FB2025_05 , released December 11, 2025
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Mcm2, Mcm6
FlyBase ID
FBig0000090438
Interaction Network
Interactions Browser links
Mcm2 network
Mcm6 network
Reported Interactions
FBrf0214314-4.CS.EM
Reference
Costa et al., 2011
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Mcm2 

Mcm2

neutral component
Mcm2 

Mcm2

neutral component
Mcm2 

Mcm2

neutral component
Mcm6 

Mcm6

neutral component
Mcm6 

Mcm6

neutral component
Mcm6 

Mcm6

neutral component
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; proteins produced in a baculovirus and insect cell system.

(Costa et al., 2011)

The CMG complex is captured as 55 pairwise direct or indirect interactions.

(Costa et al., 2011)
FBrf0218395-7522.DPiM
Reference
Guruharsha et al., 2011
Description
physical association
Assay
Collection
DPiM-2
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Mcm2 
unspecified role
Mcm2 
unspecified role
Mcm2 
unspecified role
Mcm6 
unspecified role
Mcm6 
unspecified role
Mcm6 
unspecified role
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

HGScore = 80.46035

FBrf0228822-8.EM
Reference
Costa et al., 2014
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Mcm2 

Mcm2

neutral component
Mcm2 

Mcm2

neutral component
Mcm2 

Mcm2

neutral component
Mcm6 

Mcm6

neutral component
Mcm6 

Mcm6

neutral component
Mcm6 

Mcm6

neutral component
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; proteins produced in baculovirus and insect cell system.

(Costa et al., 2014)

Paper reports structure of large complex. Interactions of neighboring proteins curated in pairwise fashion.

(Costa et al., 2014)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (3)