FB2025_01 , released February 20, 2025
Human Disease Model Report: cancer, intestinal stem cell, APC-RAS-SNA-related
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General Information
Name
cancer, intestinal stem cell, APC-RAS-SNA-related
FlyBase ID
FBhh0001110
Disease Ontology Term
Parent Disease
OMIM
Overview

This report describes a model of metastatic intestinal cancer that uses the Drosophila sna gene in combination with an existing model of intestinal cancer (FBhh0000912) using Apc or Apc2 with Ras85D. The established APC-RAS-related model of intestinal stem cell cancer does not show metastatic behavior outside the Drosophila midgut, which is analogous to the human small intestine.

This APC-RAS-SNA metastatic cancer model was designed as an extension of the existing APC-RAS model, which does not show metastatic qualities. For details about the roles of Apc, Apc2, and Ras85D in this model, see the human disease model report 'cancer, intestinal stem cell, APC-RAS-related' (FBhh0000912).

Similar to APC-RAS tumors, APC-RAS-SNA clones grow rapidly in the gut, but also metastasize to multiple other locations (head, ovary, legs) within 2-3 weeks. These tumors can cross the blood-brain barrier, and tumor allografts grow rapidly and invasively in new hosts, causing death within 2 weeks. APC-RAS-SNA tumor cells show evidence of a partial epithelial-to-mesenchymal transition, including disrupted polarity and the ability to migrate through basal lamina, but they still express E-cadherin (shg), although it was not restricted to the apical surface. Tumor cells are also found enveloping the trachea and in the hemolymph, which is similar to how tumors metastasize in mammalian models.

[updated Aug 2019 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: cancer, intestinal stem cell, APC-RAS-SNA-related
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information

SNA and its paralogs have a well-studied role in initiating the epithelial-to-mesenchymal transition during early development, but this function can be pathologic if enabled in tumor cells (Barrallo-Gimeno & Nieto 2005 and references therein, FBrf0190271).

(FlyBase Curators, 2013-)
External links
Disease synonyms
Search term: neoplastic phenotype
Ortholog Information
Human gene(s) in FlyBase
Human gene (HGNC)
Symbol / Name
HRAS; HRas proto-oncogene, GTPase
D. melanogaster ortholog (based on DIOPT)
Dmel\Ras85D
(DIOPT, 2013-)
Comments on ortholog(s)

Many to many: multiple paralogs and orthologs in both species.

Human gene (HGNC)
Symbol / Name
SNAI2; snail family transcriptional repressor 2
D. melanogaster ortholog (based on DIOPT)
Dmel\sna
(DIOPT, 2013-)
Dmel\esg
(DIOPT, 2013-)
Dmel\esg
(DIOPT, 2013-)
Comments on ortholog(s)

Many to many: multiple paralogs and orthologs in both species.

Human gene (HGNC)
Symbol / Name
APC; APC regulator of WNT signaling pathway
D. melanogaster ortholog (based on DIOPT)
Dmel\Apc
(DIOPT, 2013-)
Dmel\Apc2
(DIOPT, 2013-)
Comments on ortholog(s)

Many to many: 2 human to 2 Drosophila. There are two orthologous genes in each species, APC and APC2 in humans, Apc and Apc2 in flies.

Human gene (HGNC)
Symbol / Name
NRAS; NRAS proto-oncogene, GTPase
D. melanogaster ortholog (based on DIOPT)
Dmel\Ras85D
(DIOPT, 2013-)
Comments on ortholog(s)

Many to many: multiple paralogs and orthologs in both species.

Human gene (HGNC)
Symbol / Name
KRAS; KRAS proto-oncogene, GTPase
D. melanogaster ortholog (based on DIOPT)
Dmel\Ras85D
(DIOPT, 2013-)
Comments on ortholog(s)

Many to many: multiple paralogs and orthologs in both species.

Other mammalian ortholog(s) used
    D. melanogaster Gene Information (5)
    Dmel\Ras85D
    Gene Snapshot
    Ras oncogene at 85D (Ras85D) encodes a protein that acts downstream of several cell signals, most notably from Receptor Tyrosine Kinases, to regulate tissue growth and development. When abnormally activated it can direct developmental defects and tissue hyperplasia, mimicking aspects of human disease including Rasopathies and cancer, respectively. [Date last reviewed: 2019-03-14]
    Molecular function (GO)
    Cellular component (GO)
    Gene Groups / Pathways
    Comments on ortholog(s)

    High-scoring ortholog of human genes KRAS, HRAS, and NRAS (many to many; multiple paralogs and orthologs in both species). Dmel\Ras85D shares 78-86% identity and 86-92% similarity with KRAS, HRAS, and NRAS; for these three human genes, Ras85D is the highest-scoring ortholog in Drosophila.

    Orthologs and Alignments from DRSC
    DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
    H. sapiens (Human)
    Dmel\sna
    Gene Snapshot
    snail (sna) encodes a transcription factor that contributes to embryonic mesoderm development, epithelial to mesenchymal transition and asymmetric cell division. [Date last reviewed: 2019-03-14]
    Molecular function (GO)
    Cellular component (GO)
    Gene Groups / Pathways
    Comments on ortholog(s)

    Moderately-ranking ortholog of human SNAI2. SNAI2's best-ranking Drosophila ortholog is a sna paralog, Dmel\esg.

    Orthologs and Alignments from DRSC
    DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
    H. sapiens (Human)
    Dmel\Apc
    Gene Snapshot
    APC-like (Apc) encodes one of two Drosophila APC family proteins. It is a key negative regulator of Wingless signaling, as a critical component of the destruction complex that phosphorylates beta-catenin and thus targets it for ubiquitination and proteasomal destruction. It is the primary family member during CNS and eye development, and functions redundantly with the product of Apc2 in adult development. [Date last reviewed: 2019-03-07]
    Molecular function (GO)
    Cellular component (GO)
    Gene Groups / Pathways
    Comments on ortholog(s)

    Ortholog of human genes APC and APC2 (2 Drosophila to 2 human). Dmel\Apc shares 25-26% identity and 37% similarity with both human genes; it lacks a microtubule-binding domain found at the C terminus of the human APC gene.

    Orthologs and Alignments from DRSC
    DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
    H. sapiens (Human)
    Dmel\Apc2
    Gene Snapshot
    Adenomatous polyposis coli 2 (Apc2) encodes one of two Drosophila APC family proteins. It is a key negative regulator of Wingless signaling, as a critical component of the destruction complex that phosphorylates beta-catenin and thus targets it for ubiquitination and proteasomal destruction. It is the primary APC family member during embryonic development, and functions redundantly with the product of Apc in adult development. [Date last reviewed: 2019-03-07]
    Molecular function (GO)
    Cellular component (GO)
    Gene Groups / Pathways
    Comments on ortholog(s)

    Ortholog of human genes APC and APC2 (2 Drosophila to 2 human). Dmel\Apc2 is significantly shorter than both human genes and the orthologous fly gene, Dmel\Apc. Dmel\Apc2 shares 26-27% identity and 37-38% similarity with both human genes; it lacks a microtubule-binding domain found at the C terminus of the human APC gene.

    Orthologs and Alignments from DRSC
    DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
    H. sapiens (Human)
    Dmel\esg
    Gene Snapshot
    escargot (esg) encodes a Snail-type transcription factor that contributes to stem cell maintenance, tracheal morphogenesis and neuroblast differentiation. [Date last reviewed: 2019-03-07]
    Molecular function (GO)
    Cellular component (GO)
    Gene Groups / Pathways
    Comments on ortholog(s)

    Highest-ranking ortholog of human SNAI2.

    Orthologs and Alignments from DRSC
    DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
    H. sapiens (Human)
    Other Genes Used: Viral, Bacterial, Synthetic (0)
      Summary of Physical Interactions (68 groups)
      Ras85D
      protein-protein
      Interacting group
      Assay
      References
      Ras85D - alt
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      Ras85D - Arc1
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      Ras85D - CG31550
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      Ras85D - cindr
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      Ras85D - cno
      two hybrid, anti tag coimmunoprecipitation, autoradiography
      (Boettner and Van Aelst, 2007, Carmena et al., 2006)
      Ras85D - Droj2
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      Ras85D - eIF3i
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      Ras85D - glo
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      Ras85D - Gyc76C
      anti tag coimmunoprecipitation, anti tag western blot
      (Iwashita et al., 2020)
      Ras85D - lark
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      Ras85D - mod(mdg4)
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      Ras85D - Nf1
      gtpase assay, autoradiography
      (Walker et al., 2006)
      Ras85D - Nop60B
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      Ras85D - Pi3K92E
      pull down, western blot, two hybrid
      (Orme et al., 2006)
      Ras85D - pico
      two hybrid
      (Lyulcheva et al., 2008)
      Ras85D - Pyk
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      Ras85D - Raf
      two hybrid, pull down, anti tag coimmunoprecipitation, anti tag western blot
      (Yang and Terman, 2012, Ding et al., 2010, Mishra et al., 2005)
      Ras85D - rau
      pull down, anti tag western blot
      (Sieglitz et al., 2013)
      Ras85D - Rgl
      two hybrid
      (Mirey et al., 2003)
      Ras85D - RpL6
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      Ras85D - RpL15
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      Ras85D - RpL21
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      Ras85D - RpL23A
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      Ras85D - RpL24
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      Ras85D - RpS2
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      Ras85D - RpS27
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      Ras85D - spri
      anti tag coimmunoprecipitation, anti tag western blot
      (Jekely et al., 2005)
      Ras85D - Sumo
      anti tag coimmunoprecipitation, Identification by mass spectrometry, pull down, covalent binding, western blot
      (Nie et al., 2009)
      sna
      protein-protein
      Interacting group
      Assay
      References
      sna - CG15514
      two hybrid array
      (Shokri et al., 2019)
      sna - CG31955
      two hybrid array
      (Shokri et al., 2019)
      sna - CtBP
      two hybrid, pull down, autoradiography
      (Qi et al., 2008, Stern et al., 2007, Hasson et al., 2001, Nibu et al., 1998)
      sna - ebi
      pull down, autoradiography
      (Qi et al., 2008)
      sna - Ets65A
      two hybrid array
      (Shokri et al., 2019)
      sna - foxo
      two hybrid array, pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot
      (Guo et al., 2022, Shokri et al., 2019)
      sna - Hr78
      two hybrid array
      (Shokri et al., 2019)
      sna - sd
      anti tag coimmunoprecipitation, anti tag western blot, pull down
      (Ding et al., 2022)
      Apc
      protein-protein
      Interacting group
      Assay
      References
      Apc - Apc2
      colocalization, fluorescence microscopy, inferred by author, two hybrid
      (Mattie et al., 2010)
      Apc - arm
      coimmunoprecipitation, western blot, pull down, autoradiography
      (Hamada and Bienz, 2004, Hayashi et al., 1997)
      Apc - CtBP
      pull down, autoradiography
      (Hamada and Bienz, 2004)
      Apc - dia
      pull down, anti tag western blot
      (Jaiswal et al., 2013, Webb et al., 2009)
      Apc - Eb1
      two hybrid
      (Mattie et al., 2010)
      Apc - Kap3
      two hybrid
      (Mattie et al., 2010)
      Apc2
      protein-protein
      Interacting group
      Assay
      References
      Apc2
      anti tag coimmunoprecipitation, western blot, anti tag western blot, two hybrid
      (Kunttas-Tatli et al., 2014, Roberts et al., 2012, Zhou et al., 2011)
      Apc2 - Apc
      colocalization, fluorescence microscopy, inferred by author, two hybrid
      (Mattie et al., 2010)
      Apc2 - arm
      anti bait coimmunoprecipitation, western blot, pull down, autoradiography, anti tag coimmunoprecipitation, anti tag western blot, two hybrid
      (Croy et al., 2016, Yamulla et al., 2014, Kunttas-Tatli et al., 2012, Buttrick et al., 2008, Hamada and Bienz, 2004, McCartney et al., 1999, Yu et al., 1999)
      Apc2 - Axn
      two hybrid, anti tag coimmunoprecipitation, anti tag western blot, western blot, bimolecular fluorescence complementation, fluorescence microscopy
      (Lybrand et al., 2019, Tacchelly-Benites et al., 2018, Croy et al., 2016, Wang et al., 2016, Kunttas-Tatli et al., 2015, Pronobis et al., 2015, Peradziryi et al., 2011, Roberts et al., 2011)
      Apc2 - CtBP
      pull down, autoradiography, Identification by mass spectrometry
      (Hamada and Bienz, 2004)
      Apc2 - dia
      anti bait coimmunoprecipitation, western blot, pull down, anti tag western blot
      (Webb et al., 2009)
      Apc2 - Hmg-2
      experimental knowledge based
      (Guruharsha et al., 2011)
      Apc2 - Kap3
      anti tag coimmunoprecipitation, anti tag western blot
      (Kunttas-Tatli et al., 2014)
      Apc2 - sgg
      pull down, autoradiography
      (Yu et al., 1999)
      Apc2 - Tnks
      two hybrid, anti tag coimmunoprecipitation, western blot, pull down
      (Croy et al., 2016)
      Apc2 - trbd
      anti tag coimmunoprecipitation, anti tag western blot
      (Tran et al., 2008)
      esg
      protein-protein
      Interacting group
      Assay
      References
      esg - abd-A
      bimolecular fluorescence complementation, fluorescence microscopy
      (Bischof et al., 2018)
      esg - brk
      two hybrid array
      (Shokri et al., 2019)
      esg - CG1647
      two hybrid array
      (Shokri et al., 2019)
      esg - CG4956
      two hybrid array
      (Shokri et al., 2019)
      esg - CG6765
      two hybrid array
      (Shokri et al., 2019)
      esg - CtBP
      anti tag coimmunoprecipitation, anti tag western blot
      (Voog et al., 2014)
      esg - da
      anti tag coimmunoprecipitation, anti tag western blot, pull down
      (Yang et al., 2010)
      esg - E(spl)m8-HLH
      two hybrid array
      (Shokri et al., 2019)
      esg - HP1b
      two hybrid array
      (Shokri et al., 2019)
      esg - Ubx
      bimolecular fluorescence complementation, fluorescence microscopy
      (Bischof et al., 2018)
      RNA-RNA
      Interacting group
      Assay
      References
      esg - mir-279
      immunohistochemistry, luminiscence technology
      (Hartl et al., 2011)
      esg - mir-310
      western blot
      (Sanchez-Díaz et al., 2015)
      esg - mir-311
      western blot
      (Sanchez-Díaz et al., 2015)
      esg - mir-312
      western blot
      (Sanchez-Díaz et al., 2015)
      esg - mir-313
      western blot
      (Sanchez-Díaz et al., 2015)
      RNA-protein
      Interacting group
      Assay
      References
      esg - Fmr1
      anti bait coimmunoprecipitation, quantitative reverse transcription pcr, clip-seq
      (Buddika et al., 2021)
      Alleles Reported to Model Human Disease (Disease Ontology) (42 alleles)
      Ras85D
      Models Based on Experimental Evidence ( 16 )
      Allele
      Disease
      Evidence
      References
      Ras85DHMS01294
      model of  Noonan syndrome 3
      CEA
      (Cattaneo et al., 2020)
      Ras85DG12V.UAS
      model of  cancer
      CEA with RhoGEF2RE.UAS
      (Khoo et al., 2013)
      CEA with RokCAT.UAS
      (Khoo et al., 2013)
      CEA with sqhE20E21.UAS.cCa
      (Khoo et al., 2013)
      Ras85DG13Q.UAS
      model of  cancer
      CEA
      (Xu et al., 2023)
      CEA with PtenHMS00044, RbfHMS03004
      (Parkhitko et al., 2021)
      Ras85DN17.UAS
      model of  Noonan syndrome 3
      CEA
      (Cattaneo et al., 2020)
      Ras85DQ13.UAS
      model of  cancer
      CEA
      (Tamamouna et al., 2021)
      Ras85DV12.GMR
      model of  cancer
      CEA
      (Okada et al., 2023)
      Ras85DV12.S35.UAS
      model of  cardiomyopathy
      CEA
      (Yu et al., 2013)
      model of  carcinoma
      CEC
      (Karim and Rubin, 1998)
      Ras85DV12.UAS
      model of  carcinoma
      CEA
      (Martínez-Abarca Millán and Martín-Bermudo, 2023, Ito and Igaki, 2021, Kong et al., 2021, Rackley et al., 2021, Soler Beatty et al., 2021, Wei et al., 2021, Wu et al., 2021, Murcia et al., 2019, Zoranovic et al., 2018, Igaki et al., 2006)
      CEA with dlg1GD4689
      (Santabárbara-Ruiz and Léopold, 2021)
      CEA with l(2)gl4
      (Ding et al., 2022, Singh et al., 2022, Ito and Igaki, 2021, Wu et al., 2021, Mishra-Gorur et al., 2019, Zhang et al., 2019, Srivastava et al., 2007, Igaki et al., 2006)
      CEA with Lkb14A4-2
      (Rackley et al., 2021)
      CEA with scrib1
      (Kong et al., 2021, Mishra-Gorur et al., 2019, Srivastava et al., 2007, Igaki et al., 2006, Uhlirova and Bohmann, 2006)
      CEA with dlg114
      (Ito and Igaki, 2021, Igaki et al., 2006)
      CEA with shgk03401
      (Igaki et al., 2006)
      CEA with scrib673
      (Amcheslavsky et al., 2018)
      CEA with msn3208
      (Kong et al., 2021)
      CEA with snaUAS.cAa
      (Wu et al., 2021)
      CEA with scribKK101128
      (Murcia et al., 2019)
      CEC
      (Karim and Rubin, 1998)
      CEA with scribHMJ21977
      (Snigdha et al., 2021)
      model of  cancer
      CEA with fmt1
      (Ma et al., 2017)
      CEA with PpVΔ1
      (Ma et al., 2017)
      CEA with l(2)gl4
      (Guo et al., 2020, Ma et al., 2017, Ma et al., 2013, Pagliarini and Xu, 2003)
      CEA with PpVGD7532
      (Ma et al., 2017)
      CEA
      (Khalili et al., 2023, Martínez-Abarca Millán et al., 2023, Enomoto et al., 2021, Santabárbara-Ruiz and Léopold, 2021, Tamamouna et al., 2021, Ma et al., 2020, Jung et al., 2019, Rives-Quinto et al., 2017, Chabu and Xu, 2014, Hirabayashi et al., 2013, Ma et al., 2013)
      CEA with scrib673
      (Katheder et al., 2017)
      CEA with scrib1
      (Kakemura and Igaki, 2024, Cong et al., 2021, Hodgson et al., 2021, Katheder et al., 2017, Figueroa-Clarevega and Bilder, 2015, Külshammer et al., 2015, Stickel and Su, 2014, Willoughby et al., 2013, Wu et al., 2010, Pagliarini and Xu, 2003)
      CEA with dlg1GD4689
      (Katheder et al., 2017, Muzzopappa et al., 2017, Figueroa-Clarevega and Bilder, 2015, Willecke et al., 2011)
      CEA with scribj7B3
      (Waghmare et al., 2024, Pagliarini and Xu, 2003)
      CEA with Src64BUAS.cCa
      (Enomoto et al., 2021)
      CEA with dlg114
      (Kakemura and Igaki, 2024, Pagliarini and Xu, 2003)
      CEA with baz4
      (Pagliarini and Xu, 2003)
      CEA with sdtXN
      (Pagliarini and Xu, 2003)
      CEA with Cdc421
      (Pagliarini and Xu, 2003)
      CEA with dorC107
      (Chi et al., 2010)
      CEA with dor8
      (Chi et al., 2010)
      CEA with dorD185
      (Chi et al., 2010)
      CEA with carRNAi.UAS
      (Chi et al., 2010)
      CEA with Vps16ARNAi.UAS.WIZ
      (Chi et al., 2010)
      CEA with upd1UAS.cUa
      (Wu et al., 2010)
      CEA with upd2UAS.cUa
      (Wu et al., 2010)
      CEA with upd1UAS.cUa, upd2UAS.cUa, upd3UAS.cUa
      (Wu et al., 2010)
      CEA with l(2)glunspecified
      (Xu et al., 2023, Wu et al., 2010)
      CEA with pnutGD1512
      (Gerlach et al., 2018)
      CEA with Hsap\S100A4wt.UAS
      (Ismail et al., 2017)
      CEA with scribRNAi.UAS.cUa
      (Hodgson et al., 2021)
      CEA with CskQ156Stop
      (Hirabayashi et al., 2013)
      CEA with scribKK101128
      (Muzzopappa et al., 2017)
      CEA with mudJF02911
      (Muzzopappa et al., 2017)
      CEA with mudHMS01458
      (Muzzopappa et al., 2017)
      CEA with NRNAi.P.UAS
      (Tamamouna et al., 2021)
      CEA with NDN.UAS.cUa
      (Xu et al., 2023)
      CEA with emeiGD3587
      (Ma et al., 2020)
      CEA with Rox8GD11645
      (Guo et al., 2020)
      CEA with BacA\p35UAS.cHa
      (Khalili et al., 2023)
      CEA with dlg1RNAi.UAS.cUa
      (Bakopoulos et al., 2023)
      model of  intestinal cancer
      CEA
      (Cabrera et al., 2023, Nászai et al., 2021)
      CEA with Apc2N175K, ApcQ8
      (Martorell et al., 2014, Martorell et al., 2014)
      model of  colorectal cancer
      CEA
      (Bangi et al., 2012)
      model of  leukemia
      CEA
      (Arefin et al., 2017)
      CEA with l(2)glKK100777
      (Arefin et al., 2017)
      CEA with scribKK101128
      (Arefin et al., 2017)
      model of  benign neoplasm
      CEA with Alg9c02021
      (de Vreede et al., 2018)
      DOES NOT model  cancer
      CEA with Hsap\S100A4Δ2.UAS
      (Ismail et al., 2017)
      model of  heart disease
      CEA
      (Karekar et al., 2021)
      model of  prostate cancer
      CEA
      (Rambur et al., 2020)
      model of  high grade glioma
      CEA
      (Kumar et al., 2024)
      CEA with PtenRNAi.UAS.cUa
      (Cheng et al., 2016)
      model of  kidney cancer
      CEA
      (Zeng et al., 2010)
      model of  ovarian carcinoma
      CEA with aPKCΔN.UAS
      (Hsi et al., 2023)
      model of  hypertrophic cardiomyopathy
      CEA
      (Petersen et al., 2022)
      Ras85DV12.ey
      model of  carcinoma
      CEC
      (Karim and Rubin, 1998)
      Ras85DV12.cUa.UAS
      model of  cervical cancer
      CEA
      (Padash Barmchi et al., 2016)
      CEA with Hsap\UBE3AUAS.cRa, HPV18\E6UAS.Tag:MYC
      (Padash Barmchi et al., 2016)
      CEA with Hsap\UBE3AUAS.cRa, HPV18\E6V158A.UAS.Tag:MYC
      (Padash Barmchi et al., 2016)
      model of  cancer
      CEA with l(2)gl4
      (Fangninou et al., 2023, Liu et al., 2022, Yang et al., 2022)
      CEA with Ptp61FΔ
      (Liu et al., 2022)
      CEA with Syx73119
      (Liu et al., 2022)
      CEA with Rabex-53672
      (Liu et al., 2022)
      CEA with Vps362586
      (Liu et al., 2022)
      CEA with TSG101P26
      (Liu et al., 2022)
      CEA with NDN.UAS.cUa
      (Lee et al., 2021)
      CEA with dlg1RNAi.UAS.cUa
      (Lodge et al., 2021)
      CEA
      (Yang et al., 2022, Dong et al., 2021, Yeom et al., 2021, Dunn et al., 2018, Vicente et al., 2018)
      CEA with scrib1
      (Yang et al., 2022, Khezri et al., 2021)
      CEA with baz4
      (Yang et al., 2022)
      CEA with fmt1
      (Yang et al., 2022)
      CEA with dlg1GD4689
      (Yang et al., 2022)
      CEA with Ptip3804
      (Dong et al., 2021)
      model of  colorectal cancer
      CEA
      (Zipper et al., 2022)
      CEA with PtensgRNA.UAS
      (Zipper et al., 2022)
      CEA with MedsgRNA.UAS
      (Zipper et al., 2022)
      CEA with cicsgRNA.UAS
      (Zipper et al., 2022)
      CEA with Apc2sgRNA.UAS
      (Zipper et al., 2022)
      CEA with ApcsgRNA.UAS
      (Zipper et al., 2022)
      CEA with p53sgRNA.UAS
      (Zipper et al., 2022)
      CEA with p53VDRC.cUa, PtenGD13500, ApcVDRC.cUa, MedVDRC.cUa
      (Bangi et al., 2016)
      CEA with p53VDRC.cUa, PtenGD13500, ApcVDRC.cUa
      (Bangi et al., 2016)
      CEA with p53VDRC.cUa, ApcVDRC.cUa, MedVDRC.cUa
      (Bangi et al., 2016)
      CEA with PtenGD13500, ApcVDRC.cUa, MedVDRC.cUa
      (Bangi et al., 2016)
      model of  cardiomyopathy
      CEA
      (Yu et al., 2013)
      model of  adenocarcinoma
      CEA with l(2)glGD4047
      (Casas-Tintó et al., 2016)
      CEA with l(2)glGD4047, wupAJF02172
      (Casas-Tintó et al., 2016)
      model of  carcinoma
      CEA with Scer\GAL4nub.PU
      (Hogan et al., 2009)
      CEA with l(2)gl4
      (Sun et al., 2019)
      CEA with dlg1HMS00172
      (Toggweiler et al., 2016)
      model of  intestinal cancer
      CEA with ApcQ8
      (Campbell et al., 2019)
      CEA
      (Kim et al., 2022, Singh et al., 2016)
      CEA with Apc2N175K, ApcQ8
      (Parisi et al., 2023)
      CEA with ApcGD1333, p53GD4483
      (Quintero and Bangi, 2023)
      CEA with ApcGD1333, PtenRNAi.UAS.cUa, p53GD4483
      (Quintero and Bangi, 2023)
      CEA with ApcGD1333, MedGD1483, p53GD4483
      (Quintero and Bangi, 2023)
      model of  high grade glioma
      CEA with PtenRNAi.Exel.UAS
      (Gangwani et al., 2020)
      CEA
      (Liu et al., 2021)
      model of  brain cancer
      CEA with dlg1GD4689
      (Manzanero-Ortiz et al., 2021)
      CEA with l(2)glKK100777
      (Manzanero-Ortiz et al., 2021)
      CEA with wtsKK101055
      (Manzanero-Ortiz et al., 2021)
      CEA with scrib673
      (Manzanero-Ortiz et al., 2021)
      Ras85DV152G.UASp
      model of  Noonan syndrome 3
      CEA
      (Cattaneo et al., 2020)
      Ras85DG12V.UAS.Tag:FLAG,Tag:polyHis
      model of  cancer
      CEA
      (Washington et al., 2020)
      Ras85DY4F.G12V.UAS.Tag:FLAG,Tag:polyHis
      model of  cancer
      CEA
      (Washington et al., 2020)
      Ras85DV12.QUAS.cHa
      model of  cancer
      CEA with scrib1
      (Hodgson et al., 2021)
      Ras85DV12.QUAS.cLa
      model of  cancer
      CEA with scribQUAS.HMS01490
      (Bakopoulos et al., 2023, Lodge et al., 2021)
      Ras85DG12D.UAS.p53sh
      model of  pancreatic ductal adenocarcinoma
      CEA with CycEUAS.Tag:HA.Medsh, MedRNAi.UAS.CycE-HA, p53RNAi.UAS.RasG12D
      (Sekiya et al., 2023)
      Modifiers Based on Experimental Evidence ( 18 )
      Allele
      Disease
      Interaction
      References
      Ras85DΔC40B
      ameliorates  multiple endocrine neoplasia type 2B
      modeled by RetMEN2B.GMR
      (Read et al., 2005)
      Ras85D06677
      ameliorates  autosomal dominant cerebellar ataxia
      modeled by Hsap\ATXN182Q.UAS
      (Park et al., 2013)
      ameliorates  multiple endocrine neoplasia type 2B
      modeled by RetMEN2B.GMR
      (Read et al., 2005)
      ameliorates  multiple endocrine neoplasia type 2A
      modeled by RetMEN2A.GMR
      (Read et al., 2005)
      ameliorates  alveolar rhabdomyosarcoma
      modeled by Hsap\FOXO1::Hsap\PAX7UAS.cGa
      (Galindo et al., 2006)
      Ras85DG13Q.UAS
      model of  cancer
      is exacerbated by ITPUAS.F
      (Xu et al., 2023)
      Ras85DN17.UAS
      ameliorates  brain glioma
      modeled by btl::Egfrλ.UAS, Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
      (Read et al., 2009)
      Ras85DQ13.UAS
      model of  cancer
      is ameliorated by CatUAS.cAa
      (Tamamouna et al., 2021)
      is ameliorated by Sod1UAS.cAa
      (Tamamouna et al., 2021)
      is ameliorated by btlDN.UAS
      (Tamamouna et al., 2021)
      Ras85DV12.GMR
      model of  cancer
      is ameliorated by InRGL00139
      (Okada et al., 2023)
      is ameliorated by InRJF01183
      (Okada et al., 2023)
      is ameliorated by InRJF01482
      (Okada et al., 2023)
      is ameliorated by InRK1409A.UAS
      (Okada et al., 2023)
      is ameliorated by NetBΔ
      (Okada et al., 2023)
      is ameliorated by NetBKK103672
      (Okada et al., 2023)
      is ameliorated by NetBVSH330183
      (Okada et al., 2023)
      is ameliorated by unc-5HMS01099
      (Okada et al., 2023)
      is ameliorated by unc-5KK102074
      (Okada et al., 2023)
      is ameliorated by unc-5MI04273
      (Okada et al., 2023)
      Ras85DV12.UAS
      model of  carcinoma
      is exacerbated by mysRNAi.UAS.cUa
      (Martínez-Abarca Millán and Martín-Bermudo, 2023)
      is exacerbated by dapHMS01610
      (Ito and Igaki, 2021)
      is exacerbated by dapHMS05362
      (Ito and Igaki, 2021)
      is ameliorated by pntP1.UAS
      (Ito and Igaki, 2021)
      is exacerbated by hepAct.UAS
      (Uhlirova and Bohmann, 2006)
      is exacerbated by egrUAS.cIa
      (Igaki et al., 2006)
      is exacerbated by ZnT86DKK101698
      (Wei et al., 2021)
      is exacerbated by msn172
      (Kong et al., 2021)
      is exacerbated by msn3208
      (Kong et al., 2021)
      is exacerbated by l(2)gl4
      (Wu et al., 2021)
      is exacerbated by snaUAS.cAa
      (Wu et al., 2021)
      is ameliorated by rlGD4697
      (Murcia et al., 2019)
      is ameliorated by RafDN.UAS
      (Zoranovic et al., 2018)
      is exacerbated by Tsp29FbGD1018
      (Zoranovic et al., 2018)
      is ameliorated by Tsp29FbUAS.Tag:HA
      (Zoranovic et al., 2018)
      is ameliorated by Hsap\CDKN1AUAS.cHa
      (Karim and Rubin, 1998)
      is ameliorated by RafXS-2541
      (Karim and Rubin, 1998)
      is exacerbated by rlSem
      (Karim and Rubin, 1998)
      is exacerbated by EgfrapΔSH2
      (Soler Beatty et al., 2021)
      is exacerbated by EgfrapHMJ23378
      (Soler Beatty et al., 2021)
      is exacerbated by EgfrapLS
      (Soler Beatty et al., 2021)
      is exacerbated by EgfrapL
      (Soler Beatty et al., 2021)
      is exacerbated by PVRAPHMJ23233
      (Soler Beatty et al., 2021)
      is ameliorated by HAdV-C\E4orf4UAS.cPa
      (Rosen et al., 2019)
      is ameliorated by HAdV-C\E4orf4UAS.cPb
      (Rosen et al., 2019)
      model of  cancer
      is ameliorated by Sec6GD11616
      (Chabu and Xu, 2014)
      is ameliorated by Sec8KK101531
      (Chabu and Xu, 2014)
      is ameliorated by Sec15KK101708
      (Chabu and Xu, 2014)
      is ameliorated by Sec151
      (Chabu and Xu, 2014)
      is ameliorated by Sec15GD12109
      (Chabu and Xu, 2014)
      is ameliorated by Src64BGD12263
      (Ma et al., 2013)
      is ameliorated by DroncNIG.8091R
      (Waghmare et al., 2024)
      is ameliorated by bskDN.UAS
      (Waghmare et al., 2024)
      is ameliorated by sggS9A.UAS
      (Waghmare et al., 2024)
      is ameliorated by ykiRNAi.N.UAS
      (Waghmare et al., 2024)
      is ameliorated by ykiRNAi.C.UAS
      (Waghmare et al., 2024)
      is ameliorated by chinmo1
      (Enomoto et al., 2021)
      is exacerbated by PVRAP1
      (Martínez-Abarca Millán et al., 2023)
      is exacerbated by PVRAPHMJ23233
      (Martínez-Abarca Millán et al., 2023)
      is exacerbated by by33c
      (Martínez-Abarca Millán et al., 2023)
      is exacerbated by byVSH330366
      (Martínez-Abarca Millán et al., 2023)
      is exacerbated by CskQ156Stop
      (Hirabayashi et al., 2013)
      is exacerbated by emei1
      (Ma et al., 2020)
      is exacerbated by emei2
      (Ma et al., 2020)
      is exacerbated by emei3
      (Ma et al., 2020)
      is ameliorated by Arc1esm18
      (Khalili et al., 2023)
      is exacerbated by Nek2UAS.GFP
      (Das et al., 2013)
      model of  intestinal cancer
      is ameliorated by CortactinHMS00658
      (Cabrera et al., 2023)
      is ameliorated by CortactinKK108594
      (Cabrera et al., 2023)
      is ameliorated by shgHMS00693
      (Cabrera et al., 2023)
      is ameliorated by shgJF02769
      (Cabrera et al., 2023)
      exacerbates  alveolar rhabdomyosarcoma
      modeled by Hsap\FOXO1::Hsap\PAX7UAS.cGa
      (Galindo et al., 2006)
      exacerbates  gastrointestinal system cancer
      modeled by Apc2g10, ApcQ8
      (Wang et al., 2013)
      model of  colorectal cancer
      is ameliorated by bskDN.UAS
      (Bangi et al., 2012)
      is ameliorated by bskHMS00777
      (Bangi et al., 2012)
      is exacerbated by hepAct.UAS
      (Bangi et al., 2012)
      is exacerbated by imdUAS.cGa
      (Bangi et al., 2012)
      is ameliorated by JraNIG.2275R
      (Bangi et al., 2012)
      is ameliorated by TimpUAS.cPa
      (Bangi et al., 2012)
      ameliorates  cancer
      modeled by dlg1A40.2
      (Parisi et al., 2014)
      exacerbates  carcinoma
      modeled by scrib1
      (Brumby and Richardson, 2003)
      modeled by armUAS.Exel
      (Zhang et al., 2019)
      model of  prostate cancer
      is ameliorated by EgfrGD1654
      (Rambur et al., 2020)
      is ameliorated by Pi3K92EHMC05152
      (Rambur et al., 2020)
      is ameliorated by mTorGL00156
      (Rambur et al., 2020)
      is ameliorated by rlHMS00173
      (Rambur et al., 2020)
      is ameliorated by spiHMS01120
      (Rambur et al., 2020)
      exacerbates  intestinal cancer
      modeled by Rab11KK108297
      (Nie et al., 2019)
      exacerbates  cancer
      modeled by HipkUAS.Tag:HA
      (Blaquiere et al., 2018)
      model of  kidney cancer
      is ameliorated by Pka-C1B3
      (Zeng et al., 2010)
      is ameliorated by mTorΔP
      (Zeng et al., 2010)
      exacerbates  Alzheimer's disease 1
      modeled by Hsap\APPAβ42.UAS.cUa
      (Cheng et al., 2021)
      Ras85DV12.ey
      model of  carcinoma
      is ameliorated by RafXS-2541
      (Karim and Rubin, 1998)
      Ras85De1B
      ameliorates  alveolar rhabdomyosarcoma
      modeled by Hsap\FOXO1::Hsap\PAX7UAS.cGa
      (Galindo et al., 2006)
      exacerbates  viral infectious disease
      modeled by EBV\BZLF1GMR.PA
      (Adamson and Lajeunesse, 2012)
      exacerbates  infectious mononucleosis
      modeled by EBV\BZLF1GMR.PA
      (Adamson and Lajeunesse, 2012)
      exacerbates  Epstein-Barr virus hepatitis
      modeled by EBV\BZLF1GMR.PA
      (Adamson and Lajeunesse, 2012)
      ameliorates  gastrointestinal system cancer
      modeled by Apc2g10, ApcQ8
      (Wang et al., 2013)
      exacerbates  tuberous sclerosis
      modeled by Tsc1UAS.cTa, gigUAS.cTa
      (Tapon et al., 2001)
      ameliorates  cancer
      modeled by AlkUAS.cLa
      (Wolfstetter et al., 2020)
      Ras85De2F
      ameliorates  alveolar rhabdomyosarcoma
      modeled by Hsap\FOXO1::Hsap\PAX7UAS.cGa
      (Galindo et al., 2006)
      Ras85Dunspecified
      ameliorates  neurofibromatosis
      modeled by Nf1E2
      (Walker et al., 2006)
      Ras85DV12.cUa.UAS
      model of  cancer
      is exacerbated by exe1
      (Liu et al., 2022)
      is exacerbated by Ptp61FΔ
      (Liu et al., 2022)
      is exacerbated by Not3KK102144
      (Vicente et al., 2018)
      is exacerbated by M6W186stop
      (Dunn et al., 2018)
      is ameliorated by Ptip3804
      (Dong et al., 2021)
      is exacerbated by p53UAS.cUa
      (Dong et al., 2021)
      is ameliorated by Ilp8MI00727
      (Yeom et al., 2021)
      model of  intestinal cancer
      is ameliorated by CortactinHMS00658
      (Kim et al., 2022)
      model of  high grade glioma
      is ameliorated by Dcp-1RNAi.UAS.cUa
      (Liu et al., 2021)
      is exacerbated by NmnatUAS.PC
      (Liu et al., 2021)
      is ameliorated by NmnatRNAi.UAS.cUa
      (Liu et al., 2021)
      Ras85DGD12553
      ameliorates  colorectal cancer
      modeled by Src42ACA.UAS
      (Cordero et al., 2014)
      modeled by Src64BUAS.cCa
      (Cordero et al., 2014)
      ameliorates  neurofibromatosis
      modeled by Nf1JF01866
      (Georganta et al., 2021)
      Ras85DKK108029
      ameliorates  colorectal cancer
      modeled by Src42ACA.UAS
      (Cordero et al., 2014)
      modeled by Src64BUAS.cCa
      (Cordero et al., 2014)
      ameliorates  intestinal cancer
      modeled by EgfrUAS.cBa
      (Nászai et al., 2021)
      Ras85DJF02478
      ameliorates  colorectal cancer
      modeled by SH3PX1HMJ21552
      (Zhang et al., 2019)
      Ras85DG12V.UAS.Tag:FLAG,Tag:polyHis
      model of  cancer
      is exacerbated by Egfr2.UAS
      (Washington et al., 2020)
      is ameliorated by Rabex-5DPYT.UAS.Tag:MYC
      (Washington et al., 2020)
      is exacerbated by hopJF01267
      (Washington et al., 2020)
      Ras85DY4F.G12V.UAS.Tag:FLAG,Tag:polyHis
      model of  cancer
      is exacerbated by Egfr2.UAS
      (Washington et al., 2020)
      is ameliorated by Rabex-5DPYT.UAS.Tag:MYC
      (Washington et al., 2020)
      Ras85DDN.UAS.cUa
      ameliorates  Alzheimer's disease 1
      modeled by Hsap\APPAβ42.UAS.cUa
      (Cheng et al., 2021)
      Hsap\APC
      Models Based on Experimental Evidence ( 2 )
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      sna
      Models Based on Experimental Evidence ( 1 )
      Allele
      Disease
      Evidence
      References
      snaUAS.cAa
      model of  carcinoma
      CEA with Ras85DV12.UAS
      (Wu et al., 2021)
      CEA
      (Wu et al., 2021)
      Modifiers Based on Experimental Evidence ( 3 )
      Allele
      Disease
      Interaction
      References
      snaUAS.cAa
      exacerbates  carcinoma
      modeled by Ras85DV12.UAS
      (Wu et al., 2021)
      model of  carcinoma
      is ameliorated by CtBPHMS00677
      (Wu et al., 2021)
      is ameliorated by CtBPJF01291
      (Wu et al., 2021)
      snaGD1536
      ameliorates  carcinoma
      modeled by Ras85DV12.UAS, l(2)gl4
      (Wu et al., 2021)
      snaUAS.cUa
      exacerbates  intestinal cancer
      modeled by ApcQ8, Ras85DV12.cUa.UAS
      (Campbell et al., 2019)
      Apc
      Models Based on Experimental Evidence ( 4 )
      Modifiers Based on Experimental Evidence ( 1 )
      Allele
      Disease
      Interaction
      References
      ApcQ8
      model of  colorectal cancer
      is ameliorated by ewgP1
      (Tian et al., 2017)
      Apc2
      Models Based on Experimental Evidence ( 5 )
      Modifiers Based on Experimental Evidence ( 1 )
      Allele
      Disease
      Interaction
      References
      Apc2UAS.cUa
      ameliorates  Huntington's disease
      modeled by Hsap\HTTQ93.ex1.UAS
      (Dupont et al., 2012)
      esg
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 2 )
      Allele
      Disease
      Interaction
      References
      esgEP684
      exacerbates  Alzheimer's disease
      modeled by Hsap\APPAβ42.GMR.Tag:SS(rPENK)
      (Cao et al., 2008)
      esgEY10592
      exacerbates  carcinoma
      modeled by l(2)glGD4047
      (Chatterjee et al., 2023)
      Alleles Representing Disease-Implicated Variants
      Genetic Tools, Stocks and Reagents
      Sources of Stocks
      Contact lab of origin for a reagent not available from a public stock center.
      Bloomington Stock Center Disease Page
      Related mammalian, viral, bacterial, or synthetic transgenes
      Allele
      Transgene
      Publicly Available Stocks
      Hsap\APCCBD.UAS
      P{UAS-hAPC.CBD}
      Hsap\APCUAS.cBa
      P{UAS-hAPC.B}
      Selected Drosophila transgenes
      Allele
      Transgene
      Publicly Available Stocks
      snaUAS.cUa
      P{UAS-sna.U}
      snaUAS.cAa
      P{UAS-sna.A}
      Ras85DV152G.UASp
      P{UASp-Ras85D.V152G}
      Ras85DG12V.UAS.Tag:FLAG,Tag:polyHis
      P{UAS-FH-Ras85D.G12V}
      Ras85DY4F.G12V.UAS.Tag:FLAG,Tag:polyHis
      P{UAS-FH-Ras85D.Y4F.G12V}
      Ras85DV12.QUAS.cHa
      P{QUAS-Ras85D.V12.H}
      Ras85DV12.QUAS.cLa
      PBac{QUAS-Ras85D.V12.L}
      Ras85DDN.UAS.cUa
      P{UAS-Ras85D.DN.U}
      Ras85DG12D.UAS.p53sh
      P{UAS-Ras85D(G12D).UAS-p53(shRNA)}
      Ras85DV12.UAS
      P{UAS-Ras85D.V12}
      w1118; P{UAS-Ras85D.V12}TL1
      Ras85DN17.UAS
      P{UAS-Ras85D.N17}
      P{UAS-Ras85D.N17}TL1, w1118
      Ras85DG13Q.UAS
      P{UAS-Ras85B.Act}
      Ras85DV12.ey
      P{eyEh-Ras1V12}
      Ras85DV12.S35.UAS
      P{UAS-Ras85D.V12.S35}
      Ras85DQ13.UAS
      P{UAS-Ras85D.Q13}
      Ras85DV12.GMR
      P{GMR-Ras85D.V12}
      Ras85DG12V.UAS
      P{UAS-Ras85D.G12V}
      Ras85DV12.cUa.UAS
      P{UAS-Ras85D.V12.U}
      Apc2sgRNA.UAS
      P{UAS-Apc,Apc2,p53,Med,Pten,cic.sgRNA}
      Apc2UAS.cUa
      P{UAS-Apc2.U}
      ApcsgRNA.UAS
      P{UAS-Apc,Apc2,p53,Med,Pten,cic.sgRNA}
      RNAi constructs available
      Allele
      Transgene
      Publicly Available Stocks
      esgNIG.3758R
      P{NIG.3758R}
      P{NIG.3758R}1
      esgHMS02538
      P{TRiP.HMS02538}
      y1 sc* v1 sev21; P{TRiP.HMS02538}attP40/CyO
      esgGLC01862
      P{TRiP.GLC01862}
      y1 sc* v1 sev21; P{TRiP.GLC01862}attP2
      snaGD1536
      P{GD1536}
      w1118; P{GD1536}v6232
      snaGD17171
      P{GD17171}
      w1118 P{GD17171}v50003
      snaJF03094
      P{TRiP.JF03094}
      y1 v1; P{TRiP.JF03094}attP2
      snaHMS01252
      P{TRiP.HMS01252}
      y1 sc* v1 sev21; P{TRiP.HMS01252}attP2
      snaNIG.3956R
      P{NIG.3956R}
      P{NIG.3956R}2
      Ras85DTH201501177.S
      P{TH201501177.S}
      Ras85DGD12553
      P{GD12553}
      w1118; P{GD12553}v28129
      Ras85DKK108029
      P{KK108029}
      P{KK108029}VIE-260B
      Ras85DJF02478
      P{TRiP.JF02478}
      y1 v1; P{TRiP.JF02478}attP2
      Ras85DVDRC.cUa
      P{VDRC.Ras85D.U}
      Ras85DRNAi.UAS.cUa
      P{UAS-Ras85D.RNAi.U}
      Ras85DNIG.9375R
      P{NIG.9375R}
      Ras85DHMS01294
      P{TRiP.HMS01294}
      y1 sc* v1 sev21; P{TRiP.HMS01294}attP2
      Ras85DGL00336
      P{TRiP.GL00336}
      y1 sc* v1 sev21; P{TRiP.GL00336}attP2/TM3, Sb1
      Apc2HMS06090
      P{TRiP.HMS06090}
      y1 sc* v1 sev21; P{TRiP.HMS06090}attP40
      Apc2GD11854
      P{GD11854}
      w1118 P{GD11854}v22290
      Apc2KK103652
      P{KK103652}
      P{KK103652}VIE-260B
      Apc2HM05073
      P{TRiP.HM05073}
      y1 v1; P{TRiP.HM05073}attP2
      Apc2HMS00194
      P{TRiP.HMS00194}
      y1 sc* v1 sev21; P{TRiP.HMS00194}attP2
      Apc2VDRC.cUa
      P{VDRC.Apc2.U}
      ApcVDRC.cUa
      P{VDRC.Apc.U}
      ApcGD1333
      P{GD1333}
      w1118; P{GD1333}v51468
      ApcHM05070
      P{TRiP.HM05070}
      y1 v1; P{TRiP.HM05070}attP2
      ApcKK105718
      P{KK105718}
      P{KK105718}VIE-260B
      ApcHMS00188
      P{TRiP.HMS00188}
      y1 sc* v1 sev21; P{TRiP.HMS00188}attP2
      ApcNIG.1451R
      P{NIG.1451R}
      P{NIG.1451R}1
      esgRNAi.UAS.cUa
      P{UAS-esg.RNAi.U}
      esgGD1437
      P{GD1437}
      w1118; P{GD1437}v9793
      esgJF03134
      P{TRiP.JF03134}
      y1 v1; P{TRiP.JF03134}attP2
      esgHMS00025
      P{TRiP.HMS00025}
      y1 v1; P{TRiP.HMS00025}attP2
      esgNIG.3758R
      P{NIG.3758R}
      P{NIG.3758R}1
      esgHMS02538
      P{TRiP.HMS02538}
      y1 sc* v1 sev21; P{TRiP.HMS02538}attP40/CyO
      esgGLC01862
      P{TRiP.GLC01862}
      y1 sc* v1 sev21; P{TRiP.GLC01862}attP2
      Selected Drosophila classical alleles
      Allele
      Allele class
      Mutagen
      Publicly Available Stocks
      esgKI
      loss of function allele
      CRISPR/Cas9
      w*; TI{sfGFP}esgKI/CyO
      esgG66
      amorphic allele - genetic evidence
      Delta2-3 transposase
      w*; P{enG}esgG66/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7
      esgEP684
      P-element activity
      esg35Ce-3
      loss of function allele
      ethyl methanesulfonate
      esg35Ce-3 cn1 bw1 speck1 l(2)CA61VS/CyO
      esgL2
      amorphic allele - genetic evidence
      Delta2-3 transposase
      esg35Ce-1
      loss of function allele
      ethyl methanesulfonate
      Adcb-1 esg35Ce-1 l(2)CA61VS pr1 cn1 bw1/SM5
      esgshof
      amorphic allele - genetic evidence
      spontaneous
      esgEY10592
      y1 w67c23; P{EPgy2}EY10592
      sna18
      loss of function allele
      ethyl methanesulfonate
      sna18 cn1 bw1 speck1/CyO
      sna6
      amorphic allele - genetic evidence
      X ray
      sna1
      amorphic allele - genetic evidence
      ethyl methanesulfonate
      Adhn7 sna1 cn1 (vg1) / CyO, DuoxCy dpylv1 pr1 cn2
      Ras85D06677
      P-element activity
      P{PZ}Ras85D06677 ry506/TM3, ryRK Sb1 Ser1
      Ras85De2F
      sev14; Ras85De2F/TM3, Sb1
      Ras85De1B
      ethyl methanesulfonate
      sev14; Ras85De1B/TM3, Sb1
      Ras85Dunspecified
      Ras85DΔC40B
      loss of function allele
      Ras85Dx7b
      loss of function allele
      P-element activity
      Ras85DΔ17b
      amorphic allele - genetic evidence
      Apc2f90
      loss of function allele
      ethyl methanesulfonate
      Apc2g10
      amorphic allele - genetic evidence
      ethyl methanesulfonate
      Apc2N175K
      loss of function allele
      ethyl methanesulfonate
      w*; P{neoFRT}82B P{πM}87E sr1 e1 Apc2N175K/TM3, Sb1 Ser1
      Apc233
      Delta2-3 transposase
      ApcQ8
      w*; P{neoFRT}82B sr1 e1 Apc2N175K ApcQ8/TM3, P{ActGFP}JMR2, Ser1
      esgKI
      loss of function allele
      CRISPR/Cas9
      w*; TI{sfGFP}esgKI/CyO
      esgG66
      amorphic allele - genetic evidence
      Delta2-3 transposase
      w*; P{enG}esgG66/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7
      esgEP684
      P-element activity
      esgΔ
      loss of function allele
      Delta2-3 transposase
      esg35Ce-3
      loss of function allele
      ethyl methanesulfonate
      esg35Ce-3 cn1 bw1 speck1 l(2)CA61VS/CyO
      esgL2
      amorphic allele - genetic evidence
      Delta2-3 transposase
      esg35Ce-1
      loss of function allele
      ethyl methanesulfonate
      Adcb-1 esg35Ce-1 l(2)CA61VS pr1 cn1 bw1/SM5
      esgshof
      amorphic allele - genetic evidence
      spontaneous
      esgEY10592
      y1 w67c23; P{EPgy2}EY10592
      References (8)