FB2021_01, released Feb 18, 2021

Gene: Dmel\Ca-β

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General Information
Symbol
Dmel\Ca-β
Species
D. melanogaster
Name
Ca2+-channel-protein-β-subunit
Annotation Symbol
CG42403
Feature Type
protein_coding_gene
FlyBase ID
FBgn0287724
Gene Model Status
Current
Stock Availability
13 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

l(2)04008, Ca2+-channel-protein-β-subunit

Key Links
Genomic Location
Cytogenetic map
32D5-32E1
Sequence location
2L:11,156,118..11,203,544 [-]
Recombination map

2-44

RefSeq locus
NT_033779 REGION:11156118..11203544
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables voltage-gated calcium channel activity
inferred from mutant phenotype
(Kanamori et al., 2013)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in calcium ion transmembrane transport
inferred from mutant phenotype
(Kanamori et al., 2013)
involved_in calcium-mediated signaling
inferred from mutant phenotype
(Kanamori et al., 2013)
involved_in neuron remodeling
inferred from mutant phenotype
(Kanamori et al., 2013)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of voltage-gated calcium channel complex
inferred from electronic annotation with InterPro:IPR000584
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
traceable author statement
(Kanamori et al., 2013)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
VOLTAGE-GATED CALCIUM CHANNEL SUBUNITS -
Voltage-gated Ca2+ channels (CACN) allow the influx of extracellular Ca2+ in response to plasma membrane depolarization. CACNs are hetero-oligomeric assemblies of a pore-forming α1 subunit plus other structural and accessory subunits. (Adapted from FBrf0218524 and PMID:21746798).
Gene Model and Products
Number of Transcripts
9
Number of Unique Polypeptides
9

Please see the JBrowse view of Dmel\Ca-β for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.52

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.42

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
gene
gene_with_edited_transcript
(Rodriguez et al., 2012, Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ca-β-RE
FBtr0300536
NM_078822
3739
432
Ca-β-RG
FBtr0300115
NM_205962
4963
817
Ca-β-RJ
FBtr0306386
NM_001259049
5788
733
Ca-β-RL
FBtr0310279
NM_001273446
4514
844
Ca-β-RM
FBtr0310280
NM_001273447
5025
682
Ca-β-RN
FBtr0310281
NM_001273448
4461
455
Ca-β-RO
FBtr0343615
NM_001298907
4982
439
Ca-β-RP
FBtr0343616
NM_205963
4530
466
Ca-β-RQ
FBtr0343617
NM_001259050
5400
745
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Ca-β-PE
FBpp0289763
47.9
432
10.10
NP_523546
AAF53083
Ca-β-PG
FBpp0289392
93.0
817
8.87
NP_995684
AAS64680
Ca-β-PJ
FBpp0297478
81.9
733
9.67
NP_001245978
AFH03652
Ca-β-PL
FBpp0301962
95.5
844
7.13
NP_001260375
AGB92910
Ca-β-PM
FBpp0301963
77.6
682
7.81
NP_001260376
AGB92911
Ca-β-PN
FBpp0301964
50.1
455
9.47
NP_001260377
AGB92912
Ca-β-PO
FBpp0310210
48.7
439
10.04
NP_001285836
AHN54350
Ca-β-PP
FBpp0310211
51.3
466
9.03
NP_995685
AAS64679
Ca-β-PQ
FBpp0310212
83.1
745
9.22
NP_001245979
AFH03653
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ca-β using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ca-β in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ca-β
Transgenic constructs containing regulatory region of Ca-β
Aberrations (Deficiencies and Duplications) ( 6 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CACNB1
12 of 15
Yes
Yes
Hsap\CACNB4
12 of 15
Yes
Yes
Hsap\CACNB2
11 of 15
No
Yes
Hsap\CACNB3
8 of 15
No
Yes
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cacnb1
12 of 15
Yes
Yes
Mmus\Cacnb2
12 of 15
Yes
Yes
Mmus\Cacnb4
12 of 15
Yes
Yes
Mmus\Cacnb3
8 of 15
No
Yes
Rattus norvegicus (Norway rat) (4)
Rnor\Cacnb4
12 of 13
Yes
Yes
Rnor\Cacnb2
10 of 13
No
Yes
Rnor\Cacnb1
7 of 13
No
Yes
Rnor\Cacnb3
7 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
Xtro\cacnb4
8 of 12
Yes
Yes
Xtro\cacnb2
6 of 12
No
Yes
Xtro\cacnb3
6 of 12
No
Yes
Xtro\cacnb1
1 of 12
No
Yes
Danio rerio (Zebrafish) (7)
Drer\cacnb4a
11 of 15
Yes
Yes
Drer\cacnb1
10 of 15
No
Yes
Drer\cacnb4b
9 of 15
No
Yes
Drer\cacnb3a
7 of 15
No
Yes
Drer\cacnb2a
6 of 15
No
Yes
Drer\cacnb2b
6 of 15
No
Yes
Drer\cacnb3b
5 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\ccb-1
11 of 15
Yes
Yes
Cele\ccb-2
4 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091903N8 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001908
Drosophila simulans
Dsim\GD22184
Drosophila sechellia
Dsec\GM11112
Drosophila erecta
Dere\GG10318
Drosophila yakuba
Dyak\GE12954
Drosophila pseudoobscura pseudoobscura
Dpse\GA19509
Drosophila persimilis
Dper\GL13483
Drosophila willistoni
Dwil\GK15237
Drosophila virilis
Dvir\GJ14926
Drosophila mojavensis
Dmoj\GI18146
Drosophila grimshawi
Dgri\GH13531
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503NF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17023530
Glossina morsitans
Tsetse fly
Gmor\GMOY006585
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07593
Mayetiola destructor
Hessian fly
Mdes\Mdes012967
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013881
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL011625
Anopheles darlingi
American malaria mosquito
Adar\ADAC009129
Anopheles gambiae
Malaria mosquito
Agam\AGAP008028
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008078
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05LF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA003786
Danaus plexippus
Monarch butterfly
Dple\DPOGS210937-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL003948
Apis florea
Little honeybee
Aflo\2147484369
Apis florea
Little honeybee
Aflo\2147488273
Apis mellifera
Western honey bee
Amel\GB40089
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11499
Bombus terrestris
Buff-tailed bumblebee
Bter\15205166
Linepithema humile
Argentine ant
Lhum\LH22083
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0012a9
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001295
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02063
Tribolium castaneum
Red flour beetle
Tcas\TC033242
Pediculus humanus
Human body louse
Phum\PHUM411240
Rhodnius prolixus
Kissing bug
Rpro\RPRC014215
Rhodnius prolixus
Kissing bug
Rpro\RPRC000621
Cimex lectularius
Bed bug
Clec\CLEC005665
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008838
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005770
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17585
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05HK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW011557
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80529.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g02220
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g02180
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_52801
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G09C1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ccb2A
Ciona intestinalis
Vase tunicate
Cint\LOC100184830
Gallus gallus
Domestic chicken
Ggal\CACNB4
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000025788
Gallus gallus
Domestic chicken
Ggal\CACNB2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CACNB1; calcium voltage-gated channel auxiliary subunit beta 1
    12 of 15
    114207
        CACNB4; calcium voltage-gated channel auxiliary subunit beta 4
        12 of 15
        601949
        CACNB2; calcium voltage-gated channel auxiliary subunit beta 2
        11 of 15
        600003
        CACNB3; calcium voltage-gated channel auxiliary subunit beta 3
        8 of 15
        601958
             
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Interactions Browser
            Summary of Genetic Interactions
            esyN Network Diagram
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Linkouts
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map

            2-44

            Cytogenetic map
            32D5-32E1
            Sequence location
            2L:11,156,118..11,203,544 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            32D5-32E1
            Limits computationally determined from genome sequence between P{lacW}RfC38k13807 and P{PZ}l(2)0400804008&P{PZ}cmet04431 32D5; Limits computationally determined from genome sequence between P{lacW}RfC38k13807 and P{PZ}l(2)0400804008&P{PZ}cmet04431
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            32E1-32E2
            (determined by in situ hybridisation)
            (Spradling et al., 1999)
            21-40
            (Ren et al., 1995)
            32E1-32E2
            (BDGP Project Members, 1994-1999)
            Experimentally Determined Recombination Data
            Location

            2-44

            (FlyBase, 2016)

            2-37.8

            (Comeron et al., 2012)
            Left of (cM)
            (Levine et al., 2007)
            Right of (cM)
            (Levine et al., 2007)
            Notes
            Stocks and Reagents
            Stocks (13)
            Genomic Clones (31)
            cDNA Clones (13)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of
                Source for database merge of

                Source for merge of: Ca-β CG6320

                (Bayraktaroglu, 2000.8.7)

                Source for merge of: Ca-β CG33305

                (FlyBase Genome Annotators, 2008)

                Source for merge of: CG14922 CG14923

                (FlyBase Genome Annotators, 2004)

                Source for merge of: Ca-β l(2)04008

                (Bellen, 2020.5.15)
                Additional comments

                Annotations Ca-β and CG33305 merged as CG42403 in release 5.10 of the genome annotation.

                (FlyBase Genome Annotators, 2008)

                Annotations CG14922 and CG14923 merged as CG33305 in release 3.2 of the genome annotation.

                (FlyBase Genome Annotators, 2004)
                Other Comments

                Annotation CG14922 was eliminated in release 3.0 of the genome annotation. Annotation CG14923 was eliminated in release 3.0 of the genome annotation.

                (FlyBase Genome Annotators, 2002-2003)
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 54 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                InterPro - A database of protein families, domains and functional sites
                Linkouts
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                Synonyms and Secondary IDs (19)
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (69)