Reference Report

Reference
Citation	Gvozdev, V.A., Gostimsky, S.A., Gerasimova, T.I., Dubrovskaya, E.S., Braslavskaya, O.Y. (1975). Fine genetic structure of the 2D3-2F5 region of the X-chromosome of Drosophila melanogaster. Mol. Gen. Genet. 141: 269--275. (Export to RIS)
FlyBase ID	FBrf0027912
Publication Type	Research paper
PubMed ID	813108
PubMed Abstract	97 lethal and semilethal mutations were induced by ethyl methanesulfonate, nitrosomethyl urea and gamma-irradiation in the 2D3-F5 region of the X-chromosome of D. melanogaster. Approximately 1 per cent of the tested X-chromosomes carried a lethal in the 2D3-2F5 region. The mutation frequencies per band or DNA content in the region and the whole X-chromosome are equal. Complementation analysis revealed at least 10 functionally independent essential loci in this region including about 10 bands. The data presented in this study support the one band--one gene hypothesis. The Pgd locus coding for 6-phosphogluconate dehydrogenase (6PGD) is mapped in the 2D3 (OR 2D4) band. Isolation of 11 lethal or semilethal point mutations with null or reduced 6PGD activity shows that the Pgd locus is a vital one.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mol. Gen. Genet.
Title	Molecular and General Genetics
Publication Year	1967-2001
ISBN/ISSN	0026-8925
Data from Reference
Aberrations (5)
	Df(1)64c18 Df(1)Pgd-kz Df(1)TEM1 Df(1)TEM304 Df(1)TEM501
Alleles (105)
	crn⁵ crn⁶ crn⁷ crn⁸ crn⁹ crn¹⁰ crn¹¹ crn¹² crn¹³ crn¹⁴ crn¹⁵ crn¹⁶ kz² kz³ kz⁴ kz⁵ kz⁶ kz⁷ kz⁸ kz⁹ kz¹⁰ kz¹¹ kz¹² kz¹³ kz¹⁴ kz¹⁵ kz¹⁶ kz¹⁷ kz¹⁸ kz¹⁹ kz²¹ kz²⁴ l(1)2Dh¹ l(1)2Ea⁹ l(1)2Ea¹⁰ l(1)2Ea¹¹ l(1)2Ea¹² l(1)2Fb⁷ l(1)2Fb⁸ l(1)2Fb⁹ l(1)2Fb¹⁰ l(1)2Fb¹¹ l(1)2Fb¹² l(1)2Fb¹³ l(1)2Fb¹⁴ l(1)2Fb¹⁵ l(1)2Fb¹⁶ l(1)2Fb¹⁷ l(1)2Fb¹⁸ l(1)2Fb¹⁹ l(1)2Fb²⁰ l(1)2Fc⁴ l(1)2Fc⁵ l(1)2Fc⁶ l(1)2Fc⁷ l(1)2Fc⁸ l(1)2Fc⁹ l(1)2Fc¹⁰ l(1)2Fd⁵ l(1)2Fd⁶ l(1)2Fd⁷ l(1)2Fd⁸ l(1)2Fd⁹ l(1)2Fd¹⁰ l(1)2Fd¹¹ l(1)2Fd¹² l(1)2Fd¹³ l(1)2Fd¹⁴ l(1)2Fd¹⁵ l(1)2Fd¹⁶ l(1)2Fd¹⁷ l(1)2Fd¹⁸ Pgd^A Pgd^B Pgd^lo13 Pgd^lo50 Pgd^lo109 Pgdⁿ¹¹ Pgdⁿ³⁵ Pgdⁿ³⁹ Pgdⁿ⁴⁵ Pgdⁿ⁷¹ Pgdⁿ⁹³ Pgdⁿ⁹⁴ Pgdⁿ¹⁰⁰ Pgdⁿ¹¹¹ wapl⁴ wapl²⁵ wapl²⁹ wapl³³ wapl³⁷ wapl³⁸ wapl⁴⁰ wapl⁴⁴ wapl⁴⁶ wapl⁴⁹ wapl⁵² wapl⁵⁶ wapl⁷³ wapl⁷⁴ wapl⁷⁹ wapl⁸⁶ wapl⁸⁷ wapl⁹⁵ wapl¹¹⁰
Genes (10)
	crn kz l(1)2Dh l(1)2Ea l(1)2Fb l(1)2Fc l(1)2Fd Pgd pn wapl