FlyBase Gene Report: Dmel\tx

General Information

Symbol

Dmel\tx

Species

D. melanogaster

Name

taxi

Annotation Symbol

CG5441

Feature Type

protein_coding_gene

FlyBase ID

FBgn0288888

Gene Model Status

Current

Stock Availability

31 publicly available

Gene Summary

taxi (tx) encodes a transcription factor that affects cell adhesion by regulating the expression of mys. It is involved in the development of multiple organs and cell-types including tendon cells, chordotonal organs and the wing. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

dei, delilah, del, jumper

Key Links

Genomic Location

Cytogenetic map

97B2-97B2

Sequence location

3R:26,440,778..26,448,991 [+]

Recombination map

3-91

RefSeq locus

NT_033777 REGION:26440778..26448991

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables bHLH transcription factor binding

inferred from direct assay

(Armand et al., 1994)

contributes_to E-box binding

inferred from direct assay

(Armand et al., 1994)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from sequence or structural similarity with FLYBASE:da; FB:FBgn0267821

(Armand et al., 1994)

inferred by curator from GO:0043425,GO:0070888

(Armand et al., 1994)

enables protein dimerization activity

inferred from electronic annotation with InterPro:IPR011598, InterPro:IPR036638

(InterPro Project Members, 2004-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in cell adhesion mediated by integrin

inferred from mutant phenotype

(Egoz-Matia et al., 2011)

involved_in imaginal disc-derived wing vein specification

inferred from mutant phenotype

(Egoz-Matia et al., 2011)

involved_in mesoderm development

inferred from expression pattern

(Furlong et al., 2001)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in muscle attachment

traceable author statement

(Furlong et al., 2001)

involved_in regulation of DNA-templated transcription

inferred from sequence or structural similarity with FLYBASE:da; FB:FBgn0267821

(Armand et al., 1994)

involved_in somatic muscle development

traceable author statement

(Furlong et al., 2001)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from high throughput direct assay

(Sarov et al., 2016)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -: Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).

Protein Function (UniProtKB)

Probably plays an important role in the differentiation of epidermal cells into the tendon cells that form the attachment sites for all muscles.

(UniProt, P41894)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

ju: jumper

Flies have opened wings, oriented at an angle of 65 with respect to the longitudinal axis, and 10-30 with respect to the horizontal axis. Homozygotes show decreased flying ability and move from place to place by jumping.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\tx for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P41894)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.49

Gene model reviewed during 5.53

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

tx-RA

FBtr0085009

NM_079792

1652

384

tx-RB

FBtr0339598

NM_001300614

2411

384

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

tx-PA

FBpp0084381

41.5

384

6.19

FBpp0308670

41.5

384

6.19

P41894

NP_001287543

AHN57542

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

384 aa isoforms: tx-PA, tx-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Efficient DNA binding requires dimerization with another bHLH protein, possibly with da.

(UniProt, P41894)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tx using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.06

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 12

longitudinal trunk visceral muscle primordium

(Fisher et al., 2012)

somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

trunk visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

embryonic stage 12 -- 17

tendon cell

(Armand et al., 1994)

embryonic stage 13 -- 16

embryonic dorsal apodeme

(Fisher et al., 2012)

embryonic ventral apodeme

(Fisher et al., 2012)

larval muscle system

(Fisher et al., 2012)

larval somatic muscle cell

(Fisher et al., 2012)

larval visceral muscle cell

(Fisher et al., 2012)

embryonic stage 16 -- 17

tendon cell of pharyngeal muscle cell

Comment: Reference states 14-18 hr AEL

(Armand et al., 1994)

prepupal stage P2

wing cell | subset

(Egoz-Matia et al., 2011)

pupal stage P5 -- P7

wing cell

(Egoz-Matia et al., 2011)

Additional Descriptive Data

tx transcripts are not observed in third instar larval wing disc immediately after pupariation but are observed in wing discs 2 hr APF. They are observed in a spatially restricted pattern that probalby corresponds to certain intervein regions. No expression is observed in the dorso-ventral wing margin or in the hinge region. At 18 hr APF the expression expands to the entire prospective intervein domain, in both the dorsal and ventral wing layers. Expression remains restricted to the intervein domain and excluded from the forming veins at 30-35 hr APF. tx transcripts accumulate at higher levels in the vein/intervein border cells.

(Egoz-Matia et al., 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

pupal stage P7

wing cell

(Egoz-Matia et al., 2011)

external sensory organ of anterior wing margin

(Egoz-Matia et al., 2011)

Additional Descriptive Data

tx protein expression is observed in the entire intervein domain and excluded from the forming veins at 30-35 hr APF. tx protein accumulates at higher levels in the vein/intervein border cells and in cells of sensory organs of the anterior wing margin.

(Egoz-Matia et al., 2011)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from high throughput direct assay

(Sarov et al., 2016)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\tx in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\tx

View exonic expression by tissue for Dmel\tx

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43190/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0288888

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0288888

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5441

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 15 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of tx

Transgenic constructs containing regulatory region of tx

Aberrations (Deficiencies and Duplications) ( 18 )

Inferred from experimentation ( 18 )

Gene not disrupted in

Df(3R)ro80b

(Cook and Carpenter, 2002)

Gene partially disrupted in

Df(3R)tx^33-2

(Egoz-Matia et al., 2011)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^how-24B

tx^GD4329

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

tx^GD4329

viable, with Scer\GAL4^Mef2.PR

tx^GD4329

viable, with Scer\GAL4^pnr-MD237

tx^GD4329

Sterility

Allele

fertile

tx^e01478

Other Phenotypes

Allele

abnormal flight | adult stage, with Scer\GAL4^elav-C155

tx^UAS.cMa

abnormal flight | adult stage (with tx¹)

tx^KO-mCherry

abnormal flight | adult stage (with tx^ju-1)

tx^KO-mCherry

abnormal flight | adult stage (with tx^KO-mCherry)

abnormal flight | adult stage | recessive

abnormal neurophysiology | adult stage

tx^ju-1

decreased rate of movement | third instar larval stage

tx^e01478

flightless

tx^ju-1

flightless, with Scer\GAL4^elav-C155

tx^JF01995

uncoordinated | third instar larval stage

tx^e01478

visible

visible, with Scer\GAL4^Bx-MS1096

tx^{UAS.ORF.GW.Tag:HA}

visible, with Scer\GAL4^dpp.1.65KX

tx^UAS.cMa

visible, with Scer\GAL4^en-e16E

tx^GD4329

visible, with Scer\GAL4^how-24B

tx^GD4329

visible, with Scer\GAL4^pnr-MD237

tx^GD4329

visible (with Df(3R)ED6232)

visible (with tx¹)

tx¹⁴

visible (with tx¹⁴)

tx¹

visible | adult stage, with Scer\GAL4^elav-C155

visible | adult stage (with tx¹)

visible | adult stage (with tx^33-2)

tx^ju-1

visible | adult stage (with tx^e01478)

tx^ju-1

visible | adult stage (with tx^ju-1)

visible | adult stage (with tx^KO-mCherry)

visible | adult stage | recessive

Phenotype manifest in

Allele

chaeta | increased number, with Scer\GAL4^pnr-MD237

tx^GD4329

direct flight muscle motor neuron

tx^ju-1

direct flight muscle motor neuron | conditional

direct flight muscle motor neuron | conditional, with Scer\GAL4^elav-C155

tx^JF01995

posterior crossvein, with Scer\GAL4^dpp.1.65KX

tx^UAS.cMa

trichogen cell | increased number, with Scer\GAL4^pnr-MD237

tx^GD4329

wing

wing, with Scer\GAL4^Bx-MS1096

tx^{UAS.ORF.GW.Tag:HA}

wing, with Scer\GAL4^elav-C155

wing, with Scer\GAL4^en-e16E

tx^GD4329

wing, with Scer\GAL4^how-24B

tx^GD4329

wing (with tx¹)

wing (with tx^33-2)

tx^ju-1

wing (with tx^e01478)

tx^ju-1

wing (with tx^ju-1)

wing (with tx^KO-mCherry)

wing sensillum

tx¹

wing sensillum (with Df(3R)ED6232)

tx¹⁴

wing sensillum (with tx¹)

tx¹⁴

wing sensillum (with tx¹⁴)

tx¹

wing vein | ectopic

tx^MB03174

wing vein | ectopic (with Df(3R)ED6232)

wing vein L4, with Scer\GAL4^dpp.1.65KX

tx^UAS.cMa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (52)

Hsap\BHLHA15

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (51)

Rnor\Bhlha15

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (51)

Mmus\Bhlha15

3 of 14

Yes

Mmus\Olig1

3 of 14

Yes

Mmus\Olig2

3 of 14

Yes

Mmus\Olig3

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (32)

Xtro\bhlha15

3 of 13

Yes

Xtro\neurog1

3 of 13

Yes

Xtro\neurog2

3 of 13

Yes

Xtro\neurog3

3 of 13

Yes

Xtro\olig3

2 of 13

Yes

Xtro\olig4

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\neurod4

1 of 13

Yes

Xtro\neurod6

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (55)

Drer\bhlha15

3 of 14

Yes

Drer\olig4

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch211-196c10.13

1 of 14

Drer\si:ch211-246m6.4

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (21)

Cele\hlh-16

2 of 14

Yes

Cele\lin-32

2 of 14

Yes

Cele\ngn-1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (23)

Agam\AgaP_AGAP003876

7 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (1)

Atha\AT1G10610

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:tx. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (23)

amos

3 of 13

ato

3 of 13

cato

3 of 13

dimm

3 of 13

net

2 of 13

Oli

2 of 13

tap

2 of 13

1 of 13

crp

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

nau

1 of 13

sage

1 of 13

soul

1 of 13

twi

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

BHLHA15; basic helix-loop-helix family member a15

3 of 14

608606

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

tx - CG17568

two hybrid array

(Shokri et al., 2019)

tx - da

two hybrid

(Georgias et al., 1997)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

Adar

(Varte et al., 2022)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Egoz-Matia et al., 2011)

External Data

Subunit Structure (UniProtKB)

Efficient DNA binding requires dimerization with another bHLH protein, possibly with da.

(UniProt, P41894 )

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-91

Cytogenetic map

97B2-97B2

Sequence location

3R:26,440,778..26,448,991 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

97B2-97B2

Limits computationally determined from genome sequence between P{PZ}l(3)rQ197^rQ197 and P{lacW}scrib^j7B3

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

97B-97B

(Armand, 1994.5.31)

97B-97B

(determined by in situ hybridisation)

(Armand et al., 1994)

Experimentally Determined Recombination Data

Location

3-91

(FlyBase, 2016)

3-87.9

(Comeron et al., 2012)

3-91.09

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (31)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

625

tx¹

5071

tx^ju-1

1376

hh^bar3 tx¹

65621

w¹¹¹⁸; P{tx-GFP.FPTB}attP40

48540

w¹¹¹⁸; P{GMR13A10-GAL4}attP2

48577

w¹¹¹⁸; P{GMR13F09-GAL4}attP2

FlyORF

F001877

M{UAS-tx.ORF.3xHA.GW}ZH-86Fb

Kyoto

106016

tx¹

106293

hh^bar3 tx¹

VDRC

v102831

P{KK105148}VIE-260B

v37629

w¹¹¹⁸; P{GD4329}v37629

v318069

PBac{fTRG00166.sfGFP-TVPTBF}VK00033

More stocks available...

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (22)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH22991

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Varte et al., 2022, Egoz-Matia et al., 2011)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

ChEST reveals this is a target of Mef2.

(Junion et al., 2005)

dei is expressed in muscle attachment cells and expression is temporally correlated with the positions of muscle attachment. dei expression is not induced by muscle attachment.

(Armand et al., 1994)

Phenotypic variation of the genetic components underlying oviposition behaviour is analysed using the complete diallel mating design.

(Ruiz-Dubreuil and del Solar, 1993)

Relationship to Other Genes

Source for database merge of

Source for merge of: tx ju

(Varte et al., 2022)

Source for merge of: tx dei

(Egoz-Matia et al., 2011)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG5441

(Hassan et al., 2018, Hosono et al., 2015, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009, Perkins et al., 2009.1.15, Whitfield, 2001.1.5)

Dei

(Valdivia et al., 2017, Sarov et al., 2016, Klein et al., 2010)

Delilah

(Sarov et al., 2016, Armand, 1994.5.31)

bHLHc10

(Stevens et al., 2008)

dei

(Avetisyan et al., 2021, Hassan et al., 2018, Sarov et al., 2016, Nachman et al., 2015, Zhou et al., 2012, Egoz-Matia et al., 2011, Michelson and Volk, 2011.11.28, Kwon et al., 2008, Chanana et al., 2007, Zeitlinger et al., 2007, Sandmann et al., 2006)

del

(Hossain et al., 2005, Vorbruggen and Jackle, 1997)

delilah

(Staudt et al., 2005)

(Shokri et al., 2019, Hassan et al., 2018, Marcogliese et al., 2017, Transgenic RNAi Project members, 2017-, Brewer-Jensen et al., 2016, Schertel et al., 2015, Ugrankar et al., 2015, Rogers et al., 2014, Victorsen and White, 2014.4.15, Egoz-Matia et al., 2011)

Name Synonyms

Delilah

(Michelson and Volk, 2011.11.28)

delilah

(Tokusumi et al., 2017, Chanana et al., 2007, Sandmann et al., 2006, Staudt et al., 2005, Volk et al., 1997)

jumper

(Varte et al., 2022)

taxi

(Varte et al., 2022, Michelson and Volk, 2011.11.28)

taxi wings

(Egoz-Matia et al., 2011)

Secondary FlyBase IDs

FBgn0263118
FBgn0008649
FBgn0003904
FBgn0004684

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 33 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43190

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P41894

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P41894

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4LIQ1

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P41894

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43190/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0288888

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0288888

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG5441

MARRVEL_MODEL - MARRVEL (model organism gene)

43190

Linkouts

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0288888

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5441

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

References (116)

The following external sites may use different assemblies or annotations than FlyBase.

-1.06

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