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General Information
Interaction Type
Interacting Genes
FlyBase ID
FBig0000098888
Interaction Network
Interactions Browser links
Gem2 network
icln network
esyN Network Diagram
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Protein
RNA
Selected Interactor(s)
Common Interactor(s)
Reported Interactions
FBrf0221342-3.XC
Description
physical association
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Gem2 

Gemin2

neutral component
Gem2 

Gemin2

neutral component
Gem2 

Gemin2

neutral component
icln 

pICln

neutral component
icln 
icln 

pICln

neutral component
icln 

pICln

neutral component
icln 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
icln 
N-terminal region
sufficient binding region
aa 1-180
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Purified recombinant D. melanogaster proteins Gem2, Smn and icln were mixed with human SmD1, SmD2, SmE, SmF and SmG to reconstitute the 8S spliceosome assembly intermediate.

Electron microscopy 3D reconstruction was used to position those elements of the 8S complex that could not be traced in the crystallographic electron density.

Interaction in vitro; proteins produced as a recombinant fusion proteins in bacterial system.

External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)