FlyBase Gene Report: Dmel\eEF5

General Information

Symbol

Dmel\eEF5

Species

D. melanogaster

Name

eukaryotic translation elongation factor 5

Annotation Symbol

CG3186

Feature Type

protein_coding_gene

FlyBase ID

FBgn0285952

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

eIF-5A, l(2)01296, eIF5A

Key Links

Genomic Location

Cytogenetic map

60B6-60B7

Sequence location

2R:24,057,798..24,059,483 [+]

Recombination map

2-106

RefSeq locus

NT_033778 REGION:24057798..24059483

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables translation elongation factor activity

inferred from mutant phenotype

(assigned by UniProt )

(Patel et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables ribosome binding

inferred from electronic annotation with InterPro:IPR001884, InterPro:IPR019769, InterPro:IPR020189

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables translation elongation factor activity

inferred from biological aspect of ancestor with PANTHER:PTN000186902

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with SGD:S000000760

(FlyBase Curators, 2008--)

Biological Process (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in multicellular organism reproduction

inferred from expression pattern

(Swanson et al., 2001)

involved_in positive regulation of translational elongation

inferred from mutant phenotype

(assigned by UniProt )

(Patel et al., 2009)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in positive regulation of translational elongation

inferred from biological aspect of ancestor with PANTHER:PTN000186902

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with SGD:S000000760

(FlyBase Curators, 2008--)

involved_in positive regulation of translational termination

inferred from electronic annotation with InterPro:IPR001884, InterPro:IPR019769, InterPro:IPR020189

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in translational frameshifting

inferred from electronic annotation with InterPro:IPR019769, InterPro:IPR020189

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in cytoplasm

inferred from sequence or structural similarity with SGD:S000000760

(FlyBase Curators, 2008--)

Gene Group (FlyBase)

CYTOPLASMIC TRANSLATION ELONGATION FACTORS

Protein Family (UniProt)

Belongs to the eIF-5A family. (Q9GU68)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CYTOPLASMIC TRANSLATION ELONGATION FACTORS -: Cytoplasmic (or eukaryotic) translation elongation factors function in the chain elongation stage of ribosome-mediated polypeptide synthesis in the cytoplasm. (Adapted from FBrf0233552).

Protein Function (UniProtKB)

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

(UniProt, Q9GU68)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\eEF5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

eEF5-RA

FBtr0072173

NM_138034

752

159

eEF5-RB

FBtr0072172

NM_166654

747

159

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

eEF5-PA

FBpp0072082

17.6

159

4.76

NP_611878

AAF47151

eEF5-PB

FBpp0072081

17.6

159

4.76

NP_726411

AAM68297

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

159 aa isoforms: eEF5-PA, eEF5-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Post Translational Modification

eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).

(UniProt, Q9GU68)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9GU68

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eEF5 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\eEF5 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\eEF5

View exonic expression by tissue for Dmel\eEF5

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3186-RB

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of eEF5

Transgenic constructs containing regulatory region of eEF5

Deletions and Duplications ( 8 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Mef2.PR

eEF5^GD8700

lethal | recessive

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

eEF5^GD8700

viable, with Scer\GAL4^tin.CΔ4

eEF5^GD8700

Other Phenotypes

Allele

decreased cell size

eEF5⁰¹²⁹⁶

Phenotype manifest in

Allele

embryonic/larval fat body

eEF5⁰¹²⁹⁶

macrochaeta, with Scer\GAL4^Eq

eEF5^GD8700

wing cell, with Scer\GAL4^dpp.blk1

eEF5^GD8700

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\EIF5A

14 of 15

Yes

Hsap\EIF5A2

13 of 15

Yes

Hsap\EIF5AL1

11 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Eif5a

13 of 15

Yes

Mmus\Eif5a2

12 of 15

Yes

Rattus norvegicus (Norway rat) (2)

Rnor\Eif5a

12 of 13

Yes

Rnor\Eif5a2

11 of 13

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\eif5a

12 of 12

Yes

Danio rerio (Zebrafish) (2)

Drer\eif5a

13 of 15

Yes

Drer\eif5a2

12 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\iff-1

14 of 15

Yes

Cele\iff-2

13 of 15

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\ELF5A-1

9 of 9

Yes

Atha\ELF5A-3

9 of 9

Yes

Atha\FBR12

9 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\ANB1

13 of 15

Yes

Scer\HYP2

13 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\tif51

11 of 12

Yes

Spom\tif512

11 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190H2Z )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA16529

Drosophila persimilis

Dper\GL11658

Drosophila willistoni

Dwil\GK21925

Drosophila virilis

Dvir\GJ13513

Drosophila mojavensis

Dmoj\GI14044

Drosophila grimshawi

Dgri\GH23964

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150CSL )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17013271

Musca domestica

House fly

Mdoa\17014700

Glossina morsitans

Tsetse fly

Gmor\GMOY004167

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_11488

Mayetiola destructor

Hessian fly

Mdes\Mdes009110

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL003835

Anopheles darlingi

American malaria mosquito

Adar\ADAC001132

Anopheles gambiae

Malaria mosquito

Agam\AGAP011284

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ001289

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0FB4 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\eIF5A

Danaus plexippus

Monarch butterfly

Dple\DPOGS204668-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL016252

Apis florea

Little honeybee

Aflo\3375401172

Apis mellifera

Western honey bee

Amel\LOC552572

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP11932

Bombus terrestris

Buff-tailed bumblebee

Bter\15216882

Linepithema humile

Argentine ant

Lhum\LH18946

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG006161

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06994

Pediculus humanus

Human body louse

Phum\PHUM126820

Rhodnius prolixus

Kissing bug

Rpro\RPRC003914

Cimex lectularius

Bed bug

Clec\CLEC001499

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI002632

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_05574

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0H54 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR013506

Ixodes scapularis

Black-legged tick

Isca\ISCW020373

Stegodyphus mimosarum

African social velvet spider

Smim\KFM60147.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur02g02290

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_231006

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0P2P )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Eif5A

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_017881gn

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000025064

Gallus gallus

Domestic chicken

Ggal\EIF5A2

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

EIF5A; eukaryotic translation initiation factor 5A

14 of 15

600187

EIF5A2; eukaryotic translation initiation factor 5A2

13 of 15

605782

EIF5AL1; eukaryotic translation initiation factor 5A like 1

11 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

eEF5 - Akr1B

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - AnxB10

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - CG10638

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - CG11523

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - CG14715

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - CG2652

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

eEF5 - CG2852

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - CG6254

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

eEF5 - CG8005

two hybrid

(Hu et al., 2017.6.13)

eEF5 - Calr

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - Chd64

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - Clic

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - Df31

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - Eno

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - Fkbp14

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - HINT1

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - Inos

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - Mdh2

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - Moe

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - Nacα

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - Nlp

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - PCNA

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - PHGPx

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - Pdi

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - Prx2540-2

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - Sh3β

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - Stip1

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - awd

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - capt

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - chic

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - cib

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - fabp

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - regucalcin

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - scf

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - scu

experimental knowledge based

(Guruharsha et al., 2011)

eEF5 - smt3

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

eEF5

enhanceable

nero

(Patel et al., 2009)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

eEF5

(Bronstein et al., 2010)

png

suppressible

eEF5

(Lee et al., 2001)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

63427

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37846

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Hypusine synthesis from eIF5A-lysine

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-106

Cytogenetic map

60B6-60B7

Sequence location

2R:24,057,798..24,059,483 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

60B6-60B7

Left limit from in situ hybridisation (FBrf0157097) Right limit from in situ hybridisation (FBrf0157097)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

60B6-60B7

(Oh et al., 2003)

60B-60B

(Irion, 1999.9.16)

60B4-60B5

(determined by in situ hybridisation)

(Spradling et al., 1999)

60B4-60B5

(Beaton, 1997.12.27, BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-106

(FlyBase, 2016)

2-109.9

(Comeron et al., 2012)

(Posey, 1999.6.15)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Bloomington

39732

y¹ w^*; P{UAS-eEF5.P}4

39731

y¹ w^*; P{UAS-eEF5.P}15

11039

cn¹ P{PZ}eEF5⁰¹²⁹⁶/CyO; ry⁵⁰⁶

83524

y¹ sc^* v¹ sev²¹; P{TKO.GS04276}attP40

Kyoto

122122

w^*; P{lacW}eEF5^SH2271

VDRC

v101513

P{KK108942}VIE-260B

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (455)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Na et al., 2016, Patel et al., 2009)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: eIF-5A CG3186

(FlyBase, 1996-)

Source for identity of: eEF5 eIF-5A

(Marygold et al., 2017)

Source for database merge of

Source for merge of: eIF-5A l(2)01296

(Misra, 2000.8.25)

Source for merge of: eIF-5A anon- EST:fe2H10

(Bayraktaroglu, 2000.11.2)

Source for merge of: eEF5 l(2)SH2271

(Marygold et al., 2007)

Additional comments

Source for identity of eIF-5A CG3186 was sequence comparison ( date:000721 ).

(FlyBase, 1996-)

Other Comments

3 alleles of l(2)SH2271 recovered in a P-insertion screen.

(Oh et al., 2003)

Identification: One of a collection of genes identified with defective larval growth that extend larval life. Not studied further due to problems with background/multiple lesion effects.

(Galloni and Edgar, 1999)

Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.

(Harvie et al., 1998)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 31 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37846

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9GU68

Other crossreferences

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG3186

Linkouts

BioGRID - A database of protein and genetic interactions.

63427

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3186-RB

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37846

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Hypusine synthesis from eIF5A-lysine

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

1296

(Harvie et al., 1998)

CG3186

(Vasudevan et al., 2020, Marygold et al., 2017, Na et al., 2016, Hallier et al., 2015, Yoshigi et al., 2013, Cammarato et al., 2011, Bronstein et al., 2010, Keleman et al., 2009.8.5, Patel et al., 2009, Bolshakov et al., 2002, Misra, 2000.8.25)

anon-EST:fe2H10

chr2R:19566878..19566998

(Will et al., 2013)

eEF5

(Hall et al., 2019, Hu et al., 2017.6.13, Marygold et al., 2017)

eIF-5A

(Transgenic RNAi Project members, 2017-, Na et al., 2016, Rathore et al., 2016, Hallier et al., 2015, Ashwal-Fluss et al., 2014, Kwon et al., 2013, Yoshigi et al., 2013, Fischer et al., 2012, Bronstein et al., 2010, Parry et al., 2010, Buszczak et al., 2007, Marygold et al., 2007)

eIF5A

(Vasudevan et al., 2020, Ji et al., 2017, Patel et al., 2009)

eIF5a

(Creagh et al., 2009)

l(2)01296

(Galloni and Edgar, 1999, Spradling et al., 1999, Beaton, 1997.12.27)

l(2)SH2 2271

(Oh et al., 2002.3.26)

l(2)SH2271

Name Synonyms

Eukaryotic translation factor 5A

(Creagh et al., 2009)

anon-fast-evolving-2H10

eIF-5A

(Cammarato et al., 2011)

eukaryotic initiation factor 5A

(Patel et al., 2009)

eukaryotic translation elongation factor 5

lethal (2) SH2271

Secondary FlyBase IDs

FBgn0034967
FBgn0010483
FBgn0025208
FBgn0065208

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Study focus (0)

Experimental Role

Project

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References (72)

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