Reference Report

Reference
Citation	Lefevre, G. (1981). The distribution of randomly recovered X-ray induced sex-linked genetic effects in Drosophila melanogaster. Genetics 99(34): 461--480. (Export to RIS)
FlyBase ID	FBrf0036522
Publication Type	Research paper
PubMed ID	6806144
PubMed Abstract	Cytogenetic analysis of more than 1500 randomly recovered lethal X chromosomes derived from 2000 and 3000 r X-ray exposures of post-meiotic male germ cells has made possible a plot of the distribution in different regions of the X chromosome of: (1) gene mutations associated with cytologically normal chromosomes, (2) mutations associated with chromosomal rearrangement breakpoints, (3) deficiencies, and (4) rearrangement breakpoints whether or not they are associated with mutations. The distribution of point mutations, vital loci and rearrangement breakpoints in different regions of the X chromosome is not proportional to either the number of bands or the relative DNA content. Further, the density of vital loci (those capable of mutating to a lethal allele) is quite different in some regions as compared to others. For example, vital loci in the 3AB region, which has been thoroughly studied by Judd and others, are at least as numerous as bands; whereas, the 3CD region, equally long, has only two vital loci. Other regions densely populated with vital loci include 1B, 1F-2A, 10A, 11A, and 19EF; sparsely populated regions include 6EF and 10B-10E. It seems reasonable to conclude that the recovered X-ray-induced mutants available for analysis do not represent a random sample of those initially induced in the exposed male germ cells.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (15)
	Df(1)fog-1 Dp(1;2)sn⁺72d Dp(1;2)v⁺63i Dp(1;2)v⁺65b Dp(1;2)w-ec Dp(1;3)sn^13a1 Dp(1;3)w^vco Dp(1;Y)y²67g19.1 Dp(1;Y)y⁺mal⁺ Tp(1;2)sn⁺72d Tp(1;2)v⁺63i Tp(1;2)v⁺65b Tp(1;2)w-ec Tp(1;3)sn^13a1 Tp(1;3)w^vco
Alleles (24)
	elav² elav⁴ eo¹ ewg⁵ Exp6¹ feo¹ fliI¹⁴ Hlc^19Ff-1 intro³ l(1)1Ac¹ l(1)1Ac¹³ l(1)1Ad² l(1)1Bc¹ l(1)19Fb¹ l(1)19Fe⁴ l(1)20Ca¹ mst² Npc1b¹⁵¹ pch⁹ shakB¹¹ sph¹ stnA¹ su(f)⁴ vnd⁶
Genes (121)
	ac bb bis br cac cin cm crm ct dlg1 dm dnc dor dsh dwg dy egh elav eo ewg Exp6 feo fliI fliK fog fw gg gt Hlc hop Hsp60 intro kz l(1)1Ac l(1)1Ad l(1)1Bc l(1)3Ag l(1)3Ah l(1)3Bb l(1)3Bc l(1)3Bd l(1)3Bf l(1)6Db l(1)6Dc l(1)7Dg l(1)9Ea l(1)10Ae l(1)10Bk l(1)10Bm l(1)10Ce l(1)10Fa l(1)10Fd l(1)10Fe l(1)10Fg l(1)11Ae l(1)19Aa l(1)19Ac l(1)19Ba l(1)19Fb l(1)19Fe l(1)20Ca l(1)20Cb l(1)LefEM1 l(1)LefEM2 l(1)LefEM3 l(1)LefEM7 l(1)LefEM20 l(1)LefEM26 l(1)LefEM27 lf lfl m mal mel mell mit(1)15 mst mul mys N Npc1b oc ot pch per Pgd pn ptg ras RpII215 RpL36 rst rtv run sc sesB sev sgg shakB slc sn sph sta stnA su(f) su(w^a) svr sw tko trol tw unc uncl v vao vnd w wap wds y z