Using Drosophila, an assessment of changes in microRNA expression in response to an acute sedating dose of alcohol identified multiple miRNAs that change significantly. Two miRNAs were identified that when overexpressed significantly increased ethanol sensitivity: mir-6 (a cluster of 3 miRNA genes, mir-6-1, mir-6-2, and mir-6-3) and mir-310. MicroRNA target prediction analysis suggests that the different alcohol-responsive miRNAs target overlapping sets of mRNAs.
[updated Jan. 2018 by FlyBase; FBrf0222196]
Alcoholism can be defined as persistence of excessive drinking over a long period of time despite adverse health effects and disruption of social relations (Morozova et al., 2014; pubmed:24395673).
The 2013 Diagnostic and Statistical Manual of Mental Disorders (DSM) combined the two former categorizations of abnormal alcohol use (alcohol abuse and alcohol dependence) into one diagnosis: alcohol use disorder. The severity of an individual's AUD is broken into classifications: mild, moderate, or severe. "Alcoholism" is a non-medical term often used to describe a severe form of alcohol use disorder. (https://www.therecoveryvillage.com/recovery-blog/alcoholism-alcohol-use-disorder-whats-difference/)
Excessive alcohol consumption is associated with increased risk of different types of cancer, higher cardiovascular disease mortality, birth defects, liver diseases, and neuropsychiatric disorders (Morozova et al., 2014; pubmed:24395673).
Alcoholism is a multifactorial, genetically influenced disorder. [from MIM:103780; 2017.12.19]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (NCBI Gene, MIR9-1; 2018.01.22)
5' seed sequence homologous to that of several human microRNAs, including MIR27A, MIR27B and MIR128 (FBrf0242402).
5' seed sequence homologous to that of several human microRNAs, including MIR27A, MIR27B and MIR128 (FBrf0242402).
5' seed sequence homologous to that of several human microRNAs, including MIR27A, MIR27B and MIR128 (FBrf0242402).
Orthologous to human MIR92A (FBrf0242402).
Orthologous to human MIR92A (FBrf0242402).
Orthologous to human MIR92A, MIR92B, and MIR25 (FBrf0242402).
Orthologous to human MIR92A and MIR25 (FBrf0242402).
