FB2025_02 , released April 17, 2025
Gene: Dmel\RpS12
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General Information
Symbol
Dmel\RpS12
Species
D. melanogaster
Name
Ribosomal protein S12
Annotation Symbol
CG11271
Feature Type
protein_coding_gene
FlyBase ID
FBgn0286213
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Summary
Ribosomal protein S12 (RpS12) is an essential gene encoding a protein component of the cytoplasmic small ribosomal subunit. [Date last reviewed: 2019-03-28] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(3)s2783, S12, su(comp)3L-1

Key Links
Genomic Location
Cytogenetic map
69F5-69F5
Sequence location
Recombination map
3-39
RefSeq locus
NT_037436 REGION:13023352..13024762
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables structural constituent of ribosome
inferred from direct assay
(Anger et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables structural constituent of ribosome
inferred from electronic annotation with InterPro:IPR000530
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000217533
(GO Reference Genome Project, 2011-)
traceable author statement
(Marygold et al., 2007)
Biological Process (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
acts_upstream_of positive regulation of canonical Wnt signaling pathway
inferred from mutant phenotype
(Katanaev et al., 2020)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in cytoplasmic translation
traceable author statement
(Marygold et al., 2007)
inferred by curator from GO:0022626
(Anger et al., 2013)
involved_in maintenance of translational fidelity
inferred from biological aspect of ancestor with PANTHER:PTN008528143
(GO Reference Genome Project, 2011-)
involved_in ribosomal small subunit biogenesis
inferred from biological aspect of ancestor with PANTHER:PTN008528143
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:P25398
(Gene Ontology Curators, 2002-)
involved_in translation
inferred from electronic annotation with InterPro:IPR000530
(InterPro Project Members, 2004-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in cytosolic ribosome
inferred from direct assay
(Anger et al., 2013)
part_of small ribosomal subunit
inferred from direct assay
(Kale et al., 2018)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of cytosolic small ribosomal subunit
traceable author statement
(Marygold et al., 2007)
inferred from biological aspect of ancestor with PANTHER:PTN000217533
(GO Reference Genome Project, 2011-)
located_in ribosome
inferred from electronic annotation with InterPro:IPR000530
(InterPro Project Members, 2004-)
part_of small-subunit processome
inferred from sequence or structural similarity with UniProtKB:P25398
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the eukaryotic ribosomal protein eS12 family. (P80455)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Ribosomal protein S12 (RpS12) is an essential gene encoding a protein component of the cytoplasmic small ribosomal subunit. [Date last reviewed: 2019-03-28]
Gene Group (FlyBase)
CYTOPLASMIC SMALL RIBOSOMAL PROTEINS -
Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytoplasm. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the small subunit is to bind mRNA. (Adapted from FBrf0205398)
Protein Function (UniProtKB)
Subunit of the 40S ribosomal complex (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). In wing imaginal disks, might have a role in translation rate, growth and cell competition, probably through regulation of Xrp1 expression (PubMed:31841522). Might have a role in development and longevity (PubMed:31841522).
(UniProt, P80455)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\RpS12 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P80455)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.45

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
RpS12-RB
FBtr0075878
NM_168534
613
139
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
RpS12-PB
FBpp0075612
15.2
139
6.34
P80455
NP_729866
AAN11845
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Subunit of the 40S ribosomal complex (PubMed:23636399). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity).

(UniProt, P80455)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RpS12 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.46

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 12 -- 16
embryonic/larval tracheal section
(Chung et al., 2011)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic Malpighian tubule
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
larval muscle system
(Fisher et al., 2012)
larval somatic muscle cell
(Fisher et al., 2012)
larval visceral muscle cell
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
• membrane
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosolic ribosome
inferred from direct assay
(Anger et al., 2013)
part_of small ribosomal subunit
inferred from direct assay
(Kale et al., 2018)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\RpS12 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of RpS12
Transgenic constructs containing regulatory region of RpS12
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(3L)ED4486
(Marygold et al., 2007)
Df(3L)VW1
(Marygold et al., 2007)
Inferred from location ( 1 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (10)
Hsap\RPS12
13 of 14
Yes
Yes
1  
Hsap\SNU13
2 of 14
No
No
1  
Hsap\DOCK4
1 of 14
No
No
Hsap\GADD45A
1 of 14
No
No
Hsap\GADD45B
1 of 14
No
No
Hsap\GADD45G
1 of 14
No
No
1  
Hsap\NHP2
1 of 14
No
No
1  
Hsap\RPL7A
1 of 14
No
No
Hsap\RPP38
1 of 14
No
Yes
Hsap\RSRC1
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (14)
Rnor\LOC100360573
13 of 14
Yes
Yes
Rnor\RGD1561102
13 of 14
Yes
Yes
Rnor\Rps12
13 of 14
Yes
Yes
Rnor\LOC108352809
10 of 14
No
Yes
Rnor\LOC120100003
10 of 14
No
Yes
Rnor\LOC100359574
2 of 14
No
No
Rnor\RGD1562265
2 of 14
No
Yes
Rnor\Snu13
2 of 14
No
No
Rnor\Gadd45a
1 of 14
No
No
Rnor\Gadd45b
1 of 14
No
No
Rnor\Gadd45g
1 of 14
No
No
Rnor\Rpl7a
1 of 14
No
No
Rnor\Rpp38
1 of 14
No
Yes
Rnor\Rps12l3
1 of 14
No
Yes
Mus musculus (laboratory mouse) (12)
Mmus\Rps12
11 of 14
Yes
Yes
Mmus\Snu13
2 of 14
No
No
Mmus\Dock4
1 of 14
No
No
Mmus\Gadd45a
1 of 14
No
No
Mmus\Gadd45b
1 of 14
No
No
Mmus\Gadd45g
1 of 14
No
No
Mmus\Gm4925
1 of 14
No
Yes
Mmus\Nhp2
1 of 14
No
No
Mmus\Rpl7a
1 of 14
No
No
Mmus\Rpp38
1 of 14
No
Yes
Mmus\Rps12-ps10
1 of 14
No
Yes
Mmus\Rsrc1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (5)
Xtro\rps12
10 of 13
Yes
Yes
Xtro\gadd45a
1 of 13
No
No
Xtro\gadd45g
1 of 13
No
No
Xtro\nodal
1 of 13
No
Yes
Xtro\snu13
1 of 13
No
No
Danio rerio (Zebrafish) (13)
Drer\rps12
13 of 14
Yes
Yes
Drer\snu13a
2 of 14
No
No
Drer\snu13b
2 of 14
No
No
Drer\gadd45aa
1 of 14
No
No
Drer\gadd45ab
1 of 14
No
No
Drer\gadd45ba
1 of 14
No
No
Drer\gadd45bb
1 of 14
No
No
Drer\gadd45ga
1 of 14
No
No
Drer\gadd45gb.1
1 of 14
No
No
Drer\LOC797032
1 of 14
No
No
Drer\nhp2
1 of 14
No
No
Drer\rpp38
1 of 14
No
No
Drer\rsrc1
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\rps-12
13 of 14
Yes
Yes
Cele\snu-13
1 of 14
No
No
Cele\Y48A6B.3
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (6)
Agam\AgaP_AGAP011077
12 of 12
Yes
Yes
Agam\AgaP_AGAP008163
2 of 12
No
No
Agam\AgaP_AGAP007650
1 of 12
No
No
Agam\AgaP_AGAP007651
1 of 12
No
No
Agam\AgaP_AGAP012204
1 of 12
No
No
Agam\RL7A_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (9)
Atha\AT1G15930
12 of 13
Yes
Yes
Atha\AT2G32060
12 of 13
Yes
Yes
Atha\AT2G47610
1 of 13
No
No
Atha\AT3G62870
1 of 13
No
No
Atha\AT4G01790
1 of 13
No
No
Atha\AT4G12600
1 of 13
No
No
Atha\AT4G22380
1 of 13
No
No
Atha\AT5G08180
1 of 13
No
No
Atha\AT5G20160
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\RPS12
12 of 13
Yes
Yes
Scer\NHP2
2 of 13
No
No
Scer\SNU13
2 of 13
No
No
Scer\RPL8A
1 of 13
No
No
Scer\RPL8B
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (5)
Spom\rps1201
11 of 12
Yes
Yes
Spom\rps1202
11 of 12
Yes
Yes
Spom\nhp2
2 of 12
No
No
Spom\snu13
2 of 12
No
No
Spom\rpl8
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:RpS12. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (5)
hoip
2 of 13
CG11808
1 of 13
Gadd45
1 of 13
NHP2
1 of 13
RpL7A
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RPS12; ribosomal protein S12
    13 of 14
    603660
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        RpS12 - CG18787
        experimental knowledge based
        (Guruharsha et al., 2011)
        RpS12 - Rack1
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL10
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL10Ab
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL11
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL12
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL13
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL13A
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL14
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL15
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL17
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL18
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL18A
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL19
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL21
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL22
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL23
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL23A
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL24
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL26
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL27
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL27A
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL28
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL29
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL3
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL30
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL31
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL32
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL34a
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL35
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL35A
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL36
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL36A
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL37-1
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL37A
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL38
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL39
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL4
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL40
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL41
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL5
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL6
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL7
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL7A
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL8
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpL9
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpLP0
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpLP1
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpLP2
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS10a
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS11
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS13
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS14a
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS14b
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS15
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS15Aa
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS16
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS17
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS18
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS19a
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS2
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS20
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS21
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS23
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS24
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS25
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS26
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS27
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS27A
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS28b
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS29
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS3
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS30
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS3A
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS4
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS5a
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS6
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS7
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS8
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - RpS9
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - eEF2
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - sta
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RpS12 - vig2
        cosedimentation, Identification by mass spectrometry, electron microscopy
        (Anger et al., 2013)
        RNA-protein
        Physical Interaction
        Assay
        References
        RpS12 - 18SrRNA
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS12 - 28SrRNA
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS12 - 2SrRNA
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS12 - 5.8SrRNA
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        RpS12 - 5SrRNA
        cosedimentation, electron microscopy
        (Anger et al., 2013)
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        CycE
        suppressible
        RpS12
        (Lin et al., 2011)
        M(2)56F
        enhanceable
        RpS12
        (Kale et al., 2018)
        RpS3
        suppressible
        RpS12|Xrp1
        (Ji et al., 2019)
        RpS3
        enhanceable
        RpS12
        (Ji et al., 2019)
        RpS3
        suppressible
        RpS12
        (Ji et al., 2019)
        RpS18
        suppressible
        RpS12
        (Ji et al., 2019)
        Xrp1|RpS3
        enhanceable
        RpS12
        (Ji et al., 2019)
        External Data
        Subunit Structure (UniProtKB)
        Subunit of the 40S ribosomal complex (PubMed:23636399). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity).
        (UniProt, P80455 )
        Linkouts
        Pathways
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map
        3-39
        Cytogenetic map
        69F5-69F5
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        69F5-69F5
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        69C2-70D1
        (Tyler et al., 2007)
        69F5-69F6
        (determined by in situ hybridisation)
        (Spradling et al., 1999)
        69F5-69F6
        (BDGP Project Members, 1994-1999)
        Experimentally Determined Recombination Data
        Location

        3-39

        (FlyBase, 2016)

        3-34.0

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (4)
        Genomic Clones (4)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (362)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
                Other clones
                  RNAi and Array Information
                  Linkouts
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  polyclonal

                  (Kale et al., 2018)
                  Commercially Available Antibodies
                   
                  Cell Line Information
                  Publicly Available Cell Lines
                   
                    Other Stable Cell Lines
                     
                      Other Comments

                      Not a Minute gene.

                      (Marygold et al., 2007)

                      Deletions removing RpS12 but no other cytoplasmic ribosomal protein-encoding genes do not show Minute phenotypes.

                      (Marygold et al., 2007)
                      Relationship to Other Genes
                      Source for database merge of

                      Source for merge of: RpS12 l(3)s2783

                      (Spradling et al., 1999)

                      Source for merge of: RpS12 su(comp)3L-1

                      (Kale et al., 2018)
                      Additional comments

                      Release 4.3 annotation CG11271 split into two separate annotations in release 5.1 of the genome annotation, CG11271 (which corresponds to RpS12) and CG17672.

                      (FlyBase Genome Annotators, 2006)

                      Source for split of: CG11271

                      (Marygold, 2005.2.2)

                      It is not possible to say whether "M(3)69E" corresponds to "RpS12" or "RpS4", or whether the genetically-defined "M(3)69E" locus is a composite of both ribosomal protein genes.

                      (Deal and Cook, 2002.1.22)

                      Annotations CG11271 and CG17672 merged as CG11271 in release 3 of the genome annotation.

                      (FlyBase Genome Annotators, 2002-2003)
                      Nomenclature History
                      Source for database identify of
                      Nomenclature comments
                      Etymology
                      Synonyms and Secondary IDs (19)
                      Reported As
                      Symbol Synonym
                      BcDNA:RH29995
                      CG11271
                      (Hallier et al., 2015, Rosa-Ferreira et al., 2015, Fukuoh et al., 2014, Schertel et al., 2013, Yoshigi et al., 2013, Cammarato et al., 2011, Keleman et al., 2009.8.5, Marygold et al., 2007, Huang et al., 2005, Marygold, 2005.2.2, Accardo et al., 2004)
                      RS12
                      (Mushegian et al., 1998)
                      RpS12
                      (Joy et al., 2024, Nagata and Igaki, 2024, Baker and Montagna, 2022, Loganathan et al., 2022, Baumgartner et al., 2021, Pang et al., 2021, Paraskevopoulos and McGuigan, 2021, Polymenis, 2020, Wang et al., 2020, Baker et al., 2019, Crofton et al., 2018, Kale et al., 2018, Rennie et al., 2018, Angrisani et al., 2015, Zabidi et al., 2015, Handler et al., 2013, Kwon et al., 2013, Schertel et al., 2013, Yoshigi et al., 2013, Chung et al., 2011, Lin et al., 2011, Parry et al., 2010, Marygold et al., 2007)
                      RpS12E
                      S12
                      (Wang et al., 2014, Brogna et al., 2002)
                      S12e
                      (Anger et al., 2013)
                      dRpS12
                      (Kale et al., 2018)
                      l(3)s2783
                      (Netter et al., 1998, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)
                      rpS12
                      (Kiparaki and Baker, 2023, Kumar and Baker, 2022, Boulan et al., 2019, Ji et al., 2019)
                      su(comp)3L-1
                      (Titen and Golic, 2008, Tyler et al., 2007)
                      Name Synonyms
                      40S ribosomal component
                      (Ni et al., 2006)
                      40S ribosomal protein S12
                      (Greig, 1995.7.7)
                      Minute
                      (Kim and Jain, 2020)
                      Ribosomal Protein S12
                      (Ahrens et al., 2007)
                      Ribosomal Protein S12e
                      (Kale et al., 2018)
                      Ribosomal protein S12
                      (Cammarato et al., 2011, Xun et al., 2008, Cho et al., 2005)
                      Ribosomal protein gene 12
                      (Zabidi et al., 2015)
                      S12
                      (Hallier et al., 2015)
                      ribosomal protein
                      (Hallier et al., 2015)
                      Secondary FlyBase IDs
                      • FBgn0036339
                      • FBan0011271
                      • FBgn0011809
                      • FBgn0064825
                      • FBgn0260441
                      • FBgn0014027
                      • FBgn0086209
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      Study result (0)
                      Result
                      Result Type
                      Title
                      External Crossreferences and Linkouts ( 41 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                      Other crossreferences
                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      MARRVEL_MODEL - MARRVEL (model organism gene)
                      PDB - An information portal to biological macromolecular structures
                      Linkouts
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                      References (92)