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Citation
Hall, J.C., Kankel, D.R. (1976). Genetics of acetylcholinesterase in Drosophila melanogaster.  Genetics 83: 517--535.
FlyBase ID
FBrf0028767
Publication Type
Research paper
Abstract

Genes in Drosophila melanogaster that control acetylcholinesterase (AChE) were searched for by segmental aneuploidy techniques. Homogenates of flies containing duplications or deletions for different segments were assayed for enzyme activity. A region on the third chromosome was found for which flies having one dose consistently gave lower AChE activity than euploid flies, which in turn had lower activity than flies with three doses. The activity differences were in the approximate ratio 1:2:3 . Fine structure deletion mapping within this region revealed a very small segment for which one-dose flies have approximately half-normal activity. To obtain putative AchE-null mutations, lethal mutations within this region were assayed. Four allelic lethals have approximately half-normal activity in heterozygous condition. These lethals probably define the structural locus (symbol: Ace) for AchE.

PubMed ID
PubMed Central ID
PMC1213530 (PMC) (EuropePMC)
DOI
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference