Identified in a GWAS analysis of Chinese men with non-obstructive azoospermia (FBrf0227519), the human gene ZNF622 is proposed as a candidate gene for involvement in human male fertility. ZNF622 is a zinc finger protein postulated to act as an activator of specific transcription factors. There is a single fly ortholog, CG6769, for which RNAi-targeting constructs and an allele caused by insertional mutagenesis have been generated.
The ZNF622 gene has not been introduced into flies.
In Drosophila, tissue-specific knockdown of CG6769 using GAL4/UAS-RNAi results in reduced male fertility; functional CG6769 is required in the somatic cells of the testis for normal fertility. Physical interactions of the Dmel\CG6769 protein product have been described; see below and in the FlyBase gene report for CG6769.
[updated Apr. 2016 by FlyBase; FBrf0222196]