FlyBase Gene Report: Dmel\CG46339

FB2025_05 , released December 11, 2025

FB2025_05 , released December 11, 2025

Gene: Dmel\CG46339

General Information

Symbol

Dmel\CG46339

Species

D. melanogaster

Name

Annotation Symbol

CG46339

Feature Type

protein_coding_gene

FlyBase ID

FBgn0285963

Gene Model Status

Stock Availability

21 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

sda, slamdance

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:26,915,761..26,945,309 [+]

Recombination map

3-92

RefSeq locus

NT_033777 REGION:26915761..26945309

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables aminopeptidase activity

inferred from direct assay

(Lim et al., 2015)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables metalloaminopeptidase activity

inferred from biological aspect of ancestor with PANTHER:PTN000164250

(GO Reference Genome Project, 2011-)

enables metallopeptidase activity

inferred from electronic annotation with InterPro:IPR014782

(InterPro Project Members, 2004-)

enables zinc ion binding

inferred from electronic annotation with InterPro:IPR014782

(InterPro Project Members, 2004-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in cell dedifferentiation

inferred from mutant phenotype

(Lim et al., 2015)

involved_in germ-line stem-cell niche homeostasis

inferred from mutant phenotype

(Lim et al., 2015)

involved_in male germ-line stem cell population maintenance

inferred from mutant phenotype

(Lim et al., 2015)

involved_in protein processing

inferred from mutant phenotype

(Lim et al., 2015)

involved_in somatic stem cell population maintenance

inferred from mutant phenotype

(Lim et al., 2015)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in peptide catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000164250

(GO Reference Genome Project, 2011-)

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR001930

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000164251

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN000898749

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

M1 METALLOPEPTIDASES

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

M1 METALLOPEPTIDASES -: M1 metallopeptidases belong to MEROPS family M1. All members of the family act on the N-terminus of polypeptides, many of them being aminopeptidases. The family also contains pyroglutamyl-peptidase II, an omega peptidase that releases pyroglutamate from thyrotropin-releasing hormone, and some dipeptidases. (Adapted from FBrf0239469.)

Gene Model and Products

Number of Transcripts

6

Number of Unique Polypeptides

4

Please see the JBrowse view of Dmel\CG46339 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A0B4KH77)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 6.17

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0472695

4813

1071

FBtr0472696

5146

1182

FBtr0472697

4849

1083

FBtr0472698

5182

1194

FBtr0472699

4717

1071

FBtr0472700

5050

1182

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0422658

121.7

1071

6.00

FBpp0422659

133.0

1182

6.49

FBpp0422660

122.9

1083

5.71

FBpp0422661

134.2

1194

6.25

FBpp0422662

121.7

1071

6.00

FBpp0422663

133.0

1182

6.49

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1071 aa isoforms: CG46339-PA, CG46339-PE

1182 aa isoforms: CG46339-PB, CG46339-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG46339 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG46339 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG46339

View exonic expression by tissue for Dmel\CG46339

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44359/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0285963

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0285963

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG46339

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 16 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG46339

Transgenic constructs containing regulatory region of CG46339

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

CG46339^GD11680

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG46339^GD11680

viable, with Scer\GAL4^Mef2.PR

CG46339^GD11680

Sterility

Allele

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

CG46339^GD11680

abnormal planar polarity, with Scer\GAL4^pnr-MD237

CG46339^GD11680

decreased cell number | adult stage, with Scer\GAL4^upd1.PU

CG46339^GD11680

some die during pupal stage, with Scer\GAL4^pnr-MD237

CG46339^GD11680

Phenotype manifest in

Allele

cyst progenitor cell | adult stage, with Scer\GAL4^upd1.PU

CG46339^GD11680

hub cell | adult stage, with Scer\GAL4^upd1.PU

CG46339^GD11680

male fusome, with Scer\GAL4^upd1.PU

CG46339^UASp.Tag:HA

male germline stem cell | adult stage, with Scer\GAL4^upd1.PU

CG46339^GD11680

mesonotum, with Scer\GAL4^pnr-MD237

CG46339^GD11680

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (14)

7 of 14

Yes

No

7 of 14

Yes

No

7 of 14

Yes

No

7 of 14

Yes

No

6 of 14

No

No

1

6 of 14

No

No

6 of 14

No

No

4 of 14

No

No

3 of 14

No

No

2 of 14

No

No

2 of 14

No

No

Hsap\LOC101929950

1 of 14

No

Yes

1 of 14

No

No

1

1 of 14

No

No

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (11)

7 of 14

Yes

No

7 of 14

Yes

No

7 of 14

Yes

No

6 of 14

No

No

6 of 14

No

Yes

6 of 14

No

No

4 of 14

No

No

2 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Mus musculus (laboratory mouse) (12)

7 of 14

Yes

No

7 of 14

Yes

No

7 of 14

Yes

No

6 of 14

No

Yes

5 of 14

No

No

5 of 14

No

No

4 of 14

No

No

2 of 14

No

No

2 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Xenopus tropicalis (Western clawed frog) (12)

5 of 13

Yes

No

5 of 13

Yes

No

5 of 13

Yes

No

4 of 13

No

No

4 of 13

No

No

3 of 13

No

No

3 of 13

No

No

2 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

Danio rerio (Zebrafish) (17)

7 of 14

Yes

No

7 of 14

Yes

No

7 of 14

Yes

No

7 of 14

Yes

No

7 of 14

Yes

Yes

7 of 14

Yes

Yes

Drer\LOC100004744

7 of 14

Yes

No

Drer\si:ch211-106j24.1

7 of 14

Yes

No

6 of 14

No

No

Drer\si:ch211-276a23.5

6 of 14

No

No

5 of 14

No

No

4 of 14

No

No

2 of 14

No

No

2 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Caenorhabditis elegans (Nematode, roundworm) (14)

6 of 14

Yes

No

6 of 14

Yes

No

5 of 14

No

No

5 of 14

No

No

5 of 14

No

No

4 of 14

No

No

4 of 14

No

No

4 of 14

No

Yes

3 of 14

No

No

2 of 14

No

No

2 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Anopheles gambiae (African malaria mosquito) (24)

Agam\AgaP_AGAP000885

6 of 12

Yes

No

Agam\AgaP_AGAP003926

6 of 12

Yes

No

Agam\AgaP_AGAP003692

5 of 12

No

No

Agam\AgaP_AGAP003695

5 of 12

No

No

Agam\AgaP_AGAP004808

5 of 12

No

No

Agam\AgaP_AGAP004860

5 of 12

No

No

Agam\AgaP_AGAP013001

5 of 12

No

No

Agam\AgaP_AGAP013146

5 of 12

No

No

Agam\AgaP_AGAP013188

5 of 12

No

No

Agam\AgaP_AGAP013255

5 of 12

No

No

Agam\AgaP_AGAP013393

5 of 12

No

No

Agam\AgaP_AGAP001881

4 of 12

No

No

Agam\AgaP_AGAP002508

4 of 12

No

No

Agam\AgaP_AGAP003077

4 of 12

No

No

Agam\AgaP_AGAP004809

4 of 12

No

No

Agam\AgaP_AGAP005728

4 of 12

No

No

Agam\AgaP_AGAP012984

4 of 12

No

No

Agam\AgaP_AGAP013150

4 of 12

No

No

Agam\AgaP_AGAP013155

4 of 12

No

No

Agam\AgaP_AGAP000129

3 of 12

No

No

Agam\AgaP_AGAP012757

3 of 12

No

No

Agam\AgaP_AGAP005301

2 of 12

No

No

Agam\AgaP_AGAP000131

1 of 12

No

No

Agam\AgaP_AGAP009907

1 of 12

No

No

Arabidopsis thaliana (thale-cress) (4)

5 of 13

Yes

No

4 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Saccharomyces cerevisiae (Brewer's yeast) (4)

4 of 13

Yes

No

4 of 13

Yes

No

3 of 13

No

No

1 of 13

No

No

Schizosaccharomyces pombe (Fission yeast) (2)

4 of 12

Yes

No

Spom\SPCC1322.05c

1 of 12

No

No

Escherichia coli (enterobacterium) (1)

4 of 11

Yes

No

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG46339. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (21)

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

7 of 13

7 of 13

7 of 13

7 of 13

7 of 13

6 of 13

6 of 13

6 of 13

6 of 13

5 of 13

5 of 13

5 of 13

4 of 13

3 of 13

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ANPEP; alanyl aminopeptidase, membrane

7 of 14

ERAP1; endoplasmic reticulum aminopeptidase 1

7 of 14

ERAP2; endoplasmic reticulum aminopeptidase 2

7 of 14

LNPEP; leucyl and cystinyl aminopeptidase

7 of 14

ENPEP; glutamyl aminopeptidase

6 of 14

6 of 14

TRHDE; thyrotropin releasing hormone degrading enzyme

6 of 14

NPEPPS; aminopeptidase puromycin sensitive

4 of 14

NPEPPSP1; NPEPPS pseudogene 1

3 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Park and Song, 2008)

External Data

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

(FlyBase Genome Annotators, 2017)

protein_coding_gene

(FlyBase Genome Annotators, 2017)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-92

Cytogenetic map

Sequence location

3R:26,915,761..26,945,309 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

97D7-97D9

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-92

(FlyBase, 2016)

3-89.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (21)

Aberrations including deletions of this gene Aberrations including duplications of this gene

40673

w¹¹¹⁸; P{GMR94A08-GAL4}attP2

47246

w¹¹¹⁸; P{GMR94A10-GAL4}attP2

48005

w¹¹¹⁸; P{GMR94A02-GAL4}attP2

54312

w¹¹¹⁸; P{GMR94A03-lexA}attP40

75719

w¹¹¹⁸; P{R94A10-GAL4.DBD}attP2

37085

y¹ w^*; Mi{MIC}CG46339^MI03778

43758

y¹ w^*; Mi{MIC}CG46339^MI07724

15835

y¹ w^67c23; P{EPgy2}CG46339^EY01404

16950

y¹ w^67c23; P{EPgy2}CG46339^EY09726

v100215

P{KK107127}VIE-260B

v22144

w¹¹¹⁸; P{GD11680}v22144

v22145

w¹¹¹⁸; P{GD11680}v22145

More stocks available...

Genomic Clones (25)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (85)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

AT30002

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

The gene corresponding to the CG5518 annotation was named 'sda, slamdance', based mainly on the bang sensitive phenotypes associated with sda[iso7.8] (FBal0060899), described in FBrf0083354 and FBrf0155803. However, FBrf0235003 presents evidence that FBal0060899 instead maps to CG14509. Thus in FB2017_04, FBal0060899 and other unmapped alleles with bang sensitive phenotypes have been moved to CG14509, while those alleles and insertions mapping molecularly to the CG5518 annotation are retained with this gene. The CG5518 annotation has been renamed to CG46339 to avoid confusion.

(FlyBase Genome Annotators, 2017)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

BcDNA:GH07466

CG46339

(Floc'hlay et al., 2023, Li et al., 2022, Rust et al., 2020, Gene Disruption Project members, 2016-)

CG5518

(Ni et al., 2011.7.19, Mohammad et al., 2009)

sda

(Silva-Cardoso and N'Gouemo, 2023, Hadžić et al., 2015, Lim et al., 2015, Zwarts et al., 2015, Findlay et al., 2014, Dubruille et al., 2009, Spresser et al., 2008)

slamdance

(Loganathan et al., 2016)

Name Synonyms

Slamdance

(Kumimoto et al., 2013)

slamdance

(Park and Song, 2008, Spresser et al., 2008)

Secondary FlyBase IDs

FBgn0015541
FBgn0027573

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 44 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44359

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A0B4KH77

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A0B4KH77

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44359/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0285963

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0285963

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG46339

MARRVEL_MODEL - MARRVEL (model organism gene)

44359

Linkouts

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0285963

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG46339

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (44)