Open Close
General Information
Name
prostate cancer, PAX-related
FlyBase ID
FBhh0000455
Disease Ontology Term
Parent Disease
OMIM
Overview

This model of prostate cancer is based on the observation that the Drosophila adult male accessory gland acts as a functional homolog of the mammalian prostate. It was hypothesized that normal cell growth and migration of secondary cells in the accessory gland may be regulated by Drosophila orthologs of known regulators of human prostate cancer progression. The fly gene prd is orthologous to multiple human PAX genes, including PAX2, which may promote cell growth and migration of prostate cancer cells. (FBrf0226167)

Dmel\prd is the eponymous member of the paired-type homeodomain family of transcription factors, and is orthologous to multiple human genes. It is a high-scoring ortholog of PAX3 and PAX7, both of which have been introduced into flies (see Hsap\PAX3 and Hsap\PAX7); it is a low-scoring ortholog of PAX2, which has not been introduced into flies.

Amorphic mutations of Dmel\prd result in embryonic lethality. For assessment of function in the accessory gland, RNAi-mediated knockdown of prd was controlled by using a temperature-sensitive driver and targeting newly eclosed, newly mated males. Knockdown of prd results in a significant decrease in the number of secondary cells compared to controls; the phenotype is variable with incomplete penetrance. Genetic interactions of Dmel\prd have been characterized; see the gene report for prd.

[updated Dec. 2016 by FlyBase; FBrf0222196]

Disease Summary Information
Parent Disease Summary: prostate cancer
Symptoms and phenotype

Prostate cancer is the most common cancer in American men and is usually very slowly progressive; it is diagnosed in an estimated 80% of men who reach age 80 (http://www.webmd.com/prostate-cancer; 2016.12.20).

Specific Disease Summary: prostate cancer, PAX-related
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information
External links
Disease synonyms
Ortholog Information
Human gene(s) in FlyBase
Human gene (HGNC)
Symbol / Name
D. melanogaster ortholog (based on DIOPT)
Comments on ortholog(s)

Many to many: Dmel\sv is the highest-scoring ortholog of PAX2; Dmel\prd is one of several low-scoring orthologs.

Human gene (HGNC)
Symbol / Name
D. melanogaster ortholog (based on DIOPT)
Comments on ortholog(s)

Many to many.

Human gene (HGNC)
Symbol / Name
D. melanogaster ortholog (based on DIOPT)
Comments on ortholog(s)

Many to many.

Other mammalian ortholog(s) used
    D. melanogaster Gene Information (1)
    Gene Snapshot
    paired (prd) is a paired-rule gene that encodes a transcription factor with two independent DNA binding domains, a paired domain and a homeodomain. Its roles include embryonic segmentation, accessory gland development and male fertility. [Date last reviewed: 2019-03-14]
    Cellular component (GO)
    Gene Groups / Pathways
    Comments on ortholog(s)

    High-scoring ortholog of human PAX3 and PAX7; low-scoring ortholog of PAX2 and multiple others (many Drosophila to many human). Dmel\prd shares 41-45% identity and 50-56% similarity with human PAX3 and PAX7; it shares 32% identity and 43% similarity with PAX2.

    Orthologs and Alignments from DRSC
    DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
    Synthetic Gene(s) Used (0)
    Summary of Physical Interactions (5 groups)
    protein-protein
    Interacting group
    Assay
    References
    bimolecular fluorescence complementation, fluorescence microscopy
    far western blotting, autoradiography, pull down
    Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
    Genetic Tools, Stocks and Reagents
    Sources of Stocks
    Contact lab of origin for a reagent not available from a public stock center.
    Bloomington Stock Center Disease Page
    Selected mammalian transgenes
    Allele
    Transgene
    Publicly Available Stocks
    Selected Drosophila transgenes
    Allele
    Transgene
    Publicly Available Stocks
    RNAi constructs available
    Allele
    Transgene
    Publicly Available Stocks
    Selected Drosophila classical alleles
    Allele
    Allele class
    Mutagen
    Publicly Available Stocks
    amorphic allele - genetic evidence
    X ray
    References (4)