FlyBase Gene Report: Dmel\hoip

General Information

Symbol

Dmel\hoip

Species

D. melanogaster

Name

hoi-polloi

Annotation Symbol

CG3949

Feature Type

protein_coding_gene

FlyBase ID

FBgn0286786

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Summary

Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (By similarity). (UniProt, Q9U3Z7)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

l(2)FE3

Key Links

Genomic Location

Cytogenetic map

30C5-30C5

Sequence location

2L:9,699,791..9,700,459 [+]

Recombination map

2-36

RefSeq locus

NT_033779 REGION:9699791..9700459

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables RNA binding

inferred from biological aspect of ancestor with PANTHER:PTN004606439

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR002415, InterPro:IPR050257

(InterPro Project Members, 2004-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in muscle tissue morphogenesis

inferred from mutant phenotype

(Johnson et al., 2013)

involved_in positive regulation of translation

inferred from mutant phenotype

(Williams et al., 2015)

involved_in post-transcriptional regulation of gene expression

inferred from mutant phenotype

(Johnson et al., 2013)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in maturation of SSU-rRNA

inferred from biological aspect of ancestor with PANTHER:PTN000560317

(GO Reference Genome Project, 2011-)

involved_in mRNA splicing, via spliceosome

inferred by curator from GO:0071011

(Herold et al., 2009)

inferred from biological aspect of ancestor with PANTHER:PTN000560317

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with SGD:S000000752

(Mount and Salz, 2000)

involved_in ribosome biogenesis

inferred from electronic annotation with InterPro:IPR004037

(InterPro Project Members, 2004-)

Cellular Component (7 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of precatalytic spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

Terms Based on Predictions or Assertions (7 terms)

CV Term

Evidence

References

part_of box C/D methylation guide snoRNP complex

inferred from biological aspect of ancestor with PANTHER:PTN000560317

(GO Reference Genome Project, 2011-)

is_active_in nucleolus

inferred from biological aspect of ancestor with PANTHER:PTN000560317

(GO Reference Genome Project, 2011-)

located_in nucleolus

inferred from electronic annotation with InterPro:IPR002415

(InterPro Project Members, 2004-)

part_of precatalytic spliceosome

inferred from biological aspect of ancestor with PANTHER:PTN000560317

(GO Reference Genome Project, 2011-)

part_of ribonucleoprotein complex

inferred from electronic annotation with InterPro:IPR004037

(InterPro Project Members, 2004-)

part_of small nuclear ribonucleoprotein complex

inferred from sequence or structural similarity with SGD:S000000752

(Mount and Salz, 2000)

part_of small-subunit processome

inferred from biological aspect of ancestor with PANTHER:PTN000560317

(GO Reference Genome Project, 2011-)

part_of U4/U6 x U5 tri-snRNP complex

inferred from biological aspect of ancestor with PANTHER:PTN000560317

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

U4-U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE

U4-U6-U5 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE

SPLICEOSOME COMPLEX B

Protein Family (UniProt)

Belongs to the eukaryotic ribosomal protein eL8 family. (Q9U3Z7)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

U4-U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE -: The U4/U6 small nuclear ribonucleoprotein particle (U4/U6 snRNP) is a complex that contains base-paired U4 and U6 snRNAs. U4/U6 snRNP assembles with U5 to form the U4/U6.U5 tri-snRNP. (Adapted from PMID:21441581).
U4-U6-U5 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE -: U4/U6.U5 tri-snRNP is assembled from U5 and U4/U6 snRNPs. The complex contains U4 and U6 snRNAs base-paired with each other and U6 snRNA. This complex is recruited to the pre-catalytic splicing intermediate, complex B. (Adapted from PMID:21441581).
SPLICEOSOME COMPLEX B -: Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. After the assembly of complex A on pre-mRNA, the U4-U6 and U5 snRNPs are recruited as a preassembled tri-snRNP to form complex B. U5 snRNP binds exons at the 5' site. (Adapted from PMID:24452469 and PMID:23118483).

Protein Function (UniProtKB)

Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (By similarity).

(UniProt, Q9U3Z7)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\hoip for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9U3Z7)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

hoip-RA

FBtr0079846

NM_079975

569

127

hoip-RB

FBtr0335494

NM_001273364

607

127

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

hoip-PA

FBpp0079443

13.9

127

7.19

FBpp0307465

13.9

127

7.19

Q9U3Z7

NP_001260293

AGB92828

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

127 aa isoforms: hoip-PA, hoip-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\hoip using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.23

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9

mesoderm

(Johnson et al., 2013)

embryonic stage 9 -- 16

endoderm

(Johnson et al., 2013)

embryonic stage 14 -- 16

embryonic somatic muscle cell

(Johnson et al., 2013)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of precatalytic spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\hoip in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\hoip

View exonic expression by tissue for Dmel\hoip

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44173/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0286786

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015393

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0286786

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of hoip

Transgenic constructs containing regulatory region of hoip

Aberrations (Deficiencies and Duplications) ( 25 )

Inferred from experimentation ( 25 )

Gene not disrupted in

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

hoip^FE3

lethal (with Df(2L)30A-C)

hoip^k07104

lethal (with Df(2L)N22-3)

hoip^k07104

lethal (with Df(2L)N22-5)

hoip^k07104

lethal (with Df(2L)s1402)

hoip^k07104

lethal | recessive

lethal - all die during embryonic stage

hoip¹

lethal - all die during embryonic stage (with Df(2L)ED690)

hoip¹

lethal - all die during embryonic stage (with hoip¹)

hoip^k07104

lethal - all die during embryonic stage (with hoip^k07104)

hoip¹

lethal - all die during embryonic stage | recessive

hoip^k07104

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

hoip^GD11169

viable, with Scer\GAL4^Mef2.PR

hoip^GD11169

viable, with Scer\GAL4^pnr-MD237

hoip^GD11169

viable, with Scer\GAL4^tin.CΔ4

hoip^GD11169

Other Phenotypes

Allele

abnormal cell shape | embryonic stage

hoip¹

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

hoip^GD11169

paralytic | adult stage | heat sensitive, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

hoip^GD11169

some die during embryonic stage | recessive

hoip^k07104

Phenotype manifest in

Allele

embryonic myoblast

hoip¹

embryonic somatic muscle cell

hoip¹

embryonic somatic muscle cell (with Df(2L)ED690)

hoip¹

embryonic somatic muscle cell (with hoip¹)

hoip^k07104

embryonic somatic muscle cell (with hoip^k07104)

hoip¹

fascicle

hoip^k07104

imaginal disc

hoip^k05712

muscle cell of dorsal oblique muscle 2 | embryonic stage

hoip¹

muscle cell of dorsal oblique muscle 3 | embryonic stage

hoip¹

muscle cell of dorsal oblique muscle 4 | embryonic stage

hoip¹

muscle cell of dorsal oblique muscle 5 | embryonic stage

hoip¹

muscle cell of lateral longitudinal muscle 1 | embryonic stage

hoip¹

muscle cell of lateral oblique muscle 1 | embryonic stage

hoip¹

muscle cell of lateral transverse muscle 1 | embryonic stage

hoip¹

muscle cell of lateral transverse muscle 2 | embryonic stage

hoip¹

muscle cell of lateral transverse muscle 3 | embryonic stage

hoip¹

muscle cell of lateral transverse muscle 4 | embryonic stage

hoip¹

myotube | embryonic stage

hoip¹

presumptive embryonic/larval peripheral nervous system

hoip^k07104

sarcomere | embryonic stage

hoip¹

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (9)

Hsap\SNU13

14 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\RSRC1

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (13)

Rnor\LOC100359574

14 of 14

Yes

Rnor\Snu13

14 of 14

Yes

Rnor\RGD1566078

11 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (9)

Mmus\Snu13

14 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Rps12

1 of 14

Mmus\Rsrc1

1 of 14

Xenopus tropicalis (Western clawed frog) (5)

Xtro\snu13

11 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (13)

Drer\snu13a

14 of 14

Yes

Drer\snu13b

14 of 14

Yes

Drer\nhp2

2 of 14

Drer\rpp38

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\snu-13

14 of 14

Yes

Cele\rps-12

2 of 14

Cele\Y48A6B.3

2 of 14

Cele\rpl-7A

1 of 14

Anopheles gambiae (African malaria mosquito) (6)

Agam\AgaP_AGAP008163

12 of 12

Yes

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (9)

Atha\AT4G22380

13 of 13

Yes

Atha\AT5G20160

12 of 13

Yes

Atha\AT4G12600

7 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Atha\AT5G08180

2 of 13

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\SNU13

13 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\snu13

12 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

Escherichia coli (enterobacterium) (1)

Ecol\rplA

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:hoip. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (7)

3 of 13

3 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

hoip^k07104

exacerbates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN8OS^CTG112.UAS

(Mutsuddi et al., 2004)

hoip^NIG.3949R

exacerbates frontotemporal dementia and/or amyotrophic lateral sclerosis 1

modeled by Zzzz\poly-GR^PO-36.UAS

(Park et al., 2021)

hoip^GS7164

exacerbates Kennedy's disease

modeled by Hsap\AR^Q52AF-1.UAS

(Murata et al., 2008)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SNU13; small nuclear ribonucleoprotein 13

14 of 14

601304

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

hoip

Hsap\SNU13

(Johnson et al., 2013)

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

hoip

suppressible

Tm2

(Williams et al., 2015)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Major pathway of rRNA processing in the nucleolus and cytosol

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-36

Cytogenetic map

30C5-30C5

Sequence location

2L:9,699,791..9,700,459 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

30C5-30C5

Limits computationally determined from genome sequence between P{EP}EP361&P{EP}pelo^EP2160 and P{lacW}zf30C^k02506&P{EP}und^EP424; Left limit from inclusion within Df(2L)30A-C (FBrf0058516) Right limit from inclusion within Df(2L)30A-C (FBrf0058516)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

30C1-30C2

(Prokopenko, 1999.8.5)

30C1-30C2

(determined by in situ hybridisation)

(Spradling et al., 1999)

30C-30C

(determined by in situ hybridisation)

(Kania et al., 1995)

30C1-30C2

30C3--4 30C3--5

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-36

(FlyBase, 2016)

2-31.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

4102

hoip^FE3 P{S6.9B}3/CyO; ry⁵⁰⁶

10654

y¹ w^67c23; P{lacW}hoip^k07104/CyO

Kyoto

201055

y¹ w^67c23; P{GSV2}GS7164/SM1

102326

y¹ w^67c23 ; P{lacW}hoip^k04901 / CyO

102412

y¹ w^67c23 ; P{lacW}hoip^k05712 / CyO

NIG-Fly

3949R-1

P{NIG.3949R}1

3949R-3

P{NIG.3949R}3

2LG-1186

y² VhaAC39-1^cho-1 v¹; P{U6-hoip.NIG.sgRNA}attP40/CyO

VDRC

v106496

P{KK108514}VIE-260B

v21752

w¹¹¹⁸ P{GD11169}v21752

v318315

PBac{fTRG00964.sfGFP-TVPTBF}VK00033

v21755

w¹¹¹⁸; P{GD11169}v21755/TM3

More stocks available...

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (47)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE51843

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene results in a change in cell proliferation and cell size.

(Guertin et al., 2006)

Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells.

(Nybakken et al., 2005)

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

GH03082 is a chimeric cDNA clone containing two cDNAs in a tail-to-tail orientation that correspond to hoip (5' clone, mapped at 30C) and Cyp6g1 (GenBank accession number AF083946; 3' clone, mapped at 48F).

(Prokopenko et al., 2000)

Gene isolated in a screen of the second chromosome identifying mutants affecting disc morphology.

(Roch et al., 1998)

Relationship to Other Genes

Source for database merge of

Source for merge of: hoip CG3949

(Bayraktaroglu, 2000.8.7)

Source for merge of: hoip l(2)FE3

(Kahsai and Cook, 2018)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG3949

(National Institute of Genetics Fly Stocks, 2022-, Çiçek et al., 2016, Cammarato et al., 2011, Herold et al., 2009, Keleman et al., 2009.8.5, Kroiss et al., 2009, Laviolette et al., 2005, Nybakken et al., 2005, Wheeler et al., 2004, Mount and Salz, 2000)

FE3

(Ricard et al., 2001)

HOIP

(Sofola et al., 2007)

Hoip

(Sureka and Mishra, 2021, Ciurciu et al., 2013, Kallappagoudar et al., 2010, Murata et al., 2008, Wheeler et al., 2004)

l(2)FE3

(Kahsai and Cook, 2018, Levine et al., 2007)

Name Synonyms

Hoi Polloi

(Johnson et al., 2013)

hoi polloi

(Dubey et al., 2020, Williams et al., 2015)

hoi-polloi

(Cammarato et al., 2011, Buffin and Gho, 2010, Herold et al., 2009, Kroiss et al., 2009)

lethal (2) FE3

Secondary FlyBase IDs

FBgn0015393
FBgn0032137
FBgn0014257

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 37 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44173

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9U3Z7

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9U3Z7

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

D2NUK9

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9U3Z7

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44173/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0286786

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0286786

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3949

MARRVEL_MODEL - MARRVEL (model organism gene)

44173

Linkouts

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015393

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0286786

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC002918

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Major pathway of rRNA processing in the nucleolus and cytosol

References (94)

The following external sites may use different assemblies or annotations than FlyBase.

-0.23

Report Sections