FB2025_01 , released February 20, 2025
Gene: Dmel\Ype
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General Information
Symbol
Dmel\Ype
Species
D. melanogaster
Name
Yippee
Annotation Symbol
CG1989
Feature Type
FlyBase ID
FBgn0288857
Gene Model Status
Stock Availability
Gene Summary
Yippee (Ype) encodes a predicted member of the E3 ubiquitin ligase complex. It has roles in adult cuticle pigmentation, wing morphology, bristle formation, developmental rate, and adult emergence. [Date last reviewed: 2022-05-19] (FlyBase Gene Snapshot)
Also Known As

sable, s, eb

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
1-43
RefSeq locus
NC_004354 REGION:13385914..13387417
Sequence
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
non-traceable author statement
Biological Process (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN002302768
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the yippee family. (Q9XZF0)
Summaries
Gene Snapshot
Yippee (Ype) encodes a predicted member of the E3 ubiquitin ligase complex. It has roles in adult cuticle pigmentation, wing morphology, bristle formation, developmental rate, and adult emergence. [Date last reviewed: 2022-05-19]
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
s: sable
Body color dark with prominent trident. Classification good at 19, overlaps wild type increasingly with higher temperature. ERG normal (Hotta and Benzer, 1969, Nature 222: 354-56). Viability sometimes reduced. s is nonautonomous in gynandromorphs containing both s and + tissue (Lewis, 1955, DIS 29: 134). Tyrosinase formed in adult (Horowitz and Fling). β-alanine pools only 39% normal (Wright, 1987, Adv. Genet. 24: 127-222). s/s2 easily classified. Females hemizygous for s very dark and sterile (Craymer and Roy, 1980, DIS 55: 200-04). Suppressed by su(s). RK1 at 19.
s2
Body color less dark than s and trident more prominent. Expression best at 19, overlaps wild type at 25 and 30. Viability excellent. RK1 at 19.
seb: sable-ebonized
Fly heavily pigmented with trident pattern and scutellum very dark. Wings slightly shortened; membrane often slightly concave; wing tips occasionally truncate. Males viable and fertile; females sterile. RK2.
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Ype for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9XZF0)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.51

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0073789
1136
121
FBtr0100168
1293
110
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
FBpp0073620
13.7
121
8.96
FBpp0099522
12.7
110
10.24
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with hemolin.

(UniProt, Q9XZF0)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ype using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.60

Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ype in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ype
Transgenic constructs containing regulatory region of Ype
Aberrations (Deficiencies and Duplications) ( 21 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (5)
14 of 14
Yes
Yes
6 of 14
No
No
6 of 14
No
No
1  
6 of 14
No
No
2  
5 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (4)
14 of 14
Yes
Yes
6 of 14
No
No
6 of 14
No
No
5 of 14
No
No
Mus musculus (laboratory mouse) (5)
14 of 14
Yes
Yes
6 of 14
No
No
6 of 14
No
No
6 of 14
No
No
5 of 14
No
No
Xenopus tropicalis (Western clawed frog) (4)
2 of 13
Yes
No
2 of 13
Yes
No
2 of 13
Yes
Yes
1 of 13
No
Yes
Danio rerio (Zebrafish) (6)
13 of 14
Yes
Yes
6 of 14
No
No
6 of 14
No
No
6 of 14
No
No
5 of 14
No
No
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
9 of 14
Yes
Yes
8 of 14
No
Yes
6 of 14
No
No
Anopheles gambiae (African malaria mosquito) (2)
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (8)
7 of 13
Yes
No
7 of 13
Yes
No
6 of 13
No
No
6 of 13
No
No
6 of 13
No
No
6 of 13
No
Yes
6 of 13
No
No
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
5 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
8 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Ype. Refer to their site for version information.
Paralogs
Paralogs (via DIOPT v9.1)
Drosophila melanogaster (Fruit fly) (6)
10 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Other Interaction Browsers

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    esyN Network Key:
    Suppression
    Enhancement
    Other Interaction Browsers

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    suppressible
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Interacts with hemolin.
    (UniProt, Q9XZF0 )
    Linkouts
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-43
    Cytogenetic map
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    11F1-11F1
    Left limit from non-inclusion within Df(1)N12 (FBrf0034402) Right limit from inclusion within Df(1)C246 (FBrf0034402); Limits computationally determined from genome sequence between P{EP}CG1640EP1626 and P{EP}NFATEP1353&P{EP}NFATEP1508
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    1-42.0 +/- 1.2

    1-43.0

    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (13)
    Genomic Clones (9)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (8)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        Other clones
        RNAi and Array Information
        Linkouts
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: Ype sable

            Additional comments
            Nomenclature History
            Source for database identify of

            Source for identity of: Yippee CG1989

            Source for identity of: Ype Yippee

            Source for identity of: sable s

            Nomenclature comments

            Assigned the short symbol 'Ype' to the 'Yippee' gene, consistent with the nomenclature used for its paralog (Ypel) and its vertebrate orthologs (YPEL1-5).

            The gene symbol "s" has been changed to "sable" in order to reduce confusion with the "S" ("Star") gene symbol, from which it differed only by case.

            Etymology
            Synonyms and Secondary IDs (9)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 31 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            References (57)