FlyBase Gene Report: Dmel\Pkcδ

General Information

Symbol

Dmel\Pkcδ

Species

D. melanogaster

Name

Protein kinase C δ

Annotation Symbol

CG42349

Feature Type

protein_coding_gene

FlyBase ID

FBgn0287828

Gene Model Status

Current

Stock Availability

39 publicly available

Enzyme Name (EC)

protein kinase C (2.7.11.13)

[myosin light-chain] kinase (2.7.11.18)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

PKCd

Key Links

Genomic Location

Cytogenetic map

11A10-11A11

Sequence location

X:12,432,224..12,453,650 [+]

Recombination map

1-38

RefSeq locus

NC_004354 REGION:12432224..12453650

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables myosin light chain kinase activity

inferred from mutant phenotype

(Vaziri et al., 2020)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR017441, InterPro:IPR017892

(InterPro Project Members, 2004-)

enables diacylglycerol-dependent serine/threonine kinase activity

inferred from electronic annotation with InterPro:IPR014376

(InterPro Project Members, 2004-)

enables protein serine/threonine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000683254

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR000961, InterPro:IPR017892

(InterPro Project Members, 2004-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in flight

inferred from mutant phenotype

(Vaziri et al., 2020)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in intracellular signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000683254

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in plasma membrane

inferred from sequence or structural similarity with FLYBASE:inaC; FB:FBgn0004784

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

NOVEL PROTEIN KINASE C SUBFAMILY

Protein Family (UniProt)

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (P83099)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

myosin light chain kinase activity

(1) L-seryl-[myosin light chain] + ATP = O-phospho-L-seryl-[myosin light chain] + ADP + H(+) (2.7.11.18)

(2) L-threonyl-[myosin light chain] + ATP = O-phospho-L-threonyl-[myosin light chain] + ADP + H(+) (2.7.11.18)

RHEA 22004: diacylglycerol-dependent serine/threonine kinase activity

(1) L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) (2.7.11.13)

(2) L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) (2.7.11.13)

Summaries

Gene Group (FlyBase)

NOVEL PROTEIN KINASE C SUBFAMILY -: The Protein Kinase C (PKC) family are serine/threonine kinases regulated by auto-inhibition through a pseudosubstrate site located in the regulatory domain. Members of the novel PKC (nPKC) subfamily require diacylglycerol and but not Ca[2+] for activation. (Adapted from PMID:20094051 and FBrf0152086).

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

mfd: myofibrillar-defective (J.C. Hall)

Deletion of salivary segment 11A6-7 leads to inability to jump or fly, hemizygosity for this variant allows viability, and the phenotypic defects induced by the deletion are recessive; myofibrils or thoracic muscles shortened; spots are missing in two dimensional gel analysis of proteins from fibrillar and tubular muscles; these differences from wild type apparently due to blocking of phosphorylation of proteins in these muscles; such proteins are very likely myosins that become phosphorylated during the first day after eclosion (in wild-type), in parallel with the gradual development of flying and jumping ability (Hiromi, Ohmura, Masaki, Hirose and Hotta).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Pkcδ for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P83099)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Pkcδ-RC

FBtr0299936

NM_078616

3219

671

Pkcδ-RD

FBtr0299937

NM_001144719

3043

671

Pkcδ-RE

FBtr0340086

NM_132569

6288

1894

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Pkcδ-PC

FBpp0289213

76.3

671

8.63

FBpp0289214

76.3

671

8.63

FBpp0309085

206.6

1894

8.19

Q9VYN1

NP_572797

AAF48161

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

671 aa isoforms: Pkcδ-PC, Pkcδ-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pkcδ using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.75

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: Mi{Trojan-GAL4.1}Pkcδ^{MI09597-TG4.1}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain | restricted

(Lee et al., 2018)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Pkcδ in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Pkcδ

View exonic expression by tissue for Dmel\Pkcδ

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32191/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0287828

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0259680

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0287828

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Pkcδ

Transgenic constructs containing regulatory region of Pkcδ

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 35 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

Pkcδ^GD7247

viable

Pkcδ^e04408

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Sterility

Allele

fertile

Pkcδ^e04408

Other Phenotypes

Allele

decreased size | adult stage

Pkcδ^e04408

flightless

Pkcδ^e04408

flightless (with Df(1)BSC543)

Pkcδ^e04408

increased rate of adult locomotory behavior, with Scer\GAL4^EDTP-DJ694

Pkcδ^JF02991

increased rate of movement | adult stage, with Scer\GAL4^EDTP-DJ694

Pkcδ^JF02991

Phenotype manifest in

Allele

indirect flight muscle cell

Pkcδ^e04408

myofibril

Pkcδ^e04408

sarcomere

Pkcδ^e04408

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (79)

Hsap\PRKCD

12 of 14

Yes

Hsap\PRKCQ

11 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (35)

Rnor\Prkcd

12 of 14

Yes

Rnor\Prkcq

11 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

4 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (30)

Mmus\Prkcd

12 of 14

Yes

Mmus\Prkcq

10 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

4 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (43)

Xtro\prkcd

11 of 13

Yes

Xtro\prkcq

10 of 13

Yes

4 of 13

3 of 13

3 of 13

3 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100490294

1 of 13

Yes

Xtro\LOC100498287

1 of 13

Yes

Xtro\LOC101731388

1 of 13

Yes

Xtro\LOC101732362

1 of 13

Xtro\LOC101733298

1 of 13

Xtro\LOC101734050

1 of 13

Yes

Xtro\LOC105945216

1 of 13

Yes

Xtro\LOC105947923

1 of 13

Yes

Xtro\LOC116407815

1 of 13

Yes

Xtro\map3k1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\rassf1

1 of 13

Yes

Xtro\rock1

1 of 13

Xtro\rtbdn

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (41)

Drer\prkcda

12 of 14

Yes

Drer\prkcdb

12 of 14

Yes

Drer\prkcq

11 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\si:dkey-172j4.3

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (39)

Cele\tpa-1

13 of 14

Yes

4 of 14

4 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\rsf-1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (33)

Agam\AgaP_AGAP000418

11 of 12

Yes

4 of 12

4 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (37)

Atha\AGC1.5

2 of 13

Yes

Atha\AGC1.7

2 of 13

Yes

Atha\AT2G44830

2 of 13

Yes

Atha\AT3G44610

2 of 13

Yes

Atha\AT5G40030

2 of 13

Yes

Atha\ATPK7

2 of 13

Yes

Atha\D6PK

2 of 13

Yes

Atha\D6PKL1

2 of 13

Yes

Atha\D6PKL2

2 of 13

Yes

Atha\KIPK

2 of 13

Yes

Atha\PID2

2 of 13

Yes

Atha\PID

2 of 13

Yes

Atha\RSH3

2 of 13

Yes

Atha\WAG1

2 of 13

Yes

Atha\WAG2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT4G14350

1 of 13

Atha\AT4G16015

1 of 13

Yes

Atha\AT4G33080

1 of 13

Atha\AT5G03640

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\PHOT2

1 of 13

Yes

Atha\PK1

1 of 13

Atha\S6K2

1 of 13

Atha\UCN

1 of 13

Yes

Atha\UCNL

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (12)

Scer\PKC1

8 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\pck1

8 of 12

Yes

Spom\pck2

8 of 12

Yes

Spom\pka1

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Pkcδ. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (35)

9 of 13

9 of 13

8 of 13

6 of 13

Akt

4 of 13

Pkn

4 of 13

CG31140

2 of 13

PKD

2 of 13

RhoGAP5A

2 of 13

trc

2 of 13

unc-13

2 of 13

wts

2 of 13

CG12069

1 of 13

CG32944

1 of 13

CG34384

1 of 13

Dgk

1 of 13

Dgkε

1 of 13

dop

1 of 13

for

1 of 13

gek

1 of 13

Gprk1

1 of 13

Gprk2

1 of 13

gwl

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Rok

1 of 13

S6kII

1 of 13

S6KL

1 of 13

S6k

1 of 13

Sbf

1 of 13

sti

1 of 13

Vav

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

PRKCD; protein kinase C delta

model of autoimmune lymphoproliferative syndrome type 3

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Pkcδ^GD15429

exacerbates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Voßfeldt et al., 2012)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PRKCD; protein kinase C delta

12 of 14

176977

AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE III; ALPS3

autoimmune lymphoproliferative syndrome type 3

PRKCQ; protein kinase C theta

11 of 14

600448

PRKCA; protein kinase C alpha

5 of 14

176960

PRKCB; protein kinase C beta

5 of 14

176970

PRKCE; protein kinase C epsilon

5 of 14

176975

PRKCG; protein kinase C gamma

5 of 14

176980

SPINOCEREBELLAR ATAXIA 14; SCA14

spinocerebellar ataxia type 14

PRKCH; protein kinase C eta

5 of 14

605437

STROKE, ISCHEMIC

cerebral infarction

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Autophagy - animal

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-38

Cytogenetic map

11A10-11A11

Sequence location

X:12,432,224..12,453,650 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

11A10-11A11

Limits computationally determined from genome sequence between P{EP}EP1451&P{EP}EP1629 and P{EP}CG11138^EP1313

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Determined by mapping with synthetic T(1;Y) deletion (details unspecified).

(Lindsley and Zimm, 1992)

11A6-11A7

(Lindsley and Zimm, 1992)

Experimentally Determined Recombination Data

Location

1-38

(FlyBase, 2016)

1-38.9

(Comeron et al., 2012)

1-[38]

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (39)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

605752

w¹¹¹⁸; P{R22F05-GAL80}attP2

48990

w¹¹¹⁸; P{GMR22F05-GAL4}attP2

48993

w¹¹¹⁸; P{GMR22F08-GAL4}attP2

49018

w¹¹¹⁸; P{GMR23B09-GAL4}attP2

49875

w¹¹¹⁸; P{GMR22F03-GAL4}attP2

61641

w¹¹¹⁸; P{GMR22E03-GAL4}attP2

89696

w¹¹¹⁸; P{R22F05-p65.AD}JK22C

53546

w¹¹¹⁸; P{GMR23B09-lexA}attP40

61522

w¹¹¹⁸; P{GMR22E03-lexA}attP40

70124

w¹¹¹⁸; P{R22E03-p65.AD}attP40

VDRC

v101029

P{KK106627}VIE-260B

v33838

w¹¹¹⁸; P{GD15429}v33838

More stocks available...

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (44)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

The phosphorylation state and ATPase activity of myosin light chain isoforms has been compared in wild-type and mfd^- flies.

(Takahashi et al., 1990)

Deletion of salivary segment 11A6-7 leads to inability to jump or fly, hemizygosity for this variant allows viability and the phenotypic defects induced by the deletion are recessive; myofibrils or thoracic muscles shortened; spots are missing in two dimensional gel analysis of proteins from fibrillar and tubular muscles; these differences from wild type apparently due to blocking of phosphorylation of proteins in these muscles; such proteins are very likely myosins that become phosphorylated during the first day after eclosion (in wild-type), in parallel with the gradual development of flying and jumping ability (Hiromi, Ohmura, Masaki, Hirose and Hotta).

Relationship to Other Genes

Source for database merge of

Source for merge of: Pkcδ CG11245

(FlyBase Genome Annotators, 2008)

Source for merge of: Pkcδ CG10524

(Manning, 2001.10.8, FlyBase, 1996-)

Source for merge of: Pkcδ mfd

(Vaziri et al., 2020)

Additional comments

Annotations CG10524 and CG11245 merged as CG42349 in release 5.9 of the genome annotation.

(FlyBase Genome Annotators, 2008)

Source for merge of Pkcδ CG10524 was Swiss-Prot update ( date:011105 ).

(FlyBase, 1996-)

Only known as a deletion phenotype.

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

CG10524

(Keleman et al., 2009.8.5, Perkins et al., 2009)

CG11245

(Keleman et al., 2009.8.5)

CG42349

(Hirschhäuser et al., 2021, Meadows, 2014.12.12, FlyBase Genome Annotators, 2008)

PKCd

(Di Cara et al., 2015, Bjorklund et al., 2006, Manning, 2001.10.8, Morrison et al., 2000)

PKCdelta

(Colomb and Brembs, 2016, Shieh et al., 2002)

PKCδ

(Comyn et al., 2024, Li et al., 2020, Otani et al., 2016)

Pkcdelta

(Pang et al., 2021, Maier et al., 2019, Palmer et al., 2018, Gene Disruption Project members, 2016-, Giot et al., 2003)

Pkcδ

(Jafari and Alenius, 2021, Vaziri et al., 2020, Getahun et al., 2016, Zhou et al., 2014)

mfd

δ PKC

(Poudel et al., 2021)

Name Synonyms

CG11245

CG42349

(FlyBase Genome Annotators, 2008)

Protein kinase C delta

(Manning, 2001.10.8)

Protein kinase C δ

myofibrillar defect

protein kinase C

(Dan et al., 2001)

protein kinase C δ

(Morozova et al., 2006)

Secondary FlyBase IDs

FBgn0259680
FBgn0030387
FBgn0030388
FBgn0002727

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 52 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32191

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P83099

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P83099

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P83099

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32191/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0287828

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0287828

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG42349

MARRVEL_MODEL - MARRVEL (model organism gene)

32191

Linkouts

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0259680

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0287828

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Autophagy - animal

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (69)

The following external sites may use different assemblies or annotations than FlyBase.

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