FlyBase Gene Report: Dmel\aqz

General Information

Symbol

Dmel\aqz

Species

D. melanogaster

Name

aaquetzalli

Annotation Symbol

CG9821

Feature Type

protein_coding_gene

FlyBase ID

FBgn0286516

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

85B2-85B2

Sequence location

3R:8,813,490..8,820,682 [-]

Recombination map

3-48

RefSeq locus

NT_033777 REGION:8813490..8820682

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (1 term)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN001034975

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Proline-rich nuclear receptor coactivator 1/2

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\aqz for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VHK8)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.55

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

aqz-RA

FBtr0081932

NM_176424

2357

285

aqz-RB

FBtr0081931

NM_176425

4950

285

aqz-RC

FBtr0334659

NM_001275461

6145

285

aqz-RD

FBtr0334660

NM_001275462

4719

285

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

aqz-PA

FBpp0081414

30.1

285

12.37

FBpp0081413

30.1

285

12.37

FBpp0306721

30.1

285

12.37

FBpp0306722

30.1

285

12.37

Q9VHK8

NP_001262391

AGB95773

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

285 aa isoforms: aqz-PA, aqz-PB, aqz-PC, aqz-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Proline-rich nuclear receptor coactivator 1/2

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VHK8

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\aqz using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.25

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\aqz in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\aqz

View exonic expression by tissue for Dmel\aqz

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41058/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0286516

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037636

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0286516

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of aqz

Transgenic constructs containing regulatory region of aqz

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(3R)BSC478

(Mendoza-Ortíz et al., 2018)

Df(3R)BSC506

(Mendoza-Ortíz et al., 2018)

Df(3R)Exel6150

(Mendoza-Ortíz et al., 2018, Ryder, 2004.4.26)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

aqz^CB03335

lethal (with Df(3R)BSC478)

aqz^CB03335

lethal (with Df(3R)BSC506)

aqz^CB03335

lethal (with Df(3R)Exel6150)

aqz^CB03335

lethal | recessive

viable

aqz^EY11495

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

aqz^GD10261

viable, with Scer\GAL4^Mef2.PR

aqz^GD10261

viable, with Scer\GAL4^pnr-MD237

aqz^GD10261

viable (with aqz¹)

viable (with aqz^CB03335)

viable (with aqz^KG08159)

viable (with Df(3R)BSC478)

viable (with Df(3R)BSC506)

viable (with Df(3R)Exel6150)

viable | recessive

aqz^KG08159

Sterility

Allele

fertile

aqz^EY11495

Other Phenotypes

Allele

abnormal cell polarity | embryonic stage | recessive

aqz^CB03335

embryonic/larval segmentation phenotype

increased cell number | embryonic stage | recessive

aqz¹

neurogenic phenotype | embryonic stage | recessive

aqz^CB03335

neurogenic phenotype | recessive

Phenotype manifest in

Allele

ectoderm

aqz^CB03335

embryonic/larval cuticle

embryonic ganglion mother cell

aqz¹

larval central nervous system

larval peripheral nervous system

aqz^CB03335

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (2)

Hsap\PNRC1

2 of 14

Yes

Hsap\PNRC2

2 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (2)

Rnor\Pnrc2

2 of 14

Yes

Rnor\Pnrc1

1 of 14

Yes

Mus musculus (laboratory mouse) (2)

Mmus\Pnrc1

2 of 14

Yes

Mmus\Pnrc2

2 of 14

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\pnrc2

1 of 13

Yes

Danio rerio (Zebrafish) (2)

Drer\pnrc1

2 of 14

Yes

Drer\pnrc2

2 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP013026

5 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:aqz. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

CG32797

3 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-48

Cytogenetic map

85B2-85B2

Sequence location

3R:8,813,490..8,820,682 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

85B2-85B2

Limits computationally determined from genome sequence between P{lacW}l(3)L4740^L4740 and P{EP}D1^EP473

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-48

(FlyBase, 2016)

3-45.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

20315

y¹ w^67c23; P{EPgy2}aqz^EY11495

43171

y¹ v¹; P{TRiP.GL01513}attP2/TM3, Sb¹

14691

y¹ w^67c23; P{SUPor-P}aqz^KG08159 ry⁵⁰⁶

Kyoto

123611

w¹¹¹⁸; P{RS3}aqz^CB-5413-3

9821R-3

v110303

v21348

w¹¹¹⁸; P{GD10261}v21348

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (201)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Mendoza-Ortíz et al., 2018)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Area matching Drosophila EST AA440272. This EST forms a 1324bp contig with EST AA438941.

(Davies, 2001.3.15)

Area matching Drosophila EST AA950826.

(Davies, 2001.3.15)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG9821 anon-WO0118547.399 anon-WO0118547.424

(FlyBase, 1996-)

Source for merge of: aqz CG9821

(Mendoza-Ortíz et al., 2018)

Additional comments

Source for merge of CG9821 anon-WO0118547.399 anon-WO0118547.424 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

The gene is named "aaquetzalli", which means "fan" in nahuatl, after the mutant phenotype.

(Mendoza-Ortiz and Riesgo-Escovar, 2006)

Gene is named 'aaquezalli', which means 'fan' in nahualt, to reflect the mutant cuticular phenotype caused by aqz alleles.

(Mendoza-Ortiz, 2006.3.9)

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG31442

CG9821

(Samuels et al., 2020, Mendoza-Ortíz et al., 2018, Liu and Lasko, 2015, Chen et al., 2013, Handler et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Zhan et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Buszczak et al., 2007, Quinones-Coello, 2007, Jagadeeshan and Singh, 2005, Stanyon et al., 2004)

Ov29

(Jagadeeshan and Singh, 2005)

anon-WO0118547.399

anon-WO0118547.424

aqz

(Mendoza-Ortíz et al., 2018, Mendoza-Ortiz and Riesgo-Escovar, 2008, Mendoza-Ortiz and Riesgo-Escovar, 2007)

Name Synonyms

aaquetzalli

(Mendoza-Ortíz et al., 2018, Mendoza-Ortiz and Riesgo-Escovar, 2008, Mendoza-Ortiz and Riesgo-Escovar, 2006)

Secondary FlyBase IDs

FBgn0084617
FBgn0037636
FBgn0051442
FBgn0062018
FBgn0062041

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 35 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41058

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VHK8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VHK8

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VHK8

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41058/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0286516

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0286516

InterPro - A database of protein families, domains and functional sites

Proline-rich nuclear receptor coactivator 1/2

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9821

MARRVEL_MODEL - MARRVEL (model organism gene)

41058

Linkouts

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037636

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0286516

References (43)

The following external sites may use different assemblies or annotations than FlyBase.

-1.25

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