FB2020_02, released Apr 14, 2020

Gene: Dmel\AdamTS-A

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General Information
Symbol
Dmel\AdamTS-A
Species
D. melanogaster
Name
ADAM metallopeptidase with thrombospondin type 1 motif A
Annotation Symbol
CG14869
Feature Type
protein_coding_gene
FlyBase ID
FBgn0286071
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Snapshot
ADAM metallopeptidase with thrombospondin type 1 motif A (AdamTS-A) encodes a secreted matrix metalloprotease involved in cell migration. Loss of AdamTS-A in the salivary glands results in apical surface irregularities and cell elongation defects. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

l(3)89Aa

Key Links
Genomic Location
Cytogenetic map
89A2-89A5
Sequence location
3R:15,442,246..15,476,193 [-]
Recombination map

3-57

RefSeq locus
NT_033777 REGION:15442246..15476193
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
metalloendopeptidase activity; zinc ion binding
Summaries
Gene Group (FlyBase)
ADAM WITH THROMBOSPONDIN MOTIF -
A Disintegrin And Metalloprotease Thrombospondin motif (ADAMTS) belongs to the metzincin superfamily of metalloproteases. ADAMTS is related to ADAM proteins sharing in part their domain organisation. However, ADAMTS includes proteins that contain a variable number of thrombospondin-like repeats instead of disintegrin and cysteine rich domains. (Adapted from FBrf0214506).
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\AdamTS-A or the JBrowse view of Dmel\AdamTS-A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
AdamTS-A-RB
FBtr0083160
NM_206496
6965
1688
AdamTS-A-RC
FBtr0334629
NM_001275675
6164
1585
AdamTS-A-RE
FBtr0339398
NM_169659
5932
1537
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
AdamTS-A-PB
FBpp0082614
189.9
1688
7.81
NP_996218
AAS65157
AdamTS-A-PC
FBpp0306691
179.3
1585
8.03
NP_001262604
AGB95984
AdamTS-A-PE
FBpp0308490
173.6
1537
7.87
NP_732036
AAF55199
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\AdamTS-A using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (8 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
metalloendopeptidase activity
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
zinc ion binding
inferred from electronic annotation with InterPro:IPR002870, InterPro:IPR012314, InterPro:IPR013273
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
epithelial cell migration, open tracheal system
inferred from mutant phenotype
(Ismat et al., 2013)
extracellular matrix organization
inferred from mutant phenotype
(Ismat et al., 2013)
larval salivary gland morphogenesis
inferred from mutant phenotype
(Ismat et al., 2013)
mesodermal cell migration
inferred from mutant phenotype
(Ismat et al., 2013)
pole cell migration
inferred from mutant phenotype
(Ismat et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
proteolysis
inferred from electronic annotation with InterPro:IPR001590, InterPro:IPR002870
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 8
embryonic/larval hemocyte
(Ismat et al., 2013)
embryonic stage 11 -- 15
longitudinal visceral muscle primordium
(Ismat et al., 2013)
embryonic stage 12 -- 16
embryonic/larval salivary gland

Comment: secretory cells

(Ismat et al., 2013)
embryonic stage 14
embryonic/larval visceral branch
(Ismat et al., 2013)
embryonic stage 16
embryonic/larval midgut longitudinal visceral muscle
(Ismat et al., 2013)
adult stage
perineurial sheath glial cell
(Skeath et al., 2017)
subperineurial glial cell
(Skeath et al., 2017)
third instar larval stage
embryonic/larval salivary gland
(Skeath et al., 2017)
embryonic/larval fat body
(Skeath et al., 2017)
Additional Descriptive Data

Reporter expression is observed in all perineurial and subperineurial glial cells.

(Skeath et al., 2017)

AdamTS-A is expressed in cells that migrate as individuals, including hemocytes and in caudal visceral mesoderm. Expression is also observed in the secretory cells of the salivary gland, the visceral branch, and in longitudinal visceral muscle fibers.

(Ismat et al., 2013)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\AdamTS-A in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of AdamTS-A
Transgenic constructs containing regulatory region of AdamTS-A
Deletions and Duplications ( 19 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with AdamTS-AKO)
lethal (with AdamTS-Arnwy1)
lethal (with AdamTS-Arnwy2)
lethal (with Df(3R)88F5)
lethal | recessive
lethal - all die before end of larval stage (with Df(3R)88F5)
partially lethal - majority die (with Df(3R)88F5)
partially lethal - majority live
partially lethal - majority live (with AdamTS-Arnwy1)
partially lethal - majority live (with AdamTS-Arnwy2)
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
cell migration defective (with Df(3R)88F5)
developmental rate defective
neuroanatomy defective | third instar larval stage
neuroanatomy defective | third instar larval stage, with AdamTS-Arnwy2/AdamTS-Arnwy1, Scer\GAL4repo
neuroanatomy defective | third instar larval stage, with Scer\GAL4NP6293, Scer\GAL4Gli-rL82
neuroanatomy defective | third instar larval stage, with Scer\GAL4repo
neuroanatomy defective | third instar larval stage (with AdamTS-Arnwy1)
neuroanatomy defective | third instar larval stage (with AdamTS-Arnwy1), with AdamTS-AUAS.cIa, Scer\GAL4repo
neuroanatomy defective | third instar larval stage (with AdamTS-Arnwy1), with AdamTS-AUAS.RB, Scer\GAL4repo
neuroanatomy defective | third instar larval stage (with AdamTS-Arnwy2)
neuroanatomy defective | third instar larval stage (with AdamTS-Arnwy2), with AdamTS-AUAS.cIa, Scer\GAL4repo
neuroanatomy defective | third instar larval stage (with AdamTS-Arnwy2), with AdamTS-AUAS.RB, Scer\GAL4repo
uncoordinated
uncoordinated (with AdamTS-Arnwy1)
uncoordinated (with AdamTS-Arnwy2)
Phenotype manifest in
Allele
embryonic/larval brain | third instar larval stage
embryonic/larval brain | third instar larval stage, with AdamTS-Arnwy2/AdamTS-Arnwy1, Scer\GAL4repo
embryonic/larval brain | third instar larval stage, with Scer\GAL4NP6293, Scer\GAL4Gli-rL82
embryonic/larval brain | third instar larval stage, with Scer\GAL4repo
embryonic/larval brain | third instar larval stage (with AdamTS-Arnwy1)
embryonic/larval brain | third instar larval stage (with AdamTS-Arnwy1), with AdamTS-AUAS.cIa, Scer\GAL4repo
embryonic/larval brain | third instar larval stage (with AdamTS-Arnwy1), with AdamTS-AUAS.RB, Scer\GAL4repo
embryonic/larval brain | third instar larval stage (with AdamTS-Arnwy2)
embryonic/larval brain | third instar larval stage (with AdamTS-Arnwy2), with AdamTS-AUAS.cIa, Scer\GAL4repo
embryonic/larval brain | third instar larval stage (with AdamTS-Arnwy2), with AdamTS-AUAS.RB, Scer\GAL4repo
embryonic/larval salivary gland (with Df(3R)88F5)
embryonic/larval visceral branch (with Df(3R)88F5)
germline cell | embryonic stage (with Df(3R)88F5)
longitudinal visceral muscle primordium (with Df(3R)88F5)
ventral nerve cord | third instar larval stage, with AdamTS-Arnwy2/AdamTS-Arnwy1, Scer\GAL4repo
ventral nerve cord | third instar larval stage, with Scer\GAL4repo
ventral nerve cord | third instar larval stage (with AdamTS-Arnwy1), with AdamTS-AUAS.cIa, Scer\GAL4repo
ventral nerve cord | third instar larval stage (with AdamTS-Arnwy1), with AdamTS-AUAS.RB, Scer\GAL4repo
ventral nerve cord | third instar larval stage (with AdamTS-Arnwy2), with AdamTS-AUAS.cIa, Scer\GAL4repo
ventral nerve cord | third instar larval stage (with AdamTS-Arnwy2), with AdamTS-AUAS.RB, Scer\GAL4repo
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (31)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ADAMTS9
11 of 15
Yes
Yes
Hsap\ADAMTS20
11 of 15
Yes
Yes
Hsap\ADAMTS1
7 of 15
No
Yes
Hsap\ADAMTS5
6 of 15
No
Yes
Hsap\ADAMTS8
6 of 15
No
Yes
Hsap\ADAMTS4
5 of 15
No
Yes
Hsap\ADAMTS15
5 of 15
No
Yes
 
Hsap\ADAMTS18
5 of 15
No
Yes
Hsap\ADAMTS6
4 of 15
No
No
Hsap\ADAMTS12
4 of 15
No
No
Hsap\ADAMTS13
4 of 15
No
Yes
Hsap\ADAMTS16
4 of 15
No
No
Hsap\ADAMTS2
3 of 15
No
Yes
Hsap\ADAMTS7
3 of 15
No
No
Hsap\ADAMTS10
3 of 15
No
No
Hsap\ADAMTS17
3 of 15
No
No
Hsap\ADAMTS3
2 of 15
No
No
Hsap\ADAMTS14
2 of 15
No
No
Hsap\ADAMTS19
2 of 15
No
No
Hsap\ADAMTSL2
2 of 15
No
No
Hsap\ADAMTSL4
2 of 15
No
No
Hsap\ADAMTSL1
1 of 15
No
No
Hsap\ADAMTSL3
1 of 15
No
No
Hsap\ADAMTSL5
1 of 15
No
No
Hsap\ADGRB1
1 of 15
No
Yes
Hsap\PAPLN
1 of 15
No
No
Hsap\THSD4
1 of 15
No
No
Hsap\THSD7A
1 of 15
No
Yes
Hsap\THSD7B
1 of 15
No
Yes
Hsap\WFIKKN1
1 of 15
No
No
Hsap\WFIKKN2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (32)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Adamts20
12 of 15
Yes
Yes
Mmus\Adamts9
11 of 15
No
Yes
Mmus\Adamts1
7 of 15
No
Yes
Mmus\Adamts5
6 of 15
No
Yes
Mmus\Adamts8
6 of 15
No
Yes
Mmus\Adamts15
6 of 15
No
Yes
Mmus\Adamts18
5 of 15
No
Yes
Mmus\Adamts4
4 of 15
No
Yes
Mmus\Adamts6
4 of 15
No
Yes
Mmus\Adamts12
4 of 15
No
No
Mmus\Adamts13
4 of 15
No
Yes
Mmus\Adamts16
4 of 15
No
No
Mmus\Adamts2
3 of 15
No
Yes
Mmus\Adamts7
3 of 15
No
No
Mmus\Adamts10
3 of 15
No
No
Mmus\Adamts17
3 of 15
No
No
Mmus\Adamts3
2 of 15
No
No
Mmus\Adamts14
2 of 15
No
No
Mmus\Adamts19
2 of 15
No
No
Mmus\Adamtsl2
2 of 15
No
No
Mmus\Adamtsl4
2 of 15
No
No
Mmus\Adamtsl1
1 of 15
No
No
Mmus\Adamtsl3
1 of 15
No
No
Mmus\Adamtsl5
1 of 15
No
No
Mmus\Adgrb1
1 of 15
No
Yes
Mmus\Papln
1 of 15
No
No
Mmus\Sspo
1 of 15
No
No
Mmus\Thsd4
1 of 15
No
No
Mmus\Thsd7a
1 of 15
No
No
Mmus\Thsd7b
1 of 15
No
Yes
Mmus\Wfikkn1
1 of 15
No
Yes
Mmus\Wfikkn2
1 of 15
No
No
Rattus norvegicus (Norway rat) (29)
Rnor\Adamts1
7 of 13
Yes
Yes
Rnor\Adamts9
7 of 13
Yes
Yes
Rnor\Adamts15
6 of 13
No
Yes
Rnor\Adamts4
5 of 13
No
Yes
Rnor\Adamts8
5 of 13
No
Yes
Rnor\Adamts18
5 of 13
No
Yes
Rnor\Adamts20
5 of 13
No
Yes
Rnor\Adamts5
4 of 13
No
Yes
Rnor\Adamts12
4 of 13
No
No
Rnor\Adamts13
4 of 13
No
Yes
Rnor\Adamts16
4 of 13
No
No
Rnor\Adamts6
3 of 13
No
No
Rnor\Adamts7
3 of 13
No
No
Rnor\Adamts17
3 of 13
No
No
Rnor\Adamts19
2 of 13
No
No
Rnor\Adamtsl2
2 of 13
No
No
Rnor\Adamtsl4
2 of 13
No
No
Rnor\Adamts2
1 of 13
No
No
Rnor\Adamts3
1 of 13
No
No
Rnor\Adamts10
1 of 13
No
No
Rnor\Adamts14
1 of 13
No
No
Rnor\Adamtsl3
1 of 13
No
No
Rnor\Adamtsl5
1 of 13
No
No
Rnor\LOC102554283
1 of 13
No
Yes
Rnor\Sspo
1 of 13
No
No
Rnor\Thsd7a
1 of 13
No
Yes
Rnor\Thsd7b
1 of 13
No
Yes
Rnor\Wfikkn1
1 of 13
No
Yes
Rnor\Wfikkn2
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (29)
Xtro\adamts20
6 of 12
Yes
Yes
Xtro\adamts9
5 of 12
No
Yes
Xtro\adamts1
4 of 12
No
Yes
Xtro\adamts5
4 of 12
No
Yes
Xtro\adamts8
4 of 12
No
Yes
Xtro\adamts13
4 of 12
No
Yes
Xtro\adamts18
4 of 12
No
Yes
Xtro\adamts2
3 of 12
No
Yes
Xtro\adamts4
3 of 12
No
Yes
Xtro\adamts12
3 of 12
No
No
Xtro\adamts15
3 of 12
No
Yes
Xtro\adamts16
3 of 12
No
No
Xtro\adamts17
3 of 12
No
No
Xtro\adamts3
2 of 12
No
No
Xtro\adamts6
2 of 12
No
No
Xtro\adamts7
2 of 12
No
No
Xtro\adamts10
2 of 12
No
No
Xtro\adamts14
2 of 12
No
No
Xtro\adamtsl4
2 of 12
No
No
Xtro\adamts19
1 of 12
No
Yes
Xtro\adamtsl3
1 of 12
No
No
Xtro\adamtsl5
1 of 12
No
No
Xtro\adgrb1
1 of 12
No
Yes
Xtro\LOC100487633
1 of 12
No
No
Xtro\papln
1 of 12
No
No
Xtro\thsd7a
1 of 12
No
Yes
Xtro\thsd7b
1 of 12
No
Yes
Xtro\wfikkn1
1 of 12
No
Yes
Xtro\wfikkn2
1 of 12
No
Yes
Danio rerio (Zebrafish) (40)
Drer\adamts1
8 of 15
Yes
Yes
Drer\adamts8a
6 of 15
No
Yes
Drer\adamts15a
6 of 15
No
Yes
Drer\LOC100002059
6 of 15
No
Yes
Drer\adamts18
5 of 15
No
Yes
Drer\LOC100001991
5 of 15
No
Yes
Drer\adamts9
4 of 15
No
Yes
Drer\adamts12
4 of 15
No
No
Drer\adamts13
4 of 15
No
Yes
Drer\LOC568792
4 of 15
No
Yes
Drer\adamts2
3 of 15
No
Yes
Drer\adamts5
3 of 15
No
Yes
Drer\adamts6
3 of 15
No
No
Drer\adamts7
3 of 15
No
No
Drer\adamts10
3 of 15
No
No
Drer\adamts17
3 of 15
No
No
Drer\adamts3
2 of 15
No
No
Drer\adamtsl2
2 of 15
No
No
Drer\adamtsl7
2 of 15
No
No
Drer\LOC101886654
2 of 15
No
Yes
Drer\adamtsl3
1 of 15
No
No
Drer\adamtsl4
1 of 15
No
No
Drer\adamtsl5
1 of 15
No
No
Drer\adgrb1a
1 of 15
No
Yes
Drer\col28a1a
1 of 15
No
No
Drer\LOC100331635
1 of 15
No
Yes
Drer\LOC101885599
1 of 15
No
Yes
Drer\lrp11
1 of 15
No
No
Drer\paplna
1 of 15
No
No
Drer\paplnb
1 of 15
No
No
Drer\scospondin
1 of 15
No
No
Drer\si:ch211-154c21.1
1 of 15
No
Yes
Drer\si:ch211-267e7.3
1 of 15
No
No
Drer\si:dkeyp-73b11.8
1 of 15
No
No
Drer\thsd7aa
1 of 15
No
No
Drer\thsd7ba
1 of 15
No
No
Drer\thsd7bb
1 of 15
No
Yes
Drer\wfikkn2a
1 of 15
No
Yes
Drer\wfikkn2b
1 of 15
No
No
Drer\wu:fb59d01
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\gon-1
11 of 15
Yes
Yes
Cele\adt-1
3 of 15
No
No
Cele\adt-3
2 of 15
No
No
Cele\adt-2
1 of 15
No
No
Cele\madd-4
1 of 15
No
No
Cele\mig-17
1 of 15
No
No
Cele\T21B6.3
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900EG )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010740
Drosophila simulans
Dsim\GD20348
Drosophila sechellia
Dsec\GM25769
Drosophila erecta
Dere\GG20508
Drosophila yakuba
Dyak\GE26372
Drosophila ananassae
Dana\GF16699
Drosophila pseudoobscura pseudoobscura
Dpse\GA13308
Drosophila persimilis
Dper\GL23786
Drosophila willistoni
Dwil\GK11632
Drosophila virilis
Dvir\GJ24366
Drosophila mojavensis
Dmoj\GI24356
Drosophila grimshawi
Dgri\GH18512
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915009A )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017017
Glossina morsitans
Tsetse fly
Gmor\GMOY008456
Mayetiola destructor
Hessian fly
Mdes\Mdes002011
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL006148
Anopheles darlingi
American malaria mosquito
Adar\ADAC001059
Anopheles gambiae
Malaria mosquito
Agam\AGAP004201
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ006228
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010188
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W007A )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Apis florea
Little honeybee
Aflo\2147622963
Apis mellifera
Western honey bee
Amel\GB42740
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13195
Bombus terrestris
Buff-tailed bumblebee
Bter\15206510
Linepithema humile
Argentine ant
Lhum\LH10651
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001a98
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013652
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11749
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15139
Pediculus humanus
Human body louse
Phum\PHUM396730
Rhodnius prolixus
Kissing bug
Rpro\RPRC001849
Cimex lectularius
Bed bug
Clec\CLEC000245
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004174
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17661
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X006X )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007589
Ixodes scapularis
Black-legged tick
Isca\ISCW021991
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57446.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57444.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70753.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70756.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g03480
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_303360
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00AX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Adam/TsL3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Adamts9
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_012747gn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023761
Ciona intestinalis
Vase tunicate
Cint\adamts9
Gallus gallus
Domestic chicken
Ggal\ADAMTS8
Gallus gallus
Domestic chicken
Ggal\ADAMTS20
Gallus gallus
Domestic chicken
Ggal\ADAMTS5
Gallus gallus
Domestic chicken
Ggal\ADAMTS9
Gallus gallus
Domestic chicken
Ggal\ADAMTS15
Gallus gallus
Domestic chicken
Ggal\ADAMTS4
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (7)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
AdamTS-B
4 of 10
loh
3 of 10
Ppn
3 of 10
nolo
2 of 10
sona
2 of 10
stl
2 of 10
CG31609
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ADAMTS9; ADAM metallopeptidase with thrombospondin type 1 motif 9
    11 of 15
    605421
        ADAMTS20; ADAM metallopeptidase with thrombospondin type 1 motif 20
        11 of 15
        611681
            ADAMTS1; ADAM metallopeptidase with thrombospondin type 1 motif 1
            7 of 15
            605174
                ADAMTS5; ADAM metallopeptidase with thrombospondin type 1 motif 5
                6 of 15
                605007
                    ADAMTS8; ADAM metallopeptidase with thrombospondin type 1 motif 8
                    6 of 15
                    605175
                        ADAMTS4; ADAM metallopeptidase with thrombospondin type 1 motif 4
                        5 of 15
                        603876
                            ADAMTS15; ADAM metallopeptidase with thrombospondin type 1 motif 15
                            5 of 15
                            607509
                                 
                                ADAMTS18; ADAM metallopeptidase with thrombospondin type 1 motif 18
                                5 of 15
                                607512
                                  ADAMTS6; ADAM metallopeptidase with thrombospondin type 1 motif 6
                                  4 of 15
                                  605008
                                      ADAMTS12; ADAM metallopeptidase with thrombospondin type 1 motif 12
                                      4 of 15
                                      606184
                                          ADAMTS13; ADAM metallopeptidase with thrombospondin type 1 motif 13
                                          4 of 15
                                          604134
                                          ADAMTS16; ADAM metallopeptidase with thrombospondin type 1 motif 16
                                          4 of 15
                                          607510
                                              ADAMTS2; ADAM metallopeptidase with thrombospondin type 1 motif 2
                                              3 of 15
                                              604539
                                                ADAMTS7; ADAM metallopeptidase with thrombospondin type 1 motif 7
                                                3 of 15
                                                605009
                                                    ADAMTS10; ADAM metallopeptidase with thrombospondin type 1 motif 10
                                                    3 of 15
                                                    608990
                                                    ADAMTS17; ADAM metallopeptidase with thrombospondin type 1 motif 17
                                                    3 of 15
                                                    607511
                                                    Functional Complementation Data
                                                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                    Interactions
                                                    Summary of Physical Interactions
                                                    esyN Network Diagram
                                                    Interactions Browser
                                                    Summary of Genetic Interactions
                                                    esyN Network Diagram
                                                    esyN Network Key:
                                                    Suppression
                                                    Enhancement
                                                    View in Interactions Browser
                                                    Please look at the allele data for full details of the genetic interactions
                                                    Starting gene(s)
                                                    Interaction type
                                                    Interacting gene(s)
                                                    Reference
                                                    AdamTS-A
                                                    suppressible
                                                    Cad99C
                                                    (Ismat et al., 2013)
                                                    AdamTS-A
                                                    suppressible
                                                    LanA
                                                    (Skeath et al., 2017)
                                                    AdamTS-A
                                                    suppressible
                                                    mys
                                                    (Skeath et al., 2017)
                                                    AdamTS-A
                                                    suppressible
                                                    trol
                                                    (Skeath et al., 2017)
                                                    AdamTS-A
                                                    suppressible
                                                    vkg
                                                    (Skeath et al., 2017)
                                                    Starting gene(s)
                                                    Interaction type
                                                    Interacting gene(s)
                                                    Reference
                                                    External Data
                                                    Linkouts
                                                    BioGRID - A database of protein and genetic interactions.
                                                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                                    Pathways
                                                    Signaling Pathways (FlyBase)
                                                    Metabolic Pathways
                                                    External Data
                                                    Linkouts
                                                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                    Genomic Location and Detailed Mapping Data
                                                    Chromosome (arm)
                                                    3R
                                                    Recombination map

                                                    3-57

                                                    Cytogenetic map
                                                    89A2-89A5
                                                    Sequence location
                                                    3R:15,442,246..15,476,193 [-]
                                                    FlyBase Computed Cytological Location
                                                    Cytogenetic map
                                                    Evidence for location
                                                    89A2-89A5
                                                    Left limit from inclusion within Df(3R)R44 (FBrf0104484) Right limit from inclusion within Df(3R)c(3)G-2 (FBrf0057262)
                                                    Experimentally Determined Cytological Location
                                                    Cytogenetic map
                                                    Notes
                                                    References
                                                    Experimentally Determined Recombination Data
                                                    Location

                                                    3-57

                                                    (FlyBase, 2016)

                                                    3-56.8

                                                    (Comeron et al., 2012)

                                                    3-[58]

                                                    Left of (cM)
                                                    Right of (cM)
                                                    Notes
                                                    Stocks and Reagents
                                                    Stocks (6)
                                                    Genomic Clones (25)
                                                    cDNA Clones (27)
                                                     

                                                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                    cDNA clones, fully sequences
                                                    BDGP DGC clones
                                                    Other clones
                                                      Drosophila Genomics Resource Center cDNA clones

                                                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                        cDNA Clones, End Sequenced (ESTs)
                                                        BDGP DGC clones
                                                        Other clones
                                                        RNAi and Array Information
                                                        Linkouts
                                                        Antibody Information
                                                        Laboratory Generated Antibodies
                                                         

                                                        polyclonal

                                                        (Ismat et al., 2013)
                                                        Commercially Available Antibodies
                                                         
                                                        Other Information
                                                        Relationship to Other Genes
                                                        Source for database identify of

                                                        Source for identity of: AdamTS-A CG14869

                                                        (Ismat et al., 2013)
                                                        Source for database merge of

                                                        Source for merge of: CG14869 CG6107

                                                        (FlyBase Genome Annotators, 2002-2003)

                                                        Source for merge of: AdamTS-A l(3)89Aa

                                                        (Ismat et al., 2013)
                                                        Additional comments

                                                        The lethal allele identified as being carried on TM3 balancer chromosomes in FBrf0057262 (l(3)89Aa[1]) is an allele of AdamTS-A.

                                                        (Ismat et al., 2013)

                                                        Annotations CG6107 and CG14869 merged as CG14869 in release 3 of the genome annotation.

                                                        (FlyBase Genome Annotators, 2002-2003)
                                                        Other Comments

                                                        AdamTS-A is required for collective cell migration, including of the caudal visceral mesoderm, the visceral branch of the trachea, germ cells and the secretory portion of the salivary gland.

                                                        (Ismat et al., 2013)
                                                        Origin and Etymology
                                                        Discoverer
                                                        Etymology
                                                        Identification
                                                        External Crossreferences and Linkouts ( 31 )
                                                        Sequence Crossreferences
                                                        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                                        Other crossreferences
                                                        InterPro - A database of protein families, domains and functional sites
                                                        Linkouts
                                                        BioGRID - A database of protein and genetic interactions.
                                                        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                                        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                        Synonyms and Secondary IDs (9)
                                                        Reported As
                                                        Symbol Synonym
                                                        AdamTS-A
                                                        (Ramos-Lewis and Page-McCaw, 2019, Wittes and Schüpbach, 2019, Fochler et al., 2017, Skeath et al., 2017, Kim et al., 2016, Ismat et al., 2013)
                                                        CG14869
                                                        (Nagy et al., 2015, DeSalvo et al., 2014, Ismat et al., 2013, Mackay et al., 2012, Meyer et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5)
                                                        CG6107
                                                        (Nicholson et al., 2005, Luschnig, 2003.12.17)
                                                        CT19033
                                                        (Hynes and Zhao, 2000)
                                                        l(3)89Aa
                                                        (Miller et al., 2016)
                                                        rnwy
                                                        (Skeath et al., 2017)
                                                        Name Synonyms
                                                        ADAM metallopeptidase with thrombospondin type 1 motif A
                                                        lethal (3) 89Aa
                                                        runaway
                                                        (Skeath et al., 2017)
                                                        Secondary FlyBase IDs
                                                        • FBgn0038341
                                                        • FBgn0038340
                                                        • FBgn0002366
                                                        Datasets (0)
                                                        Study focus (0)
                                                        Experimental Role
                                                        Project
                                                        Project Type
                                                        Title
                                                        References (51)