FB2025_01 , released February 20, 2025
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
CoRest, Su(var)3-3
FlyBase ID
FBig0000113090
Interaction Network
Interactions Browser links
CoRest network
Su(var)3-3 network
esyN Network Diagram
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Protein
RNA
Selected Interactor(s)
Common Interactor(s)
Reported Interactions
FBrf0180423-6.coIP.WB
Reference
Dallman et al., 2004
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
Su(var)3-3 
CoRest 

dCR

prey

V5 tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was S2 cells; bait produced from transfected construct; prey produced from transfected construct.

(Dallman et al., 2004)
FBrf0180423-7a.coIP.WB
Reference
Dallman et al., 2004
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
CoRest 

dCRL

bait

V5-tag

Su(var)3-3 

dflavo

prey

Myc tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was S2 cells; bait produced from transfected construct; prey produced from transfected construct.

(Dallman et al., 2004)
FBrf0218194-23.CH.WB
Reference
Meier et al., 2012
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Kc
Participants
Corresponds to
Reported as
Role
Note
CoRest 

dCoRest

unspecified role
CoRest 

dCoRest

unspecified role
CoRest 

dCoRest

unspecified role
Su(var)3-3 

dLsd1

unspecified role
Su(var)3-3 

dLsd1

unspecified role
Su(var)3-3 

dLsd1

unspecified role
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was nuclear extract of Kc cell line; bait produced from endogenous gene; prey produced from endogenous gene.

(Meier et al., 2012)

CoRest fractionates in two peaks suggesting two CoRest containing complexes. CoRest co-fractionates with Su(var)3-3 in one peak.

(Meier et al., 2012)
FBrf0244272-14.coIP.WB
Reference
Mačinković et al., 2019
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-B2
Participants
Corresponds to
Reported as
Role
Note
CoRest 

dCoREST

bait

GFP tag

Su(var)3-3 

dLSD1

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was nuclear extract of S2 cell line; bait produced from tagged endogenous gene; prey produced from endogenous gene.

(Mačinković et al., 2019)
FBrf0244272-16.coIP.MS
Reference
Mačinković et al., 2019
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-B2
Participants
Corresponds to
Reported as
Role
Note
CoRest 

dCoREST

bait

FLAG tag

CoRest 
Su(var)3-3 

dLSD1

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was nuclear extract of S2 cell line; bait produced from transfected construct or endogenous gene; prey produced from endogenous gene.

(Mačinković et al., 2019)
FBrf0244272-2.coIP.WB
Reference
Mačinković et al., 2019
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-B2
Participants
Corresponds to
Reported as
Role
Note
Su(var)3-3 

dLSD1

bait

FLAG tag

CoRest 

dCoREST

prey
CoRest 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was nuclear extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Mačinković et al., 2019)
FBrf0244272-4.coIP.WB
Reference
Mačinković et al., 2019
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-B2
Participants
Corresponds to
Reported as
Role
Note
CoRest 

dCoREST

bait

FLAG tag

CoRest 
Su(var)3-3 

dLSD1

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was nuclear extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Mačinković et al., 2019)
FBrf0244272-9.coIP.WB
Reference
Mačinković et al., 2019
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
CoRest 

dCoREST

bait
CoRest 
Su(var)3-3 

dLSD1

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was extract of Sf9 cell line; bait produced from a recombinant baculovirus construct; prey produced from a recombinant baculovirus construct.

(Mačinković et al., 2019)
FBrf0259942-1.BiFC.FM
Reference
Lv et al., 2024
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
Su(var)3-3 

LSD1

bait

mCerulean tag, N-terminal fragment

CoRest 

CoRest

prey

mCerulean tag, C-terminal fragment

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Figure incorrectly labeled. Interaction based on figure legend and text.

(Lv et al., 2024)

Source was live S2 cells; proteins produced from transfected constructs.

(Lv et al., 2024)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (4)