FB2025_01 , released February 20, 2025
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
dome, Socs36E
FlyBase ID
FBig0000100967
Interaction Network
Interactions Browser links
dome network
Socs36E network
esyN Network Diagram
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Protein
RNA
Selected Interactor(s)
Common Interactor(s)
Reported Interactions
FBrf0222708-1.coIP.WB
Reference
Stec et al., 2013
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2R+
Participants
Corresponds to
Reported as
Role
Note
dome 

Dome

bait

HA tag

Socs36E 

SOCS36E

prey

FLAG tag

Socs36E 
Socs36E 
Socs36E 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Socs36E 
N-terminal region
sufficient binding region
aa 1-576
Socs36E 
N-terminal region
necessary binding region
aa 1-459
Socs36E 
SH2 domain
mutation disrupting interaction
aa 499

R499E

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2R+ cell line; bait produced from transfected construct; prey produced from transfected construct.

(Stec et al., 2013)

Binding of Socs36E to dome does not depend upon activation of the JAK/STAT pathway, or the presence of hop.

(Stec et al., 2013)

Socs36E binds dome more strongly than hop.

(Stec et al., 2013)
FBrf0238236-5.coIP.WB
Reference
Kang et al., 2018
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
dome 

Dome

bait

GFP tag

Socs36E 

SOCS36E

prey

HA tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Kang et al., 2018)

The dome-Socs36E interaction increases with coexpression of Tor and raptor.

(Kang et al., 2018)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)