Reference Report

Reference
Citation	Ganetzky, B. (1977). On the components of Segregation Distortion in Drosophila melanogaster. Genetics 86(): 321--355. (Export to RIS)
FlyBase ID	FBrf0030142
Publication Type	Research paper
PubMed ID	407128
PubMed Abstract	The segregation distorter (SD) complex is a naturally occurring meiotic drive system with the property that males heterozygous for an SD-bearing chromosome 2 and an SD(+)-bearing homolog transmit the SD-bearing chromosome almost exclusively. This distorted segregation is the consequence of an induced dysfunction of those sperm that receive the SD(+) homolog. From previous studies, two loci have been implicated in this phenomenon: the Sd locus which is required to produce distortion, and the Responder (Rsp) locus that is the site at which Sd acts. There are two allelic alternatives of Rsp-sensitive (Rsp(sens)) and insensitive (Rsp(ins)); a chromosome carrying Rsp(ins) is not distorted by SD. In the present study, the function and location of each of these elements was examined by a genetic and cytological characterization of X-ray-induced mutations at each locus. The results indicate the following: (1) the Rsp locus is located in the proximal heterochromatin of 2R; (2) a deletion for the Rsp locus renders a chromosome insensitive to distortion; (3) the Sd locus is located to the left of pr (2-54.5), in the region from 37D2-D7 to 38A6-B2 of the salivary chromosome map; (4) an SD chromosome deleted for Sd loses its ability to distort; (5) there is another important component of the SD system, E(SD), in or near the proximal heterochromatin of 2L, that behaves as a strong enhancer of distortion. The results of these studies allow a reinterpretation of results from earlier analyses of the SD system and serve to limit the possible mechanisms to account for segregation distortion.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (56)
	Df(2L)C Df(2L)C' Df(2L)D Df(2L)D' Df(2L)E71 Df(2L)E(SD)1 Df(2L)E(SD)3 Df(2L)E(SD)36 Df(2L)F Df(2L)pr-A1 Df(2L)pr-A2 Df(2L)pr-A3 Df(2L)pr-A4 Df(2L)pr-A5 Df(2L)pr-A6 Df(2L)pr-A7 Df(2L)pr-A8 Df(2L)pr-A9 Df(2L)pr-A14 Df(2L)pr-A16 Df(2L)pr-A20 Df(2L)pr-B5 Df(2L)pr-B10 Df(2L)pr-B11 Df(2L)pr-B12 Df(2L)pr-B14 Df(2L)Sd37 Df(2L)TW65 Df(2L)TW158 Df(2L)TW161 Df(2R)B Df(2R)M41A4 Df(2R)M41A10 Df(2R)rl-1G Df(2R)rl-2J Df(2R)rl-4J Df(2R)rl-5B Df(2R)rl-6C Df(2R)rl-10G Df(2R)rl-12E Df(2R)rl-13D Df(2R)rl-14C Df(2R)rl-F Df(2R)Rsp1 Df(2R)Rsp11 Df(2R)Rsp16 Df(2R)Rsp31 Dp(2;2)RanGap^SD In(2L)E(SD)3 In(2L)SD-N3 In(2LR)SD72 In(2R)NS In(2R)SD5 T(2;3)E(SD)1 Tp(2;Y)Rsp1 Tp(2;Y)Rsp31
Alleles (4)
	RanGAP^SD RanGAP^Sd-R19 Rspⁱ¹⁶ Rspⁱ³²
Balancers (1)
	SD-5
Genes (23)
	amos ap cn crc E(SD) l(2)40Fa l(2)40Fc l(2)40Fd l(2)40Fe l(2)40Ff l(2)40Fg l(2)41Aa l(2)41Ab l(2)41Ae lt Nipped-A pr RanGAP rl RpL38 Rsp stw uex