|
Reference
|
| Citation |
McGinnis, W., Farrell, J., Beckendorf, S.K. (1980). Molecular limits on the size of a genetic locus in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 77(12): 7367--7371.
|
| FlyBase ID |
FBrf0035551 |
| Type of publication |
Research paper |
| Offprint Available |
No |
|
External Crossreferences
|
| PubMed ID |
6784122 |
| PubMed Abstract |
This report places outer limits on the size of the DNA region required for expression of a Drosophila gene. This region, termed
the unit of expression, includes not only the structural gene but also any cis-acting sequences that modulate its activity.
The locus we have chosen, Sgs-4, codes for one of the glue proteins secreted by larval Drosophila salivary glands. Cytological
deficiencies have been identified that eliminate sequences on one side or the other of Sgs-4 without affecting its expression.
The ends of these deficiencies have been localized accurately with respect to restriction endonuclease sites in and near the
locus. These endpoints limit the Sgs-4 structural gene and essential flanking sequences to a 16- to 19-kilobase region of
the X chromosome. The results also show that there is no DNA sequence rearrangement in the Sgs-4 region during development
of either the polytene larval salivary glands or adult flies.
|
| Biosis |
72016848 |
| Zoological record |
|
Associated Information
|
| Comments |
|
| Text of personal communication |
|
| Associated files |
|
|
Related Publications
|
|
|
|
Also Published As
|
|
|
|
Other Reference Information
|
| Secondary IDs |
|
| Language of publication |
English |
| Additional language(s) of abstract |
|
| ISBN |
|
| Place of publication |
|
|
Published In
|
| Abbreviation |
Proc. Natl. Acad. Sci. USA |
| Title |
Proceedings of the National Academy of Sciences of the United States of America |
| Authors |
|
| Volume range |
1- |
| Year range |
1915- |
| Page range |
|
| Publisher |
|
| Place of publication |
Washington, DC |
| Language of publication |
English |
| ISBN/ISSN |
0027-8424 |
| CODEN |
PNASA6 |
|
Data from Reference
|
| Aberrations (7)
|
|
|
| Genes (4)
|
|
|
|
Home