Reference Report

Reference
Citation	Craymer, L. (1981). Techniques for manipulating chromosomal rearrangements and their application to Drosophila melanogaster. I. Pericentric inversions. Genetics 99(1): 75--97.
FlyBase ID	FBrf0036539
Type of publication	Research paper
Offprint Available	Yes
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PubMed ID	6804304
PubMed Abstract	Techniques have been developed for manipulating pericentric inversions in Drosophila that are based on the lethality of grossly aneuploid zygotes and the existence of recombinationally interconvertible genotypes for any heterozygous inversion complex: males of some of these genotypes will produce only aneuploid sperm, which can be used to rescue complementary aneuploid ova and selectively recover recombinational derivatives of inversions. Markers can be recombined into inversions through a sequence of selected single exchanges, and a novel type of duplication can be synthesized from overlapping inversions that has the characteristics of both insertional and tandem duplications; there are also applications to half-tetrad analyses.--Two cytogenetic screens are developed: (1) the dominant lethality of a large insertional-tandem duplication can be reverted by deletional events that give rise to net deficiencies or duplications, and (2) deficiencies and tandem duplications in proximal regions can be selectively recovered as the results of unequal exchanges within an inversion loop. Recombinants have been recovered between breakpoints separated by distances of as little as fifty bands, arguing against the existence of some small number of sites necessary for the initiation of recombinational pairing. In several instances, hyperploids for four to six numbered divisions were observed to be fertile in both sexes.
Biosis	74017246
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Language of publication	English
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Abbreviation	Genetics
Title	Genetics
Authors
Volume range	1-
Year range	1916-
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Place of publication	Austin, TX, etc
Language of publication	English
ISBN/ISSN	0016-6731
CODEN	GENTAE
Data from Reference
Aberrations (80)
	AS(2)C251 AS(2)S³²⁵ AS(2)Sco^rv1 AS(2)Sco^rv9 AS(2)bw^V1 AS(2)bw^V32g AS(2)ds^33k AS(2)px^52g AS(3)A114 AS(3)B158 AS(3)C190 AS(3)C267 AS(3)HR33 AS(3)LD3 AS(3)LD6 AS(3)P21 AS(3)P41 AS(3)P42 AS(3)P91 AS(3)P93 AS(3)Sta AS(3)bxd¹⁰⁶ AS(3)bxd¹⁹⁴ DS(2)S³²⁵ DS(2)bw^V1 DS(2)bw^V32g DS(2)ds^33k DS(3)HR33 DS(3)LD3 DS(3)LD6 DS(3)P21 DS(3)P41 DS(3)P42 DS(3)P93 DS(3)Sta Dp(3;3)S1 Dp(3;3)S2 In(2LR)C251 In(2LR)S³²⁵ In(2LR)Sco^rv1 In(2LR)Sco^rv9 In(2LR)bw^V1 In(2LR)bw^V32g In(2LR)ds^33k In(2LR)px^52g In(3L)HR15 In(3L)HR27 In(3L)P In(3LR)A114 In(3LR)B158 In(3LR)C190 In(3LR)C267 In(3LR)HR33 In(3LR)LD3 In(3LR)LD6 In(3LR)P21 In(3LR)P30 In(3LR)P41 In(3LR)P42 In(3LR)P91 In(3LR)P93 In(3LR)Sta In(3LR)Ubx^16R In(3LR)Ubx^U In(3LR)bxd¹⁰⁶ In(3LR)bxd¹⁹⁴ In(3LR)sep LS(2)S³²⁵ LS(2)bw^V1 LS(2)ds^33k LS(3)C267 LS(3)HR33 LS(3)LD3 LS(3)LD6 LS(3)P41 LS(3)P42 LS(3)P93 LS(3)Sta T(2;3)HR30 T(Y;3)B27
Genes (1)
	ds