l6, l(3)Lh6, l(3)80Fc, nvd-Dm, lethal 6
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nvd using the Feature Mapper tool.
nvd transcript is expressed in the ring gland in late embryos. In larvae, nvd is expressed in the region of prothoracic gland cells, but not in the corpus allatum or corpus cardiacum. RT-PCR analysis reveals that nvd transcript expression levels in the ring gland are higher at late second instar and wandering third instar larvae than in early third instar larvae. In egg chambers, nvd transcript is expressed in nurse cells, but not in oocytes.
GBrowse - Visual display of RNA-Seq signalsView Dmel\nvd in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
New annotation (CG40050) in release 3 of the genome annotation.
One of a series of EMS-induced lethals detected by failure to complement proximal heterochromatic deficiencies in 3L or 3R, which resulted from detachments, i.e., reconstitutions of normal third chromosomes, from irradiated C(3L)RM/C(3R)RM-bearing females; a large set of such proximal heterochromatic deficiencies was employed in deficiency mapping of these lethals (Marchant and Holm, 1988).
The name "neverland" is based on the prolonged first instar larval phenotype of mutants, as "neverland" is the fictional island featured in J. M. Barrie's Peter Pan, where children cease to age.