FlyBase Gene Report: Dmel\RpL19

General Information

Symbol

Dmel\RpL19

Species

D. melanogaster

Name

Ribosomal protein L19

Annotation Symbol

CG2746

Feature Type

protein_coding_gene

FlyBase ID

FBgn0285950

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Summary

Ribosomal protein L19 (RpL19) encodes a ribosomal structural constituent. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

l(2)k03704, M(2)60E, E(Dl)KP135, M(2)c, L19

Key Links

Genomic Location

Cytogenetic map

60E11-60E11

Sequence location

2R:24,967,877..24,969,547 [-]

Recombination map

2-107

RefSeq locus

NT_033778 REGION:24967877..24969547

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables structural constituent of ribosome

inferred from high throughput direct assay

(Alonso and Santaren, 2006)

inferred from direct assay

(Anger et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables RNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000076564

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR039547

(InterPro Project Members, 2004-)

enables structural constituent of ribosome

inferred from electronic annotation with InterPro:IPR000196, InterPro:IPR015972, InterPro:IPR033935, InterPro:IPR035970, InterPro:IPR039547

(InterPro Project Members, 2004-)

traceable author statement

(Marygold et al., 2007)

inferred from biological aspect of ancestor with PANTHER:PTN000076564

(GO Reference Genome Project, 2011-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cytoplasmic translation

inferred by curator from GO:0022626

(Anger et al., 2013, Alonso and Santaren, 2006)

traceable author statement

(Marygold et al., 2007)

involved_in translation

inferred from electronic annotation with InterPro:IPR000196, InterPro:IPR015972, InterPro:IPR035970

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytosolic ribosome

inferred from direct assay

(Anger et al., 2013)

inferred from high throughput direct assay

(Alonso and Santaren, 2006)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of cytosolic large ribosomal subunit

inferred from electronic annotation with InterPro:IPR033935, InterPro:IPR039547

(InterPro Project Members, 2004-)

traceable author statement

(Marygold et al., 2007)

inferred from biological aspect of ancestor with PANTHER:PTN000076564

(GO Reference Genome Project, 2011-)

located_in ribosome

inferred from electronic annotation with InterPro:IPR000196, InterPro:IPR015972, InterPro:IPR035970

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

CYTOPLASMIC LARGE RIBOSOMAL PROTEINS

Protein Family (UniProt)

Belongs to the eukaryotic ribosomal protein eL19 family. (P36241)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Ribosomal protein L19 (RpL19) encodes a ribosomal structural constituent. [Date last reviewed: 2019-07-11]

Gene Group (FlyBase)

CYTOPLASMIC LARGE RIBOSOMAL PROTEINS -: Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytoplasm. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the large subunit is to bind tRNA during the synthesis of polypeptides. (Adapted from FBrf0205398).

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

M(2)60E

Fairly strong Minute; slow development; good viability and fertility [description based on Df(2R)M60E = Df(2R)60E2-3;60E11-12]. Eclosion of Df(2R)M60E/+ delayed 49 hours (Ferrus, 1975, Genetics 79: 589-99).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\RpL19 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P36241)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

Comments on Gene Model

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

RpL19-RA

FBtr0072405

NM_057283

1361

203

RpL19-RB

FBtr0072406

NM_206219

755

203

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

RpL19-PA

FBpp0072312

24.0

203

11.64

FBpp0089141

24.0

203

11.64

P36241

NP_995941

AAS64772

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

203 aa isoforms: RpL19-PA, RpL19-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

203 (aa)

(Hart et al., 1993)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P36241

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RpL19 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.91

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosolic ribosome

inferred from direct assay

(Anger et al., 2013)

inferred from high throughput direct assay

(Alonso and Santaren, 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\RpL19 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\RpL19

View exonic expression by tissue for Dmel\RpL19

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37995/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0285950

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0002607

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0285950

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 14 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of RpL19

Transgenic constructs containing regulatory region of RpL19

Aberrations (Deficiencies and Duplications) ( 11 )

Inferred from experimentation ( 11 )

Gene disrupted in

Df(2R)ES1

(Hart et al., 1993)

Df(2R)M60E

(Marygold et al., 2007, Hart et al., 1993)

Gene not duplicated in

Dp(2;3)P

Gene not disrupted in

Df(2R)bw^VDe2LPx^KR

(Spradling et al., 1999)

Df(2R)Dll-MP

(Hart et al., 1993)

Df(2R)gsb

(Hart et al., 1993)

Df(2R)Kr10

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)M60E

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

viable

Other Phenotypes

Allele

abnormal developmental rate | dominant

decreased cell growth rate | embryonic stage, with Scer\GAL4^fkh.PH

RpL19^HMC05975

Minute

visible | dominant

Phenotype manifest in

Allele

embryonic/larval salivary gland | embryonic stage, with Scer\GAL4^fkh.PH

RpL19^HMC05975

macrochaeta

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

Hsap\RPL19

14 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (5)

Rnor\Rpl19

14 of 14

Yes

Rnor\RGD1562420

10 of 14

Yes

Rnor\LOC100364265

5 of 14

Yes

Rnor\Cnbd2

1 of 14

Rnor\RGD1560099

1 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Rpl19

13 of 14

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\rpl19

7 of 13

Yes

Xtro\vdac2

1 of 13

Danio rerio (Zebrafish) (1)

Drer\rpl19

14 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\rpl-19

14 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP004422

12 of 12

Yes

Arabidopsis thaliana (thale-cress) (4)

Atha\AT3G16780

13 of 13

Yes

Atha\AT4G02230

13 of 13

Yes

Atha\emb2386

13 of 13

Yes

Atha\AT4G16030

4 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\RPL19A

13 of 13

Yes

Scer\RPL19B

13 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\rpl1901

12 of 12

Yes

Spom\rpl1902

12 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:RpL19. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

RpL19^k03704

exacerbates nervous system disease

modeled by Atpα^DTS1

(Talsma et al., 2014)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RPL19; ribosomal protein L19

14 of 14

180466

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

RpL19 - Myc

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RpL19 - Pi3K92E

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RpL19 - Rack1

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL19 - RpL10

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL10Ab

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL11

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL12

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL13

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL13A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL14

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL15

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL17

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL18

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL18A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL21

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL22

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL23

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL23A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL24

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL26

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL27

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL27A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL28

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL29

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL3

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL30

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL31

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL32

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL34a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL35

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL19 - RpL35A

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL19 - RpL36

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL36A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL37-1

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL37A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL38

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL39

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL19 - RpL4

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL40

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL19 - RpL41

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL19 - RpL5

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL6

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL7

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL7A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL8

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpL9

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpLP0

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpLP1

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpLP2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS10a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS11

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS12

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS13

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS14a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS14b

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS15

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS15Aa

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS16

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS17

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS18

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS19a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS20

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS21

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS23

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS24

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS25

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS26

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS27

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS27A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS28b

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS29

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS3

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS30

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL19 - RpS3A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS4

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS5a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS6

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS7

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS8

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - RpS9

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - S6kII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RpL19 - e(r)

two hybrid

(Tsubota and Phillips, 2016)

RpL19 - eEF2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - foxo

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RpL19 - rictor

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RpL19 - sta

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL19 - vig2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RNA-protein

Physical Interaction

Assay

References

RpL19 - 18SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL19 - 28SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL19 - 2SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL19 - 5.8SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL19 - 5SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Delta

enhanceable

RpL19

(Klein and Campos-Ortega, 1992)

enhanceable

RpL19

(Hart et al., 1993)

enhanceable

RpL19

(Hart et al., 1993)

External Data

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ribosome

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-107

Cytogenetic map

60E11-60E11

Sequence location

2R:24,967,877..24,969,547 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

60E11-60E11

Limits computationally determined from genome sequence between P{EP}CG2790^EP412&P{EP}CG3776^EP835 and P{EP}zip^EP856&P{PZ}l(2)10481⁰³²⁶³

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

60E5-60E7

(Oh et al., 2003)

60E8-60E9

(determined by in situ hybridisation)

(Spradling et al., 1999)

60E9-60E12

(determined by in situ hybridisation)

(Hart et al., 1993)

60E8-60E9

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-107

(FlyBase, 2016)

2-111.8

(Comeron et al., 2012)

2-108

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

65117

y¹ v¹; P{TRiP.HMC05975}attP2

12209

y¹ w^67c23; P{lacW}RpL19^k03704/CyO

FlyORF

F000841

M{UAS-RpL19.ORF.3xHA}ZH-86Fb

Korea

10906

P{EP}RpL19^G2613

Kyoto

102285

y¹ w^67c23 ; P{lacW}RpL19^k03704 / CyO

NIG-Fly

2RG-0635

y² VhaAC39-1^cho-1 v¹; P{U6-RpL19.NIG.sgRNA}attP40/CyO

VDRC

v108309

P{KK102517}VIE-260B

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (645)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LD16326

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

(Goshima et al., 2007)

Minute gene.

(Marygold et al., 2007)

Molecularly-defined mutations in RpL19 result in Minute phenotypes.

(Marygold et al., 2007)

A deletion that removes RpL19 and RpL41 (a non-Minute gene) but no other cytoplasmic ribosomal protein-encoding genes shows Minute phenotypes.

(Marygold et al., 2007)

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

1 allele of l(2)SH1000 recovered in a P-insertion screen.

(Oh et al., 2003)

A screen that identified Dominant enhancers of the wing phenotype associated with Dl^9P and Dl^FE32 identified RpL19.

(Klein and Campos-Ortega, 1992)

Mutant alleles have the developmental delay and bristle phenotype that makes them useful as markers in clonal analysis.

(Lawrence et al., 1986)

One of a class of genes (see MIN record) that when present in one, rather than two, copies, produce a characteristic phenotype consisting of short slender bristles and delayed development.

Relationship to Other Genes

Source for database merge of

Source for merge of: RpL19 l(2)SH1000

(Marygold et al., 2007)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: RpL19 CG2746

(Zhong, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (25)

Reported As

Symbol Synonym

CG2746

(National Institute of Genetics Fly Stocks, 2022-, Kolkhof et al., 2017, Schertel et al., 2013, Cammarato et al., 2011, Müller et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Marygold et al., 2007)

E(Dl)KP135

(Hart et al., 1993, Klein and Campos-Ortega, 1992)

L19

(Carpenter et al., 2009, Hart and Wilcox, 1993)

L19e

(Anger et al., 2013)

M(2)60E

(Tu and Johnston, 2008, Marygold et al., 2007, Schmidt et al., 1996)

M(2)a

M(2)c

(Lawrence et al., 1986, Lindsley et al., 1972, Seattle-La Jolla Drosophila Laboratories, 1971)

M60E

(Tu et al., 2007)

RPL19

(Tsubota and Phillips, 2016)

Rp L19

(Alonso and Santaren, 2006)

Rpl19

(Fedorova et al., 2023, Morata, 2021, Vatolina et al., 2011, Vatolina et al., 2011)

anon-EST:Posey33

l(2)SH1000

l(2)SH2 1000

(Oh et al., 2002.3.24)

l(2)k03704

(Demakov et al., 2004, Spradling et al., 1999, BDGP Project Members, 1994-1999)

rpL19

(Hart, 1993.8.24, Hart and Wilcox, 1993)

rpl19

(Tu et al., 2007, Demakov et al., 2001)

Name Synonyms

Enhancer of Delta KP135

Minute

(Kim and Jain, 2020)

Minute(2)60E

Ribosomal protein L19

(Cammarato et al., 2011, Cho et al., 2005)

lethal (2) SH1000

lethal (2) k03704

ribosomal protein L19

(Tsubota and Phillips, 2016, Demakov et al., 2004, Yoon, 1994)

Secondary FlyBase IDs

FBgn0002607
FBgn0010030
FBgn0022215
FBgn0025292
FBgn0065557

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37995

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P36241

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P36241

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P36241

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37995/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0285950

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0285950

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG2746

MARRVEL_MODEL - MARRVEL (model organism gene)

37995

PDB - An information portal to biological macromolecular structures

Linkouts

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0002607

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0285950

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ribosome

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (106)

The following external sites may use different assemblies or annotations than FlyBase.

-0.91

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