FB2025_05 , released December 11, 2025
Gene: Dmel\Vha44
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General Information
Symbol
Dmel\Vha44
Species
D. melanogaster
Name
Vacuolar H+ ATPase 44kD subunit
Annotation Symbol
CG8048
Feature Type
protein_coding_gene
FlyBase ID
FBgn0287825
Gene Model Status
Current
Stock Availability
20 publicly available
Gene Summary
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). In enterocytes, acts as part of a pHCl-2 sensory pathway which mediates Tor-dependent larval growth and metabolism in response to zinc availability (PubMed:32269334). Likely acts in maintaining enterocyte lysosomal acidification which consequently promotes Tor activation at the lysosome membrane (PubMed:32269334). (UniProt, Q9V7N5)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Vacuolar H+ ATPase 44kD C subunit, l(2)02836, Vacuolar H+ ATPase 44kD C subunit

Key Links
Genomic Location
Cytogenetic map
53B5-53C1
Sequence location
Recombination map
2-79
RefSeq locus
NT_033778 REGION:16324813..16336637
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables proton transmembrane transporter activity
inferred from electronic annotation with InterPro:IPR036132
(InterPro Project Members, 2004-)
contributes_to proton-transporting ATPase activity, rotational mechanism
inferred by curator from GO:0033181
(Allan et al., 2005)
enables proton-transporting ATPase activity, rotational mechanism
inferred from electronic annotation with InterPro:IPR004907
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000015490
(GO Reference Genome Project, 2011-)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in proton transmembrane transport
inferred from electronic annotation with InterPro:IPR004907, InterPro:IPR036132
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity
(Harvie et al., 1998)
inferred by curator from GO:0033181
(Allan et al., 2005)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
part_of plasma membrane proton-transporting V-type ATPase complex
inferred from mutant phenotype
(Allan et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of proton-transporting V-type ATPase, V1 domain
inferred from electronic annotation with InterPro:IPR004907, InterPro:IPR036132
(InterPro Project Members, 2004-)
part_of vacuolar proton-transporting V-type ATPase, V1 domain
inferred from sequence or structural similarity with SGD:S000001563
(Dow, 1999)
inferred from biological aspect of ancestor with PANTHER:PTN000015490
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity
(Harvie et al., 1998)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the V-ATPase C subunit family. (Q9V7N5)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
proton-transporting ATPase activity, rotational mechanism
RHEA 57721:
Summaries
Gene Group (FlyBase)
VACUOLAR ATPASE V1 DOMAIN NON-CATALYTIC SUBUNITS -
The V1 domain of V-ATPases is a peripheral membrane domain composed of eight different subunits (A-H) that are expressed as multiple isoforms in a tissue-specific manner. The V1 domain is responsible for ATP hydrolysis. The non-catalytic V1 subunits do not hydrolyze ATP directly but provide regulatory functions and/or interact with the V0 domain. (Adapted from PMID:20450191 and FBrf0188241).
Protein Function (UniProtKB)
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). In enterocytes, acts as part of a pHCl-2 sensory pathway which mediates Tor-dependent larval growth and metabolism in response to zinc availability (PubMed:32269334). Likely acts in maintaining enterocyte lysosomal acidification which consequently promotes Tor activation at the lysosome membrane (PubMed:32269334).
(UniProt, Q9V7N5)
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Vha44 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9V7N5)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Vha44-RA
FBtr0087173
NM_057918
1470
388
Vha44-RB
FBtr0087176
NM_134313
1431
388
Vha44-RC
FBtr0087175
NM_166163
2693
442
Vha44-RE
FBtr0290031
NM_166164
3875
836
Vha44-RF
FBtr0290032
NM_001144207
3820
836
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Vha44-PA
FBpp0086317
44.5
388
7.96
NP_477266
AAF58011
Vha44-PB
FBpp0086320
44.5
388
7.96
NP_599140
AAM68515
Vha44-PC
FBpp0086319
51.2
442
8.94
NP_725564
AAF58012
Vha44-PE
FBpp0288470
92.4
836
7.59
Q9V7N5
NP_725565
AAF58013
Vha44-PF
FBpp0288471
92.4
836
7.59
Q9V7N5
NP_001137679
ACL83133
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

836 aa isoforms: Vha44-PE, Vha44-PF
388 aa isoforms: Vha44-PA, Vha44-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2 (By similarity).

(UniProt, Q9V7N5)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Vha44 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.02

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of plasma membrane proton-transporting V-type ATPase complex
inferred from mutant phenotype
(Allan et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Vha44 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 18 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Vha44
Transgenic constructs containing regulatory region of Vha44
Aberrations (Deficiencies and Duplications) ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Df(2R)Exel6063)
lethal | recessive
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal developmental rate, with Scer\GAL4pHCl-2.PR
abnormal neuroanatomy | adult stage | somatic clone
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
abnormal size | somatic clone, with Scer\GAL4αTub84B.PC
abnormal size | somatic clone | third instar larval stage, with Scer\GAL4αTub84B.PC
decreased rate of feeding behavior | larval stage, with Scer\GAL4pHCl-2.PR
some die during pupal stage, with Scer\GAL4pnr-MD237
visible | adult stage | somatic clone
visible | somatic clone
Phenotype manifest in
Allele
cell cortex | larval stage | somatic clone
egg chamber, with Scer\GAL4GR1
eye | somatic clone
larval somatic muscle cell, with Scer\GAL4Mef2.PR
lipid droplet | somatic clone, with Scer\GAL4αTub84B.PC
lipid droplet | somatic clone | third instar larval stage, with Scer\GAL4αTub84B.PC
nurse cell, with Scer\GAL4GR1
wing disc, with Scer\GAL4dpp.PU
wing disc, with Scer\GAL4ptc-559.1
wing disc | larval stage | somatic clone
wing disc dorsal compartment, with Scer\GAL4ap-md544
wing margin | somatic clone
wing margin bristle | absent | somatic clone
wing pouch, with Scer\GAL4nub.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\ATP6V1C1
12 of 14
Yes
Yes
1  
Hsap\ATP6V1C2
10 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (2)
Rnor\Atp6v1c1
13 of 14
Yes
Yes
Rnor\Atp6v1c2
10 of 14
No
Yes
Mus musculus (laboratory mouse) (2)
Mmus\Atp6v1c1
13 of 14
Yes
Yes
Mmus\Atp6v1c2
9 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
Xtro\atp6v1c1
10 of 13
Yes
Yes
Xtro\atp6v1c2
6 of 13
No
Yes
Xtro\fam241a
1 of 13
No
Yes
Xtro\scml2
1 of 13
No
No
Danio rerio (Zebrafish) (3)
Drer\atp6v1c1a
13 of 14
Yes
Yes
Drer\atp6v1c1b
12 of 14
No
Yes
Drer\atp6v1c2
9 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\vha-11
11 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP005845
11 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\DET3
12 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\VMA5
11 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\vma5
10 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Vha44. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Allele
Disease
Evidence
References
Vha44UAS.cPa
model of  cancer
CEA
(Petzoldt et al., 2013)
Vha44UAS.Tag:HA
model of  cancer
CEA
(Petzoldt et al., 2013)
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
ATP6V1C1; ATPase H+ transporting V1 subunit C1
12 of 14
603097
       
      ATP6V1C2; ATPase H+ transporting V1 subunit C2
      10 of 14
      618070
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Summary of Genetic Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Vha44
          suppressible
          bsk
          (Petzoldt et al., 2013)
          Vha44
          suppressible
          egr
          (Petzoldt et al., 2013)
          Vha44
          suppressible
          puc
          (Petzoldt et al., 2013)
          Vha44
          enhanceable
          Ras85D
          (Petzoldt et al., 2013)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          External Data
          Subunit Structure (UniProtKB)
          V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2 (By similarity).
          (UniProt, Q9V7N5 )
          Linkouts
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          FlyBase
          External Links
          KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          External Data
          Linkouts
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2R
          Recombination map
          2-79
          Cytogenetic map
          53B5-53C1
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          53B5-53C1
          Limits computationally determined from genome sequence between P{lacW}Lis-1k11702&P{EP}CG8443EP969 and P{lacW}l(2)k07824k07824&P{lacW}vegk03402
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Complementation tests with molecularly defined deletions place the P{PZ}l(2)02836a02836a insertion in the interval 2R:16187888--16386515 (release 6 genome), equivalent to a cytological location of 52F6--53C4.
          (Kahsai et al., 2016)
          52F6-53C4
          (Kahsai et al., 2016)
          53B3-53B4
          (Oh et al., 2003)
          53B1-53B2
          (determined by in situ hybridisation)
          (Spradling et al., 1999)
          53B1-53B2
          (BDGP Project Members, 1994-1999)
          Experimentally Determined Recombination Data
          Location

          2-79

          (FlyBase, 2016)

          2-82.2

          (Comeron et al., 2012)

          2-

          (Harvie, 1997.6.3)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (20)
          Genomic Clones (20)
          cDNA Clones (123)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Petzoldt et al., 2013)
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments

                dsRNA made from templates generated with primers directed against Vha44 that is transfected into S2 treated with Listeria monocytogenes reveals Vha44 to be involved in Listeria monocytogenes entry and vacuolar escape.

                (Cheng et al., 2005)

                22 alleles of l(2)SH1339 recovered in a P-insertion screen.

                (Oh et al., 2003)

                Area matching Drosophila EST AA699128. This EST matches the 5' of drosophila V-ATP ase gene AF006655 gene.

                (Davies, 2001.3.15)
                Relationship to Other Genes
                Source for database merge of

                Source for merge of: Vha44 l(2)SH1339

                (Allan et al., 2005)

                Source for merge of: Vha44 l(2)02836a

                (Mo et al., 2020)
                Additional comments

                l(2)02836a may correspond to Vha44: the P{lacW}l(2)02836ak05440 insertion maps within the transcription unit.

                (Gene Disruption Project members, 2015.10.8)
                Nomenclature History
                Source for database identify of
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (20)
                Reported As
                Symbol Synonym
                6072
                (Harvie et al., 1998)
                ATP6V1C
                (Adamson et al., 2011)
                ATP6V1C1
                (Rujano et al., 2017)
                CG8048
                (National Institute of Genetics Fly Stocks, 2022-, Hosono et al., 2015, Serysheva et al., 2013, Serysheva et al., 2013, Cammarato et al., 2011, Khanna et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Terhzaz et al., 2006, Allan et al., 2005, Wang et al., 2004)
                Vha44
                (Bandyadka et al., 2025, Zhang et al., 2025, Jain et al., 2024, Portela et al., 2024, Wang et al., 2024, Ham et al., 2023, Cunningham et al., 2020, Fan et al., 2020, Mo et al., 2020, Redhai et al., 2020, Vásquez-Procopio et al., 2020, Chua et al., 2019, Mondragon et al., 2019, Şentürk et al., 2019, Troha et al., 2019, Lee et al., 2018, Portela et al., 2018, Tamirisa et al., 2018, Rujano et al., 2017, Transgenic RNAi Project members, 2017-, Sarov et al., 2016, Gene Disruption Project members, 2015-, Zhang et al., 2015, Ashwal-Fluss et al., 2014, Gonzalez et al., 2014, Luck et al., 2014, Chang et al., 2013, Hermle et al., 2013, Petzoldt et al., 2013, Serysheva et al., 2013, Serysheva et al., 2013, Gistelinck et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Stotz and Clapham, 2012, Seong et al., 2011, Anholt and Williams, 2010, Cook et al., 2010.2.12, Blard et al., 2007, Stuart et al., 2007, Mack et al., 2006, Liebl and Featherstone, 2005, Terashima and Bownes, 2005)
                l(2)02836
                (Spradling et al., 1999)
                l(2)02836a
                l(2)6072
                (Harvie, 1997.6.4)
                l(2)SH1339
                l(2)SH2 1339
                (Oh et al., 2002.3.25)
                vha44
                (Zhao et al., 2018, Wang et al., 2014, Chintapalli et al., 2013, Gistelinck et al., 2012, Adamson et al., 2011, Terhzaz et al., 2006, Allan et al., 2005, Cheng et al., 2005, Stark et al., 2005, Wang et al., 2004, Dow, 1999, Harvie, 1997.6.3)
                Name Synonyms
                C subunit
                (Dow et al., 1997)
                V-ATPase C subunit
                (Harvie et al., 1998)
                Vacuolar H+ ATPase 44kD C subunit
                (Khanna et al., 2010, Mack et al., 2006)
                Vacuolar H+ ATPase 44 kDa subunit
                (Terashima and Bownes, 2005)
                Vacuolar H+ ATPase 44kD C subunit
                (Cammarato et al., 2011)
                Vacuolar H+ ATPase 44kD subunit
                lethal (2) 02836a
                lethal (2) SH1339
                vacuolar ATPase C-subunit
                (Lafont, 2000)
                Secondary FlyBase IDs
                • FBgn0020611
                • FBgn0262511
                • FBgn0065466
                • FBgn0010522
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 65 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                References (131)