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General Information
Interaction Type
Interacting Genes
FlyBase ID
FBig0000092834
Interaction Network
Interactions Browser links
Dis3 network
Rrp6 network
esyN Network Diagram
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Protein
RNA
Selected Interactor(s)
Common Interactor(s)
Reported Interactions
FBrf0210480-9.coIP.WB
Description
physical association
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Dis3 

dDis3

bait

FLAG tag

Dis3 
Dis3 
Dis3 
Dis3 
Dis3 
Dis3 
Rrp6 

dRrp6

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Dis3 
PIN domain
mutation decreasing interaction
aa 62-189

deletion of PIN domain

Dis3 
C3 domain
mutation decreasing interaction
aa 31-63

deletion of C3 domain

Dis3 
STAG domain
mutation decreasing interaction
aa 205-222

deletion of STAG domain

Dis3 
OB1 domain
mutation decreasing interaction
aa 253-312

deletion of OB1 domain

Dis3 
OB domains
mutation decreasing interaction
aa 298-364

deletion of OB domains

Dis3 
OB2 domain
necessary binding region
aa 365-438
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

FBrf0211792-9.coIP.WB
Description
physical association
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Dis3 

dDis3

bait

FLAG tag

Dis3 
Rrp6 

dRrp6

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Dis3 
N-terminal domain
sufficient binding region
aa 1-188
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

FBrf0218395-4062.DPiM
Description
physical association
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Rrp6 
unspecified role
Rrp6 
unspecified role
Rrp6 
unspecified role
Dis3 
unspecified role
Dis3 
unspecified role
Dis3 
unspecified role
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

HGScore = 94.49542

External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (3)