|Citation||Ish-Horowicz, D., Pinchin, S.M., Schedl, P., Artavanis-Tsakonas, S., Mirault, M.E. (1979). Genetic and molecular analysis of the 87A7 and 87C1 heat-inducible loci of Drosophila melanogaster. Cell 18(): 1351--1358. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||Two different types of heat-inducible sequences are found at the cytogenetic loci 87A7 and 87C1 of D. melanogaster. One of these codes for the 70,000 dalton heat shock protein (hsp 70) and is found at both loci. The other type of sequence (alpha beta) codes for an RNA of unknown function and is found only at 87C1. We have completed a study of the organization of the two loci, using deficiencies that delete one or other locus, and have estimated the number of the hsp 70 genes at each locus. Thus in at least three strains of files there are a total of five coding sequences, three at 87C1 and two at 87A7. Restriction mapping of the coding regions at the two loci reveals that each of the two cytogenetic loci has its own characteristic coding sequence. The overall organization of the two loci appears to differ considerably. The alpha beta and hsp 70 heat-induced sequences at 87C1 are closely linked and are contained within two Eco RI restriction fragments.|
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|Language of Publication||English|
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