FB2021_01, released Feb 18, 2021

Physical Interaction report

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General Information
Interaction Type
physical association
Interacting Genes
mxc, Spt6
FlyBase ID
FBig0000095048
Interaction Network
Interactions Browser links
mxc network
Spt6 network
esyN Network Diagram
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Protein
RNA
Selected Interactor(s)
Common Interactor(s)
Reported Interactions
FBrf0213662-2.coIP.WB
Reference
White et al., 2011
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
mxc 

MPM-2

bait
Spt6 

Spt6

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

The MPM-2 antibody, raised against human mitotic phosphoproteins, marks the histone locus body (HLB) during the S phase of Drosophila cells and reacts with phosphorylated mxc among other proteins.

(White et al., 2011)

Spt6 may coimmunoprecipitate with the MPM-2 antibody because it reacts with mxc and/or some other MPM-2-reactive HLB protein.

(White et al., 2011)

Spt6 and mxc colocalize at the HLB during S phase.

(White et al., 2011)

Bait endogenous to nuclear extract.

(White et al., 2011)

Prey endogenous to nuclear extract.

(White et al., 2011)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)