Parkinson disease (PD) is a neurodegenerative disease usually typified by slow onset in mid to late adulthood; there are also early-onset and juvenile forms of the disease. Symptoms worsen over time and include resting tremor, muscular rigidity, bradykinesia [abnormal slowness of movement], and postural instability [impaired balance and coordination]; additional symptoms may include postural abnormalities, dysautonomia [symptoms caused by malfunction of the autonomic nervous system], dystonic cramps, and dementia. Parkinson disease is the second-most common neurodegenerative disease (after Alzheimer disease), affecting approximately 1% of the population over 50 (Polymeropoulos et al., 1996, pubmed:8895469). [from OMIM:168600; 2013.07.23]
[PARKINSON DISEASE 14, AUTOSOMAL RECESSIVE; PARK14](https://omim.org/entry/612953)
[PHOSPHOLIPASE A2, GROUP VI; PLA2G6](https://omim.org/entry/603604)
Patients diagnosed with PARK14 show little or no brain iron accumulation.