The SRC gene encodes a non-receptor protein tyrosine kinase that participates in multiple signaling pathways involved in gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, cell migration, and transformation. SRC is overexpressed or activated in multiple human malignancies, including a high incidence in colorectal cancers. The highest-scoring orthologous gene in Drosophila is Src64B, for which classical amorphic and hypomorphic alleles, RNAi-targeting constructs, and alleles caused by insertional mutagenesis have been generated. A lower-scoring ortholog, Dmel\Src42A has also been used to investigate the role of SRC in colorectal cancer. There are multiple other paralogous and orthologous genes in both species.
The human SRC gene has not been introduced into flies.
Animals homozygous for an amorphic allele of Dmel\Src64B survive to adulthood; female fertility is severely reduced. When wild-type Src64B is over-expressed in stem cells of the adult gut, intestinal stem cell hyperproliferation and hyperplasia of the adult intestine is observed. Physical and genetic interactions for Dmel\Src64B have been described; see below and in the gene report for Src64B.
Animals homozygous for hypomorphic alleles of Dmel\Src42A die during embryogenesis. When an activated form of Src42A is expressed in stem cells of the adult gut, the resulting phenotype is very similar to that seen for overexpression of Src64B : intestinal stem cell hyperproliferation and hyperplasia of the adult intestine. Many physical and genetic interactions for Dmel\Src42A have been described; see below and in the gene report for Src42A.
[updated Jan. 2017 by FlyBase; FBrf0222196]
The SRC gene is frequently implicated in cancer. [from MIM:190090; 2017.01.17]
The SRC protein participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. [from Gene Cards, SRC; 2017.01.17]
The SRC gene encodes a nonreceptor tyrosine kinase homologous in sequence to the v-src gene of the Rous sarcoma virus. [from MIM:190090; 2017.01.17]
Many to many: multiple paralogs and orthologs in both species.
Highest-scoring ortholog of human gene SRC (many to many; multiple paralogs and orthologs in both species). Dmel\Src64B shares 50% identity and 67% similarity with human SRC.
High-scoring ortholog of human gene FRK; lower-scoring ortholog of human SRC (many to many; multiple paralogs and orthologs in both species). Dmel\Src42A shares 54% identity and 68% similarity with human FRK.
