A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Reference Report

Reference
Citation Holden, J.J., Suzuki, D.T. (1973). Temperature-sensitive mutations in Drosophila melanogaster. XII. The genetic and developmental effects of dominant lethals on chromosome 3. Genetics 73(): 445--458.
FlyBase ID FBrf0025064
Type of publication Research paper
Offprint Available Yes
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PubMed ID 4349421
PubMed Abstract Out of 25,000 EMS-treated third chromosomes examined, ten dominant temperature-sensitive (DTS) lethal mutations which are lethal when heterozygous at 29 degrees C but survive at 22 degrees C were recovered. Seven of the eight mutations mapped were tested for complementation; these mutants probably define eight loci. Only DTS-2 survived in homozygous condition at 22 degrees C; homozygous DTS-2 females expressed a maternal effect on embryonic viability. Two of the mutant-bearing chromosomes, DTS-1 and DTS-6, exhibited dominant phenotypes similar to those associated with Minutes. Each of the seven mutants examined exhibited a characteristic phenotype with respect to the time of death at 29 degrees C and the temperature-sensitive period during development. Only DTS-4 exhibited dominant lethality in triploid females.
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Language of publication English
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Abbreviation Genetics
Title Genetics
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Volume range 1-
Year range 1916-
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Place of publication Austin, TX, etc
Language of publication English
ISBN/ISSN 0016-6731
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