Gene model reviewed during 6.29
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Osi10b using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Osi10b in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Osi10b CG46437
CG15593 annotation split into CG46436 and CG46437 in release 6.29 of the genome annotation. Split based on RNA-seq data and conserved protein sequence for amino end of CG46437.
The Tpl region is both triplo-lethal and haplo-lethal and neither point nor insertional mutations of Tpl have been isolated despite extensive mutagenesis analysis. This raises the possibility that Tpl consists of a cluster of genes with at least partial redundancy. Osi10 is a member of the "Osiris" family of genes. Most of the "Osiris" genes (including Osi10) are located in a cluster within the Tpl region of the genome at 83D-83E (the remaining 3 members - Osi21, Osi22 and Osi23 - are located at three different sites in the genome. None of these 3 loci are triplo-lethal or are located within a haplo-insufficient region). The "Osiris" gene family is also present in the A. gambiae genome and shows remarkable synteny and sequence conservation with the D. melanogaster cluster. There appears to have been selection on the "Osiris" family both for expression level and function. It is suggested that the "Osiris" gene family cluster corresponds to Tpl.