FlyBase Gene Report: Dmel\AdamTS-A

General Information

Symbol

Dmel\AdamTS-A

Species

D. melanogaster

Name

ADAM metallopeptidase with thrombospondin type 1 motif A

Annotation Symbol

CG14869

Feature Type

protein_coding_gene

FlyBase ID

FBgn0286071

Gene Model Status

Stock Availability

6 publicly available

Gene Summary

ADAM metallopeptidase with thrombospondin type 1 motif A (AdamTS-A) encodes a secreted matrix metalloprotease involved in cell migration. Loss of AdamTS-A in the salivary glands results in apical surface irregularities and cell elongation defects. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

l(3)89Aa

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:15,442,246..15,476,193 [-]

Recombination map

3-57

RefSeq locus

NT_033777 REGION:15442246..15476193

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables metalloendopeptidase activity

inferred from biological aspect of ancestor with PANTHER:PTN000347317

(assigned by GO_Central )

(Gaudet et al., 2011)

enables zinc ion binding

inferred from electronic annotation with InterPro:IPR002870, InterPro:IPR012314, InterPro:IPR013273

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in epithelial cell migration, open tracheal system

inferred from mutant phenotype

(Ismat et al., 2013)

involved_in extracellular matrix organization

inferred from mutant phenotype

(Ismat et al., 2013)

involved_in larval salivary gland morphogenesis

inferred from mutant phenotype

(Ismat et al., 2013)

involved_in mesodermal cell migration

inferred from mutant phenotype

(Ismat et al., 2013)

involved_in pole cell migration

inferred from mutant phenotype

(Ismat et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in extracellular matrix organization

inferred from biological aspect of ancestor with PANTHER:PTN000347317

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR001590, InterPro:IPR002870

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in extracellular matrix

inferred from biological aspect of ancestor with PANTHER:PTN000347317

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

ADAM WITH THROMBOSPONDIN MOTIF

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Snapshot

ADAM metallopeptidase with thrombospondin type 1 motif A (AdamTS-A) encodes a secreted matrix metalloprotease involved in cell migration. Loss of AdamTS-A in the salivary glands results in apical surface irregularities and cell elongation defects. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

ADAM WITH THROMBOSPONDIN MOTIF -: A Disintegrin And Metalloprotease Thrombospondin motif (ADAMTS) belongs to the metzincin superfamily of metalloproteases. ADAMTS is related to ADAM proteins, sharing in part their domain organisation. However, ADAMTS includes proteins that contain a variable number of thrombospondin-like repeats instead of disintegrin and cysteine rich domains. ADAMTS proteases are included in MEROPS family M12, subfamily B. (Adapted from FBrf0214506).

Gene Model and Products

Number of Transcripts

3

Number of Unique Polypeptides

3

Please see the JBrowse view of Dmel\AdamTS-A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q8SXB0)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.47

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0083160

6965

1688

FBtr0334629

6164

1585

FBtr0339398

5932

1537

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0082614

189.9

1688

7.81

FBpp0306691

179.3

1585

8.03

FBpp0308490

173.6

1537

7.87

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\AdamTS-A using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 8

embryonic/larval hemocyte

(Ismat et al., 2013)

embryonic stage 11 -- 15

longitudinal visceral muscle primordium

(Ismat et al., 2013)

embryonic stage 12 -- 16

embryonic/larval salivary gland

Comment: secretory cells

(Ismat et al., 2013)

embryonic stage 14

embryonic/larval visceral tracheal branch

(Ismat et al., 2013)

embryonic stage 16

embryonic/larval midgut longitudinal visceral muscle cell

(Ismat et al., 2013)

third instar larval stage

embryonic/larval salivary gland

(Skeath et al., 2017)

embryonic/larval fat body

(Skeath et al., 2017)

perineurial glial cell

(Skeath et al., 2017)

subperineurial glial cell

(Skeath et al., 2017)

Additional Descriptive Data

Reporter expression is observed in all perineurial and subperineurial glial cells.

(Skeath et al., 2017)

AdamTS-A is expressed in cells that migrate as individuals, including hemocytes and in caudal visceral mesoderm. Expression is also observed in the secretory cells of the salivary gland, the visceral branch, and in longitudinal visceral muscle fibers.

(Ismat et al., 2013)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: Mi{Trojan-GAL4.0}AdamTS-A^{MI09007-TG4.0}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

perineurial glial cell

(Skeath et al., 2017)

subperineurial glial cell

(Skeath et al., 2017)

embryonic/larval salivary gland

(Skeath et al., 2017)

embryonic/larval fat body

(Skeath et al., 2017)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\AdamTS-A in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\AdamTS-A

View exonic expression by tissue for Dmel\AdamTS-A

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41887/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0286071

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038341

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0286071

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of AdamTS-A

Transgenic constructs containing regulatory region of AdamTS-A

Aberrations (Deficiencies and Duplications) ( 19 )

Inferred from experimentation ( 19 )

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with AdamTS-A^KO)

lethal (with AdamTS-A^rnwy1)

AdamTS-A^KO

lethal (with AdamTS-A^rnwy2)

AdamTS-A^KO

lethal (with Df(3R)88F5)

AdamTS-A^rnwy1

lethal | recessive

AdamTS-A^89Aa-1

lethal - all die before end of larval stage (with Df(3R)88F5)

AdamTS-A^KO

partially lethal - majority die (with Df(3R)88F5)

AdamTS-A^rnwy2

partially lethal - majority live

AdamTS-A^rnwy1

partially lethal - majority live (with AdamTS-A^rnwy1)

AdamTS-A^rnwy2

partially lethal - majority live (with AdamTS-A^rnwy2)

AdamTS-A^rnwy1

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

AdamTS-A^GD3002

viable, with Scer\GAL4^pnr-MD237

AdamTS-A^GD3002

viable, with Scer\GAL4^tin.CΔ4

AdamTS-A^GD3002

Other Phenotypes

Allele

abnormal cell migration (with Df(3R)88F5)

AdamTS-A^KO

abnormal developmental rate

AdamTS-A^rnwy1

abnormal neuroanatomy | third instar larval stage

AdamTS-A^rnwy1

abnormal neuroanatomy | third instar larval stage, with AdamTS-A^rnwy2/AdamTS-A^rnwy1, Scer\GAL4^repo

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^NP6293, Scer\GAL4^Gli-rL82

AdamTS-A^KK102087

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^repo

abnormal neuroanatomy | third instar larval stage (with AdamTS-A^rnwy1)

AdamTS-A^rnwy2

abnormal neuroanatomy | third instar larval stage (with AdamTS-A^rnwy1), with AdamTS-A^UAS.cIa, Scer\GAL4^repo

AdamTS-A^rnwy2

abnormal neuroanatomy | third instar larval stage (with AdamTS-A^rnwy1), with AdamTS-A^UAS.RB, Scer\GAL4^repo

AdamTS-A^rnwy2

abnormal neuroanatomy | third instar larval stage (with AdamTS-A^rnwy2)

AdamTS-A^rnwy1

abnormal neuroanatomy | third instar larval stage (with AdamTS-A^rnwy2), with AdamTS-A^UAS.cIa, Scer\GAL4^repo

AdamTS-A^rnwy1

abnormal neuroanatomy | third instar larval stage (with AdamTS-A^rnwy2), with AdamTS-A^UAS.RB, Scer\GAL4^repo

AdamTS-A^rnwy1

AdamTS-A^rnwy1

uncoordinated (with AdamTS-A^rnwy1)

AdamTS-A^rnwy2

uncoordinated (with AdamTS-A^rnwy2)

AdamTS-A^rnwy1

Phenotype manifest in

Allele

embryonic/larval brain | third instar larval stage

AdamTS-A^rnwy1

embryonic/larval brain | third instar larval stage, with AdamTS-A^rnwy2/AdamTS-A^rnwy1, Scer\GAL4^repo

embryonic/larval brain | third instar larval stage, with Scer\GAL4^NP6293, Scer\GAL4^Gli-rL82

AdamTS-A^KK102087

embryonic/larval brain | third instar larval stage, with Scer\GAL4^repo

embryonic/larval brain | third instar larval stage (with AdamTS-A^rnwy1)

AdamTS-A^rnwy2

embryonic/larval brain | third instar larval stage (with AdamTS-A^rnwy1), with AdamTS-A^UAS.cIa, Scer\GAL4^repo

AdamTS-A^rnwy2

embryonic/larval brain | third instar larval stage (with AdamTS-A^rnwy1), with AdamTS-A^UAS.RB, Scer\GAL4^repo

AdamTS-A^rnwy2

embryonic/larval brain | third instar larval stage (with AdamTS-A^rnwy2)

AdamTS-A^rnwy1

embryonic/larval brain | third instar larval stage (with AdamTS-A^rnwy2), with AdamTS-A^UAS.cIa, Scer\GAL4^repo

AdamTS-A^rnwy1

embryonic/larval brain | third instar larval stage (with AdamTS-A^rnwy2), with AdamTS-A^UAS.RB, Scer\GAL4^repo

AdamTS-A^rnwy1

embryonic/larval salivary gland (with Df(3R)88F5)

AdamTS-A^KO

embryonic/larval visceral tracheal branch (with Df(3R)88F5)

AdamTS-A^KO

germline cell | embryonic stage (with Df(3R)88F5)

AdamTS-A^KO

larval ventral nerve cord | third instar larval stage, with AdamTS-A^rnwy2/AdamTS-A^rnwy1, Scer\GAL4^repo

larval ventral nerve cord | third instar larval stage, with Scer\GAL4^repo

larval ventral nerve cord | third instar larval stage (with AdamTS-A^rnwy1), with AdamTS-A^UAS.cIa, Scer\GAL4^repo

AdamTS-A^rnwy2

larval ventral nerve cord | third instar larval stage (with AdamTS-A^rnwy1), with AdamTS-A^UAS.RB, Scer\GAL4^repo

AdamTS-A^rnwy2

larval ventral nerve cord | third instar larval stage (with AdamTS-A^rnwy2), with AdamTS-A^UAS.cIa, Scer\GAL4^repo

AdamTS-A^rnwy1

larval ventral nerve cord | third instar larval stage (with AdamTS-A^rnwy2), with AdamTS-A^UAS.RB, Scer\GAL4^repo

AdamTS-A^rnwy1

longitudinal visceral muscle primordium (with Df(3R)88F5)

AdamTS-A^KO

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (31)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

11 of 15

Yes

Yes

11 of 15

Yes

Yes

7 of 15

No

Yes

1

6 of 15

No

Yes

6 of 15

No

Yes

5 of 15

No

Yes

5 of 15

No

Yes

1

5 of 15

No

Yes

4 of 15

No

No

4 of 15

No

No

4 of 15

No

Yes

4 of 15

No

No

3 of 15

No

Yes

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (32)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

12 of 15

Yes

Yes

11 of 15

No

Yes

7 of 15

No

Yes

6 of 15

No

Yes

6 of 15

No

Yes

6 of 15

No

Yes

5 of 15

No

Yes

4 of 15

No

Yes

4 of 15

No

Yes

4 of 15

No

No

4 of 15

No

Yes

4 of 15

No

No

3 of 15

No

Yes

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

Rattus norvegicus (Norway rat) (29)

7 of 13

Yes

Yes

7 of 13

Yes

Yes

6 of 13

No

Yes

5 of 13

No

Yes

5 of 13

No

Yes

5 of 13

No

Yes

5 of 13

No

Yes

4 of 13

No

Yes

4 of 13

No

No

4 of 13

No

Yes

4 of 13

No

No

3 of 13

No

No

3 of 13

No

No

3 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Rnor\LOC102554283

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

Yes

Xenopus tropicalis (Western clawed frog) (29)

6 of 12

Yes

Yes

5 of 12

No

Yes

4 of 12

No

Yes

4 of 12

No

Yes

4 of 12

No

Yes

4 of 12

No

Yes

4 of 12

No

Yes

3 of 12

No

Yes

3 of 12

No

Yes

3 of 12

No

No

3 of 12

No

Yes

3 of 12

No

No

3 of 12

No

No

2 of 12

No

No

2 of 12

No

No

2 of 12

No

No

2 of 12

No

No

2 of 12

No

No

2 of 12

No

No

1 of 12

No

Yes

1 of 12

No

No

1 of 12

No

No

1 of 12

No

Yes

Xtro\LOC100487633

1 of 12

No

No

1 of 12

No

No

1 of 12

No

Yes

1 of 12

No

Yes

1 of 12

No

Yes

1 of 12

No

Yes

Danio rerio (Zebrafish) (40)

8 of 15

Yes

Yes

6 of 15

No

Yes

6 of 15

No

Yes

Drer\LOC100002059

6 of 15

No

Yes

5 of 15

No

Yes

Drer\LOC100001991

5 of 15

No

Yes

4 of 15

No

Yes

4 of 15

No

No

4 of 15

No

Yes

4 of 15

No

Yes

3 of 15

No

Yes

3 of 15

No

Yes

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

Drer\LOC101886654

2 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

Drer\LOC100331635

1 of 15

No

Yes

Drer\LOC101885599

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Drer\scospondin

1 of 15

No

No

Drer\si:ch211-154c21.1

1 of 15

No

Yes

Drer\si:ch211-267e7.3

1 of 15

No

No

Drer\si:dkeyp-73b11.8

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

Drer\wu:fb59d01

1 of 15

No

No

Caenorhabditis elegans (Nematode, roundworm) (7)

11 of 15

Yes

Yes

3 of 15

No

No

2 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (7)

Gene Symbol

Score

Source

Alignment

4 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

ADAMTS13; ADAM metallopeptidase with thrombospondin type 1 motif 13

model of thrombotic thrombocytopenic purpura

IEA

(FlyBase, 2019-)

ADAMTS2; ADAM metallopeptidase with thrombospondin type 1 motif 2

model of Ehlers-Danlos syndrome dermatosparaxis type

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ADAMTS9; ADAM metallopeptidase with thrombospondin type 1 motif 9

11 of 15

ADAMTS20; ADAM metallopeptidase with thrombospondin type 1 motif 20

11 of 15

ADAMTS1; ADAM metallopeptidase with thrombospondin type 1 motif 1

7 of 15

ADAMTS5; ADAM metallopeptidase with thrombospondin type 1 motif 5

6 of 15

ADAMTS8; ADAM metallopeptidase with thrombospondin type 1 motif 8

6 of 15

ADAMTS4; ADAM metallopeptidase with thrombospondin type 1 motif 4

5 of 15

ADAMTS15; ADAM metallopeptidase with thrombospondin type 1 motif 15

5 of 15

ADAMTS18; ADAM metallopeptidase with thrombospondin type 1 motif 18

5 of 15

MICROCORNEA, MYOPIC CHORIORETINAL ATROPHY, AND TELECANTHUS; MMCAT

ADAMTS6; ADAM metallopeptidase with thrombospondin type 1 motif 6

4 of 15

ADAMTS12; ADAM metallopeptidase with thrombospondin type 1 motif 12

4 of 15

ADAMTS13; ADAM metallopeptidase with thrombospondin type 1 motif 13

4 of 15

THROMBOTIC THROMBOCYTOPENIC PURPURA, HEREDITARY; TTP

thrombotic thrombocytopenic purpura

ADAMTS16; ADAM metallopeptidase with thrombospondin type 1 motif 16

4 of 15

ADAMTS2; ADAM metallopeptidase with thrombospondin type 1 motif 2

3 of 15

EHLERS-DANLOS SYNDROME, DERMATOSPARAXIS TYPE; EDSDERMS

Ehlers-Danlos syndrome dermatosparaxis type

ADAMTS7; ADAM metallopeptidase with thrombospondin type 1 motif 7

3 of 15

ADAMTS10; ADAM metallopeptidase with thrombospondin type 1 motif 10

3 of 15

WEILL-MARCHESANI SYNDROME 1; WMS1

Weill-Marchesani syndrome

ADAMTS17; ADAM metallopeptidase with thrombospondin type 1 motif 17

3 of 15

WEILL-MARCHESANI SYNDROME 4; WMS4

Weill-Marchesani syndrome

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Ismat et al., 2013)

suppressible

(Skeath et al., 2017)

suppressible

(Skeath et al., 2017)

suppressible

(Skeath et al., 2017)

suppressible

(Skeath et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

66948

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

O-glycosylation of TSR domain-containing proteins

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-57

Cytogenetic map

Sequence location

3R:15,442,246..15,476,193 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

88F5-88F6

Limits computationally determined from genome sequence between P{lacW}MRG15^j6A3 and P{PZ}l(3)06536⁰⁶⁵³⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-57

(FlyBase, 2016)

3-56.8

(Comeron et al., 2012)

3-[58]

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

26325

w^*; Mi{ET1}AdamTS-A^MB04384/TM6B, Tb¹

60820

y¹ w^*; Mi{MIC}AdamTS-A^MI09007/TM6B, Tb¹

61726

y¹ w^*; Mi{MIC}AdamTS-A^MI14156/TM6B, Tb¹

v110157

P{KK102087}VIE-260B

v33346

w¹¹¹⁸; P{GD3002}v33346/CyO

v33347

w¹¹¹⁸; P{GD3002}v33347/TM3

Genomic Clones (25)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (27)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH16393

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Ismat et al., 2013)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: AdamTS-A CG14869

(Ismat et al., 2013)

Source for database merge of

Source for merge of: CG14869 CG6107

(FlyBase Genome Annotators, 2002-2003)

Source for merge of: AdamTS-A l(3)89Aa

(Ismat et al., 2013)

Additional comments

The lethal allele identified as being carried on TM3 balancer chromosomes in FBrf0057262 (l(3)89Aa[1]) is an allele of AdamTS-A.

(Ismat et al., 2013)

Annotations CG6107 and CG14869 merged as CG14869 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Other Comments

AdamTS-A is required for collective cell migration, including of the caudal visceral mesoderm, the visceral branch of the trachea, germ cells and the secretory portion of the salivary gland.

(Ismat et al., 2013)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 36 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41887

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q8SXB0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q8SXB0

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41887/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0286071

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038341

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0286071

InterPro - A database of protein families, domains and functional sites

MARRVEL_MODEL - MARRVEL (model organism gene)

41887

Linkouts

BioGRID - A database of protein and genetic interactions.

66948

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

O-glycosylation of TSR domain-containing proteins

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

ADAMTS-A

(Pastor-Pareja, 2020)

AdamTS-A

(Slaidina et al., 2021, Orthofer et al., 2020, Ramos-Lewis and Page-McCaw, 2019, Wittes and Schüpbach, 2019, Fochler et al., 2017, Skeath et al., 2017, Kim et al., 2016, Ismat et al., 2013)

CG14869

(Nagy et al., 2015, DeSalvo et al., 2014, Ismat et al., 2013, Mackay et al., 2012, Meyer et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5)

CG6107

(Nicholson et al., 2005, Luschnig, 2003.12.17)

CT19033

(Hynes and Zhao, 2000)

l(3)89Aa

(Miller et al., 2016)

rnwy

(Skeath et al., 2017)

Name Synonyms

ADAM metallopeptidase with thrombospondin type 1 motif A

lethal (3) 89Aa

runaway

(Skeath et al., 2017)

Secondary FlyBase IDs

FBgn0038341
FBgn0038340
FBgn0002366

Datasets (8)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (8)

Result

Result Type

Title

scRNAseq_2020_Cattenoz_NI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from non-infested third instar larvae

scRNAseq_2020_Cattenoz_WI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from wasp-infested third instar larvae

scRNAseq_2020_Cho_NI72LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying

scRNAseq_2020_Cho_NI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying

scRNAseq_2020_Cho_WI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI96HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying

References (56)