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Reference
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| Citation |
Spencer, F.A., Hoffmann, F.M., Gelbart, W.M. (1982). Decapentaplegic: A gene complex affecting morphogenesis in Drosophila melanogaster. Cell 28(3): 451--461. |
| FlyBase ID |
FBrf0037609 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
6804094 |
| PubMed Abstract |
The decapentaplegic gene complex (2-4.0) in Drosophila melanogaster is defined by a series of allelic mutations affecting
imaginal disk development. Decapentaplegic (dpp) mutant individuals exhibit a variety of pattern deficiencies and duplications
in structures derived from one or more of the 15 major imaginal disks. Based on dpp mutant phenotypes, we suggest that the
dpp gene complex is involved in the elaboration of positional information within developing epidermal tissue. The dpp mutations
are recessive and fall into six phenotypic classes. Milder alleles (classes I and II) affect only one or a few disks while
most alleles (classes III, IV, V and EL) affect all major imaginal disks. Class EL homozygotes are embryonic lethals; development
is arrested before germ-band shortening late in gastrulation. Presently inseparable from EL, is a haplo-insufficient function
(Hin-d) associated with the distal (left) end of the dpp gene complex. The dpp gene complex occupies most or all of 22F1--3,
three densely staining polytene chromosome bands. A colinearity exists between map positions of the four identified functional
units within the complex and the severities of mutant phenotypes caused by disruption of these functions. Most dpp mutations
are gross chromosomal rearrangements; they exert polar effects on the decapentaplegic functions that are proximal to the rearrangement
breakpoints in 22F. Many structural similarities exist between the decapentaplegic and bithorax gene complexes.
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| Biosis |
74031857 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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| Associated files |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
Cell |
| Title |
Cell |
| Authors |
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| Volume range |
1- |
| Year range |
1974- |
| Page range |
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| Publisher |
Cell Press |
| Place of publication |
Cambridge, MA |
| Language of publication |
English |
| ISBN/ISSN |
0092-8674 |
| CODEN |
CELLB5 |
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Data from Reference
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| Aberrations (47)
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| Alleles (14)
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| Genes (5)
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