FB2025_01 , released February 20, 2025
Gene: Dmel\mRpS5
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General Information
Symbol
Dmel\mRpS5
Species
D. melanogaster
Name
mitochondrial ribosomal protein S5
Annotation Symbol
CG40049
Feature Type
protein_coding_gene
FlyBase ID
FBgn0287187
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

l8, l(3)Lh8, l(3)80Fa

Key Links
Genomic Location
Cytogenetic map
80F9-80F9
Sequence location
Recombination map
3-47
RefSeq locus
NT_037436 REGION:24537236..24543534
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables RNA binding
inferred from electronic annotation with InterPro:IPR000851, InterPro:IPR013810
(InterPro Project Members, 2004-)
enables structural constituent of ribosome
inferred from biological aspect of ancestor with PANTHER:PTN000346706
(GO Reference Genome Project, 2011-)
traceable author statement
(Marygold et al., 2007)
inferred from electronic annotation with InterPro:IPR000851, InterPro:IPR005324, InterPro:IPR013810
(InterPro Project Members, 2004-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in mitochondrial translation
traceable author statement
(Marygold et al., 2007)
involved_in translation
inferred from electronic annotation with InterPro:IPR000851, InterPro:IPR005324, InterPro:IPR013810
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000346706
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of mitochondrial small ribosomal subunit
inferred from sequence or structural similarity with UniProtKB:P82675
(Koc et al., 2001)
inferred from biological aspect of ancestor with PANTHER:PTN000346855
(GO Reference Genome Project, 2011-)
traceable author statement
(Marygold et al., 2007)
located_in ribosome
inferred from electronic annotation with InterPro:IPR000851, InterPro:IPR005324, InterPro:IPR013810
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
MITOCHONDRIAL SMALL RIBOSOMAL COMPONENTS -
Mitochondrial ribosomes are found in the mitochondrial matrix and translate genes involved in oxidative phosphorylation encoded by the mitochondrial genome. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the small subunit is to bind mRNA. (Adapted from FBrf0205398).
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\mRpS5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q8SYP9)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
mRpS5-RA
FBtr0111146
NM_001043188
1379
407
mRpS5-RC
FBtr0111147
NM_001043187
1422
407
mRpS5-RD
FBtr0111144
NM_001043186
479
47
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
mRpS5-PA
FBpp0110438
46.0
407
10.87
Q8SYP9
NP_001036653
EAA46075
mRpS5-PC
FBpp0110439
46.0
407
10.87
Q8SYP9
NP_001036652
ABI31280
mRpS5-PD
FBpp0110436
5.4
47
11.36
Q0E8A8
NP_001036651
ABI31279
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

407 aa isoforms: mRpS5-PA, mRpS5-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mRpS5 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.19

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
• membrane
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\mRpS5 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of mRpS5
Transgenic constructs containing regulatory region of mRpS5
Aberrations (Deficiencies and Duplications) ( 38 )
Inferred from experimentation ( 38 )
Gene disrupted in
Df(3L)1-16
(Schulze et al., 2001, Pauli et al., 1995, Marchant and Holm, 1988)
Df(3L)1-104
(Marchant and Holm, 1988)
Df(3L)4A-1677
(Syrzycka et al., 2019)
Df(3L)8-15
(Marchant and Holm, 1988)
Df(3L)9-52
(Marchant and Holm, 1988)
Df(3L)18A-1677
(Syrzycka et al., 2019)
Df(3L)FX33
(Syrzycka et al., 2019)
Df(3L)FX53
(Syrzycka et al., 2019)
Df(3L)O-1
(Syrzycka et al., 2019)
Df(3L)Snap253
(Syrzycka et al., 2019)
Df(3L)TTT
(Syrzycka et al., 2019)
Df(3L)XXX
(Syrzycka et al., 2019)
Gene not disrupted in
Df(3L)1-166
(Schulze et al., 2001)
Df(3L)2-66
(Schulze et al., 2001)
Df(3L)2-85
(Marchant and Holm, 1988)
Df(3L)3-52
(Schulze et al., 2001, Marchant and Holm, 1988)
Df(3L)3-164
(Marchant and Holm, 1988)
Df(3L)5-84
(Marchant and Holm, 1988)
Df(3L)6B-29+Df(3R)6B-29
(Schulze et al., 2001)
Df(3L)9-56
(Schulze et al., 2001)
Df(3L)10-14
(Marchant and Holm, 1988)
Df(3L)10-39
(Marchant and Holm, 1988)
Df(3L)C-2
(Schulze et al., 2001)
Df(3L)G-1
(Schulze et al., 2001)
Df(3L)γ-26
(Schulze et al., 2001)
Df(3L)γ-28
(Schulze et al., 2001)
Df(3L)γ-29
(Schulze et al., 2001)
Df(3L)K-2
(Schulze et al., 2001)
Df(3L)MX18
(Honda, 2019.5.6)
Df(3L)O-1
(Schulze et al., 2001)
Df(3L)vtd2
(Schulze et al., 2001)
Df(3L)vtd3
(Schulze et al., 2001)
Df(3L)vtd6
(Schulze et al., 2001)
Df(3L)vtd7
(Schulze et al., 2001)
Df(3L)vtd8
(Schulze et al., 2001)
Df(3L)vtd10
(Schulze et al., 2001)
Df(3L)vtd11
(Schulze et al., 2001)
Df(3L)vtd12
(Schulze et al., 2001)
In(3L)vtd9
(Schulze et al., 2001)
Inferred from location ( 12 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\MRPS5
14 of 14
Yes
Yes
1  
Hsap\RPS2
2 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (4)
Rnor\Mrps5
14 of 14
Yes
Yes
Rnor\Rps2
2 of 14
No
No
Rnor\LOC100125366
1 of 14
No
No
Rnor\Rps2-ps6
1 of 14
No
No
Mus musculus (laboratory mouse) (2)
Mmus\Mrps5
13 of 14
Yes
Yes
Mmus\Rps2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (1)
Xtro\mrps5
7 of 13
Yes
Yes
Danio rerio (Zebrafish) (2)
Drer\mrps5
14 of 14
Yes
Yes
Drer\rps2
2 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\mrps-5
14 of 14
Yes
Yes
Cele\rps-2
2 of 14
No
No
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP004091
12 of 12
Yes
Yes
Agam\AgaP_AGAP003768
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (8)
Atha\AT1G64880
6 of 13
Yes
Yes
Atha\EMB3113
5 of 13
No
Yes
Atha\AT1G58684
2 of 13
No
No
Atha\AT1G58983
2 of 13
No
No
Atha\AT1G59359
2 of 13
No
No
Atha\AT2G41840
2 of 13
No
No
Atha\AT3G57490
2 of 13
No
No
Atha\XW6
2 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\MRPS5
7 of 13
Yes
Yes
Scer\RPS2
2 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\mrps5
7 of 12
Yes
Yes
Spom\rps2
2 of 12
No
No
Escherichia coli (enterobacterium) (1)
Ecol\rpsE
5 of 11
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:mRpS5. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (1)
RpS2
4 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    MRPS5; mitochondrial ribosomal protein S5
    14 of 14
    611972
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Other Interaction Browsers
        Summary of Genetic Interactions
        esyN Network Diagram
        Other Interaction Browsers
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map
        3-47
        Cytogenetic map
        80F9-80F9
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        80F9-80F9
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Heterochromatic, cytological location not yet determined.
        (FlyBase Genome Annotators, 2002-2003)
        Experimentally Determined Recombination Data
        Location

        3-47

        (FlyBase, 2016)

        3-44.1

        (Comeron et al., 2012)

        3-

        (Drosophila Heterochromatin Genome Project, 2004)

        3-[47]

        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (7)
        Genomic Clones (9)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (151)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                  Other Comments

                  New annotation (CG40049) in release 3 of the genome annotation.

                  (FlyBase Genome Annotators, 2002-2003)

                  One of a series of EMS-induced lethals detected by failure to complement proximal heterochromatic deficiencies in 3L or 3R, which resulted from detachments, i.e., reconstitutions of normal third chromosomes, from irradiated C(3L)RM/C(3R)RM-bearing females; a large set of such proximal heterochromatic deficiencies was employed in deficiency mapping of these lethals (Marchant and Holm, 1988).

                  Relationship to Other Genes
                  Source for database merge of

                  Source for merge of: CG40049 BcDNA:RE47909

                  (FlyBase, 1996-)

                  Source for merge of: mRpS5 CG40049

                  (FlyBase, 1996-)

                  Source for merge of: mRpS5 l(3)80Fa

                  (Syrzycka et al., 2019)
                  Additional comments

                  Source for merge of CG40049 BcDNA:RE47909 was a shared cDNA ( date:030728 ).

                  (FlyBase, 1996-)
                  Nomenclature History
                  Source for database identify of
                  Nomenclature comments
                  Etymology
                  Synonyms and Secondary IDs (14)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 38 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  References (42)