Identified in a GWAS analysis of Chinese men with non-obstructive azoospermia (FBrf0227519), the human gene YIPF5 is proposed as a candidate gene for involvement in human male fertility. YIPF5 is a transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum. There is a single fly ortholog, Yip1d1, for which RNAi-targeting constructs and alleles caused by insertional mutagenesis have been generated. Dmel\Yip1d1 is also orthologous to the human gene YIPF7.
A UAS construct of a wild-type human Hsap\YIPF5 gene has been introduced into flies, but has not been characterized.
[updated Oct. 2019 by FlyBase; FBrf0222196]