FlyBase Gene Report: Dmel\Cyp6a21

CYTOCHROME P450 - CYP3 CLAN -: Cytochrome P450, or CYP genes, constitute one of the largest families of genes, with representatives in virtually all living organisms. P450 enzymes are heme-thiolate proteins best known for their monooxygenase role, catalyzing the transfer of one atom of molecular oxygen to a substrate and reducing the other to water. The CYP3 clan includes D. melanogaster CYP6, 9, 28, 308-310 and 317 family genes. Few CYP3 enzymes have been characterized, though many have been shown to metabolize xenobiotics and plant natural compounds. (Adapted from FBrf0248421.)

Protein Function (UniProtKB)

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.

(UniProt, Q9V774)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cyp6a21 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V774)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cyp6a21-RA

FBtr0087456

NM_137159

1631

504

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Cyp6a21-PA

FBpp0086586

57.8

504

8.45

Q9V774

NP_611003

AAF58186

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9V774

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cyp6a21 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.56

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult fat body

Comment: cyclical, peak ZT21-0

(Xu et al., 2011)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 2

organism

Comment: maternal

(Chung et al., 2009)

embryonic stage 3 -- 4

yolk

Comment: maternal

(Chung et al., 2009)

third instar larval stage

embryonic/larval midgut

Comment: m1-4

(Chung et al., 2009)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult fat body

Comment: cyclical, peak ZT0

(Erion et al., 2016)

Additional Descriptive Data

Expressed cyclically in the adult fat body.

(Xu et al., 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cyp6a21 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cyp6a21

View exonic expression by tissue for Dmel\Cyp6a21

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36665/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0288232

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033981

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0288232

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cyp6a21

Transgenic constructs containing regulatory region of Cyp6a21

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cyp6a21^GD1185

viable, with Scer\GAL4^Mef2.PR

Cyp6a21^GD1185

viable, with Scer\GAL4^pnr-MD237

Cyp6a21^GD1185

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (29)

Hsap\CYP3A5

7 of 14

Yes

Hsap\CYP3A7-CYP3A51P

7 of 14

Yes

Hsap\CYP3A43

7 of 14

Yes

Hsap\TBXAS1

7 of 14

Yes

6 of 14

6 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CYP26A1

1 of 14

Hsap\CYP26B1

1 of 14

Hsap\CYP26C1

1 of 14

Yes

Hsap\CYP39A1

1 of 14

Yes

Hsap\CYP46A1

1 of 14

Hsap\CYP51A1

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (29)

Rnor\Cyp3a9

10 of 14

Yes

Rnor\Cyp3a18

10 of 14

Yes

Rnor\Cyp3a62

10 of 14

Yes

Rnor\Tbxas1

10 of 14

Yes

Rnor\Cyp3a2

9 of 14

Rnor\Cyp3a23-3a1

9 of 14

Rnor\Cyp3a71-ps

1 of 14

Yes

Rnor\Cyp3a73

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Cyp26b1

1 of 14

Yes

Rnor\Cyp26c1

1 of 14

Yes

Rnor\Cyp46a1

1 of 14

Rnor\Cyp51

1 of 14

Yes

Mus musculus (laboratory mouse) (35)

Mmus\Tbxas1

8 of 14

Yes

7 of 14

7 of 14

7 of 14

7 of 14

7 of 14

7 of 14

7 of 14

7 of 14

6 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Cyp26b1

1 of 14

Yes

Mmus\Cyp26c1

1 of 14

Yes

Mmus\Cyp46a1

1 of 14

Mmus\Cyp51

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (25)

Xtro\cyp3a4.1

5 of 13

Yes

Xtro\cyp3a4.2

5 of 13

Yes

Xtro\tbxas1

5 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\cyp26a1

1 of 13

Xtro\cyp26b1

1 of 13

Xtro\cyp26c1

1 of 13

Yes

Xtro\cyp51a1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\lrrtm3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (18)

Drer\tbxas1

10 of 14

Yes

9 of 14

9 of 14

8 of 14

8 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\cyp26b1

1 of 14

Yes

Drer\cyp26c1

1 of 14

Yes

Drer\cyp39a1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\zgc:123299

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (31)

Cele\cyp-25A1

10 of 14

Yes

Cele\cyp-25A2

10 of 14

Yes

Cele\cyp-25A3

10 of 14

Yes

Cele\cyp-25A4

10 of 14

Yes

7 of 14

7 of 14

7 of 14

7 of 14

7 of 14

7 of 14

7 of 14

7 of 14

7 of 14

7 of 14

7 of 14

7 of 14

6 of 14

5 of 14

4 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (87)

Agam\AgaP_AGAP002865

10 of 12

Yes

Agam\AgaP_AGAP002866

10 of 12

Yes

Agam\AgaP_AGAP002868

10 of 12

Yes

Agam\AgaP_AGAP002869

10 of 12

Yes

Agam\CYP6P4

10 of 12

Yes

Agam\AgaP_AGAP002870

7 of 12

Yes

Agam\AgaP_AGAP008205

7 of 12

Yes

Agam\AgaP_AGAP008206

7 of 12

Agam\AgaP_AGAP008207

7 of 12

Yes

7 of 12

7 of 12

7 of 12

7 of 12

7 of 12

7 of 12

Yes

Agam\CYP6AA1

7 of 12

Yes

Agam\AgaP_AGAP008203

6 of 12

Yes

Agam\AgaP_AGAP008204

6 of 12

Yes

Agam\AgaP_AGAP010961

6 of 12

Agam\AgaP_AGAP011028

6 of 12

Yes

Agam\AgaP_AGAP011029

6 of 12

Yes

6 of 12

6 of 12

6 of 12

6 of 12

6 of 12

5 of 12

5 of 12

Yes

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

Yes

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

3 of 12

Yes

3 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (70)

Atha\CYP711A1

10 of 13

Yes

Atha\BAS1

3 of 13

Atha\AT1G73340

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\BR6OX1

1 of 13

Yes

Atha\BR6OX2

1 of 13

Yes

Atha\CPD

1 of 13

Atha\CYP51G1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\KAO2

1 of 13

Atha\ROT3

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\ERG11

3 of 13

Yes

Scer\DIT2

1 of 13

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\erg5

3 of 12

Yes

Spom\erg11

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cyp6a21. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (67)

12 of 13

12 of 13

12 of 13

12 of 13

12 of 13

12 of 13

12 of 13

11 of 13

11 of 13

11 of 13

11 of 13

11 of 13

11 of 13

11 of 13

11 of 13

11 of 13

11 of 13

10 of 13

10 of 13

10 of 13

10 of 13

10 of 13

10 of 13

10 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

8 of 13

8 of 13

7 of 13

7 of 13

7 of 13

6 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

CYP3A5; cytochrome P450 family 3 subfamily A member 5

model of essential hypertension

IEA

(FlyBase, 2019-)

TBXAS1; thromboxane A synthase 1

model of Ghosal hematodiaphyseal syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CYP3A5; cytochrome P450 family 3 subfamily A member 5

7 of 14

605325

HYPERTENSION, ESSENTIAL

essential hypertension

CYP3A7-CYP3A51P; CYP3A7-CYP3A51P readthrough

7 of 14

CYP3A43; cytochrome P450 family 3 subfamily A member 43

7 of 14

606534

TBXAS1; thromboxane A synthase 1

7 of 14

274180

GHOSAL HEMATODIAPHYSEAL DYSPLASIA; GHDD

Ghosal hematodiaphyseal syndrome

CYP3A4; cytochrome P450 family 3 subfamily A member 4

6 of 14

124010

VITAMIN D-DEPENDENT RICKETS, TYPE 3; VDDR3

CYP3A7; cytochrome P450 family 3 subfamily A member 7

6 of 14

605340

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Cyp6a21 - Cyp6a9

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-73

Cytogenetic map

51D1-51D1

Sequence location

2R:14,885,264..14,886,947 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

51D1-51D1

Limits computationally determined from genome sequence between P{lacW}Rpn6^k00103 and P{PZ}chn⁰²⁰⁶⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

51C-51C

(Dunkov, 2000.6.29)

Experimentally Determined Recombination Data

Location

2-73

(FlyBase, 2016)

2-76.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (2)

Aberrations including deletions of this gene Aberrations including duplications of this gene

VDRC

v102671

P{KK105149}VIE-260B

v3318

w¹¹¹⁸; P{GD1185}v3318

Genomic Clones (8)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (6)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RH16046

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RE27587

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.

(Claridge-Chang et al., 2001)

Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day.

(McDonald and Rosbash, 2001)

Transcription unit identified during molecular analysis of the Cyp6a8 and Cyp6a9 genomic region.

(Maitra et al., 1996)

Relationship to Other Genes

Source for database merge of

Source for merge of: Cyp6a21 Cyp6a9-rAF4-2

(FlyBase, 1996-)

Additional comments

The genes Cyp6a21 and Cyp6a9 share >70% identity and close proximity, and so may have been derived from a DNA-based tandem duplication.

(Langille and Clark, 2007)

FBrf0091117 (published 1996) states that "In the genome, Cyp6a8 and Cyp6a9 genes are closely clustered within 4 kb and map at region 51C of the second chromosome. In between them another Cyp gene is present which is more related to Cyp6a9 than to Cyp6a8." A comparison of their restriction map in Fig 2 to the current GBrowse annotation demonstrates that this gene, referred to in the paper as 'AF4-2' and named in FlyBase as 'Cyp6a9-rAF4-2' corresponds to the 3' half of Cyp6a21.

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

6a21

(Nelson, 2001.2.5)

AF4-2

(Maitra et al., 1996)

CG10247

(Chen et al., 2012, Zhang et al., 2010, Keleman et al., 2009.8.5, Vinci et al., 2008)

CYP6A21

(Nirusimhan et al., 2022)

Cyp6A21

(Li et al., 2008)

Cyp6a21

(Bordet et al., 2021, Kumar et al., 2021, Ågren et al., 2020, Scanlan et al., 2020, Rivera et al., 2019, Zhou et al., 2012, Niwa et al., 2011, Xu et al., 2011, Giraudo et al., 2010, Langille and Clark, 2007, King-Jones et al., 2006, Cirelli et al., 2005)

Cyp6a9-rAF4-2

P-450

(Danielson et al., 1995)

P450

(Arking, 1998, Zakharenko and Zakharov, 1998, Frolich and Wurgler, 1991)

cyp6a21

(Ceriani et al., 2002)

Name Synonyms

Cyp6a21

Cyp6a9-related

(Maitra et al., 1996)

Cytochrome P450 6a21

(Radyuk et al., 2012)

Cytochrome P450-6a9 related AF4-2

(Maitra et al., 1996)

cytochrome P450

(Chung et al., 2009)

Secondary FlyBase IDs

FBgn0020757
FBgn0033981

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 25 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36665

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V774

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V774

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V774

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36665/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0288232

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0288232

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG10247

MARRVEL_MODEL - MARRVEL (model organism gene)

36665

Linkouts

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033981

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0288232

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

References (66)

The following external sites may use different assemblies or annotations than FlyBase.

-0.56

Report Sections