
(Jin et al., 2012)
neuron of adult optic lobe | faint
(Jin et al., 2012)
adult mushroom body | intense
(Jin et al., 2012, Chan et al., 2011)
adult antennal lobe
(Jin et al., 2012)
adult insulin secreting cell of pars intercerebralis | intense
(Jin et al., 2012)
neuron of lamina | intense
(Jin et al., 2012)
ellipsoid body
(Jin et al., 2012)
fan-shaped body
(Jin et al., 2012)
neuron of adult brain
(Chan et al., 2011)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Rab1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Rab1
Transgenic constructs containing regulatory region of Rab1
Deletions and Duplications ( 4 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
cell lethal
lethal
lethal, with Scer\GAL4pnr-MD237
lethal, with Scer\GAL4Rab1.ATG
lethal (with Df(3R)ED10838)
lethal (with Df(3R)ED10845)
lethal - all die before end of larval stage
lethal - all die before end of larval stage (with Rab1e01287)
lethal - all die before end of larval stage (with Rab1S147213)
viable
Sterility
Allele
female sterile | germline clone | recessive
Other Phenotypes
Allele
body size defective, with Scer\GAL4Ilp2.PW
cytokinesis defective | adult stage | male (with Df(3R)ED10838)
cytokinesis defective | adult stage | male (with Rab1S147213)
cytokinesis defective | adult stage | male (with Rab1Z4144)
cytokinesis defective | male (with Df(3R)e-F1)
cytokinesis defective | male | recessive
developmental rate defective, with Scer\GAL4Ilp2.PW
exocytosis defective | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
heat stress response defective, with Scer\GAL4ppk.PG
meiotic cell cycle defective | male (with Df(3R)e-F1)
meiotic cell cycle defective | male | recessive
neuroanatomy defective
neuroanatomy defective | larval stage, with Scer\GAL4Ilp2.PW
short lived (with Df(3R)ED10838)
Phenotype manifest in
Allele
cis-Golgi network | third instar larval stage, with Scer\GAL4Cg.PA
contractile ring & meiotic telophase I | male
contractile ring & meiotic telophase I | male (with Df(3R)e-F1)
contractile ring & meiotic telophase II | male
contractile ring & meiotic telophase II | male (with Df(3R)e-F1)
contractile ring | adult stage | male (with Df(3R)ED10838)
contractile ring | larval stage (with Df(3R)ED10838)
dendrite, with Scer\GAL4Ilp2.PW
dendrite & dendritic arborising neuron
embryonic/larval fat body | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
endoplasmic reticulum exit site | third instar larval stage, with Scer\GAL4Cg.PA
extracellular matrix | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
Golgi apparatus & photoreceptor cell, with Scer\GAL4hs.PB
Golgi apparatus | adult stage | male (with Df(3R)ED10838)
larval insulin secreting cell of pars intercerebralis, with Scer\GAL4Ilp2.PW
microvillus & photoreceptor cell, with Scer\GAL4hs.PB
Nebenkern
Nebenkern (with Df(3R)ED10838)
Nebenkern (with Df(3R)e-F1)
Nebenkern (with Rab1S147213)
Nebenkern (with Rab1Z4144)
neuroblast | larval stage (with Df(3R)ED10838)
rough endoplasmic reticulum & photoreceptor cell, with Scer\GAL4hs.PB
spermatid (with Df(3R)ED10838)
spermatid (with Rab1S147213)
spermatid (with Rab1Z4144)
spermatid & nucleus | supernumerary
spermatid & nucleus | supernumerary (with Df(3R)e-F1)
spermatocyte (with Df(3R)ED10838)
spindle & meiotic telophase I | male
spindle & meiotic telophase I | male (with Df(3R)e-F1)
spindle & meiotic telophase II | male
spindle & meiotic telophase II | male (with Df(3R)e-F1)
vesicle | adult stage | male (with Df(3R)ED10838)
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\RAB1A
13 of 15
Yes
Yes
Hsap\RAB1B
11 of 15
No
Yes
Hsap\RAB1C
4 of 15
No
Yes
Hsap\RAB19
2 of 15
No
No
Hsap\ACADVL
1 of 15
No
No
Hsap\RAB3A
1 of 15
No
No
Hsap\RAB3B
1 of 15
No
No
Hsap\RAB3C
1 of 15
No
No
Hsap\RAB3D
1 of 15
No
No
Hsap\RAB8A
1 of 15
No
No
Hsap\RAB8B
1 of 15
No
No
Hsap\RAB10
1 of 15
No
No
Hsap\RAB13
1 of 15
No
No
Hsap\RAB15
1 of 15
No
No
Hsap\RAB30
1 of 15
No
No
1  
Hsap\RAB33A
1 of 15
No
Yes
Hsap\RAB33B
1 of 15
No
No
Hsap\RAB43
1 of 15
No
No
1  
Hsap\RABL6
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Rab1a
13 of 15
Yes
Yes
1  
Mmus\Rab1b
11 of 15
No
Yes
Mmus\Rab19
2 of 15
No
No
Mmus\Rab43
2 of 15
No
No
Mmus\Rab3a
1 of 15
No
No
Mmus\Rab3b
1 of 15
No
No
Mmus\Rab3c
1 of 15
No
No
Mmus\Rab3d
1 of 15
No
No
Mmus\Rab8a
1 of 15
No
No
Mmus\Rab8b
1 of 15
No
No
Mmus\Rab10
1 of 15
No
No
Mmus\Rab12
1 of 15
No
No
Mmus\Rab13
1 of 15
No
No
Mmus\Rab15
1 of 15
No
No
Mmus\Rab30
1 of 15
No
No
Mmus\Rab33a
1 of 15
No
Yes
Mmus\Rab33b
1 of 15
No
No
Mmus\Rab35
1 of 15
No
No
Mmus\Rabl6
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (22)
Rnor\Rab1a
8 of 13
Yes
Yes
Rnor\LOC102555167
6 of 13
No
Yes
Rnor\Rab1b
6 of 13
No
Yes
Rnor\LOC100363782
2 of 13
No
Yes
Rnor\Rab19
2 of 13
No
No
Rnor\Rab35
2 of 13
No
No
Rnor\Rab43
2 of 13
No
No
Rnor\Rab1b-ps1
1 of 13
No
Yes
Rnor\Rab3a
1 of 13
No
No
Rnor\Rab3b
1 of 13
No
No
Rnor\Rab3c
1 of 13
No
No
Rnor\Rab3d
1 of 13
No
No
Rnor\Rab8a
1 of 13
No
No
Rnor\Rab8b
1 of 13
No
No
Rnor\Rab10
1 of 13
No
No
Rnor\Rab12
1 of 13
No
No
Rnor\Rab13
1 of 13
No
No
Rnor\Rab15
1 of 13
No
No
Rnor\Rab30
1 of 13
No
No
Rnor\Rab33a
1 of 13
No
Yes
Rnor\Rab33b
1 of 13
No
No
Rnor\Rabl6
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (19)
Xtro\rab1a
7 of 12
Yes
Yes
Xtro\rab19
2 of 12
No
No
Xtro\rab35
2 of 12
No
No
Xtro\rab35
2 of 12
No
No
Xtro\LOC100135070
1 of 12
No
No
Xtro\rab3a
1 of 12
No
No
Xtro\rab3b
1 of 12
No
No
Xtro\rab3c
1 of 12
No
No
Xtro\rab3d
1 of 12
No
No
Xtro\rab8a
1 of 12
No
No
Xtro\rab8b
1 of 12
No
No
Xtro\rab10
1 of 12
No
No
Xtro\rab12
1 of 12
No
No
Xtro\rab13
1 of 12
No
No
Xtro\rab15
1 of 12
No
No
Xtro\rab30
1 of 12
No
No
Xtro\rab33a
1 of 12
No
No
Xtro\rab33b
1 of 12
No
No
Xtro\rabl6
1 of 12
No
Yes
Danio rerio (Zebrafish) (29)
Drer\rab1ab
12 of 15
Yes
Yes
Drer\rab1aa
11 of 15
No
Yes
Drer\rab1ba
10 of 15
No
Yes
Drer\rab1bb
10 of 15
No
Yes
Drer\zgc:171927
4 of 15
No
Yes
Drer\LOC555645
2 of 15
No
No
Drer\rab35a
2 of 15
No
No
Drer\rab35b
2 of 15
No
No
Drer\rab43
2 of 15
No
No
Drer\si:dkey-16l2.16
2 of 15
No
No
Drer\rab3aa
1 of 15
No
No
Drer\rab3ab
1 of 15
No
No
Drer\rab3b
1 of 15
No
No
Drer\rab3c
1 of 15
No
No
Drer\rab3da
1 of 15
No
No
Drer\rab3db
1 of 15
No
No
Drer\rab8a
1 of 15
No
No
Drer\rab8b
1 of 15
No
No
Drer\rab10
1 of 15
No
No
Drer\rab12
1 of 15
No
No
Drer\rab13
1 of 15
No
No
Drer\rab15
1 of 15
No
No
Drer\rab19
1 of 15
No
Yes
Drer\rab30
1 of 15
No
No
Drer\rab33a
1 of 15
No
No
Drer\rab33ba
1 of 15
No
Yes
Drer\rabl6a
1 of 15
No
Yes
Drer\rabl6b
1 of 15
No
Yes
Drer\zgc:101559
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (10)
Cele\rab-1
11 of 15
Yes
Yes
Cele\rab-35
2 of 15
No
No
Cele\F08G12.1
1 of 15
No
Yes
Cele\K02E10.1
1 of 15
No
No
Cele\rab-3
1 of 15
No
No
Cele\rab-8
1 of 15
No
No
Cele\rab-10
1 of 15
No
No
Cele\rab-19
1 of 15
No
No
Cele\rab-30
1 of 15
No
No
Cele\rab-33
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (4)
Atha\RA-5
8 of 9
Yes
Yes
Atha\RAB1A
7 of 9
No
Yes
Atha\RAB1C
7 of 9
No
Yes
Atha\ATFP8
4 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\YPT1
10 of 15
Yes
Yes
Scer\SEC4
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\ypt1
9 of 12
Yes
Yes
Spom\ypt2
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190FFN )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010818
Drosophila simulans
Dsim\GD19996
Drosophila sechellia
Dsec\GM15089
Drosophila erecta
Dere\GG14761
Drosophila yakuba
Dyak\Rab1
Drosophila ananassae
Dana\GF17263
Drosophila pseudoobscura pseudoobscura
Dpse\GA17362
Drosophila persimilis
Dper\GL27164
Drosophila willistoni
Dwil\GK12772
Drosophila virilis
Dvir\GJ14443
Drosophila mojavensis
Dmoj\GI10837
Drosophila grimshawi
Dgri\GH18937
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150D07 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17014301
Glossina morsitans
Tsetse fly
Gmor\GMOY008795
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12835
Mayetiola destructor
Hessian fly
Mdes\Mdes011713
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005069
Anopheles darlingi
American malaria mosquito
Adar\ADAC009218
Anopheles gambiae
Malaria mosquito
Agam\AGAP004146
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ005366
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0FML )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\rabB
Danaus plexippus
Monarch butterfly
Dple\DPOGS204191-PA
Apis florea
Little honeybee
Aflo\2247288260
Apis mellifera
Western honey bee
Amel\Ame.3590
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18729
Bombus terrestris
Buff-tailed bumblebee
Bter\15216383
Linepithema humile
Argentine ant
Lhum\LH12803
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001ca2
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005975
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05318
Tribolium castaneum
Red flour beetle
Tcas\TC009965
Pediculus humanus
Human body louse
Phum\PHUM220030
Rhodnius prolixus
Kissing bug
Rpro\RPRC003793
Rhodnius prolixus
Kissing bug
Rpro\RPRC008122
Cimex lectularius
Bed bug
Clec\CLEC007552
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000150
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03653
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0FML )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR015600
Strigamia maritima
European centipede
Smar\SMAR003012
Ixodes scapularis
Black-legged tick
Isca\ISCW015757
Ixodes scapularis
Black-legged tick
Isca\ISCW003929
Ixodes scapularis
Black-legged tick
Isca\ISCW006071
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70918.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74897.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77572.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g00590
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g00570
Tetranychus urticae
Two-spotted spider mite
Turt\tetur19g02010
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_195992
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_223052
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0LA6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rab1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rab8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rab35
Ciona intestinalis
Vase tunicate
Cint\LOC100185758
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000016136
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000022390
Ciona intestinalis
Vase tunicate
Cint\LOC100185850
Gallus gallus
Domestic chicken
Ggal\RAB8B
Gallus gallus
Domestic chicken
Ggal\RAB10
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028851
Gallus gallus
Domestic chicken
Ggal\RAB35
Gallus gallus
Domestic chicken
Ggal\RAB1A
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (34)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Rab9Db
4 of 10
Rab9D
4 of 10
Rab9Fb
4 of 10
Rab19
4 of 10
Rab35
4 of 10
RabX2
4 of 10
Rab3
3 of 10
Rab8
3 of 10
Rab9E
3 of 10
Rab9Fa
3 of 10
Rab10
3 of 10
Rab30
3 of 10
RabX4
3 of 10
CG4789
2 of 10
Rab2
2 of 10
Rab4
2 of 10
Rab5
2 of 10
Rab6
2 of 10
Rab7
2 of 10
Rab9
2 of 10
Rab11
2 of 10
Rab14
2 of 10
Rab18
2 of 10
Rab21
2 of 10
Rab23
2 of 10
Rab26
2 of 10
Rab27
2 of 10
Rab32
2 of 10
Rab39
2 of 10
RabX1
2 of 10
RabX5
2 of 10
CG15399
1 of 10
Rab40
1 of 10
RabX6
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RAB1A; RAB1A, member RAS oncogene family
    13 of 15
    179508
        RAB1B; RAB1B, member RAS oncogene family
        11 of 15
        612565
            RAB1C; RAB1C, member RAS oncogene family pseudogene
            4 of 15
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Show neighbor-neighbor interactions:
                Select Layout:
                Legend:
                Protein
                RNA
                Selected Interactor(s)
                Interactions Browser
                View in Interactions Browser
                Please see the Physical Interaction reports below for full details
                protein-protein
                Physical Interaction
                Assay
                References
                Rab1 - ATPsynγ
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Arf79F
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Arl8
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Atpα
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - CG13220
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - CG1416
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - CG2064
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - CG33303
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - CG3566
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - COX4
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Chc
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Cisd2
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Cog6
                two hybrid
                (Frappaolo et al., 2017)
                Rab1 - Cog7
                pull down, western blot, anti tag western blot
                (Frappaolo et al., 2017, Sechi et al., 2017)
                Rab1 - Cyp12d1-p
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - GM130
                two hybrid, anti tag coimmunoprecipitation, western blot
                (Liu et al., 2017, Sinka et al., 2008)
                Rab1 - Gale
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Gdi
                pull down, peptide massfingerprinting
                (Gillingham et al., 2014)
                Rab1 - Hel25E
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - KdelR
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Kr-h2
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Ldh
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Mcad
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Mec2
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Ocrl
                pull down, peptide massfingerprinting
                (Gillingham et al., 2014)
                Rab1 - Ost48
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Ostγ
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Rab2
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Rab5
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Rab6
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Rab7
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Rap1
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - SERCA
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Sc2
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - ScsβA
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - ScsβG
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - SsRβ
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - Tango1
                anti tag coimmunoprecipitation, western blot
                (Liu et al., 2017)
                Rab1 - Tspo
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - apolpp
                pull down, peptide massfingerprinting
                (Gillingham et al., 2014)
                Rab1 - garz
                anti tag coimmunoprecipitation, western blot, pull down, peptide massfingerprinting
                (Sechi et al., 2017, Gillingham et al., 2014)
                Rab1 - jagn
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - l(1)G0320
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - mt:CoII
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - p38b
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Belozerov et al., 2012)
                Rab1 - p38c
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Belozerov et al., 2012)
                Rab1 - sau
                anti bait coimmunoprecipitation, western blot, proximity ligation assay, fluorescence microscopy, pull down, anti tag western blot, two hybrid
                (Frappaolo et al., 2017, Sechi et al., 2017)
                Rab1 - spidey
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - strat
                pull down, peptide massfingerprinting, experimental knowledge based
                (Gillingham et al., 2014, Guruharsha et al., 2011)
                Rab1 - temp
                anti tag coimmunoprecipitation, anti tag western blot
                (Charng et al., 2014)
                Rab1 - vib
                pull down, western blot
                (Frappaolo et al., 2017)
                Rab1 - wal
                experimental knowledge based
                (Guruharsha et al., 2011)
                Rab1 - βggt-II
                enzymatic study, western blot
                (Charng et al., 2014)
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement
                View in Interactions Browser
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Bet3
                suppressible
                Rab1
                (Ke et al., 2018)
                cact
                suppressible
                Rab1
                (Zang et al., 2015)
                Cog7
                suppressible
                Rab1
                (Frappaolo et al., 2017)
                Spt-I
                suppressible
                Rab1
                (Oswald et al., 2015)
                Tl
                suppressible
                Rab1
                (Zang et al., 2015)
                Trs23
                suppressible
                Rab1
                (Ke et al., 2018)
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                External Data
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3R
                Recombination map

                3-71

                Cytogenetic map
                93D2-93D2
                Sequence location
                3R:21,266,029..21,269,060 [-]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                93D2-93D2
                Limits computationally determined from genome sequence between P{PZ}Atpα01164 and P{PZ}mod(mdg4)07038&P{lacW}mod(mdg4)L3101
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                93C6-93E1
                (Giansanti et al., 2004)
                Location based on deficiency mapping.
                (Giansanti et al., 2004)
                93D1-93D5
                (Ozaki, 1996.4.3)
                93D1-93D5
                (determined by in situ hybridisation)
                (Satoh et al., 1997)
                Experimentally Determined Recombination Data
                Location

                3-71

                (FlyBase, 2016)

                3-74.1

                (Comeron et al., 2012)

                3-

                (Giansanti et al., 2004)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (16)
                Genomic Clones (19)
                cDNA Clones (223)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  polyclonal

                  (Otsuka et al., 2019, Liu et al., 2017, Sechi et al., 2017)
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of

                  Source for identity of: Rab1 CG3320

                  (Gong, 1999.11)
                  Source for database merge of

                  Source for merge of: Rab1 omt

                  (Sechi et al., 2017)
                  Additional comments
                  Other Comments

                  Mutants have reduced dendritic arbors but normal axonal growth in the class IV dendritic arborization (da) neurons.

                  (Ye et al., 2007)

                  dsRNA has been made from templates generated with primers directed against this gene.

                  (Kouranti et al., 2006)

                  dsRNA made from templates generated with primers directed against Rab1 that is transfected into S2 treated with Listeria monocytogenes reveals Rab1 to be involved in Listeria monocytogenes entry and vacuolar escape.

                  (Cheng et al., 2005)

                  dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                  (Kiger et al., 2003)

                  RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells; cells become round and detached.

                  (Kiger et al., 2003)

                  Isolated from a Drosophila head cDNA library.

                  (Satoh et al., 1997)

                  In photoreceptor cells Rab1 contributes to the maintenance of local cell structure by mediating vesicle transport between the rough endoplasmic reticulum (rER) and Golgi body.

                  (Satoh et al., 1997)
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification

                  In a screen for mutations affecting dendritic and/or axonal development in the class IV dendritic arborization (da) neurons. 2 alleles have been isolated.

                  (Ye et al., 2007)
                  External Crossreferences and Linkouts ( 26 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Synonyms and Secondary IDs (19)
                  Reported As
                  Symbol Synonym
                  AAF55873
                  (Armstrong, 2000)
                  CG3320
                  (Laffafian and Tepass, 2019, Meadows, 2018.10.31, Kolkhof et al., 2017, Sechi et al., 2017, Çiçek et al., 2016, Dunst et al., 2015, McEachern et al., 2014, Christis and Munro, 2012, Jaspers et al., 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Sinka et al., 2008, Zhang et al., 2007, Cermelli et al., 2006, Dorer et al., 2006, Colicelli, 2004, Dunne et al., 2002, Verstreken and Bellen, 2000.9.4)
                  DRAB1
                  (Kohno et al., 1994)
                  DRab1
                  (Satoh et al., 1997)
                  Dar6
                  (Puram and Bonni, 2013)
                  Dm Rab1
                  (Jekely, 2003)
                  DmRab1
                  (Pereira-Leal and Seabra, 2001, Pereira-Leal and Seabra, 2001)
                  O18332
                  (Rojas et al., 2012)
                  RAB1a
                  (Dorer et al., 2006)
                  Rab1
                  (Naz et al., 2020, Hodgson et al., 2019, Krämer et al., 2019, Laffafian and Tepass, 2019, Otsuka et al., 2019, Artiushin et al., 2018, Bellec et al., 2018, Pichaud, 2018, Wang et al., 2018, Coutinho-Budd et al., 2017, Frappaolo et al., 2017, Schopf and Huber, 2017, Sechi et al., 2017, Solis et al., 2017, Alfa and Kim, 2016, Caviglia et al., 2016, Choudhury et al., 2016, Nässel and Vanden Broeck, 2016, Dent et al., 2015, Oswald et al., 2015, Van Bortle et al., 2015, White et al., 2015, Zang et al., 2015, Zirin et al., 2015, Charng et al., 2014, Garg and Wu, 2014, Gillingham et al., 2014, Gillingham et al., 2014, Gillingham et al., 2014, Fan et al., 2013, Kwon et al., 2013, Macleod et al., 2013, Xiong and Bellen, 2013, Zhang et al., 2013, Belozerov et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Rincon-Limas et al., 2012, Wang et al., 2012, Oberegelsbacher et al., 2011, Asensio et al., 2010, Kallappagoudar et al., 2010, Li et al., 2010, Winslow et al., 2010, Zhang et al., 2010, Hilger et al., 2009, Perkins et al., 2009.8.10, Thomas et al., 2009, Ching et al., 2008, Sinka et al., 2008, Buszczak et al., 2007, Li et al., 2007, Stuart et al., 2007, Ye et al., 2007, Zhang et al., 2007, Zhang et al., 2007, Cermelli et al., 2006, Comet et al., 2006, Kouranti et al., 2006)
                  Rab1a
                  (Wang et al., 2010)
                  dRab1
                  (Solis et al., 2017, Dunne and Rabouille, 2001)
                  dar6
                  (Ye et al., 2007)
                  drab1
                  (Dunne et al., 2002)
                  omt
                  (Sechi et al., 2017, Lesch and Page, 2012)
                  rab1
                  (Lammers et al., 2017, Kanamori et al., 2015, Lye et al., 2014, Jin et al., 2012, Chan et al., 2011, Mudiganti et al., 2010, Zhang et al., 2010, Nairz et al., 2002, Ozaki, 1996.4.3)
                  Name Synonyms
                  Rab-protein 1
                  (McEachern et al., 2014, Jaspers et al., 2012, Cammarato et al., 2011)
                  Rab1
                  dendritic arbor reduction 6
                  (Ye et al., 2007)
                  omelette
                  (Sechi et al., 2017, Lesch and Page, 2012, Giansanti et al., 2004)
                  Secondary FlyBase IDs
                  • FBgn0016700
                  • FBgn0083070
                  Datasets (1)
                  Study focus (1)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  • bait_protein
                  Rab_Effectors_interaction_map
                  Interaction map generated by purification of most Rab factors, with identification of copurifying effectors by mass spectrometry.
                  References (141)