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General Information
Interaction Type
Interacting Genes
FlyBase ID
FBig0000098659
Interaction Network
Interactions Browser links
Pvr network
Cbl network
esyN Network Diagram
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Protein
RNA
Selected Interactor(s)
Common Interactor(s)
Reported Interactions
FBrf0187407-3.Y2H
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Pvr 

PVR

bait

fused to GAL4 DNA-binding domain

Pvr 
Pvr 
Pvr 
Cbl 

Cbl

prey

fused to GAL4 activation domain

Cbl 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Pvr 
intracellular domain
sufficient binding region
Pvr 
intracellular domain
mutation disrupting interaction
aa 985-1286

\'YFc\', nine Tyr-to-Phe mutations in this region

Pvr 
kinase domain
mutation disrupting interaction

kinase dead

Cbl 
PTB domain
sufficient binding region
aa 1-365
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was yeast cell line; bait produced as transgenic fusion protein; prey produced as transgenic fusion protein (prey was previously cloned reagent).

Two-hybrid system: yeast GAL4-BD/GAL4-AD

External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)