FlyBase Gene Report: Dmel\cv-c

General Information

Symbol

Dmel\cv-c

Species

D. melanogaster

Name

crossveinless c

Annotation Symbol

CG34389

Feature Type

protein_coding_gene

FlyBase ID

FBgn0285955

Gene Model Status

Current

Stock Availability

51 publicly available

Gene Summary

crossveinless c (cv-c) encodes a RhoGTPase activating protein required for the morphogenesis of many tissues through the regulation of actin organization and localization of basement membrane receptors. It regulates synaptic homeostasis at the neuromuscular junction and is required for sleep homeostasis. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

RhoGAP88C, l(3)06951

Key Links

Genomic Location

Cytogenetic map

88B8-88C2

Sequence location

3R:14,391,683..14,481,713 [-]

Recombination map

3-55

RefSeq locus

NT_033777 REGION:14391683..14481713

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (29 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables GTPase activator activity

inferred from mutant phenotype

(Simões et al., 2006)

inferred from genetic interaction with FLYBASE:Rac1; FB:FBgn0010333,FLYBASE:Rac2; FB:FBgn0014011,FLYBASE:Rho1; FB:FBgn0014020

(Denholm et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables GTPase activator activity

inferred from biological aspect of ancestor with PANTHER:PTN000974804

(GO Reference Genome Project, 2011-)

enables lipid binding

inferred from electronic annotation with InterPro:IPR002913

(InterPro Project Members, 2004-)

Biological Process (25 terms)

Terms Based on Experimental Evidence (22 terms)

CV Term

Evidence

References

involved_in assembly of actomyosin apparatus involved in cytokinesis

inferred from mutant phenotype

(Carreno et al., 2008)

involved_in cell morphogenesis

inferred from mutant phenotype

(Carreno et al., 2008)

involved_in cortical actin cytoskeleton organization

inferred from mutant phenotype

(Carreno et al., 2008, Brodu and Casanova, 2006, Denholm et al., 2005)

involved_in dorsal closure

inferred from mutant phenotype

(Denholm et al., 2005)

involved_in establishment of mitotic spindle orientation

inferred from mutant phenotype

(Carreno et al., 2008)

involved_in head involution

inferred from mutant phenotype

(Denholm et al., 2005)

involved_in imaginal disc-derived wing vein morphogenesis

inferred from mutant phenotype

(Jantrapirom et al., 2019, Matsuda et al., 2013, Pilgram et al., 2011, Denholm et al., 2005)

involved_in maintenance of epithelial integrity, open tracheal system

inferred from mutant phenotype

(Cela and Llimargas, 2006)

involved_in Malpighian tubule morphogenesis

inferred from mutant phenotype

(Denholm et al., 2005)

involved_in metaphase/anaphase transition of mitotic cell cycle

inferred from mutant phenotype

(Carreno et al., 2008)

involved_in midgut development

inferred from mutant phenotype

(Denholm et al., 2005)

involved_in mitotic spindle organization

inferred from mutant phenotype

(Carreno et al., 2008)

involved_in negative regulation of Rho protein signal transduction

inferred from mutant phenotype

(Simões et al., 2006)

involved_in neuromuscular synaptic transmission

inferred from mutant phenotype

(Pilgram et al., 2011)

involved_in open tracheal system development

inferred from mutant phenotype

(Lovegrove et al., 2006)

involved_in positive regulation of synaptic transmission

inferred from mutant phenotype

(Donlea et al., 2014)

involved_in regulation of dendrite morphogenesis

inferred from mutant phenotype

(Sato et al., 2010)

involved_in Rho protein signal transduction

inferred from genetic interaction with FLYBASE:Rac1; FB:FBgn0010333,FLYBASE:Rac2; FB:FBgn0014011,FLYBASE:Rho1; FB:FBgn0014020

(Denholm et al., 2005)

involved_in sleep

inferred from mutant phenotype

(Donlea et al., 2014)

involved_in spindle localization

inferred from mutant phenotype

(Carreno et al., 2008)

involved_in spiracle morphogenesis, open tracheal system

inferred from mutant phenotype

(Simões et al., 2006, Denholm et al., 2005)

involved_in tracheal pit formation in open tracheal system

inferred from mutant phenotype

(Brodu and Casanova, 2006)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in actin cytoskeleton organization

inferred from biological aspect of ancestor with PANTHER:PTN000974804

(GO Reference Genome Project, 2011-)

involved_in regulation of Rho protein signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000974804

(GO Reference Genome Project, 2011-)

involved_in signal transduction

inferred from electronic annotation with InterPro:IPR000198

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in basolateral plasma membrane

inferred from direct assay

(Simões et al., 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in cell cortex

inferred by curator from GO:0030866

(Denholm et al., 2005)

Gene Group (FlyBase)

RHO GTPASE ACTIVATING PROTEINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

RHO GTPASE ACTIVATING PROTEINS -: RhoGAPs are GTPase activating proteins for Rho family GTPases. (Adapted from PMID:15731001 and FBrf0158741).

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

cv-c: crossveinless-c

Posterior crossvein usually absent or greatly reduced. Anterior crossvein usually present but often detached. Eye flattened or with vertical shallow furrow. Legs weak, especially tarsal joints. Occasionally overlaps wild type. RK2.

Summary (Interactive Fly)

required in tissues actively undergoing morphogenesis -- regulates GTPase function of Rho to promote the coordinated organization of the actin cytoskeleton

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\cv-c for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A8JR05)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

cv-c-RA

FBtr0112631

NM_169583

4478

1017

cv-c-RC

FBtr0112630

NM_001104316

9298

2351

cv-c-RD

FBtr0112632

NM_001104318

8631

2351

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

cv-c-PA

FBpp0111543

115.2

1017

9.95

FBpp0111542

255.9

2351

8.58

FBpp0111544

255.9

2351

8.58

A8JR05

NP_001097788

ABW08671

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

2351 aa isoforms: cv-c-PC, cv-c-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cv-c using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.04

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

larval brain | restricted

(Pilgram et al., 2011)

eye-antennal disc | restricted

(Pilgram et al., 2011)

wing disc | restricted

(Pilgram et al., 2011)

embryonic/larval hypodermal muscle cell

(Pilgram et al., 2011)

prepupal stage P3

leg | ubiquitous

(Greenberg and Hatini, 2011)

pupal stage P6

crossvein

(Matsuda et al., 2013)

longitudinal vein | faint

(Matsuda et al., 2013)

Additional Descriptive Data

Expression in stage P3 pupal leg discs is ubiquitous.

(Greenberg and Hatini, 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in basolateral plasma membrane

inferred from direct assay

(Simões et al., 2006)

Expression Deduced from Reporters

Reporter: P{GawB}cv-c^C5

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

wing disc | restricted

(Yeh et al., 1995)

wandering third instar larval stage

wing pouch

(Forés et al., 2017)

adult stage

large field neuron | vicinity of

Comment: expression is tangential to large field

(Martin et al., 1999)

fan-shaped body | dorsal | ventral

(Young and Armstrong, 2010)

adult lateral fan-shaped body tangential-protocerebrum neuron ExFl1

(Young and Armstrong, 2010)

adult lateral fan-shaped body tangential-protocerebrum neuron ExFl2

(Flybrain Neuron Database et al., 2018.6.28, Young and Armstrong, 2010)

fan-shaped body | dorsal

(Donlea et al., 2014)

adult brain | restricted

(Donlea et al., 2014)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\cv-c in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\cv-c

View exonic expression by tissue for Dmel\cv-c

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41749/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0285955

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0086901

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0285955

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 38 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 33 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of cv-c

Transgenic constructs containing regulatory region of cv-c

Aberrations (Deficiencies and Duplications) ( 25 )

Inferred from experimentation ( 25 )

Gene duplicated in

Dp(3;1)O5

(Lindsley and Grell, 1958)

Dp(3;3)E(var)88D11

(Green et al., 1990)

Gene disrupted in

Df(3R)Exel6267

(Ryder, 2004.4.26)

Df(3R)kar^5l

(Green et al., 1990)

Df(3R)red1

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(3R)red3l

(Spradling et al., 1999, BDGP Project Members, 1994-1999, Green et al., 1990)

Gene not duplicated in

Dp(3;2)ry⁺

(Green et al., 1990)

Gene partially disrupted in

Df(3R)natalisin^attP

(Rao and Deng, 2019.10.23)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^αTub84B.PL

cv-c^RNAi.UAS

lethal | recessive

cv-c⁰⁶⁹⁵¹

lethal - all die during embryonic stage

partially lethal

cv-c^c

partially lethal, with Scer\GAL4^Mef2.PR

cv-c^GD10227

partially lethal - majority die, with Scer\GAL4^pnr-MD237

cv-c^GD5690

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Sterility

Allele

fertile

cv-c^c

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

cv-c^GD5690

abnormal developmental rate

abnormal locomotor behavior | dominant

cv-c^C5

abnormal memory | adult stage, with Scer\GAL4^GMR23E10

cv-c^RNAi.UAS

abnormal memory | adult stage | conditional (with cv-c^C524)

cv-c^MB03717

abnormal memory | adult stage | conditional (with cv-c^MB03717)

cv-c^C524

abnormal neuroanatomy

cv-c¹

abnormal neuroanatomy | embryonic stage

cv-c¹²⁶⁰

abnormal neuroanatomy | embryonic stage (with cv-c¹²⁶⁰)

abnormal neuroanatomy | embryonic stage (with cv-c⁰⁶⁹⁵¹)

cv-c¹²⁶⁰

abnormal neuroanatomy | embryonic stage (with cv-c^f04940)

cv-c¹²⁶⁰

abnormal neuroanatomy | embryonic stage (with cv-c^f07633)

cv-c¹²⁶⁰

abnormal neurophysiology

cv-c¹

abnormal neurophysiology, with Scer\GAL4^G14

cv-c^RNAi.UAS

abnormal neurophysiology, with Scer\GAL4^RapGAP1-OK6, cv-c¹

cv-c^UAS.cDa

abnormal neurophysiology, with Scer\GAL4^RapGAP1-OK6, cv-c^UAS.cDa

cv-c¹

abnormal neurophysiology (with cv-c¹)

abnormal neurophysiology (with cv-c^C524)

cv-c¹

abnormal neurophysiology (with cv-c^M62)

cv-c¹

abnormal neurophysiology | adult stage (with cv-c^C524)

cv-c^MB03717

abnormal neurophysiology | adult stage (with cv-c^MB03717)

cv-c^C524

abnormal neurophysiology | dominant

abnormal planar polarity | embryonic stage, with Scer\GAL4^en.PU

abnormal size | late embryonic stage (with cv-c⁷)

cv-c^M62

abnormal size | late embryonic stage (with cv-c^M62)

cv-c⁷

abnormal sleep | adult stage, with Scer\GAL4^104Y

cv-c^RNAi.UAS

abnormal sleep | adult stage, with Scer\GAL4^cv-c-C5, cv-c^C5

cv-c^RNAi.UAS

abnormal sleep | adult stage, with Scer\GAL4^cv-c-C5, cv-c^RNAi.UAS

cv-c^C5

abnormal sleep | adult stage, with Scer\GAL4^GMR23E10

cv-c^RNAi.UAS

abnormal sleep | adult stage (with cv-c^C5)

cv-c^MB03717

abnormal sleep | adult stage (with cv-c^C524)

abnormal sleep | adult stage (with cv-c^DG20401)

abnormal sleep | adult stage (with cv-c^MB01956)

abnormal sleep | adult stage (with cv-c^MB03717)

abnormal stress response | adult stage, with Scer\GAL4^GMR23E10

cv-c^RNAi.UAS

abnormal stress response | adult stage (with cv-c^C524)

cv-c^MB03717

abnormal stress response | adult stage (with cv-c^MB03717)

cv-c^C524

increased mortality during development, with Scer\GAL4^en.PU

cv-c^UAS.C.Venus

some die during embryonic stage

visible, with Scer\GAL4^pnr-MD237

cv-c^GD5690

visible, with Scer\GAL4^T80

cv-c^RNAi.UAS

visible | adult stage

cv-c¹

visible | recessive

Phenotype manifest in

Allele

anterior crossvein

anterior crossvein, with Scer\GAL4^Bx-MS1096

cv-c^RNAi.UAS

cortical actin cytoskeleton & embryonic posterior spiracle

cv-c⁷

dendritic tree | embryonic stage

cv-c¹²⁶⁰

dorsal bridge

cv-c^M62

dorsal tracheal branch primordium

cv-c⁷

embryo | dorsal closure stage

cv-c⁷

embryonic/first instar larval cuticle | dorsal

embryonic/larval midgut primordium

cv-c^M62

embryonic/larval salivary gland | embryonic stage, with Scer\GAL4^69B

embryonic/larval spiracle primordium

cv-c⁷

embryonic epidermis, with Scer\GAL4^en.PU

embryonic head

cv-c⁷

embryonic leading edge cell

cv-c¹²⁶⁰

embryonic Malpighian tubule

cv-c^M62

embryonic Malpighian tubule, with Scer\GAL4^ct.CtB

cv-c^UAS.cDa

embryonic Malpighian tubule | late embryonic stage (with cv-c⁷)

cv-c^M62

embryonic Malpighian tubule | late embryonic stage (with cv-c^M62)

cv-c⁷

embryonic Malpighian tubule tip cell, with Scer\GAL4^ct.CtB

cv-c^UAS.cDa

embryonic trachea & cortical actin cytoskeleton

cv-c⁷

eye

cv-c¹

fan-shaped body tangential neuron | adult stage (with cv-c^C524)

cv-c^MB03717

fan-shaped body tangential neuron | adult stage (with cv-c^MB03717)

cv-c^C524

filzkorper

cv-c^M62

hypostomal sclerite

cv-c^M62

larval dorsal multidendritic neuron ddaC | embryonic stage

cv-c¹²⁶⁰

larval dorsal multidendritic neuron ddaC | embryonic stage (with cv-c¹²⁶⁰)

larval dorsal multidendritic neuron ddaC | embryonic stage (with cv-c⁰⁶⁹⁵¹)

cv-c¹²⁶⁰

larval dorsal multidendritic neuron ddaC | embryonic stage (with cv-c^f04940)

cv-c¹²⁶⁰

larval dorsal multidendritic neuron ddaC | embryonic stage (with cv-c^f07633)

cv-c¹²⁶⁰

larval dorsal multidendritic neuron ddaD | embryonic stage

cv-c¹²⁶⁰

larval dorsal multidendritic neuron ddaE | embryonic stage

cv-c¹²⁶⁰

leg

cv-c¹

median tooth

cv-c^M62

mesonotum, with Scer\GAL4^pnr-MD237

cv-c^GD5690

neuromuscular junction

neuromuscular junction, with Scer\GAL4^G14

cv-c^RNAi.UAS

neuromuscular junction, with Scer\GAL4^RapGAP1-OK6, cv-c¹

cv-c^UAS.cDa

neuromuscular junction, with Scer\GAL4^RapGAP1-OK6, cv-c^UAS.cDa

cv-c¹

neuromuscular junction (with cv-c¹)

neuromuscular junction (with cv-c^C524)

cv-c¹

neuromuscular junction (with cv-c^M62)

cv-c¹

posterior crossvein

posterior crossvein, with Scer\GAL4^Bx-MS1096

cv-c^RNAi.UAS

posterior crossvein (with cv-c¹)

cv-c^M62

posterior crossvein (with cv-c^M62)

cv-c¹

posterior spiracle primordium

posterior spiracle primordium, with Scer\GAL4^ems.HRE

cv-c^UAS.cDa

presumptive embryonic/larval tracheal system

cv-c⁷

presumptive wing vein | pupal stage

cv-c¹

t-bar

cv-c¹

tracheal primordium

cv-c⁷

trichogen cell, with Scer\GAL4^pnr-MD237

cv-c^GD5690

wing

wing disc | pupal stage

cv-c¹

wing vein L2, with Scer\GAL4^T80

cv-c^RNAi.UAS

wing vein L3

cv-c^c

wing vein L4

cv-c^c

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (56)

Hsap\DLC1

9 of 14

Yes

Hsap\STARD8

9 of 14

Yes

Hsap\STARD13

9 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (38)

Rnor\Dlc1

9 of 14

Yes

Rnor\Stard8

9 of 14

Yes

Rnor\Stard13

9 of 14

Yes

Rnor\Arhgap18

2 of 14

Rnor\Abr

1 of 14

Rnor\Acot12

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (33)

Mmus\Dlc1

9 of 14

Yes

Mmus\Stard8

9 of 14

Yes

Mmus\Stard13

9 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (36)

Xtro\dlc1

7 of 13

Yes

Xtro\stard13

5 of 13

Yes

Xtro\LOC100490096

4 of 13

Yes

Xtro\stard8

4 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\arhgap11a.2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\tagap

1 of 13

Danio rerio (Zebrafish) (57)

Drer\dlc1

10 of 14

Yes

Drer\stard8

10 of 14

Yes

Drer\stard13a

10 of 14

Yes

Drer\si:dkeyp-23e4.3

9 of 14

Yes

Drer\stard13b

9 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch211-247j9.1

1 of 14

Drer\si:dkey-33c9.6

1 of 14

Drer\si:dkey-91m11.5

1 of 14

Drer\si:dkey-191m6.4

1 of 14

Drer\si:dkey-219e20.2

1 of 14

Yes

Drer\star2

1 of 14

Drer\stard7

1 of 14

Drer\stard10

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (16)

Cele\gei-1

8 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (18)

Agam\AgaP_AGAP005279

9 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (9)

Atha\AT2G28320

2 of 13

Yes

Atha\AT3G54800

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT5G45560

1 of 13

Yes

Atha\AT5G49800

1 of 13

Yes

Atha\EDR2

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\BAG7

1 of 13

Yes

Scer\LRG1

1 of 13

Yes

Scer\RGA1

1 of 13

Yes

Scer\SAC7

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\rga7

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:cv-c. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (12)

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

46,XY gonadal dysgenesis (postulated), STARD8-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

cv-c^C524

model of gonadal dysgenesis

CEA

(Sotillos et al., 2022)

cv-c^{ΔSTART.UAS.Venus}

model of gonadal dysgenesis

CEA

(Sotillos et al., 2022)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

DLC1; DLC1 Rho GTPase activating protein

model of colorectal cancer

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

cv-c^C524

model of gonadal dysgenesis

is ameliorated by Hsap\STARD8^{UAS.α.Tag:MYC}

(Sotillos et al., 2022)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DLC1; DLC1 Rho GTPase activating protein

9 of 14

604258

COLORECTAL CANCER; CRC

colorectal cancer

9 of 14

300689

STARD13; StAR related lipid transfer domain containing 13

9 of 14

609866

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

cv-c

Hsap\DLC1

(Sotillos et al., 2018)

cv-c

Hsap\STARD8

(Sotillos et al., 2018)

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

cv-c - Rho1

anti tag coimmunoprecipitation, anti tag western blot

(Neisch et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

cv-c

suppressible

cv-c::Hsap\DLC1

(Sotillos et al., 2018)

cv-c

enhanceable

Dyb

(Jantrapirom et al., 2019)

cv-c

suppressible

Dys

(Pilgram et al., 2011)

cv-c

enhanceable

Rac1|Rac2

(Denholm et al., 2005)

cv-c

suppressible

Rho1

(Sotillos et al., 2018, Sato et al., 2010, Denholm et al., 2005)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Egfr

suppressible

cv-c

(Brodu and Casanova, 2006)

Rac1|Rac2

suppressible

cv-c

(Denholm et al., 2005)

Rho1

suppressible

cv-c

(Brodu and Casanova, 2006)

spi

enhanceable

cv-c

(Brodu and Casanova, 2006)

External Data

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-55

Cytogenetic map

88B8-88C2

Sequence location

3R:14,391,683..14,481,713 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

88B8-88C2

Limits computationally determined from genome sequence between P{lacW}trx^j14A6&P{PZ}trx⁰⁰³⁴⁷ and P{PZ}cv-c⁰⁶⁹⁵¹;

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Cytological location determined by SNP mapping.

(Denholm et al., 2005)

88B-88C

(Denholm et al., 2005)

88C1-88C4

(determined by in situ hybridisation)

(Spradling et al., 1999)

88C1-88C4

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

3-55

(FlyBase, 2016)

3-54.0

(Comeron et al., 2012)

3-57.9

(Edmondson, 1952)

3-54.1

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (51)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

472

w¹¹¹⁸; cv-c¹

30839

w^*; P{GawB}cv-c^C5

24001

w¹¹¹⁸; Mi{ET1}cv-c^MB03489

105929

14847R-1

14847R-2

v100247

v102207

v105435

v109824

v32329

w¹¹¹⁸; P{GD8463}v32329

v40238

w¹¹¹⁸; P{GD10227}v40238/TM3

More stocks available...

Genomic Clones (71)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (55)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE02250

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

cv-c is a mediator of trh and Egfr-induced invagination.

(Brodu and Casanova, 2006)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Loss of vein mutations cause suppression of rho^hs.PSt ectopic vein phenotype and enhancement of the rho^ve-1 loss of vein phenotype.

(Sturtevant and Bier, 1995)

Mutations in cv-c remove transverse veins or crossveins: crossvein specific. Shows additive interactions with vn, ve, ci, cg, shv, ast, H, Vno, vvl, ri, tg, tt and ab.

(Diaz-Benjumea and Garcia-Bellido, 1990)

ri, tg, tt, ab, cv, cv-2, cv-c and cv-d belong to the radius incompletus phenotypic group within the 'lack-of-vein' mutant class. Loss-of-function alleles at these loci remove stretches of veins in two or more longitudinal veins. Double mutants of this group have additive phenotypes suggesting the genes are vein-specific, and have small lanceolate wings. Genes are involved in whole vein region-specification rather than vein differentiation.

(Diaz-Benjumea et al., 1989)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG14848 CG14849

(FlyBase Genome Annotators, 2002-2003)

Source for merge of: cv-c RhoGAP88C l(3)06951

(Denholm et al., 2005)

Source for merge of: cv-c CG31330 CG14847 CG14846

(FlyBase Genome Annotators, 2007)

Source for merge of: CG14845 RhoGAP88C

(FlyBase Genome Annotators, 2002-2003)

Source for merge of: cv-c C5

(Donlea et al., 2014)

Additional comments

Annotations CG31319, CG31330, CG14847 and CG14846 merged as CG34389 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Annotations CG14845 and CG8480 merged as CG31319 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Annotations CG14848 and CG14849 merged as CG31330 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (18)

Reported As

Symbol Synonym

CG14845

CG14846

CG14847

CG14848

(Furlong et al., 2001)

CG14849

CG31319

CG31330

(Manak et al., 2006)

CG34389

(Greenberg and Hatini, 2011, Sato et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, FlyBase Genome Annotators, 2007)

CG8480

(Bernards, 2003, Billuart et al., 2001)

Cv-c

(Segal et al., 2018, Frank, 2014, Neisch et al., 2013, Shimmi and Newfeld, 2013, Sotillos et al., 2013)

RhoGAP88C

(Yoong et al., 2020, Hughes and Marcus, 2008, Ferjoux et al., 2007, Kolesnikov and Beckendorf, 2007, Zeitlinger et al., 2007, Manak et al., 2006, Manak et al., 2006)

cv-c

(Chvilicek et al., 2024, Ko et al., 2024, di Pietro et al., 2023, Molina-Gil et al., 2023, Marcogliese et al., 2022, Girard et al., 2021, Michki et al., 2021, Pang et al., 2021, Dissel, 2020, Guan et al., 2019, Hall et al., 2019, Jantrapirom et al., 2019, Rao and Deng, 2019.10.23, Ariss et al., 2018, Lavoy et al., 2018, Sotillos et al., 2018, Nakamura et al., 2017, Rohde et al., 2017, Tomita et al., 2017, Clandinin and Owens, 2016-, Duff et al., 2015, Gene Disruption Project members, 2015-, Schleede and Blair, 2015, Ashwal-Fluss et al., 2014, Donlea et al., 2014, Denholm, 2013, Kwon et al., 2013, Terriente-Felix et al., 2013, Weavers and Skaer, 2013, Japanese National Institute of Genetics, 2012.5.21, Mackay et al., 2012, Greenberg and Hatini, 2011, Pilgram et al., 2011, Campbell et al., 2010, Sato et al., 2010, Wasbrough et al., 2010, Hughes and Marcus, 2008, Cela and Llimargas, 2006, Lovegrove et al., 2006, Simões et al., 2006, Denholm et al., 2005)

l(3)06951

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

rhoGAP88C

(Magalhaes et al., 2007)

Name Synonyms

CG14846

CG14847

CG31330

Crossveinless-c

(Sotillos et al., 2013, Weavers and Skaer, 2013, Kolesnikov and Beckendorf, 2007)

crossveinless c

crossveinless-c

(Donlea, 2019, Tomita et al., 2017, Denholm, 2013, Pilgram et al., 2011, Sato et al., 2010, Hughes and Marcus, 2008, Brodu and Casanova, 2006, Manak et al., 2006)

lethal (3) 06951

Secondary FlyBase IDs

FBgn0086901
FBgn0086696
FBgn0010910
FBgn0051319
FBgn0040560
FBgn0038227
FBgn0038228
FBgn0051330
FBgn0000397
FBgn0038231
FBgn0038232
FBgn0085418
FBgn0038226
FBgn0028839

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 41 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41749

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A8JR05

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A8JR05

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41749/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0285955

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0285955

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG34389

MARRVEL_MODEL - MARRVEL (model organism gene)

41749

Linkouts

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0086901

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0285955

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004611

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (129)

The following external sites may use different assemblies or annotations than FlyBase.

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